scholarly journals INHIBITORY EFFECT AND FACTORS OF CHEMICAL STRUCTURE OF VINYL ETHERS OF AMINO ALCOHOLS

2020 ◽  
Vol 2020 (1) ◽  
pp. 76-81
Author(s):  
Elena Kovalyuk
Keyword(s):  
Molecular Weight ◽  
Nitrogen Atom ◽  
Total Energy ◽  
Ionization Potential ◽  
Chemical Structure ◽  
Amino Alcohols ◽  
Inhibitory Effect ◽  
Vinyl Ethers ◽  
The Relationship ◽  
Atom Ionization

The article presents the results of a study of the relationship between the inhibitory properties and factors of the chemical structure (electron density on the nitrogen atom, ionization potential, molecular weight, total energy) of vinyl ethers of amino alcohols

scholarly journals Inhibitory Effect of Gamma-Irradiated Chitosan on the Growth of Denitrifiers

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Javier Vilcáez ◽  
Tomohide Watanabe
Keyword(s):  
Molecular Weight ◽  
Surface Charge ◽  
Growth Rates ◽  
Chemical Structure ◽  
Inhibitory Effect ◽  
Denitrifying Bacteria ◽  
Environmentally Benign ◽  
Inhibitory Agents ◽  
Gamma Irradiated ◽  
Modification Of The Surface

In order to find an environmentally benign substitute to hazardous inhibitory agents, the inhibitory effect of -irradiated chitosans against a mixed culture of denitrifying bacteria was experimentally evaluated. Unlike other studies using pure aerobic cultures, the observed effect was not a complete inhibition but a transient inhibition reflected by prolonged lag phases and reduced growth rates. Raw chitosan under acid conditions (pH 6.3) exerted the strongest inhibition followed by the 100 kGy and 500 kGy irradiated chitosans, respectively. Therefore, because the molecular weight of chitosan decreases with the degree of -irradiation, the inhibitory properties of chitosan due to its high molecular weight were more relevant than the inhibitory properties gained due to the modification of the surface charge and/or chemical structure by -irradiation. High dosage of -irradiated appeared to increase the growth of mixed denitrifying bacteria in acid pH media. However, in neutral pH media, high dosage of -irradiation appeared to enhance the inhibitory effect of chitosan.

Modeling Shear Viscosity of Asphalt through Nonequilibrium Molecular Dynamics Simulation

2018 ◽  
Vol 2672 (28) ◽  
pp. 235-243
Author(s):  
Yongjie Ding ◽  
Baoshan Huang ◽  
Xiang Shu
Keyword(s):  
Molecular Dynamics ◽  
Molecular Weight ◽  
Strain Rate ◽  
Shear Viscosity ◽  
Chemical Structure ◽  
Asphalt Binder ◽  
Dynamics Simulation ◽  
Nonequilibrium Molecular Dynamics ◽  
Aromatic Carbon ◽  
The Relationship

This paper investigates a quantifiable relationship between the chemical composition and the shear viscosity of the asphalt binder through the nonequilibrium molecular dynamics (NEMD) simulation. The fix Deform and fix NVT/SLLOD ensembles were used to perform a shear effect on the model. The relationship between the shear viscosity and the microstructure characteristics of the asphalt model was studied. The results indicated that the asphalt model exhibited shear thinning as the strain rate increases. The effects of energy and chemical structure (molecular weight, aromatic carbon and heteroatom percentage) on shear viscosity were studied from the perspective of microstructure. The results showed that the larger fused aromatic ring core caused a nonlinear relationship between viscosity and strain rate. The viscosity of the asphalt model increased with the molecular weight, the percentage of aromatic carbon and heteroatoms. The molecular weight had a greater effect on viscosity than aromatic carbon and heteroatom percentage. Considering energy variations with strain rate and chemical structure, the NEMD method can be used to predict the behavior of the asphalt molecules under shear strain at a certain level.

scholarly journals Combustion and gasification characteristics of low-temperature pyrolytic semi-coke prepared through atmosphere rich in CH4 and H2

2021 ◽  
Vol 10 (1) ◽  
pp. 189-200
Author(s):  
Yuan She ◽  
Chong Zou ◽  
Shiwei Liu ◽  
Keng Wu ◽  
Hao Wu ◽  
...  
Keyword(s):  
Functional Groups ◽  
Chemical Structure ◽  
Nitrogen Adsorption ◽  
Inhibitory Effect ◽  
X Ray ◽  
Coke Reactivity ◽  
Reducing Gas ◽  
Reactivity Indexes ◽  
Infrared Spectrometer ◽  
Reducing Gases

Abstract Thermoanalysis was used in this research to produce a comparative study on the combustion and gasification characteristics of semi-coke prepared under pyrolytic atmospheres rich in CH4 and H2 at different proportions. Distinctions of different semi-coke in terms of carbon chemical structure, functional groups, and micropore structure were examined. The results indicated that adding some reducing gases during pyrolysis could inhibit semi-coke reactivity, the inhibitory effect of the composite gas of H2 and CH4 was the most observable, and the effect of H2 was higher than that of CH4; moreover, increasing the proportion of reducing gas increased its inhibitory effect. X-ray diffractometer and Fourier-transform infrared spectrometer results indicated that adding reducing gases in the atmosphere elevated the disordering degree of carbon microcrystalline structures, boosted the removal of hydroxyl- and oxygen-containing functional groups, decreased the unsaturated side chains, and improved condensation degree of macromolecular networks. The nitrogen adsorption experiment revealed that the types of pore structure of semi-coke are mainly micropore and mesopore, and the influence of pyrolytic atmosphere on micropores was not of strong regularity but could inhibit mesopore development. Aromatic lamellar stack height of semi-coke, specific surface area of mesopore, and pore volume had a favorable linear correlation with semi-coke reactivity indexes.

scholarly journals The inhibitory effect of melatonin on human prostate cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Dexin Shen ◽  
Lingao Ju ◽  
Fenfang Zhou ◽  
Mengxue Yu ◽  
Haoli Ma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Trials ◽  
Theoretical Basis ◽  
Inhibitory Effect ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Anti Oxidant ◽  
Androgen Depletion ◽  
The Relationship ◽  
Future Utilization

AbstractProstate cancer (PCa) is one of the most commonly diagnosed human cancers in males. Nearly 191,930 new cases and 33,330 new deaths of PCa are estimated in 2020. Androgen and androgen receptor pathways played essential roles in the pathogenesis of PCa. Androgen depletion therapy is the most used therapies for primary PCa patients. However, due to the high relapse and mortality of PCa, developing novel noninvasive therapies have become the focus of research. Melatonin is an indole-like neurohormone mainly produced in the human pineal gland with a prominent anti-oxidant property. The anti-tumor ability of melatonin has been substantially confirmed and several related articles have also reported the inhibitory effect of melatonin on PCa, while reviews of this inhibitory effect of melatonin on PCa in recent 10 years are absent. Therefore, we systematically discuss the relationship between melatonin disruption and the risk of PCa, the mechanism of how melatonin inhibited PCa, and the synergistic benefits of melatonin and other drugs to summarize current understandings about the function of melatonin in suppressing human prostate cancer. We also raise several unsolved issues that need to be resolved to translate currently non-clinical trials of melatonin for clinic use. We hope this literature review could provide a solid theoretical basis for the future utilization of melatonin in preventing, diagnosing and treating human prostate cancer.

scholarly journals Inhibitory effect of low-molecular-weight peptides (0–3 kDa) from Spirulina platensis on H2O2-induced oxidative damage in L02 human liver cells

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Jun Ma ◽  
Xiankun Zeng ◽  
Min Zhou ◽  
Le Cheng ◽  
Difeng Ren
Keyword(s):  
Molecular Weight ◽  
Oxidative Damage ◽  
Spirulina Platensis ◽  
Radical Scavenging ◽  
Inhibitory Effect ◽  
Control Group ◽  
Low Molecular Weight ◽  
Sod Activity ◽  
Liver Health ◽  
L02 Cells

AbstractSpirulina platensis protein hydrolysates were prepared by digesting protein extracts with papain, and the hydrolysates were separated into 30, 10, and 3 kDa weights using membrane ultrafiltration. The 0–3 kDa low-molecular-weight Spirulina peptides (LMWSPs) proved the highest chemical antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, hydroxyl radical (·OH) scavenging activities and total antioxidant capacity. Cellular antioxidant ability of LMWPs fractions against 2000 μg/mL H2O2 induced oxidative damage of L02 cells were investigated. The MTT assay results displayed that LMWSPs at different concentrations (0–1000 μg/mL) had proliferation effect on the L02 cells and that treatment of the L02 cells with the 1000 μg/mL LMWSPs (0–3 kDa) significantly prevented H2O2-induced oxidative damage compared with control cells. Moreover, the 2′,7′-dichlorofluorescein diacetate (DCFH-DA) fluorescent probe assay showed that the levels of ROS and NO were significantly lower in the experimental group that was treated with the peptides for 24 h than in the control group. Furthermore, using the corresponding kits, the treatment inhibited the reduction of SOD activity and the increase of MDA contents in the L02 cells. Therefore, LMWSPs (0–3 kDa) may have potential applications in antioxidant and liver health products.

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