scholarly journals COVID-19 in pediatric population

2021 ◽  
pp. 100-114
Author(s):  
G. P. Evseeva ◽  
R. S. Telepneva ◽  
E. V. Knizhnikova ◽  
S. V. Suprun ◽  
S. V. Pichugina ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Clinical Manifestations ◽  
Limited Data ◽  
Biological Mechanisms ◽  
Missed Opportunities ◽  
Persistent Symptoms ◽  
Global Spread ◽  
Patients At Risk ◽  
Coronavirus Infection

Introduction. The global spread of SARS-CoV-2 coronavirus infection worldwide determines the need to study the clinical features, complications, extrapulmonary manifestations and long-term consequences of the infection in children. While many studies have been described in adult patients, there are limited data analyzing the clinical course of the disease in pediatric patients infected with SARS-CoV-2. Aim. Review of the literature containing currently reported cases of SARS-CoV-2 infection in children to present the state of the art, understand the direction of research and unresolved issues. Materials and methods. An analysis of publications containing data from studies of SARS-CoV-2 cases in children was carried out. Results. Researchers from different countries agree that children are less susceptible to COVID19. This can create a dangerous situation, which can lead to a weakening of attention to children. Although their clinical manifestations are mainly mild to moderate symptoms, nevertheless, severe cases of the disease occur in children, which can lead to death. Conclusion. The complexity and variability of COVID-19 manifestations support the hypothesis that further research is needed on the long-term and chronic symptoms of COVID-19 in children. Failure to understand the underlying biological mechanisms behind these persistent symptoms increases missed opportunities to identify patients at risk of chronicity in order to prevent such conditions and seek rehabilitation approaches for children with COVID-19. 

scholarly journals Long COVID: long-term effects?

2021 ◽  
Vol 23 (Supplement_E) ◽  
pp. E1-E5
Author(s):  
Alessandro Di Toro ◽  
Antonio Bozzani ◽  
Guido Tavazzi ◽  
Mario Urtis ◽  
Lorenzo Giuliani ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Long Term Effects ◽  
Non Invasive ◽  
Clinical Events ◽  
Cardiovascular Involvement ◽  
Patients At Risk ◽  
Ischaemic Attack ◽  
Diagnostic Framework ◽  
Open Question

Abstract The term Long COVID (or Post COVID) describes a condition characterized by persistence of symptoms for at least 12 weeks after the onset of COVID-19. It may last several months but the duration is still matter of observation. The symptoms and the clinical manifestations are clinically heterogeneous and suggesting involvement of multi-organs/systems, including the cardiovascular system. The general recurrent symptoms include fatigue, breathlessness, myalgia, headache, loss of memory, and impaired concentration. Patients report loss of their previous psychophysical performance. Cardiovascular involvement manifests with common symptoms such as palpitations and chest pain, and, less commonly, with events such as late arterial and venous thromboembolisms, heart failure episodes, strokes or transient ischaemic attack, ‘myo-pericarditis’. The diagnostic criteria are mainly based on the narrative of the patients. Measurable biomarkers or instrumental findings or clinical events are not yet framed in a shared diagnostic framework. The open question for clinicians and researchers is whether biomarkers, electrocardiogram, non-invasive imaging, and clinical monitoring should be included in a shared diagnostic protocol aimed at defining the diagnostic path and protecting patients at risk of unexpected events.

TUBERCULOSIS UNDER CONDITIONS OF NOVEL CORONAVIRUS INFECTION

2021 ◽  
Vol 100 (2) ◽  
pp. 153-157
Author(s):  
A.A. Starshinova ◽  
◽  
A.M. Malkova ◽  
A.Ya. Starshinova ◽  
V.E. Karev ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Skin Tests ◽  
High Incidence ◽  
Treatment Facilities ◽  
Coronavirus Infection ◽  
The One ◽  
Novel Coronavirus ◽  
Made In

Tuberculosis (TB) remains an important medical and social problem up to today. In recent years, great strides have been made in the fight against tuberculosis infection (TI) in reducing TB morbidity and mortality, especially in the Russian Federation. Emergence of new COVID-19 infection in the world has led to the need for long-term isolation of the population, on the one hand, and the need to resort to personal protective equipment, on the other. The spread of COVID-19 may have an impact on the increase in TB morbidity, despite the decrease in the incidence rate, which is related to objective difficulties in detecting TB and complexity of the structure of clinical manifestations of the disease against the background of coronavirus infection and severe complications after COVID-19. The use of immunosuppressive therapy in the treatment of COVID-19 may cause immunosuppression, which will affect the results of TI immunodiagnostics using skin tests. At the same time, IGRA tests can be useful in these conditions, since they are of great diagnostic value. Equally important is the reduction of patient visits to treatment facilities in the context of a pandemic or a high incidence of COVID-19.

scholarly journals Pediatric HIV Long-Term Nonprogressors

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
B. H. Rimawi ◽  
R. H. Rimawi ◽  
M. Micallef ◽  
L. Pinckney ◽  
S. L. Fowler ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Adult Population ◽  
Viral Fitness ◽  
Pediatric Hiv ◽  
Limited Data ◽  
Viral Loads ◽  
Rapid Progressors ◽  
Perinatally Infected ◽  
Serologic Evidence

Patients infected with HIV are best categorized along a continuum from rapid progressors to HIV long-term nonprogressors. Long-term nonprogressors (LTNPs) are those in which AIDS develop many years after being infected with HIV, often beyond the 10-year mark, and represent 15–20% of the HIV infected patients. Many of these patients are able to control their infection and maintain undetectable viral loads for long periods of time without antiretroviral therapy. After a comprehensive literature search, we found extensive data related to HIV LTNPs in the adult population; however, very limited data was available related to LTNPs within the pediatric population. We present a case of pediatric HIV LTNPs, perinatally infected patient with undetectable viral loads, despite never receiving ART. Although there are not many instances of LTNPs among children, this child may be one, though she had intermittent viremia. She has continued to manifest serologic evidence of infection, with yearly ELISA and western blot positive tests. Based on the viral fitness studies that were performed, this case exemplifies an adolescent LTNP.

scholarly journals Postacute COVID-19: An Overview and Approach to Classification

2020 ◽  
Vol 7 (12) ◽  
Author(s):  
Eva M Amenta ◽  
Amy Spallone ◽  
Maria C Rodriguez-Barradas ◽  
Hana M El Sahly ◽  
Robert L Atmar ◽  
...  
Keyword(s):  
Large Volume ◽  
Medical Literature ◽  
Acute Infection ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Persistent Symptoms

Abstract As the coronavirus disease 2019 (COVID-19) pandemic has progressed, a large volume of literature has developed delineating the clinical manifestations of acute infection. Recent reports have also started to describe persistent symptoms extending beyond the period of initial illness or hospitalization. Anecdotes of different signs and symptoms occurring after acute infection have also arisen in the lay press. Here we describe the current existing medical literature on the emerging concept of postacute COVID-19 and suggest an approach to classifying different manifestations of the syndrome. We also review long-term clinical manifestations observed in patients who recovered from infection due to other epidemic coronaviruses and briefly discuss potential mechanisms driving the phenomenon of postacute COVID-19.

scholarly journals Living with ‘Long COVID-19’: The long-term complications and sequelae

2021 ◽  
Vol 5 (1) ◽  
pp. 011-021
Author(s):  
Nikhra Vinod
Keyword(s):  
Healthcare Providers ◽  
Clinical Manifestations ◽  
Organ Damage ◽  
Long Term Effects ◽  
Genomic Changes ◽  
Persistent Symptoms ◽  
Inflammatory Changes ◽  
Symptoms And Signs ◽  
Variable Presentation

Introduction - the perennial pandemic: It is being increasingly realised that the COVID-19 may have become the new reality associated with human existence world over and the mankind may have to live with it for years or even decades. Further, the grievous nature of the disease is evolving further with the genomic changes in the virus in form of mutations and evolution of variants, with enhanced infectivity and probably virulence. There are serious challenges posed by the SARS-CoV-2 virus and COVID-19 as the disease. COVID-19 as acute and chronic disease: On exposure to the SARS-CoV-2 virus, not all patients develop a disease. Further, for those who develop the disease, there is a large variation in disease severity. The known factors including the constituent factors and several still unknown factors influence the disease manifestations, its course, and later the convalescent phase as well. In fact, substantial continuing morbidity after resolution of the infection indicates persisting multisystem effects of COVID-19. The ‘long COVID-19’ or ‘long haulers’: The patients who continue to suffer with persisting symptoms have been described as long haulers and the clinical condition has been called post-COVID-19 or ‘long COVID-19’. The diagnosis should be entertained if various symptoms and signs linger well beyond the period of convalescence in COVID-19. With the chronicity, there occur inflammatory changes and damage in various organs, and the extent of organ damage determines the long-term effects. Management of ‘long COVID’ syndrome: The ‘long COVID’ syndrome has multi-system involvement, variable presentation, and unpredictable course. Following clinical and investigational assessment, the patients should be managed as per clinical manifestations, extent of organ damage and associated complications. The findings from various studies indicate that preventing further organ damage in ‘long COVID’ is crucial. The long COVID’s prognostic challenges: As apparent, the ‘long COVID’ afflictions are more common than realized earlier. The symptoms can escalate in patients with co-morbid conditions. The persistent symptoms among COVID-19 survivors pose new challenges to the healthcare providers and may be suitably managed with a combination of pharmacological and non-pharmacological treatments, and holistic healthcare.

scholarly journals Coronavirus Infection in Children

2020 ◽  
Vol 3 (S1) ◽  
pp. 5-8
Author(s):  
Bannova Svetlana Leonidovna ◽  
Puzyrev Viktor Gennadievich
Keyword(s):  
High Mortality ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Age Group ◽  
Coronavirus Infection

SARS-COV-2 is a highly contagious anthroponotic infection. The relevance of the study of the disease is due to the wide prevalence of the pandemic worldwide to the extent that it affects all age groups and populations, the lack of long-term and intense immunity, and high mortality, mainly among adults.Children are also susceptible to SARS-COV-2 infection, but this age group is more likely to be asymptomatic. This article summarizes the main trends in clinical manifestations and treatment of coronavirus infection in children available in current moment.

scholarly journals Beyond the adrenals: Organ manifestations in inherited primary adrenal insufficiency in children

2020 ◽  
Vol 182 (3) ◽  
pp. C9-C12
Author(s):  
Clemens Kamrath
Keyword(s):  
Adrenal Insufficiency ◽  
Bone Growth ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Term Treatment ◽  
Primary Adrenal Insufficiency ◽  
Long Term Treatment ◽  
Wide Range ◽  
Organ Manifestations

Primary adrenal insufficiency (PAI) in children is mostly due to genetic defects. The understanding of the molecular genetics of the causes of adrenal insufficiency in the pediatric population has made significant progress during the last years. It has been shown that inherited PAI can lead to certain clinical manifestations and health problems in children beyond the adrenals. Organ dysfunctions associated with different forms of PAI in children include a wide range of organs such as gonads, brain, heart, bone, growth, bone marrow, kidney, skin, parathyroid, and thyroid. Diagnosing the correct genetic cause of PAI in children is therefore crucial to adequately control long-term treatment and follow-up in such patients.

ENDOSCOPIC TREATMENT OF CHRONIC PANCREATITIS IN PEDIATRIC POPULATION: LONG-TERM EFFICACY AND SAFETY

2019 ◽  
Author(s):  
D Kohoutova ◽  
A Tringali ◽  
G Paparella ◽  
V Perri ◽  
I Boškoski ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Endoscopic Treatment ◽  
Pediatric Population ◽  
Efficacy And Safety ◽  
Term Efficacy

Skull base aneurysmal bone cyst presenting with hydrocephalus: progressive residuum obliterated by Gamma Knife stereotactic radiosurgery in a pediatric patient

2020 ◽  
Vol 26 (1) ◽  
pp. 76-81
Author(s):  
George H. Tse ◽  
Feng Y. Jiang ◽  
Matthias W. R. Radatz ◽  
Saurabh Sinha ◽  
Hesham Zaki
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Pediatric Population ◽  
Bone Cyst ◽  
Disease Free Survival ◽  
Long Term Follow Up ◽  
Aneurysmal Bone Cysts ◽  
Gamma Knife Stereotactic Radiosurgery

Aneurysmal bone cysts (ABCs) are an uncommon entity predominantly encountered in the pediatric population. The skull is rarely involved, but these cysts have been reported to arise in the skull base. Traditional treatment has been with surgery alone; however, there is a gathering body of literature that reports alternative treatments that can achieve long-term disease-free survival. However, these therapies are predominantly directed at peripheral skeletal lesions. To the authors’ knowledge, this report is the first to describe long-term follow-up of the efficacy of Gamma Knife stereotactic radiosurgery for treatment of ABC residuum in the skull base that resulted in long-term patient stability and likely ABC obliteration.

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