scholarly journals RESPONSE RATE OF DONORS FOR COUNSELING & NOTIFICATION AT UNIVERSITY LEVEL BLOOD CENTER OF NORTH INDIA

2020 ◽  
pp. 68-69
Author(s):  
Kusum Thakur ◽  
Kajal Khajuria ◽  
Achchhar Singh ◽  
Simranjeet Kour
Keyword(s):  
Adverse Reactions ◽  
Response Rate ◽  
Vital Role ◽  
North India ◽  
Blood Safety ◽  
Donor Pool ◽  
Major Threat ◽  
Blood Center ◽  
Blood Donor Screening ◽  
University Level

Background: Blood transfusion plays a vital role in the management of many diseases but with risk of TTI transmission & many adverse reactions. Blood donor screening and transfusion transmitted infections testing ensures blood safety, so become more stringent all over the world. Aims & objective: The main aim of this study was to assess the response rate of sero-reactive donors. Material and Methods: It was an observational and prospective study done in our department for a period of 13 months during which response rate of TTI reactive donors was analyzed from reactive donor registry. Results: In this study, total 7901 units were screened to TTI screening test. Out of which 130 units (1.6%) were found to be seroreactive. Out of 130 reactive donors, 90 (69.2%) donors were contacted and only 51 (56.6%) donors responded to call & attended counselling and referral to other department for treatment. Conclusion: Universal guidelines, protocols and confidentiality is maintained by every blood center for donor notification. Response rate of reactive donors helps us to frame guidelines to track non responding donors who pose major threat to the healthy donor pool.

scholarly journals Impact of COVID-19 pandemic on the pattern of blood donation and blood safety: Experience from a hospital-based blood center in North India

2021 ◽  
Vol 15 (2) ◽  
pp. 119
Author(s):  
Singh Bharat ◽  
Katharia Rahul ◽  
Das Indraneel ◽  
Srivastava Anubha ◽  
Priyadarshi Atul ◽  
...  
Keyword(s):  
Blood Donation ◽  
North India ◽  
Blood Safety ◽  
Blood Center

Adverse Drug Reactions to Radiographic Contrast Media in a Teaching Hospital in North India: An Observational Study

2019 ◽  
Vol 14 (2) ◽  
pp. 122-126
Author(s):  
Deepti Chopra ◽  
Abhinav Jain ◽  
Richa Garg ◽  
Shreya Dhingra
Keyword(s):  
Observational Study ◽  
Contrast Media ◽  
Adverse Drug Reactions ◽  
Teaching Hospital ◽  
Adverse Reactions ◽  
North India ◽  
Drug Reactions ◽  
Iodinated Contrast ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

Background: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non-ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. Methods:An observational study carried out for a period of six months in a teaching hospital. Contrast media induced adverse reactions were analyzed in terms of affected organs, rate, causality assessment, severity and preventability. The treatment and outcomes of adverse events were also recorded. Naranjo Probability Scale was used to evaluate the relationship between the contrast agent used and the suspected ADR. The severity of the suspected ADRs was determined using Hartwig Scale and preventability was assessed using modified Schumock and Thornton criterion. Results:A total of 15 suspected ADRs occurred in 11 patients with an incidence of 1.4%. It included 5 (45.4%) males and 6 (54.5%) females (p < 05). The highest percentage (72.7 %) of ADRs was seen in adult patients, the mean age being 40.8 years. Vomiting (33.3%) was the most common ADR noted followed by severe nausea and rashes. 64.7 % of ADRs were categorized as probable and 35.3 % were possible. Adverse reactions required treatment in 46.6% patients. There was no fatality reported. Conclusion:The reactions observed were mild to moderate in severity and occurred within 30 minutes of the administration of the contrast.

scholarly journals Medical Student Attitudes Toward Blood Donation in Times of Increased Need

2021 ◽  
pp. 000313482110110
Author(s):  
Rahima Khatun ◽  
Banan W. Otaibi ◽  
Anna Ssentongo ◽  
Joshua P. Hazelton ◽  
AmandaB. Cooper
Keyword(s):  
Medical Students ◽  
Student Attitudes ◽  
Response Rate ◽  
Blood Donation ◽  
Multivariable Analysis ◽  
The United States ◽  
Mass Casualty ◽  
Academic Institution ◽  
Donor Pool ◽  
Willingness To Donate

Background In situations of increased need, such as mass casualty incidents (MCIs) and COVID-19, donated blood products are in shortage across the United States. Medical students are a potential pool for blood donors. The aim of this study was to determine overall attitudes of medical students at a single academic institution toward blood donation during times of increased need. Methods Three anonymous REDCap surveys were administered to all medical students at a rural academic institution. Surveys 1 and 2 were administered preceding and after an institution-wide MCI drill, in September and November 2019, respectively. Survey 3 was administered following a student-organized COVID-19 blood drive in June 2020. Multivariable analysis was performed to determine if factors, ie, experience with MCI drills and emergency medical services (EMS) training, were associated with willingness to donate blood. Furthermore, barriers to donation among those not willing to donate were assessed. Results Overall response rate for MCI surveys (surveys 1 and 2) was 38% (mean age 25.2 years and 50% women). 91% (n = 210) of respondents were willing to donate blood. Previous participation in MCI drills and EMS training was not associated with higher willingness to donate blood. Response rate for survey 3 was 15.6% (59.4% women), and 30 (31.3%) respondents indicated they did not volunteer to donate blood during the COVID-19 drive. Most common reasons for not donating were “other,” medical concerns, and being out-of-town. Conclusions Majority of medical students are willing to donate blood during times of increased need and offer a possible solution to increase blood donor pool.

scholarly journals A Randomized Response Technique for Reducing the Effect of Initial Non-response of the Regression Estimator in Panel Surveys

2021 ◽  
Author(s):  
Mursala Khan
Keyword(s):  
Response Rate ◽  
Vital Role ◽  
Complex Nature ◽  
Randomized Response ◽  
Sensitive Questions ◽  
Cross Sectional ◽  
Panel Surveys ◽  
Survey Technique ◽  
Planning Methods ◽  
Family Planning Methods

Abstract The results of Sample surveys play a vital role in decision making. One of the main issues being faced by survey statisticians during the collection of survey data is the problem of non-response which may affect survey cost and accuracy of estimates. The problem of non-response becomes more severe if the survey contains sensitive questions like related to family planning methods, use of drugs. To diminish the non-response rate arising in the case of direct questioning (DQ) technique, Warner (1965) proposed an indirect survey technique known as the randomized response (RR) technique. He addressed this problem for a cross-sectional data. This method is a well-known procedure that produces more valid responses on sensitive questions in surveys. The method avoids the direct link between respondent’s response and the sensitive question through the help of a randomization device. Thereby protecting respondent’s privacy which in turn greatly increases survey response rate. However, due to the complex nature of panel estimator, the work is missing the in the context of RR technique. To cover this gap, we propose a linear regression model in the context of panel surveys/longitudinal studies under the application of the RR technique. We solve all these issues through simulation study.

scholarly journals New Clinical Applications-sintilimab Combined with Albumin-bound Paclitaxel/cisplatin in Treatment of Relapsed or Refractory ES-SCLC

2021 ◽  
Author(s):  
Lei Han ◽  
Li Li ◽  
Jinli Hao ◽  
Yuanli Lu ◽  
Shicheng Li ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Response Rate ◽  
Objective Response ◽  
Second Line ◽  
Efficacy Evaluation ◽  
Peripheral Neurotoxicity ◽  
Extensive Stage ◽  
Grade 3 ◽  
Positive Effect ◽  
Severe Adverse Reactions

Abstract Introduction: This study is aimed to evaluate the efficacy and safety of sintilimab combined with albumin-bound paclitaxel/ cisplatin as a second-line treatment in these patients with relapsed or refractory extensive-stage small cell lung cancer (ES-SCLC). Methods and Materials: ES-SCLC patients received a second-line regimen of sintilimab combined with albumin-bound paclitaxel/cisplatin. Albumin-bound paclitaxel/cisplatin can be used for up to 6 cycles. Sintilimab use was not stopped until the disease progressed or untolerable side effects occurred. After 2 cycles of chemotherapy or when the patient's condition progressed significantly, computed tomography was rechecked to observe the clinical curative effect and adverse reactions. Results: Totally 38 patients with recurrent SCLC were included for efficacy evaluation. The objective response rate and disease control rate were 26.3% and 84.2% respectively. The median PFS and OS were 6.5 months (95% CI: 3.8-7.8) and 10.8 months (95% CI: 8.5-16.2), respectively. The main adverse reactions are bone marrow suppression, alopecia, peripheral neurotoxicity, muscle and joint pain, gastrointestinal reactions, and fatigue. The severe adverse reactions (grade 3-4) are mainly leukopenia (21.1%), neutropenia (21.1%) and decreased hemoglobin (7.9%). No significant correlation was found between PD-L1 expression and efficacy.Conclusion: Sintilimab combined with albumin-bound paclitaxel/cisplatin has a positive effect on the treatment of ES-SCLC, and the adverse reactions are tolerable.

scholarly journals New Records of Cubozoan and Scyphozoan Jellyfish from Sabah Waters, Malaysia

Diversity ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 420
Author(s):  
Chee Hoe Chuan ◽  
Balu Alagar Venmathi Maran ◽  
Tzuen Kiat Yap ◽  
Kai Ching Cheong ◽  
Muhammad Ali Syed Hussein ◽  
...  
Keyword(s):  
Power Generation ◽  
Human Activities ◽  
Adverse Reactions ◽  
New Records ◽  
Skin Irritation ◽  
Vital Role ◽  
Tourism Industry ◽  
Coral Triangle ◽  
Jellyfish Species ◽  
Scyphozoan Jellyfish

Jellyfish play a vital role in the ocean’s ecosystem, acting as a nursery for young fishes, crabs, and brittle stars, as well as a source of food for certain charismatic megafauna, such as sunfish and sea turtles. They also pose a threat to human activities, with jellyfish blooms negatively impacting fisheries, power generation, and tourism. However, very little information is available on the biodiversity of jellyfish within the waters of Borneo. Here, we present new records of jellyfish found along the coast of Sabah, Malaysia, located in northern Borneo, bordering the megadiverse region of the Coral Triangle. A total of six species belonging to two classes and six families hitherto not recorded to the state are reported, Chironex yamaguchii, Acromitus maculosus, Crambione mastigophora, Linuche aquila, Netrostoma sp., and Phyllorhiza punctata. Of these, two species (C. yamaguchii and L. aquila) are harmful to humans, with C. yamaguchii capable of causing human fatalities. Reports of harmful jellyfish are useful to the medical and tourism industry, as some of these species may inflict stings and adverse reactions to humans ranging from rashes and skin irritation to fatal envenomation. A checklist has also been provided for all collected jellyfish species from Sabah waters of Borneo, Malaysia.

Automated Review of Blood Donor Screening Test Patterns at a Regional Blood Center

1992 ◽  
Vol 98 (3) ◽  
pp. 334-344 ◽  
Author(s):  
James M. Sorace ◽  
Gary E. Carnahan ◽  
G. William Moore ◽  
Jules J. Berman
Keyword(s):  
Blood Donor ◽  
Screening Test ◽  
Donor Screening ◽  
Blood Center ◽  
Blood Donor Screening

A single-arm, prospective, multicenter study on the efficacy and safety of low-dose transdermal fentanyl patch in opioid-naive patients with moderate to severe cancer pain.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24149-e24149
Author(s):  
Yong Liu ◽  
Qing Li ◽  
Yang Yu ◽  
Jie Jun Wang ◽  
Han Ping Shi
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Pain Relief ◽  
Cancer Pain ◽  
Adverse Reactions ◽  
Low Dose ◽  
Response Rate ◽  
Mainland China ◽  
Efficacy And Safety

e24149 Background: The efficacy and safety of low-dose fentanyl transdermal patch (TDF) in the treatment of opioid-naive patients with moderate-to-severe cancer pain has no tyet been confirmed. There are little international studies, and none in mainland China. The aim of this study was to explore the effect and tolerability of low dose of TDF in opioid-naive patients with Chinese moderate-to-severe cancer pain, and evaluate the influence on quality of life and cognitive function. Methods: A prospective, single-arm, non-randomized, open-label, multicenter trial was conducted with 285 opioid-naivepatients with moderate-to-severe cancer pain in 14 tertiary hospitals in mainland China. The initial analgesic dose of TDF was 12.5 µg/h, pain assessment (pain score, pain relief and pain response rate) was performed every 3 days for a total of 9 cycles.Adverse reactions and events were monitored over 24 days. In the meantime, quality of life and cognitive function of patient were evaluated with EORTC QLQ-C30 and MMSE. Results: 285 patients with 267(92.00%) completed the trial were enrolled. The average age was 60 (range 28-87) and the average effective therapeutic dose was 6.3±6.08mg.The total pain relief rate was 98.12% (mean pain score ±SD, 5.7±0.89 vs 3.9±1.28; P < 0.001). The efficacy of low-dose TDF on pain relief was consistent in groups separated by gender (p < 0.001), age (p < 0.001), types of cancer (p < 0.001), and baseline pain intensity (p < 0.001). There were 79 patients (29.59%) in the low-dose subgroup, and the pain response rate of the low-dose subgroup was better than other dose groups within one week (p = 0.0018).The adverse effects were mild. The most common adverse reactions are constipation 7.87%, followed by nausea 11.24%, vomiting 4.12%, drowsiness 1.87% and urine retention 1.5%.There was no difference in the incidence of adverse reactions between the low-dose subgroup and the other groups (p > 0.05). Meanwhile, TDF improved the quality of life of patients with moderate-to-severe cancer pain (mean± SD: 46.44±16.96 vs. 67.04±18.02;p < 0.05), without impairing cognitive function(mean ±SD, 29.13±1.54 vs. 28.98±1.99; p > 0.05). Conclusions: Low-dose TDF is effective for opioid-naive patients with moderate-to-severe cancer pain. Adverse reactions are mild and the quality of life of patients is improvedwith little losson cognitive function. Further randomized controlled studies are warranted to investigate the value of low-dose TDF in the treatment of opioid intolerant cancer pain. Clinical trial information: ChiCTR-ONC-17014080 .

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