PARKINSON'S DISEASE MEDICAL REHABILITATION METHODS

Parkinson's disease ranks first among the neurodegenerative pathology. The approach to the treatment of Parkinson's disease must be comprehensive. Medical rehabilitation methods include not only basic drug therapy, surgical methods of treatment, but also methods of physiotherapy, reflexology, physiotherapy, speech therapy and psychotherapy. When prescribing physical factors in patients at different stages of the disease, it is possible to recommend those methods that will have a more pronounced effect on the clinical symptoms of Parkinson's disease. From physical factors, balneotherapy, thermal mud therapy, impulse currents, electrophoresis, electrostatic field, microwave therapy, phototherapy, barotherapy are prescribed. The use of transcerebral Electrotherapy methods and computer-stabilographic programs in complex treatment based on biofeedback by statokinesogram will reduce the severity of the main symptoms of the disease. Key words: medical rehabilitation, physiotherapy, Parkinson's disease

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Parkinson’s puzzle

Orvosi Hetilap ◽

10.1556/oh.2012.29461 ◽

2012 ◽

Vol 153 (52) ◽

pp. 2060-2069 ◽

Cited By ~ 4

Author(s):

András Guseo

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Clinical Symptoms ◽

Critical Factor ◽

Unknown Origin ◽

Symptomatic Improvement ◽

Blue Green Algae ◽

Clinical Observations ◽

Degenerative Disorders ◽

Local Cell

Parkinson’s disease is one of the most frequent progressive degenerative disorders with unknown origin of the nervous system. The commutation of the disease on Guam led to the discovery of a neurotoxin which was also found in other continents. This neurotoxin was identified in the common cyanobacteria (blue-green algae). Early clinical observations suggested some loose correlations with gastric and duodenal ulcer and Parkinson’s disease, while recent studies revealed a toxin, almost identical to that found in cyanobacteria in one strain of Helicobacter pylori, which proved to cause Parkinson like symptoms in animals. Therefore, it cannot be ruled out that there is a slowly progressive poisoning in Parkinson’s disease. The disease specific alpha-sinuclein inclusions can be found in nerve cells of the intestinal mucosa far before the appearance of clinical symptoms indicating that the disease may start in the intestines. These results are strengthened by the results of Borody’s fecal transplants, after which in Parkinson patients showed a symptomatic improvement. Based on these observations the Parkinson puzzle is getting complete. Although these observations are not evidence based, they may indicate a new way for basic clinical research, as well as a new way of thinking for clinicians. These new observations in psycho-neuro-immunology strengthen the fact that immunological factors may also play a critical factor facilitating local cell necrosis which may be influenced easily. Orv. Hetil., 2012, 153, 2060–2069.

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The Role of Salivary Biomarkers in the Early Diagnosis of Alzheimer’s Disease and Parkinson’s Disease

Diagnostics ◽

10.3390/diagnostics11020371 ◽

2021 ◽

Vol 11 (2) ◽

pp. 371

Author(s):

Patrycja Pawlik ◽

Katarzyna Błochowiak

Keyword(s):

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

Early Diagnosis ◽

Neurodegenerative Diseases ◽

Diagnostic Tool ◽

Clinical Symptoms ◽

Early Screening ◽

Salivary Biomarkers

Many neurodegenerative diseases present with progressive neuronal degeneration, which can lead to cognitive and motor impairment. Early screening and diagnosis of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are necessary to begin treatment before the onset of clinical symptoms and slow down the progression of the disease. Biomarkers have shown great potential as a diagnostic tool in the early diagnosis of many diseases, including AD and PD. However, screening for these biomarkers usually includes invasive, complex and expensive methods such as cerebrospinal fluid (CSF) sampling through a lumbar puncture. Researchers are continuously seeking to find a simpler and more reliable diagnostic tool that would be less invasive than CSF sampling. Saliva has been studied as a potential biological fluid that could be used in the diagnosis and early screening of neurodegenerative diseases. This review aims to provide an insight into the current literature concerning salivary biomarkers used in the diagnosis of AD and PD. The most commonly studied salivary biomarkers in AD are β-amyloid1-42/1-40 and TAU protein, as well as α-synuclein and protein deglycase (DJ-1) in PD. Studies continue to be conducted on this subject and researchers are attempting to find correlations between specific biomarkers and early clinical symptoms, which could be key in creating new treatments for patients before the onset of symptoms.

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Posterior and Anterior Spinal Fusion for the Management of Deformities in Patients with Parkinson's Disease

Case Reports in Orthopedics ◽

10.1155/2013/140916 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Masashi Sato ◽

Takeshi Sainoh ◽

Sumihisa Orita ◽

Kazuyo Yamauchi ◽

Yasuchika Aoki ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Low Back Pain ◽

Back Pain ◽

Deformity Correction ◽

Pedicle Screws ◽

Anterior Fusion ◽

Low Back ◽

Surgical Methods ◽

Correction Surgery

Introduction. Spinal scoliosis and kyphosis in elderly people sometimes cause severe low back pain. Surgical methods such as osteotomy are useful for correcting the deformity. However, complications during and after surgery are associated with the osteotomy procedure. In particular, it is difficult to manage deformity correction surgery for patients with Parkinson's disease. Here, we present two cases of combined anterior and posterior surgery for deformity in patients with adult scoliosis and kyphosis due to Parkinson's disease.Case Presentation. Two 70-year-old women had spinal scoliosis and kyphosis due to Parkinson's disease. They had severe low back pain, and conservative treatment was not effective for the pain. Surgery was planned to correct the deformity in both patients. We performed combined posterior and anterior correction surgery. At first, posterior fusions were performed from T4 to the ilium using pedicle screws. Next, cages and autograft from the iliac crest were used in anterior lumbar surgery. The patients became symptom free after surgery. Bony fusion was observed 12 months after surgery.Conclusions. Combined posterior and anterior fusion surgery is effective for patients who show scoliosis and kyphosis deformity, and symptomatic low back pain due to Parkinson's disease.

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Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease

Parkinson s Disease ◽

10.4061/2011/307875 ◽

2011 ◽

Vol 2011 ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

Kyota Fujita ◽

Yusaku Nakabeppu ◽

Mami Noda

Keyword(s):

Oxidative Stress ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Animal Models ◽

Animal Studies ◽

Clinical Symptoms ◽

Therapeutic Effects ◽

Therapeutic Approaches ◽

Cellular Apoptosis ◽

6 Hydroxydopamine

Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD.

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The Impact of an Application of TelerehabilitationTechnology on Caregiver Burden

International Journal of Telerehabilitation ◽

10.5195/ijt.2009.5559 ◽

2009 ◽

Vol 1 (1) ◽

pp. 3-8 ◽

Cited By ~ 24

Author(s):

Lyn R. Tindall ◽

Ruth A. Huebner

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Caregiver Burden ◽

Speech Therapy ◽

Structured Interview ◽

Elderly Persons ◽

Work Time ◽

Financial Obligation ◽

The Impact ◽

Therapy Protocol

The objective of this research was to assess the effects of an application of telerehabilitation reducing time and financial obligation on caregiver burden among eleven caregivers of elderly persons with Parkinson’s disease. Clients (care receivers) participated in speech therapy delivered via videophones in their homes; the protocol required 16 treatments delivered four times a week for four weeks. At the conclusion of treatment, caregivers completed a structured interview about the impact of telerehabilitation on time and financial aspects of the burden of care. On average, this speech therapy protocol delivered by videophones saved 48 hours of time, more than 92 hours of work time, and $1024 for each caregiver. Savings were significant and previous research demonstrated nearly equal outcomes using the videophone delivery method. Implications for practice and research are discussed. Keywords: Telerehabilitation, Speech Therapy, Parkinson’s Disease.

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Urinary dysfunction with detrusor hyperactivity in women with Parkinson's disease cannot be blamed as a factor of worsening motor performance

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20130101 ◽

2013 ◽

Vol 71 (9A) ◽

pp. 591-595 ◽

Cited By ~ 6

Author(s):

Raimundo Nonato Campos-Sousa ◽

Elizabeth Maria Aparecida Barasnevicius Quagliato ◽

Kelson James Almeida ◽

Inacio Augusto Dias de Castro ◽

Viriato Campelo

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Performance ◽

Rating Scale ◽

Clinical Symptoms ◽

Urinary Dysfunction ◽

Clinical Aspects ◽

Yahr Scale ◽

Disease Rating ◽

Detrusor Hyperactivity

Introduction Detrusor hyperactivity is the leading cause of urinary dysfunction in Parkinson's disease (PD). There are few studies correlating PD clinical aspects with this autonomic feature. Methods A cohort of 63 women with PD were prospectively examined for assessment of clinical aspects and disease severity using unified Parkinson's disease rating scale and Hoehn-Yahr scale, respectively. The urologic function was evaluated by the urodynamic study. Two groups were categorized at this time - groups with and without detrusor hyperactivity. After seven years, the same parameters were re-evaluated. Results Progression of the disease on mental scores was found in the group with detrusor hyperactivity. On follow-up, clinical symptoms and severity did not show significant worsening between the groups. Conclusion Detrusor hyperactivity is a frequent urodynamic finding in PD, and even though it is associated with dopaminergic dysfunction, it cannot be blamed as a factor of worsening motor performance, but is probably associated with poor cognitive and mental prognosis.

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