scholarly journals АGE ASPECTS OF CHANGE OF REPRODUCTIVE FUNCTION TREASURES MANUFACTURERS

2020 ◽  
Author(s):  
О.А. Карелина ◽  
О.А. ФЕДОСОВА ◽  
Е.А. Мурашова ◽  
А.М. ЗАЙЦЕВ
Keyword(s):  
Alkaline Phosphatase ◽  
Creatine Phosphokinase ◽  
Age Groups ◽  
Reproductive Function ◽  
Abnormal Sperm ◽  
Genetic Potential ◽  
Age Related ◽  
Normative Criterion ◽  
Current Standards

Проведено исследование качества спермы с учетом возраста жеребцов-производителей. Такие показатели как объем эякулята и концентрация спермиев во всех возрастных группах соответствовали действующим нормам. Показатели активности и живучести спермиев были ниже нормативного критерия у жеребцов молодого и старшего возраста, а по количеству спермиев с анормальной морфологией в этих группах данный показатель превышен в два раза. Отмечено, что количество неполноценных спермиев у производителя уменьшается к моменту его физиологической зрелости. У полновозрастных жеребцов наблюдалось 16,8% патологий шейки и хвоста, однако это в 1,5-2 раза меньше по сравнению с другими возрастными группами производителей. Биохимические показатели спермы жеребцов, такие как общий белок и его фракции, ферменты лактатдегидрогеназа, креатинфосфокиназа, щелочная фосфатаза и гамма-глутамилтранспептидаза имели возрастную динамику и характеризовались наибольшим содержанием у полновозрастных жеребцов. Так, у молодых жеребцов и жеребцов старшего возраста было отмечено наиболее низкое содержание КФК – 1757,33 Ед/л и 783 Ед/л соответственно. У полновозрастных жеребцов уровень КФК составлял 1993,25 Ед/л. Анализ результатов позволил нам выявить четкое различие между возрастными группами по активности щелочной фосфатазы: содержание ЩФ у полновозрастных жеребцов превышает данный показатель у молодых особей в 2,6 раза и в 6,2 раза у старшего возраста. Установлено, что наиболее высоко по качеству была оценена сперма полновозрастных жеребцов. Для сохранения генетического потенциала в племенной работе следует рекомендовать выборочное использование молодых перспективных жеребцов, а также использование спермы ценных жеребцов старшего возраста. A study of the quality of sperm, taking into account the age of the stallions-producers. Such indicators as the volume of ejaculate and the concentration of sperm in all age groups corresponded to current standards. Sperm activity and vitality were lower than the normative criterion for young and older stallions, and this indicator was doubled in the number of sperm with abnormal morphology in these groups. With age, at the time of the physiological maturity of the producer, the number of abnormal sperm decreases. In full-aged stallions, 16.8% of pathologies of the neck and tail were observed, but this is 1.5-2 times less compared to other age groups of producers. Biochemical parameters of stallion sperm, such as total protein and its fractions, enzymes lactate dehydrogenase, creatine phosphokinase, alkaline phosphatase and gamma-glutamyltranspeptidase, had age-related dynamics and were characterized by the highest content in full-aged stallions. So, among young stallions and older stallions, the lowest CPK content was 1757.33 U / L and 783 U / L, respectively. In full-aged stallions, the CPK level was 1993.25 U / L. An analysis of the results allowed us to identify a clear difference between age groups in alkaline phosphatase activity: the content of alkaline phosphatase in full-aged stallions exceeds this indicator in young individuals by 2.6 times and 6.2 times in older adults. It was established that sperm of full-aged stallions was rated the highest in quality. To preserve the genetic potential in breeding, we recommend the selective use of promising young stallions, as well as the use of sperm of valuable older stallions.

scholarly journals Plasma alkaline phosphatase as a sensitive indicator of age and skeletal development in wild coscoroba swans

2010 ◽  
Vol 37 (6) ◽  
pp. 504 ◽  
Author(s):  
Cecilia P. Calabuig ◽  
Miguel Ferrer ◽  
Roberto Muriel ◽  
Vallo Tilgar
Keyword(s):  
Alkaline Phosphatase ◽  
Skeletal Development ◽  
Age Groups ◽  
Age Group ◽  
Normal Variation ◽  
Age Classes ◽  
Free Living ◽  
Longitudinal Measure ◽  
Age Related ◽  
Plasma Alkaline Phosphatase

Context. Recent studies have suggested that plasma alkaline phosphatase (ALP) can be used to assess skeletal development as well as health status in wild animals. Aims. However, the information about age-related dynamics of ALP in birds, especially in precocial species, is very scarce. Therefore, before ALP measurements can be effectively interpreted, it is necessary to determine its normal variation for each species, age group and sex. Methods. Here, we report total-ALP levels of free-living coscoroba swans (Coscoroba coscoroba) from the most important breeding and moulting population in Brazil. Data were gathered during the moulting period and categorised according to sex and the following three different age classes: chick (n = 11), young (n = 14) and mature (n = 29). Key results. ALP levels were related to the longitudinal measure of the bones, gradually diminishing with age and showing significant differences among birds of different age classes. In all age groups, no effect of sex on T-ALP concentration was detected. Conclusions. We conclude that measuring ALP facilitates the discrimination among different-aged individuals with similar plumage characteristics and body size.

Impact of patient age on quality of care in the treatment of colorectal cancer: Results from the Florida Initiative for Quality Cancer Care (FIQCC)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6548-6548
Author(s):  
E. Siegel ◽  
D. Shibata ◽  
M. Malaga ◽  
W. Fulp ◽  
J. Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Quality Of Care ◽  
Quality Indicators ◽  
Quality Care ◽  
Age Groups ◽  
Quality Improvement Effort ◽  
Patient Age ◽  
Age Related ◽  
Patient Âgé

6548 Background: The quality of colorectal cancer (CRC) treatment has been suggested to vary by age, with older patients receiving poorer quality care. As part of a state-wide quality improvement effort, the FIQCC developed and implemented methods to assess the quality of care of several cancers among practices across the state of Florida. The current report focuses on the variability of adherence to CRC quality indicators for treatment and surveillance by patient age. Methods: Medical chart reviews were conducted of all patients first seen by a medical oncologist for CRC in 2006 at one of the 10 FIQCC sites (2 academic/8 community). Abstractors were trained and periodically monitored. Abstraction focused on assessing adherence to quality indicators consistent with evidence-, consensus-, and regulatory-based guidelines. Variability in adherence across age quartiles was evaluated using a Fisher's exact test. Of the 475 patients whose charts were reviewed, 53% were male, 80% were diagnosed with colon cancer and the median age was 65 years (range 27 to 92 years). Results: Adherence was consistently (p values>.05) high across all age quartiles for presence of chemotherapy flow sheets (85%-93%), assessment of body-surface area (98%-100%) and performance of complete colon evaluation within 12 months of surgery (87%-89%). Moderate-to-low adherence was consistent by age for performance of CEA test before (74%-84%) or in the 6 months after (75%-82%) surgery/chemotherapy, and documentation of planned chemotherapy dose (51%-59%). Adherence decreased with increasing age for documentation of discussion/referral for chemotherapy in non-metastatic CRC cases (100%, 99%, 93%, and 89%; p = 0.001), but was consistently adhered to for all ages among metastatic cases (100%). The documentation of consent for patients treated with chemotherapy also varied by age-quartile (63%. 57%, 79%, and 73%; p = 0.02). Conclusions: Overall quality of CRC treatment was not consistent across the broad spectrum of patient age. Our data suggest age related disparity in the recommendation for adjuvant chemotherapy. Efforts should be made to understand the reasons for these differences and to improve and standardize the quality of CRC care for patients across all age groups. No significant financial relationships to disclose.

Age-related responses to mild restraint in the rat

1983 ◽  
Vol 55 (5) ◽  
pp. 1408-1412 ◽  
Author(s):  
B. A. Rattner ◽  
S. D. Michael ◽  
P. D. Altland
Keyword(s):  
Creatine Phosphokinase ◽  
Age Groups ◽  
Plasma Corticosterone ◽  
Aged Rats ◽  
Middle Aged ◽  
Corticosterone Concentration ◽  
Reduced Body ◽  
Age Related ◽  
Vasodilatory Activity ◽  
Luteinizing Hormone Concentration

Immature, postpubertal, young adult, and middle-aged rats were lightly restrained for 4 h. Relative to untreated controls, restraint uniformly reduced body weight and plasma luteinizing hormone concentration and elevated plasma corticosterone concentration in all age groups. However, restraint increased activities of plasma alanine and aspartate aminotransferase, creatine phosphokinase, and fructose-diphosphate aldolase in only immature and middle-aged animals. This age-related release of tissue enzymes is hypothesized to reflect enhanced responsiveness to catecholamines in immature rats, and possible ischemia related to diminished vasodilatory activity in middle-aged rats. On the basis of these changes, tolerance to restraint in postpubertal and young adults appears to be slightly greater than that of immature and middle-aged rats.

scholarly journals Blepharoptosis among Korean adults: Age-related prevalence and threshold age for evaluation

2019 ◽  
Author(s):  
Ji Sun Paik ◽  
Kyungdo Han ◽  
Suk-Woo Yang ◽  
Yongku Park ◽  
Kyungsun Na ◽  
...  
Keyword(s):  
Strong Association ◽  
Age Groups ◽  
Obese Patients ◽  
Age Group ◽  
Nutrition Examination Survey ◽  
Korean Adults ◽  
Health And Nutrition ◽  
Age Related ◽  
High Bmi

Abstract Purpose: To evaluate the prevalence of blepharoptosis among Korean adults and the characteristics of blepharoptosis patients, and to determine an appropriate age threshold for recommending blepharoptosis evaluation. Methods: The Korean National Health and Nutrition Examination Survey (KNHANES-V) was conducted in 2010–2012. We extracted data on 17,878 Korean adults aged ≥ 19 years included in KNHANES-V, and determined blepharoptosis prevalence according to age to determine the cutoff age for recommending blepharoptosis evaluation. We also determined the possible association between blepharoptosis and obesity parameters, such as body mass index (BMI) and waist circumference (WC). Results: There was a strong association between older age and the prevalence of blepharoptosis. The cutoff age for recommending blepharoptosis evaluation was 63 years for males, 70 years for females, and 66 years for all patients. Patients with a high BMI and large WC had a higher prevalence of blepharoptosis in all age groups except for those aged > 80 years. The association of blepharoptosis with BMI according to age group showed that in the 50–59 and 60–69 years age groups, blepharoptosis prevalence and BMI were higher. However, in the 70–79 and 80–89 years age groups, extremely obese patients (BMI > 30) showed a decreased blepharoptosis prevalence. Conclusions: Moderate to severe blepharoptosis can result in poor visual function and exacerbate headaches and depression, leading to decreased quality of life. This study proposed an appropriate age threshold for recommending evaluation of patients with blepharoptosis among the general population of Korea.

scholarly journals Blepharoptosis among Korean adults: Age-related prevalence and threshold age for evaluation

2020 ◽  
Author(s):  
Ji-Sun Paik ◽  
Kyungdo Han ◽  
Suk-Woo Yang ◽  
Yongkyu Park ◽  
Kyungsun Na ◽  
...  
Keyword(s):  
Strong Association ◽  
Age Groups ◽  
Obese Patients ◽  
Age Group ◽  
Nutrition Examination Survey ◽  
Korean Adults ◽  
Health And Nutrition ◽  
Age Related ◽  
High Bmi

Abstract Purpose: To evaluate the prevalence of blepharoptosis among Korean adults and the characteristics of blepharoptosis patients, and to determine an appropriate age threshold for recommending blepharoptosis evaluation. Methods: The Korean National Health and Nutrition Examination Survey (KNHANES-V) was conducted in 2010–2012. We extracted data on 17,878 Korean adults aged ≥ 19 years included in KNHANES-V, and determined blepharoptosis prevalence according to age to determine the cutoff age for recommending blepharoptosis evaluation. We also determined the possible association between blepharoptosis and obesity parameters, such as body mass index (BMI) and waist circumference (WC). Results: There was a strong association between older age and the prevalence of blepharoptosis. The cutoff age for recommending blepharoptosis evaluation was 63 years for males, 70 years for females, and 66 years for all patients. Patients with a high BMI and large WC had a higher prevalence of blepharoptosis in all age groups except for those aged > 80 years. The association of blepharoptosis with BMI according to age group showed that in the 50–59 and 60–69 years age groups, blepharoptosis prevalence and BMI were higher. However, in the 70–79 and 80–89 years age groups, extremely obese patients (BMI > 30) showed a decreased blepharoptosis prevalence. Conclusions: Moderate to severe blepharoptosis can result in poor visual function and exacerbate headaches and depression, leading to decreased quality of life. This study proposed an appropriate age threshold for recommending evaluation of patients with blepharoptosis among the general population of Korea.

Wheat-Germ Lectin Affinity Electrophoresis for Alkaline Phosphatase Isoforms in Children: Age-Dependent Reference Ranges and Changes in Liver and Bone Disease

1992 ◽  
Vol 38 (5) ◽  
pp. 663-670 ◽  
Author(s):  
P M Crofton
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Disease ◽  
Age Groups ◽  
Clinical Information ◽  
Reference Ranges ◽  
Normal Children ◽  
Lectin Affinity ◽  
Affinity Electrophoresis ◽  
Age Related ◽  
Hepatobiliary Complications

Abstract This modified lectin affinity electrophoresis method is suitable for simultaneous measurement of liver, bone, and high-molecular-mass (high-Mr) isoforms of alkaline phosphatase (ALP; EC 3.1.3.1) in children. Age-related isoform reference ranges were derived for 247 children, ages 0-13 years. Liver ALP did not appear in plasma until after six months of age, and remained constant after one year of age. Bone ALP was highest in the youngest age group, and declined to relatively constant activities thereafter. High-MrALP was not detected in normal children. In bone disease, the bone isoform was increased in all age groups. In liver disease, only 5 of 30 infants younger than six months had detectable liver ALP, although half had increased bone ALP. Among children older than six months, 5 patients with biliary atresia and 15 patients with hepatitis A all had increased liver isoform activity. Liver ALP was also a sensitive index of early hepatobiliary complications in 27 nonjaundiced children with cystic fibrosis. Measurement of ALP isoforms therefore yields useful clinical information in children older than six months but is of doubtful value in younger infants.

scholarly journals Multimodal health promotion – An approach to successful aging

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
J Gudlaugsson ◽  
P Jonsson ◽  
L Janusdottir ◽  
D Janusson ◽  
A Janusson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Promotion ◽  
Age Groups ◽  
Older Age ◽  
Metabolic Risk Factors ◽  
High Rate ◽  
Metabolic Risk ◽  
Functional Fitness ◽  
Age Related

Abstract Multimodal health promotion (MHP) is especially relevant for older persons, because of their high rate of disability, functional dependence, and use of healthcare resources. The purpose of this health promotion and research project was to assess the immediate and long-term effects of MHP on functional fitness (FF), body composition (BC), health and quality of live (HQL), and cardio metabolic risk factors (CMRF). The main objectives of the project are; 1) to promote health of older age groups so they; a) can take part in the future, both better and longer, in the activities of daily life, b) can live longer in an independent residence, c) can prevent or delay entry into residential and nursing homes, d) have the opportunity to work longer in the labor market; 2) to improve the quality of life of older age groups; 3) to reduce government and municipalities expenditures. The MHP consisted of three 6-month periods with emphasis on daily endurance training and twice-a-week strength training. This was supported by monthly lectures with emphasis on nutrition, use of medicine in connection with training, healthy ageing, mindfulness, goal-settings in old age, endurance, strength and flexibility training, and how to train. The design was a suitable sample with baseline assessment and three 6-month MHP phases. After each MHP phase, positive improvement was seen in FF, BC, HQL and CMRF. Males and females retained achieved changes and improved further at the end of each 6-month measurement. Our results suggest that regular MHP can improve or prevent decline in functional fitness in older individuals, reduce cardio metabolic risk factors, influence their health and lifestyle and positively affect their ability to stay independent, thus reducing the need for institutional care. MHP is feasible and beneficial in older populations as an integral part of prevention in municipalities and management of chronic age-related disorders.

Quality of life of Malaysian children with CHD

2017 ◽  
Vol 27 (7) ◽  
pp. 1306-1313 ◽  
Author(s):  
Lai C. Ong ◽  
Ching S. Teh ◽  
Joyce Darshinee ◽  
Asma Omar ◽  
Hak L. Ang
Keyword(s):  
Quality Of Life ◽  
Age Groups ◽  
Correlation Coefficients ◽  
Psychosocial Health ◽  
Quality Of Life Inventory ◽  
Age Related ◽  
Perception Of Quality ◽  
Life Inventory ◽  
Level Of Agreement

AbstractObjectivesThe objectives of this study were to compare the quality-of-life scores of Malaysian children with CHD and their healthy siblings, to determine the level of agreement between proxy-reports and child self-reports, and to examine variables that have an impact on quality of life in those with CHD.MethodsParental-proxy scores of the Pediatric Quality of Life Inventory 4.0 core scales were obtained for 179 children with CHD and 172 siblings. Intra-class coefficients were derived to determine the levels of proxy–child agreement in 66 children aged 8–18 years. Multiple regression analysis was used to determine factors that impacted Pediatric Quality of Life Inventory scores.ResultsProxy scores were lower in children with CHD than siblings for all scales except physical health. Maximum differences were noted in children aged 5–7 years, whereas there were no significant differences in the 2–4 and 13–18 years age groups. Good levels of proxy–child agreement were found in children aged 8–12 years for total, psychosocial health, social, and school functioning scales (correlation coefficients 0.7–0.8). In children aged 13–18 years, the level of agreement was poor to fair for emotional and social functioning. The need for future surgery and severity of symptoms were associated with lower scores.ConclusionDifferences in proxy perception of quality of life appear to be age related. The level of proxy–child agreement was higher compared with other reported studies, with lower levels of agreement in teenagers. Facilitating access to surgery and optimising control of symptoms may improve quality of life in this group of children.

scholarly journals Features of Cytokine Profile in Different Age Groups

2014 ◽  
Vol 3 ◽  
Author(s):  
Alikhan Shortanbayev ◽  
Beibitgul Bizhigitova ◽  
Anel Tarabayeva ◽  
Aliya Nurmuchanbetova
Keyword(s):  
Gradual Increase ◽  
Age Groups ◽  
The Elderly ◽  
Cytokine Profile ◽  
Age Group ◽  
Immune Parameters ◽  
Age Related ◽  
Cytokine Levels ◽  
Middle Aged Adults

Introduction. The study of the cytokine profile during aging is interesting because age-related changes of the immune status are usually correlate with the onset of specific diseases. Characteristics of cytokine activity in the elderly can not only detail the pathogenesis of the disease but also help to choose the appropriate therapeutic strategy, which in addition to the therapeutic effect could improve the quality of life of the elderly. The purpose of this study was to examine cytokine levels in older adults.Material and methods. We examined 268 people aged 45-80 years and older. All surveyed individuals were divided into 8 different age groups. All participants were tested for concentrations of IL-1β, IL-2, TNF-a and IFN-γ.Results. The study found that concentrations of TNF-a increased with age. For age group 45-49, the concentration of TNF-a was 5.94 pcg/ml. In older age groups, there was a gradual increase in cytokine concentration. In a group of centenarians, concentration of TNF-a  reached 20.55 pcg/ml, which is 3.4 times higher compared to the middle age group. Similar trends were found in the concentration of IL-1. For the age group of 45-49, the concentration of IL-1 b was 3.38 pcg/ml, and in the age group of 80 years and older, levels of this cytokine increased almost 5 times. It was found that with age-related there is a gradual decrease in the level of IL-2, and a gradual increase of IFN-γ. The decrease in IL-2 is due to the typical aging decrease in the amount of T-lymphocytes.Conclusion. Thus, our results indicate that there are significant deviations of immune parameters, particularly in cytokine concentrations, in older adults compared to middle aged adults. 

scholarly journals Assessment of the state of the reproductive system of males of Northern sled dog breeds in a kennel

2020 ◽  
Vol 222 ◽  
pp. 02052
Author(s):  
A.S. Barkova ◽  
I.M. Milshtein ◽  
E.I. Shurmanova ◽  
Aleksandr Ustiugov
Keyword(s):  
Structural Changes ◽  
Semen Quality ◽  
Sperm Quality ◽  
Age Groups ◽  
Reproductive Function ◽  
Sled Dogs ◽  
Sled Dog ◽  
Working Dogs ◽  
The Stability

Due to the increased interest in sledding in dogs, the assessment of their reproductive function, in particular breeding males, is also relevant at the present time. In the course of the work, the prostate condition was assessed in breeding working animals in a kennel, as well as the quality of sperm in working dogs of different ages, as well as in non-working groups. The results showed that in 16.8% of males the prostate is not enlarged, the echostructure is uniform, the contours are even, and the echogenicity is normal. A slight increase in the organ without structural changes is observed in 42% of the examined animals and the same number of dogs (42%), have echostructural changes and increased organ size. Prostate enlargement in most of the examined males of the kennel may be associated with the crowding of their content, as well as the presence of bitches in neighboring enclosures. When assessing semen quality in workers of different age groups and non-group males in various time intervals at different intensity of physical activity. it is noted that the stability of sperm quality identified in males outside of the group, while animals in the system having both long and short-term physical load sperm quality is subject to considerable fluctuations. Thus, under intense load, the sperm quality indicators correspond to the reference values in animals of all groups, while during the long period of rest, working sled dogs have a significant decrease in the quality of sperm, which negatively affects their fertility.

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