ANTIPHOSPHOLIPID AND ANTINEUTROPHIL ANTIBODIES LEVELS IN MEN WITH STABLE CORONARY HEART DISEASE AND POSTINFARCTION CARDIOSCLEROSIS AND ITS RELATIONSHIP WITH THE DISEASE MANIFESTATION

The aim is to study the levels of antiphospholipid (aPL) and antineutrophil antibodies in men with stable coronary heart disease (CHD) with postinfarction cardiosclerosis and to evaluate its relationship with the disease manifestation. Materials and methods: 164 men with stable CHD and postinfarction cardiosclerosis (53.0 ± 9.14 (M ± σ) years) and 48 age-matched men without CHD were examined. The total aPL IgG and IgM, beta-2 glycoprotein 1 antibodies (anti-β2-GP 1) IgG and IgM, and antibodies for neutrophil proteinase-3 / myeloperoxidase (anti-PR3 / MPO) IgG were determined by ELISA. Results: Positive levels of aPL and anti-β2-GP 1 of IgG were identified in 56.7% (33.5% double positivity of aPL + anti-β2-GP 1) and 29.2% of control group (p < 0.001), while the IgM was lower (11.6% vs. 6.2%, p = 0.55, respectively). Significantly higher (1.5-1.7 times) levels of aPL and anti-β2-GP 1 were identified in patients who underwent myocardial infarction (MI) aged less than 44 years, after Q-MI, recurrent MI, in the presence of ischemic stroke, livedo reticularis. In 6.7% of patients with positive levels of aPL and anti-β2-GP 1 low IgG anti-PR3 / MPO levels were detected. Conclusions: In men with postinfarction cardiosclerosis, IgG positivity according to total aPL and anti-β2-GP 1 is associated with a higher incidence of Q-MI and with recurrent MI. Men with postinfarction cardiosclerosis have a tendency to increase anti-PR3 / MPO levels of IgG under conditions of double aPL positivity and anti-β2-GP1 of IgG.

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Distribution of paraoxon hydrolytic activity in the serum of patients after myocardial infarction.

Clinical Chemistry ◽

10.1093/clinchem/32.4.671 ◽

1986 ◽

Vol 32 (4) ◽

pp. 671-673 ◽

Cited By ~ 146

Author(s):

J McElveen ◽

M I Mackness ◽

C M Colley ◽

T Peard ◽

S Warner ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Myocardial Infarct ◽

Hydrolytic Activity ◽

Control Group ◽

Paraoxonase Activity

Abstract The activity of paraoxonase in serum was found to be bimodally distributed, both in a control group and in a group of patients who had suffered myocardial infarction. Activity in the myocardial infarct group was significantly lower than in the control group. Low paraoxonase activity in serum may provide an indication of susceptibility to the development of coronary heart disease.

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P6249Screening multiple biomarkers for associations with acute ischemic stroke in patients with stable coronary heart disease

European Heart Journal ◽

10.1093/eurheartj/ehy566.p6249 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

M Olszowka ◽

A Siegbahn ◽

N Eriksson ◽

C Held ◽

R Stewart ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Stable Coronary Heart Disease ◽

Multiple Biomarkers

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Development of information panels for laboratory diagnosis of myocardial infarction risk in patients with stable ischemic heart disease

Medical alphabet ◽

10.33667/2078-5631-2019-1-9(384)-33-37 ◽

2019 ◽

Vol 1 (9) ◽

pp. 33-37

Author(s):

Yu. A. Kotova ◽

A. A. Zuykova ◽

N. V. Strakhova ◽

O. N. Krasnorutskaya

Keyword(s):

Oxidative Stress ◽

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Atherosclerosis ◽

Chaperone Activity ◽

Reactive Protein ◽

Stable Coronary Heart Disease ◽

History Of ◽

Group 2

The high incidence of stable coronary heart disease, the increasing frequency of myocardial infarction, disability and mortality determine the relevance of the search for new risk markers and laboratory criteria for predicting this severe complication. The aim of the study was to develop an information panel for diagnosing the risk of myocardial infarction in patients with stable coronary heart disease, including significant generally accepted and potentially possible new laboratory parameters characterizing various pathogenetic links of coronary atherosclerosis. The study included 168 patients who were divided into 2 groups: Group 1 - with a history of myocardial infarction, Group 2 - without a history of myocardial infarction. In addition to the standard laboratory and instrumental examination, all patients were identified parameters of endothelial dysfunction, oxidative stress and chaperone activity as potential markers of myocardial infarction in patients with stable coronary heart disease. Assessment of the risk of myocardial infarction in patients with stable coronary heart disease was carried out using a logical and mathematical model, which combined the most informative laboratory indicators of oxidative stress, endothelial dysfunction, and chaperone activity, which are important in the occurrence and progression of coronary atherosclerosis, according to the results of preliminary comparative and correlation analysis. The basis for the development of the information panel was the method of decision trees. The study confirmed the relationship between the severity of coronary atherosclerosis and the occurrence of myocardial infarction. Comparative analysis of the selected groups of patients showed a higher level of oxidative stress, serum homocysteine concentrations and lower values of chaperone activity in Group 1. In patients with a history of myocardial infarction, C-reactive protein was significantly higher than in Group 2, indicating a more pronounced inflammatory response in patients with large atherosclerotic lesions. The study suggests the possibility of using mathematical information panels based on decision trees as a system for assessing the risk of acute myocardial infarction in patients with stable coronary heart disease. As a result of the analysis of the obtained model, laboratory biochemical factors of high risk of myocardial infarction were identified. Such factors were chaperone activity, serum homocysteine level, serum C-reactive protein concentration and superoxide dismutase activity.

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Responses to Bortner's Scale and the Eight Basic Emotions by Patients with Acute Coronary Heart Disease at Hospital Admission and Discharge

Psychological Reports ◽

10.2466/pr0.1996.79.1.259 ◽

1996 ◽

Vol 79 (1) ◽

pp. 259-267 ◽

Cited By ~ 7

Author(s):

Katija ČAtipović-Veselica ◽

Vesna Ilakovac ◽

Josip ĐUrjančEk ◽

Vjekoslav AmidžIć ◽

Dinko Burić ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Hospital Admission ◽

Unstable Angina ◽

Type A ◽

Type A Behavior ◽

Control Group ◽

Basic Emotions ◽

Recurrent Myocardial Infarction

We examined the prevalence of Type A behavior indicated on Bonner's scale and the Emotion Profiles of Plutchik in 190 patients, 134 men and 56 women ( M age = 50 yr., SD = 9) with acute coronary heart disease at hospital admission and discharge. Type A classification was significantly more common for patients with acute coronary heart disease (75.5% versus 65%) than for the control group. Pa-dents with acute coronary heart disease scored lower on Distrust and Dyscontrolled than the control group. Patients with unstable angina had significantly higher mean scores on Bortner's scale than patients with acute myocardial infarction and recurrent myocardial infarction at hospital discharge. Patients with recurrent myocardial infarction scored lower on Distrust and higher on Timid than patients with unstable angina at hospital admission and discharge. This research suggests that Type A behavior and some emotions are associated with acute coronary heart disease. There was a difference in scores on the Emotions Profiles and scores on Type A behavior in relation to type of acute coronary heart disease. The addition of counseling for Type A behavior to standard cardiac counseling was suggested for reduction in scores on Type A behavior.

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The Type 2 Construct and its Relation to Coronary Heart Disease

Psychological Reports ◽

10.2466/pr0.1995.76.1.3 ◽

1995 ◽

Vol 76 (1) ◽

pp. 3-13 ◽

Cited By ~ 8

Author(s):

Geir Arild Espnes

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Strong Association ◽

Self Report ◽

Control Group ◽

Report Data ◽

Self Report Data

The main aim of this study was to scrutinise the link postulated in 1988 between the Type 2 construct of Grossarth-Maticek, Eysenck, and Vetter and the incidence of coronary heart disease. Self-report data were collected from 58 men who had suffered an infarct, had been hospitalised, and had later enrolled at a physical outpatient clinic as well as from a randomly assigned control group of 70 men. Analysis showed that the Type 2 scores in the infarct group did not differ significantly from those of the control group or from measures taken immediately after an acute myocardial infarction and measures taken 3 months later. The results do not support the hypothesis of a strong association between coronary heart disease and Type 2 scores.

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Psychosomatic correlates of coronary heart disease during the socio-economic crisis of post-communist Bulgaria

Open Medicine ◽

10.2478/s11536-008-0078-y ◽

2009 ◽

Vol 4 (1) ◽

pp. 91-97

Author(s):

Emilia Karaslavova ◽

Mariana Dyakova ◽

Desislava Todorova ◽

Stoilka Tufkova

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Transition Period ◽

Heart Diseases ◽

Depression Scale ◽

Anxiety And Depression ◽

Control Group ◽

Self Rating

AbstractPost-communist Bulgaria has experienced the full impact of a socioeconomic disaster. Under prolonged and powerful stress the human body may exhaust its adaptive potential and a variety of pathophysiological symptoms may occur. The cardiovascular system is most vulnerable to stress. The aim of this study is to analyze the role of psychological factors correlating with Acute Myocardial Infarction (AMI) during the transition period in post-communist Bulgaria. A case-control epidemiological study was performed. 306 cases of acute myocardial infarction (AMI) and 210 controls were studied. Analysis of patients’ records was made and a direct face-to-face interview was carried out. The study covers a 15-year transition period lasting from 1989 until 2005. The interview questions are based on W. Zung’s standardized self-evaluation tests of anxiety and depression (Self Rating Depression Scale — SDS, 1965, SAS-Self Rating Anxiety Scale, 1976) and on a test of aggression, as a part of the Minnesota Multiphase personality inventory, adapted from A.A. Krilov and F. Korozi’s FPI test. Average levels of anxiety and depression appear to be higher among patients suffering from coronary heart diseases than in control group members. Levels of aggression do not show a direct correlation with coronary heart disease. Both groups demonstrate symptoms of psychological disturbances caused, most probably, by the socio-economic instability of the transition period. In conclusion, certain socioeconomic factors significantly increase the level of anxiety and depression in the respondents. The AMI patients are considerably more anxious and depressed than the controls. The results provide evidence that high levels of anxiety and depression may correlate to and be interpreted as a potential risk factor for coronary heart disease.

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The role of markers of endothelial dysfunction, oxidative and cellular stress in the prediction of myocardial infarction in comorbid patients with stable coronary heart disease

Cardiosomatics ◽

10.26442/22217185.2021.1.200768 ◽

2021 ◽

Vol 12 (1) ◽

pp. 23-27

Author(s):

Yuliya A. Kotova ◽

Anna A. Zuikova ◽

Natalia V. Strahova ◽

Olga N. Krasnorutskaya ◽

Elena Y. Esina

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Endothelial Dysfunction ◽

Average Strength ◽

Stable Coronary Heart Disease ◽

History Of ◽

Modified Proteins ◽

Hs Crp

Aim. To study the role of markers of endothelial dysfunction, oxidative and cellular stress in the prediction of myocardial infarction (MI) in comorbid patients with stable coronary heart disease (CHD). Material and methods. The study involved 336 patients with a diagnosis of CHD. The presence of CHD was confirmed by diagnostic coronary angiography with the calculation of the Gensini index. All patients were divided into 2 groups: group 1288 patients without a history of MI, group 248 patients with a history of MI. All patients were assessed for the levels of oxidized modified proteins, high-sensitivity C-reactive protein (hs-CRP), homocysteine, heat shock protein (HSP70), and superoxide dismutase activity. Results. All patients were comparable in age. For other clinical and anthropometric characteristics, we saw significant differences (according to the MannWhitney criterion): patients with previous MI had higher BMI, waist circumference, and blood pressure. The correlation analysis revealed positive significant average strength relationships between past MI and the Gensini index, low-density lipoprotein level, total cholesterol level, homocysteine level, hs-CRP level, and the level of oxidized modified proteins; and negative significant average strength relationships between past MI and SOD activity level (r=-0.374, p=6.4 E-07) and HSP70 level (r=-0.563, p=2.6 E-15). The ROC analysis revealed that not all markers were significant in predicting the risk of MI. It is shown that the most expected characteristics were shown by the hs-СRP. However, further analysis of the predictive significance of the markers demonstrated that the addition of HSP70 to hs-CRP increases the predictive significance of hs-CRP in relation to the risk of developing MI. Conclusion. We have demonstrated that a strategy using a cumulative risk assessment consisting of 2 biomarkers (individually involved in inflammation and stress-induced cellular responses) can identify patients with an established diagnosis of CHD who have an increased risk of acute MI.

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Usefulness of Heart Rate at Rest as a Predictor of Mortality, Hospitalization for Heart Failure, Myocardial Infarction, and Stroke in Patients With Stable Coronary Heart Disease (Data from the Treating to New Targets [TNT] Trial)

The American Journal of Cardiology ◽

10.1016/j.amjcard.2009.11.035 ◽

2010 ◽

Vol 105 (7) ◽

pp. 905-911 ◽

Cited By ~ 59

Author(s):

Jennifer E. Ho ◽

Vera Bittner ◽

David A. DeMicco ◽

Andrei Breazna ◽

Prakash C. Deedwania ◽

...

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Heart Rate ◽

Coronary Heart Disease ◽

Heart Disease ◽

New Targets ◽

Stable Coronary Heart Disease

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XKR6 rs7014968 SNP Increases Serum Total Cholesterol Levels and the Risk of Coronary Heart Disease and Ischemic Stroke

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029620902844 ◽

2020 ◽

Vol 26 ◽

pp. 107602962090284

Author(s):

Kai-Guang Li ◽

Rui-Xing Yin ◽

Feng Huang ◽

Wu-Xian Chen ◽

Jin-Zhen Wu ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Ischemic Stroke ◽

Total Cholesterol ◽

Serum Lipid ◽

Serum Total Cholesterol ◽

Control Group ◽

Nucleotide Polymorphisms ◽

Related Family ◽

Increased Risk

The X Kell blood group complex subunit-related family member 6 ( XKR6) gene single-nucleotide polymorphisms (SNPs) have been associated with serum lipid profiles and the risk of coronary heart disease (CHD) and ischemic stroke (IS) in several previous studies, but the association between the XKR6 rs7014968 SNP and serum lipid levels and the risk of CHD and IS has not been detected previously. This study aims to explore the association between the XKR6 rs7014968 SNP and serum lipid traits and the susceptibility to CHD and IS in the Guangxi Han Chinese population. Snapshot technology was used to determine the genotypes of the XKR6 rs7014968 SNP in 624 controls, 588 patients with CHD, and 544 patients with IS. The XKR6 rs7014968C allele carriers in the control group had higher serum total cholesterol (TC) levels than the C allele noncarriers ( P = .025). The XKR6 rs7014968C allele carriers also had an increased risk of CHD and IS ( P < .05-.01). Stratified analysis showed that the patients with the rs7014968C allele in the female, age >60 years, body mass index (BMI) >24 kg/m2, and hypertension subgroups had a higher risk of CHD than those in the subgroup counterparts. The patients with the rs7014968C allele in the male, BMI > 24 kg/m2, smoker, and hypertension subgroups also had a higher risk of IS than those in the subgroup counterparts. These results suggest that the XKR6 rs7014968 SNP is likely to increase the risk of CHD and IS by increasing serum TC levels in our study populations.

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