scholarly journals Knowledge, Attitude, and Opinions of Egyptian Medical Students Toward Biobanking Issues

2021 ◽  
Author(s):  
Ahmed S. Abdelhafiz ◽  
Walaa A. Khairy ◽  
Merhan A. Fouda ◽  
Rania M. Labib ◽  
Eman A. Sultan ◽  
...  
Keyword(s):  
Medical Students ◽  
Family History ◽  
Data Protection ◽  
Positive Attitude ◽  
Research Community ◽  
Inherited Disease ◽  
Negative Family History ◽  
Similar Attitude ◽  
History Of ◽  
The Subject

ABSTRACT Introduction Biobanking is an emerging concept in Egypt. Medical students represent important future stakeholders in the research community. The objective of this work was to evaluate the knowledge, attitude, and opinions of Egyptian medical students toward biobanking issues. Methods We designed a structured survey about these issues, which was communicated online with medical students at three universities in Egypt. Results A total of 315 of 364 questionnaires were completed. More than half the students have heard the term “biobanking” before. Approximately 77% had a general positive attitude toward the concept of biobanking; however, only 57.7% were willing to participate with their own or family samples. The positive attitude toward donation was significantly higher in participants with negative family history of inherited diseases (p = 0.02). Conclusion Although some students had limited knowledge of biobanking, they had a positive attitude toward the concept in general. However, this was not reflected in a similar attitude toward donating biospecimens, especially in those with a family history of inherited disease. Moreover, they expressed concerns about data protection and samples sharing with different stakeholders. Taking all these into account, educational activities about biobanking should be given to medical students to fill the knowledge gap on the subject.

Language Onset and Concomitant Speech and Language Problems in Subgroups of Stutterers and Their Siblings

1982 ◽  
Vol 25 (4) ◽  
pp. 482-486 ◽  
Author(s):  
Robin A. Seider ◽  
Keith L. Gladstien ◽  
Kenneth K. Kidd
Keyword(s):  
Family History ◽  
Same Sex ◽  
Speech And Language ◽  
Negative Family History ◽  
Late Talkers ◽  
Language Problems ◽  
History Of ◽  
Language Onset

Time of language onset and frequencies of speech and language problems were examined in stutterers and their nonstuttering siblings. These families were grouped according to six characteristics of the index stutterer: sex, recovery or persistence of stuttering, and positive or negative family history of stuttering. Stutterers and their nonstuttering same-sex siblings were found to be distributed identically in early, average, and late categories of language onset. Comparisons of six subgroups of stutterers and their respective nonstuttering siblings showed no significant differences in the number of their reported articulation problems. Stutterers who were reported to be late talkers did not differ from their nonstuttering siblings in the frequency of their articulation problems, but these two groups had significantly higher frequencies of articulation problems than did stutterers who were early or average talkers and their siblings.

Apolipoprotein E genotypes in offspring with a positive and negative family history of premature myocardial infarction

2008 ◽  
Vol 53 (5) ◽  
pp. 387-390 ◽  
Author(s):  
Katarina Rašlová ◽  
Božena Smolková ◽  
Branislav Vohnout ◽  
Branislav Schifferdecker ◽  
Rudolf Poledne ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Family History ◽  
Apolipoprotein E ◽  
Negative Family History ◽  
Apolipoprotein E Genotypes ◽  
History Of ◽  
Premature Myocardial Infarction

scholarly journals UNRAVELING INCONTINENTIA PIGMENTI: A COMPARISON OF PHENOTYPE AND GENOTYPE VARIANTS

2018 ◽  
Vol 23 (suppl_1) ◽  
pp. e32-e32
Author(s):  
Rebecca Wang ◽  
Irene Lara-Corrales ◽  
Peter Kannu ◽  
Elena Pope
Keyword(s):  
Family History ◽  
Molecular Genetic ◽  
Retrospective Chart Review ◽  
Incontinentia Pigmenti ◽  
Clinical Approach ◽  
Negative Family History ◽  
Vesicular Rash ◽  
History Of ◽  
Phenotypic Variations ◽  
Ikbkg Gene

Abstract BACKGROUND Incontinentia pigmenti (IP) is a rare X-linked dominant genodermatosis that predominantly affects the skin, beginning with a characteristic linear vesicular rash shortly after birth. Multisystem abnormalities can further be seen in hair, nail, ocular, dental, and central nervous system. Although most affected individuals carry a common pathological deletion of the IKBKG gene, approximately 20% have no molecular confirmation. There remains a lack of understanding of phenotypic variations between mutation positive and negative patients with IP. OBJECTIVES We aim to 1) Describe clinical characteristics, phenotype, and genotype of patients with IP, and 2) Compare clinical differences between mutation positive and negative cohorts. DESIGN/METHODS A retrospective chart review was conducted at a large tertiary paediatric centre from January 1990 to June 2017, for children under 19 with a clinical diagnosis of IP by a paediatric dermatologist or geneticist. Baseline characteristics, diagnostic history, family history, cutaneous and extracutaneous symptoms were extracted. Further subspecialty reports such as dental and ophthalmology, and available laboratory results including bloodwork, histopathology, and genetic reports were reviewed. Patients who had undergone molecular genetic testing were further divided into either positive (IKBKG mutation) or negative (no identifiable mutation) genetics cohorts for analyses. RESULTS A total of 44 children with IP were identified, including 79% female, 64% white (non-hispanic), 24% with IP family history, and 85% were confirmed on biopsy. Median age at first dermatology or genetics consult was 6 weeks and 26% had undergone a full septic workup (cultures negative) prior for the IP rash. Extracutaneous involvements were common: dental (49%), ocular (32%), hair (31%), nail (15%), and neurodevelopmental (24%). Compared to the mutation positive (59%) cohort, those with negative mutations (41%) were significantly more likely to be male, have a negative family history of IP, and lower incidences of dental and hair anomalies (P <0.05). CONCLUSION Clinical approach to IP should involve not only dermatology and genetics evaluation, but may benefit from multidisciplinary monitoring for extracutaneous manifestations. Findings of unique clinical variations between positive and negative mutation cohorts suggests the need for further in-depth evaluation into key differences as they may affect disease counselling and future prognosis.

Kinetics of Ca2(+)-ATPase activation in platelet membranes of essential hypertensives and normotensives

1990 ◽  
Vol 258 (6) ◽  
pp. C988-C994 ◽  
Author(s):  
J. Takaya ◽  
N. Lasker ◽  
R. Bamforth ◽  
M. Gutkin ◽  
L. H. Byrd ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Family History ◽  
Positive Family History ◽  
Plasma Renin ◽  
Initial Reaction ◽  
Activation Kinetics ◽  
Negative Family History ◽  
History Of ◽  
Blacks And Whites ◽  
Kinetics Of

To explore the etiology of altered Ca metabolism in essential hypertension, we studied parameters, i.e., maximal initial reaction velocity (Vmax) and Michaelis constant (Km), of Ca activation kinetics of Ca2(+)-ATPase in membrane fractions (isolated by a sucrose gradient) from platelets of blacks and whites, 27 of whom were essential hypertensives, 17 of whom were normotensives with a family history of essential hypertension, and 10 of whom were normotensives without a family history of the disease. The Vmax of hypertensives was significantly lower than in normotensives without a family history of essential hypertension (hypertensives, 14.99 +/- 1.71 nmol Pi.mg protein-1.min-1; normotensives, positive family history, 22.67 +/- 3.17 nmol Pi.mg protein-1.min-1; normotensives, negative family history, 27.54 +/- 4.37 nmol Pi.mg protein-1.min-1; overall, P = 0.0078). The Km was lower in both hypertensives and normotensives with a positive family history of essential hypertension as compared with normotensives with a negative family history of the disease (hypertensives, 1.70 +/- 0.23 microM; normotensives, positive family history, 1.38 +/- 0.2 microM; normotensives, negative family history, 2.79 +/- 0.58 microM; overall, P = 0.0251). Furthermore, the Km in whites was inversely related to plasma renin activity (r = 0.50; P less than 0.005). We propose that a lower Vmax for Ca2(+)-ATPase may play a role in the higher level of free Ca in platelets of essential hypertensives and that a higher affinity of the enzyme to Ca may reflect a process compensating for the lower Vmax. We also suggest that a higher Km for Ca2(+)-ATPase in juxtaglomerular cells of whites would result in blunting the release of renin.

scholarly journals Georgy Maslov and Leonid Martynov: Meetings in the White Capital (Omsk, 1919)

2020 ◽  
Vol 15 (2) ◽  
pp. 236-253
Author(s):  
I. G. Devyatyarova
Keyword(s):  
Professional Development ◽  
Civil War ◽  
Young People ◽  
Cultural History ◽  
Positive Attitude ◽  
Decisive Role ◽  
Archival Documents ◽  
History Of ◽  
The Subject ◽  
Labor School

The subject of this article arose in connection with the study of the cultural history of Siberia during the Civil War (1918–1922). An appeal to archival documents and L. N. Martynov’s memoirs made it possible to reveal many interesting facts from the life of the White capital and recall one of its significant episodes – the meeting of the schoolboy Leonid Martynov with the Petrograd poet Georgy Maslov in the summer of 1919. They met at the book collection office creating hospital libraries in August 1919. The meeting with the first real poet made a strong impression on Leonid. Young people met often, came to each other’s homes. It is not difficult to imagine how fascinating and informatively rich were he stories of the participant in the Pushkin seminary and the university’s “Circle of Poets” for the Omsk schoolboy. Maslov introduced the schoolboy and his friends N. Kalmykov and V. Shebalin to all the “stray” writers. Maslov wrote a lot and published poetry in local periodicals, and Martynov was probably one of the first to read them. Maslov firmly adhered to the anti-Bolshevik position, and in poetry on contemporary themes he expressed his high patriotic feelings, calling on his compatriots to enlightenment. These moods influenced the young Omsk citizen. In line with the influence of Maslov on the worldview of young Martynov – a positive attitude towards the personality of A. V. Kolchak. In the spring in Soviet Omsk, Leonid left the gymnasium, which, under the new government, has now become the United Labor School. This decision, formed, of course, under the influence of Maslov, was an expression of protest and a demonstration of Martynov’s attitude to the new government. At the end of May 1920, fifteen-year-old Martynov went to Krasnoyarsk, where he met with E. Ivanov, who told him about the long, painful retreat to the east, the death of Maslov, showed him the poems he had written on the way. Returning to Omsk, Martynov meets with Maslov’s friend Tanya Solovyova, with whom they remember the poet and read his poems. At this time, Martynov conceived the idea of a poem dedicated to the memory of a friend – “Harlequinade”. In May 1922, Martynov is in Moscow, where he meets with the participants of the Omsk literary meetings and participates in an evening in memory of Maslov. The short friendship between the “Pushkinist and the Futurist” was fruitful for the young Martynov. It played a decisive role in his professional development, the forming of his literary tastes, social guidelines. The name of Georgy Maslov remained dear to Leonid Martynov until the end of his life.

scholarly journals Primary dysmenorrhea: evaluation and treatment pattern among female medical students

2018 ◽  
Vol 7 (10) ◽  
pp. 1873
Author(s):  
Sapna Gupta ◽  
Sharminder Kaur ◽  
Shamiya Sadiq ◽  
Vijay Khajuria
Keyword(s):  
Medical Students ◽  
Family History ◽  
Positive Family History ◽  
Young Female ◽  
Female Students ◽  
Age Group ◽  
Self Medication ◽  
Drug Usage ◽  
College Going ◽  
History Of

Background: Dysmenorrhea is a very common condition in females in fertile age group and its affective and somatic features often limit female mobility which results in loss of work hours. The aim of the study was to evaluate prevalence, severity, drug usage and loss of work days among young female medical students.Methods: The current questionnaire based study was done in Department of pharmacology, GMC Jammu over a period of 3 months. Female students aged between 17-24 years who consented for participation were included. The demographic profile and detailed history of dysmenorrhea was recorded.Results: Out of 342 participants, 218 females (63.7%) had history of dysmenorrhea. Most of the dysmenorrhic females had menarche between 13-14 yrs of age (73.3%) and menstrual cycle of 21-34 days (82.5%), duration of bleeding less than 6 days (91.6%) and had a positive family history of dysmenorrhea (58.7%). Majority of females had mild to moderate features of dysmenorrhea (93.4%). Most common medication was Mefenemic acid alone and in combination (90.5%). Most of the females took self-medication (69.8%) and only 30.2% took medicines on advice of doctor. 71.5% students missed their classes due to symptoms of dysmennorhea.Conclusions: Dysmenorrhea is quite prevalent among college going medical students. Most of them had positive family history. Mefenemic acid and its combination was frequently used to treat symptoms. On an average 1-2days were lost due to dysmenorrhea.

scholarly journals Dietary intake and anthropometric indices in Mexican medical students, stratified by family history of Type 2 Diabetes

2020 ◽  
Vol 24 (4) ◽  
pp. 374
Author(s):  
Gabriela Vazquez-Marroquin ◽  
Rebeca G. Elguezabal-Rodelo ◽  
Leonardo M. Porchia ◽  
Enrique Torres-Rasgado ◽  
Ricardo Pérez-Fuentes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Medical Students ◽  
Family History ◽  
Dietary Intake ◽  
Anthropometric Indices ◽  
History Of ◽  
De Medicina ◽  
Diabetes Tipo 2

Introducción: Nuestro objetivo fue evaluar la ingesta dietética y los índices antropométricos en estudiantes de medicina con historia familiar positiva de diabetes tipo 2 (FH-T2D)(+) y sin antecedentes familiares FH-T2D(-).Material y métodos: 144 estudiantes fueron analizados en este estudio transversal y observacional realizado durante el año escolar 2017-2018 mediante entrevistas y un diario de alimentos de 7 días. Los participantes se caracterizaron antropométricamente. Se calculó el ínidce cintura-cadera (WHR) y el índice cintura-altura (WHtR), el área muscular corregida de la mitad del brazo (MAMA), el índice de grasa del brazo (FAI) así como el pliegue cutáneo tricipital (TSF).Resultados:El 79,2% (95%CI: 72,5- 85,8) tenían FH-T2D. El IMC fue significativamente mayor en los participantes con FH-T2D que en aquellos sin FH-T2D (23,7 ± 3,8 v 25,0 ± 3,7, respectivamente, p <0,05). No se determinaron diferencias significativas en los índices basados en la distribución de grasa central (WHtR y WHR), la distribución periférica (FAI y TSF) o la masa muscular (MAMA), cuando se estratificó por FH-T2D. Al comparar la ingesta dietética de participantes con y sin FH-T2D, respectivamente, observamos un consumo bajo / ninguno de leguminosas [30% (95%CI: 21,4-38,2) frente a 23% (95%CI: 8,2-38,5)], dietas altas en proteínas [38,6% (95%CI: 29,7-47,5) frente a 46,7% (95%CI: 28,8-64,5)], bajas en carbohidratos [84,2% (95%CI: 77,5-90,9) frente a 83,3% (95%CI: 70,0-96,7)], y la ingesta de energía insuficiente [64% (95%CI: 55,2-72,8) frente a 56,7% (95%CI: 38,9-74,4)], donde las alteraciones en el patrón de la dieta fueron más perjudiciales para el grupo FH-T2D(+). Los participantes con FH-T2D consumieron al final del día [60% (95%CI: 50,6-68,6) frente a 54% (95%CI: 35,5-71,2)].Conclusiones: Aunque hubo diferencias mínimas significativas con el consumo por categorías de alimentos, aquellos estudiantes con FH-T2D presentaron un patrón dietético deficiente, poco variado y desequilibrado con un consumo de energía principalmente por la noche. Estos factores, si se prolongan, podrían aumentar el riesgo de desarrollar diabetes tipo 2.

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