scholarly journals TOXICOLOGICAL STUDY OF CARBORANES (on the example of isopropyl methacarborane)

2021 ◽  
Vol 2021 (1) ◽  
pp. 236-242
Author(s):  
Konstantin Usov ◽  
Gennadiy Yushkov ◽  
Veronika Makarova
Keyword(s):  
Hazardous Substance ◽  
Toxicological Study ◽  
Toxicological Studies

The article presents the results of toxicological studies of carboranes, which made it possible to classify isopropylmethacarborane as a moderately hazardous substance, given the absence of the possibility of acute inhalation poisoning.

scholarly journals TOXICOLOGICAL STUDY OF MUGDHA RASA, AN AYURVEDIC FORMULATION

2020 ◽  
Vol 8 (10) ◽  
pp. 4626-4632
Author(s):  
Soumya T G ◽  
Surekha S Medikeri
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Albino Rats ◽  
Acute Administration ◽  
Hazardous Substance ◽  
Toxicological Study ◽  
Acute Toxicity Study ◽  
Dose Levels ◽  
Oral Acute Toxicity ◽  
Oecd Guideline

Mugdha Rasa is one type of Kharaliya Rasayana and comes under Nirgandha, Niragni Murchana of Parada. Parada and Khatika are the main ingredients of Mugdha Rasa. This investigation is an attempt to perform toxicological study of Mugdha Rasa. Acute toxicological study and sub-acute toxicological study were carried out as per OECD guideline 425 and 407 respectively. Oral acute toxicity study was carried out at the limit dose of 2000 mg/ kg orally in Swiss albino mice. Sub- acute toxicity study of Mugdha Rasa was carried out in Albino rats and it was administered at therapeutic equivalent dose (TED), TED ×2 and TED×5. No signs of toxicity and mortality were observed Mugdha Rasa in acute toxicity study. So, LD50 of Mugdha Rasa is greater than 2000 mg/kg body weight and Mugdha Rasa can be considered assafe on acute exposure. The data generated during sub-acute toxicity study are indicated that it is not a hazardous substance for sub-acute administration at TED dose level. Higher dose levels show mild changes in parameters.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Toxicological studies on the Eugenia dysenterica DC and Caryocar brasiliense Cambess leaves in rats

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
F Elias ◽  
T Zils ◽  
FGL Aguiar ◽  
ELE Barros ◽  
ME Molica ◽  
...  
Keyword(s):  
Toxicological Studies ◽  
Caryocar Brasiliense ◽  
Eugenia Dysenterica ◽  
Caryocar Brasiliense Cambess

Analysis of stably expressed genes with low-dose etoposide for toxicological studies in osteosarcoma

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
JMP Ferreira de Oliveira ◽  
L Almeida ◽  
F Pimentel ◽  
EJJ Van Zoelen ◽  
C Santos
Keyword(s):  
Low Dose ◽  
Toxicological Studies

Actual issues of hygienic regulation and creation of safe working conditions at pharmaceutical manufacturing enterprises

2020 ◽  
Vol 60 (10) ◽  
pp. 640-644
Author(s):  
Vadim M. Vasilkevich ◽  
Ruslan V. Bogdanov ◽  
Elena V. Drozdova
Keyword(s):  
Pharmaceutical Industry ◽  
Working Conditions ◽  
Experimental Studies ◽  
Pharmaceutical Products ◽  
Laboratory Animals ◽  
Production Environment ◽  
Basic Principles ◽  
Toxicological Studies ◽  
Health Disorders ◽  
Safe Working

Introduction. The working conditions of pharmaceutical industry workers are characterized by the combined effect of unfavorable factors of the production environment, among which the leading one is chemical. The aim of study is to substantiate the basic principles and criteria for hygienic regulation of pharmaceutical products in their production to ensure safe working conditions for employees based on the results of their own research and existing requirements of technical regulations. Materials and methods. Analysis of working conditions and the prevalence of health disorders in pharmaceutical workers (according to literature data), toxicological studies of pharmaceutical substances on laboratory animals, scientific justification of hygiene standards in the air of the working area. Results. Among employees of the pharmaceutical industry, the predominant forms of production-related health disorders are diseases of the respiratory system, as well as skin dermatitis of allergic origin, liver and biliary tract diseases. Based on the results of experimental studies of domestic pharmaceutical products for the treatment of cardiovascular, oncological and mental diseases that have priority socio-economic significance, the basic principles and features of the practice of justifying the hygienic standards of medicines in the air of the working area are developed and systematized. Conclusions. During hygienic rationing of medicines, it is necessary to use a differentiated approach that allows, based on the analysis of information about the chemical structure, physical and chemical characteristics, production conditions, pharmacotherapeutic activity, and the results of studying the toxic effect in an experiment on laboratory animals, to determine the maximum permissible content in the air of the working area of medicines or to justify the prohibition of isolation with reasoned recommendations for their safe production.

ASSESSMENT OF THE TOXICITY AND HAZARD OF SODIUM LAURYL SULFATE AT DIFFERENT EXPOSURE ROUTES

2020 ◽  
pp. 56-59
Author(s):  
M. V. Bidevkina ◽  
M. I. Golubeva ◽  
A. V. Limantsev ◽  
I. N. Razumnaya ◽  
T. N. Potapova ◽  
...  
Keyword(s):  
Sodium Lauryl Sulfate ◽  
Exposure Level ◽  
Hazardous Substance ◽  
Lauryl Sulfate ◽  
Upper Respiratory Tract ◽  
Mucous Membranes ◽  
Chloroprene Rubber ◽  
Upper Respiratory ◽  
Exposure Routes ◽  
Number Of Cells

Sodium lauryl sulfate is the most common surfactant used in the production of detergents, chloroprene rubber, plastics, artificial furs and in pharmaceutical industry. Sodium lauryl sulfate is a moderately hazardous substance when introduced into the stomach (DL50 for white mice and rats is in the range of 2086-2700 mg/kg), has a pronounced local irritant effect on the skin and mucous membranes of the eyes, has a skin-resorptive, sensitizing and pronounced cumulative effects. The threshold for acute inhalation action is set at 15,3 mg/m3 for changes in the function of the nervous system and irritating effects on the mucous membranes of the upper respiratory tract (an increase in the total number of cells in the nasal flushes).Recommended for approval tentative safe exposure level of sodium lauryl sulfate in the air of the working area is 0.2+ mg/m3 (aerosol).

ASSESSMENT OF TOXICITY OF GERMANIUM COORDINATION COMPOUNDS

2019 ◽  
pp. 16-21
Author(s):  
A. V. Kadomtsevа ◽  
I. V. Zhdanovich ◽  
M. S. Piskunovа ◽  
A. N. Lineva ◽  
A. N. Novikova ◽  
...  
Keyword(s):  
Coordination Compounds ◽  
Organometallic Compounds ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Toxicological Studies ◽  
Methods Of Synthesis ◽  
Promising Area

The synthesis of biologically active coordination compounds and the design on their basis of effective pharmacological preparations is currently the promising area. This paper presents the results of the toxicological studies on digermanium and its complex derivatives. It should be noted that the positive medical properties of organometallic compounds of germanium are confirmed by numerous studies, therefore, the development of the methods of synthesis, as well as investigations of physicochemical and pharmacological properties of these compounds are at the center of attention.

Effect of carbon source on Phenobarbital metabolism by Rhizopus stolonifer

2010 ◽  
Vol 3 (2) ◽  
pp. 1022-1027
Author(s):  
Kavitha K ◽  
Asha S ◽  
Hima Bindu T.V.L ◽  
Vidyavathi M
Keyword(s):  
Carbon Source ◽  
High Performance ◽  
Carbon Sources ◽  
In Vitro Models ◽  
Rhizopus Stolonifer ◽  
Safety And Efficacy ◽  
Alternative Systems ◽  
Toxicological Studies ◽  
Microbial Model

The safety and efficacy of a drug is based on its metabolism or metabolite formed. The metabolism of drugs can be studied by different in vitro models, among which microbial model became popular. In the present study, eight microbes were screened for their ability to metabolize phenobarbital in a manner comparable to humans with a model to develop alternative systems to study human drug metabolism. Among the different microbes screened, a filamentous fungi Rhizopus stolonifer metabolized phenobarbital to its metabolite which is used for further pharmacological and toxicological studies. The transformation of phenobarbital was identified by high- performance liquid chromatography (HPLC). Interestingly, Rhizopus stolonifer sample showed an extra metabolite peak at 3.11min. compared to its controls. The influence of different carbon sources in media used for growth of fungus, on metabolite production was studied, to find its effect in production of metabolite as the carbon source may influence the growth of the cell.

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