scholarly journals RECURRENT CYSTOSACROMA PHYLLOIDES TUMOUR OF BREAST WITH LIPOSRCOMATOUS DIFFERENTIATION

2020 ◽  
pp. 72-73
Author(s):  
R. Jayaraghavan
Keyword(s):  
Striated Muscle ◽  
Wedge Resection ◽  
Phyllodes Tumor ◽  
Malignant Neoplasms ◽  
Cystosarcoma Phylloides ◽  
Stromal Sarcoma ◽  
Breast Neoplasia ◽  
Stromal Component ◽  
Phyllodes Tumours ◽  
Multiple Recurrences

Cysteosarcoma phylloides (CP) constitutes a rare form of breast neoplasia, which represents less than 1% of total breast neoplasias and only 2,3% of all fibro-epithelial breast tumors.It is termed "cystosarcoma phylloides" because of the extensions of the tumor mimicking the shape of leaves, intruding within the cystic cavities of the tumor. Phyllodes tumours of the breast are characterized by having both an epithelial as well as stromal component and these usually comprise almost 3% of all fibroepithelial tumours. They are exceptional in this aspect to convert into a stromal sarcoma of the breast after multiple recurrences. The stromal component of phyllodes tumor has the potential to undergo metaplasia to cartilage, bone, smooth muscle and striated muscle as well as their respective malignant neoplasms. The liposarcomatous differentiation of the stromal elements of phyllodes tumor is extremely rare. The recurrence rate is 1 6-28% after mastectomy or wide-wedge resection and 28- 46% after simple enucleation of the tumor. The tumor metastasizes via the vascular route; about two thirds of metastases are to the lungs, fewer are to the bone, liver, and myocardium. Phylloides tumor occurs mostly in women in their fifth or sixth decade, and occasionally in women younger than 20 years old.

scholarly journals Hormone Receptor Expression in Non Cancer Breast Lesions

2020 ◽  
pp. 180
Author(s):  
Keyword(s):  
Progesterone Receptors ◽  
Phyllodes Tumor ◽  
Receptor Expression ◽  
Breast Lesions ◽  
Ki 67 ◽  
Cancer Breast ◽  
Stromal Component ◽  
Hormone Receptor Expression ◽  
Phyllodes Tumours ◽  
A Prospective Study

Background Estrogen receptors (ER), Progesterone receptors (PR) expression is seen in non cancer breast lesions like juvenile fibroadenomas and phyllodes tumour. Materials and Methods This is a prospective study on a study population that comprised fibroadenomas and phyllodes tumor. Results While a few studies indicate that ER/PR expression correlates with a more benign outcome ,we did not see the same in our population. Ki 67 proliferation was greater in the stromal component of phyllodes tumours,compared to fibroadenomas.

scholarly journals Fine-Needle Aspiration Cytology of Cellular Basaloid Neoplasms of the Salivary Gland

2019 ◽  
Vol 143 (11) ◽  
pp. 1338-1345 ◽  
Author(s):  
Richard L. Cantley
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Malignant Neoplasm ◽  
Needle Aspiration ◽  
Malignant Neoplasms ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Stromal Component ◽  
Needle Aspiration Cytology

Context.— Cellular basaloid neoplasms of the salivary gland represent a diverse group of benign and malignant neoplasms with significant cytomorphologic overlap on fine-needle aspiration cytology. All are marked by the presence of monotonous and usually bland basaloid epithelium. Distinction between basaloid neoplasms on fine-needle aspiration cytology is based on the presence or absence of additional features, including a second cell population (eg, myoepithelial cells), an acellular stromal component, and/or cytologic atypia within the basaloid epithelium. This review highlights the cytomorphologic features of the most common cellular basaloid neoplasms of the salivary gland, with an emphasis on classification and subclassification within the Milan System. Objective.— To provide a comprehensive review of the cytologic features of basaloid epithelial neoplasms of the salivary gland, with an emphasis on classification within the Milan System for Reporting Salivary Gland Cytopathology. Data Sources.— Peer-reviewed literature, recent textbooks, and personal experiences of the author. Conclusions.— Some basaloid neoplasms, in particular pleomorphic adenomas and adenoid cystic carcinomas, may have characteristic findings on fine-needle aspiration that allow for definitive diagnosis. In other cases, however, fine-needle aspiration can confirm a neoplastic basaloid process, but specific classification of a benign or malignant neoplasm cannot be rendered. The Milan System for Reporting Salivary Gland Cytopathology acknowledges this difficulty, and recommends benign or malignant classification only when definitive diagnostic features of a specific neoplasm are present. For indeterminate cases, the subcategorization of salivary neoplasm of uncertain malignant potential is recommended.

scholarly journals Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Sawsan Ismail ◽  
Sara Alaidi ◽  
Sarah Jouni ◽  
Yahya Kassab ◽  
Zuheir Al-Shehabi
Keyword(s):  
Premenopausal Women ◽  
Phyllodes Tumor ◽  
Left Breast ◽  
Cystosarcoma Phyllodes ◽  
Rare Case Report ◽  
Long Term Follow Up ◽  
Multiple Recurrences ◽  
High Possibility

Abstract Background Fibroadenoma is the most prevalent benign breast lesion that generally affects middle-aged women; it is rare in adolescents and younger children. The transformation into malignancy is not common. However, multiple recurrences of rapidly enlarging fibroadenomas suggest a high possibility of transforming into phyllodes tumors, which are uncommon fibroepithelial lesions that account for 0.3–0.5% of female breast tumors and typically present in premenopausal women. Case presentation We report a case of a 17-year-old Syrian girl who previously had three episodes of recurrence of multiple rapidly enlarging fibroadenomas in her left breast and underwent three operations for complete resection of the lesions. However, a few months later, she was readmitted with multiple large masses in the same breast, and pathological findings confirmed a surprising combination of multiple fibroadenomas for the fourth time with a malignant phyllodes tumor (cystosarcoma phyllodes). The patient underwent lumpectomies followed by adjuvant radiotherapy. Long-term follow-up was recommended. Conclusion Our patient had an extraordinary number of episodes of recurrence at a young age and a rare combination of malignant and benign lesions in the same breast with multiple recurrences. We present her unique, very challenging case with the aim of highlighting the importance of clinical correlation, detailed diagnosis, and careful follow-up.

scholarly journals Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Hye Min Kim ◽  
Yu Kyung Lee ◽  
Ja Seung Koo
Keyword(s):  
Overall Survival ◽  
Immunohistochemical Staining ◽  
Univariate Analysis ◽  
Phyllodes Tumor ◽  
Tissue Microarrays ◽  
Histologic Grade ◽  
Cancer Associated Fibroblast ◽  
Stromal Component ◽  
Clinicopathologic Parameters ◽  
Related Proteins

Purpose. The purpose of this study was to investigate the expression of cancer-associated fibroblast- (CAF-) related proteins and the implications in breast phyllodes tumor (PT).Methods. Tissue microarrays of 194 PT cases (151 benign PT, 27 borderline PT, and 16 malignant PT) were constructed. We performed immunohistochemical staining for CAF-related proteins (podoplanin, prolyl 4-hydroxylase, FAPα, S100A4, PDGFRα/β, and NG2) and analyzed the results according to clinicopathologic parameters.Results. Expression of PDGFRαand PDGFRβin the stromal component increased with increasing histologic grade of PT (p=0.003andp=0.034, resp.). Among clinicopathologic parameters, only expression of FAPαin stroma was associated with distant metastasis (p=0.002). In univariate analysis, stromal expression of PDGFRαwas associated with shorter overall survival (p=0.002). In Cox multivariate analysis, stromal overgrowth and PDGFRαstromal positivity were associated with shorter overall survival (p=0.006andp=0.050, resp.). Furthermore, expression of PDGFRβin stroma was associated with shorter overall survival in patients with malignant PT (p=0.041).Conclusion. Stromal expression of PDGFRαand PDGFRβincreased with increasing histologic grade of PT. In addition, PDGFR stromal positivity was associated with shorter overall survival. These results suggest that CAFs are associated with breast PT progression.

scholarly journals Periductal Stromal Sarcoma of the Breast: A Case Report

2021 ◽  
Author(s):  
Elham Nazar ◽  
Zohre Shabanzadeh
Keyword(s):  
Breast Cancer ◽  
Radical Mastectomy ◽  
Phyllodes Tumor ◽  
Pathology Report ◽  
Low Grade ◽  
Case Presentation ◽  
Adjuvant Therapies ◽  
Stromal Sarcoma ◽  
Spindle Cells

Introduction: Periductal Stromal Sarcoma (PSS), especially spindle and epithelioid types, is a rare subtype of the malignant fibroepithelial tumor with benign ductal elements and a sarcomatous stroma composed of spindle cells. The therapeutic management of PSS is based on wide surgery with free margins, and adjuvant therapies are not required. Case Presentation: This report describes a 37-year-old woman who presented to Shariati hospital with a right breast mass for review and a second opinion pathology report. The patient had undergone a radical mastectomy in another hospital three months previously. Histological and immunohistochemical examinations revealed PSS and all dissected lymph nodes were free of tumor. Based on the diagnosis, the patient received no adjuvant treatment (such as chemotherapy or radiotherapy). After nine months of close follow-up examinations, no recurrence was observed. Conclusion: PSS is an extremely rare disease with low-grade sarcomatous behavior, which may evolve into a phyllodes tumor or an entity of breast cancer. Therefore, frequent follow-up examinations are required.

scholarly journals Not Every Fat-Containing Lesion on Mammogram is a Benign Finding: Case Report and Review of Breast Malignant Phyllodes Tumor with Heterologous Liposarcomatous Differentiation

2019 ◽  
Vol 9 ◽  
pp. 10
Author(s):  
Neetu Soni ◽  
Nour T Aly ◽  
Aditi Vidholia ◽  
Fabiana Policeni
Keyword(s):  
Case Report ◽  
Phyllodes Tumor ◽  
Imaging Findings ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Epithelial Component ◽  
Sarcomatous Transformation ◽  
Increased Risk ◽  
Stromal Component ◽  
Proven Case

Phyllodes tumors (PTs) are a rare fibroepithelial tumor of the breast. Histopathological confirmation of stromal and epithelial component is required for making the diagnosis of PT, and stromal component carries an increased risk of sarcomatous transformation. We present imaging findings of a histologically proven case of malignant PT with heterologous liposarcomatous transformation of the breast.

Phyllodes Tumors

2017 ◽  
Author(s):  
Tina J Hieken ◽  
Rafael E Jimenez
Keyword(s):  
High Risk ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Phyllodes Tumor ◽  
Oncologic Outcomes ◽  
Breast Adenocarcinoma ◽  
Adjuvant Radiation ◽  
Core Needle ◽  
Phyllodes Tumors ◽  
Stromal Component

Phyllodes tumors are rare primary breast neoplasms graded as benign, borderline, or malignant based on pathology characterization of the stromal component. Core-needle biopsy is recommended as the first diagnostic step for breast lesions suspicious for phyllodes. Surgical excisional biopsy is recommended for a core-needle biopsy showing cellular fibroepithelial lesion or a mass suspicious for phyllodes tumor as pathology diagnosis is challenging, especially on limited tissue specimens. Surgical treatment parallels that for soft tissue sarcoma rather than breast adenocarcinoma. Wide local excision and mastectomy, with 1 cm tumor-free margins, provide equivalent oncologic outcomes. Tumor enucleation, subtotal resection, and positive final margins should be avoided. Axillary surgery is not recommended as lymph node metastases are rare. Adjuvant radiation is not recommended as routine, nor is adjuvant chemotherapy, although either or both may be considered for primary or recurrent high-risk malignant phyllodes tumors on a case-by-case basis. Local recurrence rates are influenced by margin status and tumor grade. Distant metastases occur in up to 25% of patients with borderline/malignant tumors and bestow a poor prognosis. Recent molecular genetic analyses of phyllodes tumors have identified potentially targetable mutations that may guide future therapy for high-risk, recurrent, or metastatic phyllodes tumors. This review contains 5 figures, 5 tables, and 53 references. Key words: biomarkers, breast sarcoma, diagnosis, outcomes, pathology, phyllodes tumor, surgery, treatment

scholarly journals Rare and Challenging Tumor Entity: Phyllodes Tumor of the Prostate

2009 ◽  
Vol 2009 ◽  
pp. 1-3 ◽  
Author(s):  
Andreas Bannowsky ◽  
Andreas Probst ◽  
Helmut Dunker ◽  
Tillmann Loch
Keyword(s):  
Malignant Tumor ◽  
Transurethral Resection ◽  
Phyllodes Tumor ◽  
Malignant Potential ◽  
Histological Diagnosis ◽  
Uncertain Malignant Potential ◽  
Stromal Tumors ◽  
Stromal Sarcoma ◽  
Resection Specimen ◽  
Tumor Entity

Cystic epithelial-stromal tumors of the prostate are rare, with 82 cases reported in literature. These cases have been published under a variety of diagnoses, including phyllodes tumor and prostatic stromal proliferation of uncertain malignant potential as well as a malignant tumor called “prostatic stromal sarcoma”. We report a case of a 60-year-old man with the histological diagnosis of phyllodes tumor of the prostate in transurethral resection specimen.

scholarly journals Phyllodes Tumor of Breast: A Review Article

ISRN Surgery ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Shashi Prakash Mishra ◽  
Satyendra Kumar Tiwary ◽  
Manjaree Mishra ◽  
Ajay Kumar Khanna
Keyword(s):  
Local Excision ◽  
Surgical Planning ◽  
Tumour Size ◽  
High Sensitivity ◽  
Phyllodes Tumor ◽  
Review Article ◽  
Phyllodes Tumour ◽  
Blue Discoloration ◽  
Phyllodes Tumours

Introduction. Phyllodes tumours are rare fibroepithelial lesions. Accurate preoperative pathological diagnosis allows correct surgical planning and avoidance of reoperation. Treatment can be either wide local excision or mastectomy to achieve histologically clear margins. Discussion. The exact aetiology of phyllodes tumour and its relationship with fibroadenoma are unclear. Women aged between 35 and 55 years are commonly involved. The median tumour size is 4 cm but can grow even larger having dilated veins and a blue discoloration over skin. Palpable axillary lymphadenopathy can be identified in up to 10–15% of patients but <1% had pathological positive nodes. Mammography and ultrasonography are main imaging modalities. Cytologically the presence of both epithelial and stromal elements supports the diagnosis. The value of FNAC in diagnosis of phyllodes tumour remains controversial, but core needle biopsy has high sensitivity and negative predictive value. Surgical management is the mainstay and local recurrence in phyllodes tumours has been associated with inadequate local excision. The role of adjuvant radiotherapy and chemotherapy remains uncertain and use of hormonal therapy has not been fully investigated. Conclusion. The preoperative diagnosis and proper management are crucial in phyllodes tumours because of their tendency to recur and malignant potential in some of these tumours.

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