Clinical Biochemistry Laboratory Workload Trends 2007-2016 Including Liver Function Test in a Tertiary Care Centre

Background: The systemic antifungals like Griseofulvin, Itraconazole, Terbinafine, Ketoconazole and Fluconazole are widely used for superficial fungal infection. Hepatotoxicity with oral antifungals is well established fact. The rate of transient asymptomatic changes in liver function tests accounts for about 0.5 - 10% of all patients treated with systemic antifungals. Clinical hepatic toxicity is seen less frequently. The aim of this study is to evaluate the effect of oral Itraconazole on hepatic function and it’s efficacy in patients with extensive dermatophytosis.Methods: The total of 524 patients with extensive dermatophytosis were included in our study which was conducted in a tertiary care hospital in Navi Mumbai.Results: Itraconazole, a systemic antifungal agent is efficiently used in treatment of superficial and deep mycoses. It inhibits fungal cytochrome P450 dependent enzyme and thus impaires conversion of lanosterol to ergosterol. Adverse reactions to itraconazole includes drug reactions, gastrointestinal upset, headache, dizziness, thrombocytopenia, gynecomastia, reversible edema of extremities and metabolic side effects like hypokalemia, and hypertriglyceridemia. The level of hepatic transaminases increases in about 1%-5% of patients who have received continuous therapy with systemic itraconazole. Clinical hepatitis rarely occurs in patients and, recovery generally ensues with the cessation of medication.Conclusions: The baseline and post treatment liver function test is important to monitor if patient is on higher dose and longer duration of itraconazole therapy. The screening for high risk patients like poor liver function test, history of alcoholism, history of liver disease should be taken before stating the therapy.

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The Effect of Daily versus Weekly Levothyroxine Replacement on Thyroid Function Test in Hypothyroid Patients at a Tertiary Care Centre in Haryana

European Thyroid Journal ◽

10.1159/000477348 ◽

2017 ◽

Vol 6 (5) ◽

pp. 250-254 ◽

Cited By ~ 2

Author(s):

Rajesh Rajput ◽

Vaibhav Pathak

Keyword(s):

Thyroid Function ◽

Tertiary Care ◽

Thyroid Function Test ◽

Care Centre ◽

Tertiary Care Centre ◽

Function Test ◽

Levothyroxine Replacement ◽

Hypothyroid Patients

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Evaluation of liver function test in malaria positive cases in tertiary care hospital of Bareilly

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20202470 ◽

2020 ◽

Vol 7 (6) ◽

pp. 2193

Author(s):

Ajay Kumar Agarwal ◽

Ghanshyam Dass Katiyar ◽

Swati Khan ◽

Bharat Chand Chaudhary ◽

Arun Singh ◽

...

Keyword(s):

Liver Function ◽

Liver Function Test ◽

Serum Bilirubin ◽

Tertiary Care ◽

Plasmodium Species ◽

Care Hospital ◽

Age Group ◽

Major Health Problem ◽

Malarial Infection ◽

Function Test

Background: Malaria is a life-threatening disease. The aim of this study was to evaluate liver function test in malaria positive cases.Methods: A cross sectional study was done to find out changes in liver function test in malaria positive cases. Study was done in Central Pathology Lab, RMCH, Bareilly, Uttar Pradesh. Blood samples were collected in EDTA and plain vacutainer tube. Blood smear was examined for malaria parasite within RBCs. Malaria rapid test was done for detection of Plasmodium species and liver function test was done for effect of malaria.Results: In this study it was found that maximum malaria positive cases (25.50%) in 21-30 years age group. and in males (22.56%) in 11-20 years age group and in females (34.75%) in 21-30 years age group. Maximum cases of P. vivax (27.66%) in 21-30 years age group, P. falciparum (33.33%) in 21-30 and 41-50 years age group and mixed malarial infection (21.92%) in 31-40 years age group was found maximum P. vivax cases (51.06%) and mixed malarial infection (65.75%) in male and maximum P. falciparum (66.67%) in female was found. Maximum above normal limit serum bilirubin (63.75%), direct serum bilirubin (67.93%), SGPT (38.45%), SGOT (70.52%) and ALP (48.01%) was found in malaria positive cases. Maximum deranged serum bilirubin (83.33%), direct bilirubin (100.00%), SGOT (100.00%), ALP (83.33%) was found in P. falciparum and maximum deranged SGPT (50.68%) was found in mixed infection.Conclusions: Malaria remains a major health problem in developing countries it affects the liver function test which helps in management of malaria patient.

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Dengue: experience from a tertiary care centre in Northern Karnataka, India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20192923 ◽

2019 ◽

Vol 7 (7) ◽

pp. 2803

Author(s):

Mohammad A. Waheed

Keyword(s):

Dengue Infection ◽

Tertiary Care ◽

Public Health Problem ◽

Febrile Illness ◽

Severe Thrombocytopenia ◽

Acute Febrile Illness ◽

Care Centre ◽

Tertiary Care Centre ◽

Old Patients ◽

Function Test

Background: Epidemiology of dengue infection is evolving, and research gap exists in the region. The clinical features, laboratory parameters, complications and treatment outcomes of patients diagnosed of dengue infection at a tertiary care centre were analysed in the present study.Methods: More than 12 years old patients, presenting with features suggestive of acute febrile illness were subjected to detailed history taking and thorough clinical examination. All the suspected cases were further evaluated with complete blood count, liver function test, kidney function test, along with ultrasonography of abdomen. Blood samples were tested for dengue antibodies (IgG and IgM) by hemagglutination inhibition method for confirmation of the diagnosis. The clinical course was closely monitored during hospital stay and complications and deaths, if any, were noted.Results: Total 140 patients were studied. Fever (100%), headache (80%) and myalgia (73.6%) were the commonest symptoms. Thrombocytopenia (136, 97.1%) was the commonest hematological finding, while severe thrombocytopenia (<50,000/cu. mm) was observed in 38 (27.1%) cases. Hepatomegaly (61, 43.6%), splenomegaly (42, 30.0%), ascites (54, 38.6%), pleural effusion and gall bladder edema (18, 12.9% each) were the commonest findings on ultrasonography. Shock and ARDS were the major complications.Conclusions: Dengue remains an important public health problem even at a tertiary care centre and strong suspicion is needed in adult patients with acute febrile illness. The management should focus on averting shock and ARDS, which would help in larger aim of reduction in mortality.

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RETROSPECTIVE EVALUATION OF PRE-ANALYTICAL ERRORS IN CLINICAL BIOCHEMISTRY LABORATORY AT A TERTIARY CARE CENTRE IN RAJSAMAND, RAJASTHAN.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i7.1311 ◽

2020 ◽

Vol 4 (7) ◽

Author(s):

Richa K. Lath ◽

Umeshkumar Pareek ◽

Renu Sharma ◽

Aniruddha N. Jibhkate ◽

Ashish A. Jadhav ◽

...

Keyword(s):

Clinical Biochemistry ◽

Tertiary Care ◽

Tertiary Care Centre ◽

Percentage Occurrence ◽

Preventive Actions ◽

Ensure Patient Safety ◽

Different Types ◽

Analytical Phase ◽

Clinical Biochemistry Laboratory ◽

Analytical Errors

Background: This study was carried out to identify the causes of pre-analytical errors in the clinical biochemistry laboratory and their percentage occurrence so as to formulate the strategy for necessary corrective and preventive actions. Methods: A retrospective quantitative study was conducted in the department of biochemistry to identify the different causes of pre-analytical errors in the outpatient and inpatient samples. The sample rejection register and test requisition forms for the period of May 2018 to April 2019 were analysed and the percentage occurrence of the different types of errors was calculated. Results: Data analysis revealed that the occurrence of different errors was as follows: hemolysis (46.43%), sample not received (28.32%), insufficient quantity (8.16%), improper collection technique (7.14%), delayed transport (5.87%), wrong container (1.79%), sample clotted (1.28%), lipemic sample (0.77%) and sample exchanged during separation in lab (0.26%). Conclusion: The decline in the errors during the analytical phase of sample processing has shifted the focus towards reducing errors occurring in the pre-analytical phase. This is necessary to ensure patient safety. Keywords: Pre-analytical errors, Biochemistry, hemolysis.

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