PREVALENCE OF PSEUDOMONAS CAUSING SECONDARY INFECTION IN PULMONARY TUBERCULOSIS PATIENTS

2021 ◽  
pp. 229-230
Author(s):  
Manoj Saini ◽  
Chand Bhandari
Keyword(s):  
Pulmonary Tuberculosis ◽  
Bacterial Infection ◽  
Secondary Infection ◽  
Gram Negative Bacteria ◽  
Single Centre ◽  
Tuberculosis Patients ◽  
Secondary Bacterial Infection ◽  
Active Pulmonary Tuberculosis ◽  
Pseudomonas Species ◽  
Centre Hospital

Background: Secondary bacterial infection is one of the most common complications in pulmonary tuberculosis (PTB) patients. Gram negative bacteria were commonly isolated from from adults hospitalized with secondary bacterial infection. So we conducted this study to assess the prevalence of secondary infection caused by Pseudomonas among active pulmonary tuberculosis patients. Materials and Method: It is a single centre hospital based observational study. 115 pulmonary tuberculosis patients aged above 14 years, with suspicion of secondary infection clinically or having complaints of fever, productive cough, chest pain, shortness of breath, and increased sputum purulence, inspite of taking antitubercular therapy or pulmonary tuberculosis patients with high total leucocyte counts were included. Results: Out of 115 samples sent for sputum pyogenic culture, approximately one fth (17.39%) were positive for Pseudomonas. Mean age was 46.69 ± 16.40 years in our study. Conclusion: Pseudomonas species are a major cause of secondary bacterial infection in patients with PTB on treatment.

scholarly journals Procalcitonin Increase Is Associated with the Development of Critical Care-Acquired Infections in COVID-19 ARDS

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1425
Author(s):  
Owen Richards ◽  
Philip Pallmann ◽  
Charles King ◽  
Yusuf Cheema ◽  
Charlotte Killick ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Secondary Infection ◽  
Ventilator Associated Pneumonia ◽  
C Reactive Protein ◽  
Comparative Efficacy ◽  
Blood Cell Count ◽  
Single Centre ◽  
Secondary Bacterial Infection ◽  
Reactive Protein ◽  
Insight Into

Secondary bacterial infection in COVID-19 patients is associated with increased mortality and disproportionately affects critically ill patients. This single-centre retrospective observational study investigates the comparative efficacy of change in procalcitonin (PCT) and other commonly available biomarkers in revealing or predicting microbiologically proven secondary infection in critical COVID-19 patients. Adult patients admitted to an intensive care unit (ICU) with confirmed SARS-CoV-2 infection between 9 March 2020 and 5 June 2020 were recruited to the study. For daily biomarker and secondary infection, laboratory-confirmed bloodstream infection (LCBI) and ventilator-associated pneumonia/tracheobronchitis (VAP/VAT) data were collected. We observed a PCT rise in 53 (81.5%) of the patients, a C-reactive protein (CRP) rise in 55 (84.6%) and a white blood cell count (WBC) rise in 61 (93.8%). Secondary infection was confirmed in 33 (50.8%) of the patients. A PCT rise was present in 97.0% of patients with at least one confirmed VAP/VAT and/or LCBI event. CRP and WBC rises occurred in 93.9% and 97.0% of patients with confirmed VAP/VAT and/or LCBI, respectively. Logistic regression analysis found that, when including all biomarkers in the same model, there was a significant association between PCT rise and the occurrence of LCBI and/or VAP/VAT (OR = 14.86 95%CI: 2.20, 342.53; p = 0.021). Conversely, no statistically significant relationship was found between either a CRP rise (p = 0.167) or a WBC rise (p = 0.855) and the occurrence of VAP/VAT and/or LCBI. These findings provide a promising insight into the usefulness of PCT measurement in predicting the emergence of secondary bacterial infection in ICU.

scholarly journals Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259006
Author(s):  
Ashutosh Nath Aggarwal ◽  
Ritesh Agarwal ◽  
Sahajal Dhooria ◽  
Kuruswamy Thurai Prasad ◽  
Inderpaul Singh Sehgal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pulmonary Tuberculosis ◽  
Patient Outcomes ◽  
Meta Analysis ◽  
Severe Disease ◽  
Random Effects Models ◽  
Tuberculosis Patients ◽  
Active Pulmonary Tuberculosis ◽  
Risk Of Mortality ◽  
Related Mortality

Objective The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. Methods We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. Results We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. Conclusion Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.

Is There Evidence That Antibiotics Prevent Oral Infections?

PEDIATRICS ◽  
1975 ◽  
Vol 55 (2) ◽  
pp. 294-294
Author(s):  
William T. Speck
Keyword(s):  
Bacterial Infection ◽  
Secondary Infection ◽  
Secondary Bacterial Infection ◽  
Oral Infections ◽  
Herpetic Gingivostomatitis

Dr. Alan M. Polson's article on gingival and periodontal problems in children was most informative.1 However, I found the last sentence somewhat puzzling, i.e., "Antibiotics are a help in preventing secondary infection." I wonder if the author could (1) provide evidence to substantiate his suggestion that secondary bacterial infection occur with acute herpetic gingivostomatitis and (2) substantiate his claim that antibiotics prevent such a complication?

scholarly journals Poor Vitamin D Status in Active Pulmonary Tuberculosis Patients and Its Correlation with Leptin and TNF-α

2019 ◽  
Vol 65 (5) ◽  
pp. 390-398 ◽  
Author(s):  
Qiuzhen WANG ◽  
Aiguo MA ◽  
Tianlin GAO ◽  
Yufeng LIU ◽  
Lisheng REN ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Vitamin D Status ◽  
Tuberculosis Patients ◽  
Active Pulmonary Tuberculosis ◽  
Tnf Α

scholarly journals Identification of intestinal abnormalities in patients with active pulmonary tuberculosis using small bowel capsule endoscopy

2018 ◽  
Vol 06 (09) ◽  
pp. E1103-E1108 ◽  
Author(s):  
Miwako Saitou ◽  
Daiki Nemoto ◽  
Kenichi Utano ◽  
Tomoko Suzuki ◽  
Alan Kawarai Lefor ◽  
...  
Keyword(s):  
Small Bowel ◽  
Pulmonary Tuberculosis ◽  
Capsule Endoscopy ◽  
Primary Outcome ◽  
Ileocecal Valve ◽  
Tuberculosis Patients ◽  
Active Pulmonary Tuberculosis ◽  
Intestinal Lesions ◽  
Smear Positive Pulmonary Tuberculosis ◽  
Small Intestinal

Abstract Background and study aims Mycobacterium tuberculosis is often detected in the feces of patients with active pulmonary tuberculosis. However, no study has examined the small intestine using small bowel capsule endoscopy (SBCE). This study aimed to investigate intestinal abnormalities in patients with active pulmonary tuberculosis. Patients and methods SBCE was performed in sputum/feces smear-positive pulmonary tuberculosis patients. From December 2013 to November 2016, 15 patients were enrolled from a dedicated tuberculous ward. The primary outcome was intestinal abnormalities identified by SBCE. Results Fourteen patients (median age 81 years, range 29 – 91; 3 female) underwent SBCE to the terminal ileum. The video was not recorded for one patient who was excluded from the analysis. Intestinal lesions, including 5 annular ulcers in 4 patients, were observed in 64 % (9/14). In subgroup analysis, prevalence tended to be higher in patients undergoing SBCE within 1 month of anti-tuberculous therapy (P = 0.051). Distribution of small intestinal lesions tended to be distal. Four of five annular ulcers were located close to the ileocecal valve. Conclusion Prevalence of intestinal lesions in patients with pulmonary tuberculosis is higher than expected before (UMIN 000017292)

Trace elements in blood samples of smoker and nonsmoker active pulmonary tuberculosis patients from Jamshoro, Pakistan

2017 ◽  
Vol 24 (34) ◽  
pp. 26513-26520 ◽  
Author(s):  
Zainab Manzoor Memon ◽  
Erkan Yilmaz ◽  
Afsheen Mushtaque Shah ◽  
Ugur Sahin ◽  
Tasneem Gul Kazi ◽  
...  
Keyword(s):  
Trace Elements ◽  
Pulmonary Tuberculosis ◽  
Blood Samples ◽  
Tuberculosis Patients ◽  
Active Pulmonary Tuberculosis
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