scholarly journals Awesome repetition of number 3 in correction of Trimorphic Extreme Clubfoot Deformities by Triple Surgical Skin Expansion (An Evolutionary, Multifaceted, Scientific Perspective)

2020 ◽  
pp. 01-11
Author(s):  
Dr. R.L. Mittal
Keyword(s):  
Daily Living ◽  
Scientific Explanation ◽  
Fixed Time ◽  
Original Research ◽  
Skin Expansion ◽  
Ancient Times ◽  
Similar Vein ◽  
Google Search ◽  
Global Population ◽  
International Orthopaedics

Author, a passionate researcher in Clubfoot, since over half a century, published an article on trimorphic extreme clubfoot deformities https://doi.org/10.1007/s00264-017-3741-6, in International Orthopaedics (SICOT) in 2018. This was original research in this grey area, prevalent in LMICs with more than 80 % global population. AIM: Continuing in similar vein, author was motivated to write this unique article with certain “believe-it-or-not” events, under three headings: FIRSTLY; many things are destined to happen in nature at a fixed time and place. This research, happening pointedly at Patiala, is another such event. HOW and WHY of this, are given in PREFACE and INTRODUCTION of author’s Clubfoot Book [57]. SECONDLY: unprecedented, 20 repetitions of number 3 in any research, besides five in personal life and THIRDLY, on Google search, number 3 in numerology, symbolic of planet Jupiter, has innumerable good attributes for the related people. This number has also been found to have, since ancient times, myriad unbelievable, evolutionary bonds, in every area of humanity, on planet earth and beyond; which are scientific, spiritual, socio- religious, political etc. MATERIAL has been derived from the contents of author’s clubfoot research and METHODS have been Google Search, daily living human activities and author’s experience. CONCLUSIONS: 1. Many events are completely scientific; 2. Others are unique coincidences with scientific explanation and 3. Still others are amazing truths, proving once again veracity of famous quote “Truth is Stranger than Fiction”. Because of its uniqueness, this article does need a loud awakening call, to spread its wings.

scholarly journals Incredible Repetition of Number 3 in Adorable Game of Cricket

2021 ◽  
pp. 01-07
Keyword(s):  
Scientific Explanation ◽  
Fixed Time ◽  
Orthopedic Surgeon ◽  
Clinical Journal ◽  
Ancient Times ◽  
Google Search ◽  
International Orthopaedics

Author, an orthopedic surgeon and passionate researcher in Clubfoot for over fifty years, published an article in International Orthopaedics (SICOT) in 2018; https://doi.org/10.1007/s00264-017-3741-6. In that article, there was an incredible discovery i.e., 23 times repetition, of number3, besides-the publication, DOI: https://doi.org/10.36811/cjo.2020.110002 CJO(Clinical Journal of Orthopedics): August-2020 and some references of repeating number 3 about CRICKET also in them. AIM: Motivated by this, the author explored the game of cricket further and this too was incredibly true, to be described under different headings in this article. Material has been derived from contents of cricket namely: equipment, actions, famous world cricketers, and places related to cricket. Methods were Google search, under three headings: firstly; many things in cricket are destined to happen at a fixed time and place, just like in author’s clubfoot publications. Secondly: Unprecedented repetitions of number 3 in cricket under various headings, and THIRDLY, on Google search, number 3 in numerology, symbolic of planet Jupiter, has innumerable good attributes for the related people. This number has been found to have myriad, evolutionary bonds, in every area of humanity, on planet earth and beyond, since ancient times, which are scientific, spiritual, socio-religious, political, etc. Conclusions: 1. Many events are completely scientific; 2. Others are unique coincidences with scientific explanation and 3. Still, others are amazing truths, proving again that “Truth is Stranger than Fiction”. Because of its uniqueness, this article needs to spread its wing.

scholarly journals Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise

Genes ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 1043
Author(s):  
Italia Di Liegro
Keyword(s):  
Physical Exercise ◽  
Cognitive Processes ◽  
Sedentary Lifestyle ◽  
Research Articles ◽  
Original Research ◽  
Special Issue ◽  
Cell Functions ◽  
Ancient Times ◽  
Epigenetic Modulation ◽  
Molecular Bases

Since ancient times, the importance of physical activity (PA) and of a wholesome diet for human health has been clearly recognized. However, only recently, it has been acknowledged that PA can reverse at least some of the unwanted effects of a sedentary lifestyle, contributing to the treatment of pathologies such as hypertension and diabetes, to the delay of aging and neurodegeneration, and even to the improvement of immunity and cognitive processes. At the same time, the cellular and molecular bases of these effects are beginning to be uncovered. The original research articles and reviews published in this Special Issue on “Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise” focus on different aspects of the genetics and molecular biology of PA effects on health and, in addition, on the effects of different genotypes on the ability to perform PA. All authors have read and agreed to the published version of the manuscript.

scholarly journals Comprehensive Analysis and Assessment of the Role of Major Bioactive Compounds Isolated from Justicia Adhatoda Leaves as Potent Antimycobacterial Agents

2022 ◽  
Author(s):  
Smita Mishra ◽  
Manisha Khatri ◽  
Varsha Mehra
Keyword(s):  
Bioactive Compounds ◽  
Ex Vivo ◽  
Scientific Evidence ◽  
Traditional Medicines ◽  
Ancient Times ◽  
Infectious Pathogen ◽  
Justicia Adhatoda ◽  
Global Population

Abstract Tuberculosis (TB) continues to be one of the world's leading causes of death by the infectious pathogen Mycobacterium tuberculosis, which infects one-third of the global population. The emergence of the COVID-19 pandemic made its spread rapid and the treatment task more daunting. With the havoc of infectious disease expansion, traditional medicines have triggered tremendous interest worldwide. However, less availability of scientific evidence still hinders its practical use. In the present study, we evaluated the potential of the traditional medicinal plant, Justicia adhatoda, which has been used to treat respiratory ailments since ancient times. We have successfully isolated and characterized several bioactive compounds viz- Vasicoline, Vasicolinone, Adhatodine, Adhavasine, Aniflorine, and Vasicinone from J. adhatoda plant leaves, including Vasicine as the principal compound, and showed their anti-tubercular activity on nutrient-starved Mycobacterium smegmatis and Mycobacterium bovis. The study also directs their in-vitro and ex-vivo antimycobacterial potential on THP1 macrophages with internalized Mycobacterium. Our study is one of its first kind, where we assessed the synergistic antimycobacterial effect of the isolated compounds with the first-line drug Isoniazid (INH). Their potential role in promoting phagolysosome fusion and apoptosis of M. bovis infected THP1 macrophages is further evaluated.

scholarly journals Natural Cytotoxic Diterpenoids, a Potential Source of Drug Leads for Melanoma Therapy

2019 ◽  
Vol 24 (36) ◽  
pp. 4237-4250 ◽  
Author(s):  
Jose M. Prieto ◽  
Dâmaris Silveira
Keyword(s):  
Anticancer Agents ◽  
Phorbol Esters ◽  
Biological Activities ◽  
Complex Structure ◽  
Melanoma Cells ◽  
Original Research ◽  
Research Reporting ◽  
Present Complex ◽  
Ancient Times ◽  
Drug Leads

Diterpenes present complex structure and due to their unique carbon skeleton and interesting biological activities, have been the focus of continuous studies for the development of new anticancer agents. Phorbol esters have been known for their activity against skin malignancies since ancient times. Taxol was first studied in melanoma cells, and recently, ingenol mebutate has been approved for the chemoprevention of melanoma in actinic keratosis patients. Therefore, there is a scope for research on this class of compounds. We here aim to review the relevant original research reporting on isolated diterpenes with cytotoxic and/or antitumoral activities upon melanoma cells. By collating and discussing the implications of past and current developments on diterpenes, we hope to steer further interest on this field and facilitate the drug discovery activities of the scientific community towards finding potential alternatives to current melanoma chemotherapy.

scholarly journals Sonographic Assessment of Kidneys in Human Immunodeficiency Virus Sero-Positive Patients: A systematic Review

2020 ◽  
Vol 34 (1) ◽  
pp. 7-11
Author(s):  
Mohammed Sidi ◽  
Abbas Kabir
Keyword(s):  
Human Immunodeficiency Virus ◽  
Doppler Ultrasound ◽  
English Language ◽  
Subject Area ◽  
Sub Saharan Africa ◽  
Research Articles ◽  
Original Research ◽  
Secondary Source ◽  
Immunodeficiency Virus ◽  
Google Search

Background: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) remains a major challenge globally, and approximately 180,000 people died from AIDS-related illnesses in Nigeria in 2015. HIV associated nephropathy is the third most common cause of end-stage renal failure. Objectives: To review published original research articles on the sonographic evaluation of kidneys in HIV seropositive patients, identifying missing gaps and coming up with an area of further study. Methodology: The study was retrospective and a secondary source of data from published original research articles was used. The search was performed through Google search using Google Scholar, EMBASE, PubMed and Medline. All the published original research articles in the English language and the availability of full-text articles were included in the study. The results: An electronic search using the search terms had identified 58 related published articles, but only 12 articles were reviewed. This study found out that human immunodeficiency virus-associated nephropathy (HIVAN) to be most predominant renal disease in HIV positive patients leaving in sub-Saharan Africa with increased renal parenchymal echogenicity and decreased corticomedullary differentiation sonographically, which correlate in raised of serum creatinine level and the degree of patients' immune competence (CD4 count). Few studies correlated the sonographic findings with histopathological feature and none use Doppler ultrasound. Conclusion: This study has identified a correlation between the sonographic findings with the histopathological features and the use of Doppler ultrasound as the missing gaps from the previously published research articles in the subject area.

scholarly journals Understanding the molecular–pharmaceutical basis of sartan recalls focusing on valsartan

2020 ◽  
Vol 2020 (2) ◽  
Author(s):  
Avik Ray ◽  
Shubham Atal ◽  
Balakrishnan Sadasivam
Keyword(s):  
Manufacturing Process ◽  
Angiotensin Receptor Blockers ◽  
Relevant Information ◽  
Original Research ◽  
Medical Subject Headings ◽  
Pharmaceutical Ingredients ◽  
Pharmaceutical Firms ◽  
Mesh Terms ◽  
Receptor Blockers ◽  
Global Population

Angiotensin receptor blockers (ARBs) or the ‘sartans’ are widely used for the management of hypertension and heart failure. There have been a series of recent incidents where drug formulations containing different ARBs as active pharmaceutical ingredients have been recalled by various pharmaceutical firms. This article addresses valsartan as well as other sartan recalls besides discussing the recent recalls of ranitidine and metformin, giving insights  into the molecular-pharmaceutical basis of the recalls. A thorough literature search of PubMed/Medline and Google Scholar databases was performed to identify all relevant articles and information published up to 29th April 2020 using Medical Subject Headings (MeSH terms) and Boolean operators. We also searched for relevant information on the web using web-browsers and reference lists from original research papers and review articles. The main impurity found was N-nitrosodimethylamine (NDMA) which was thought to be formed due to a change in the manufacturing process of valsartan. Besides, other impurities such N- nitrosodiethylamine (NDEA) and N-nitroso-N-methyl-4-aminobutyric acid (NMBA) were found in batches of other sartans, such as losartan and irbesartan. All of these are carcinogens and harmful if consumed at a level beyond a certain acceptable daily limit. Ranitidine, and more recent metformin recalls, have also been linked with valsartan in view of the presence of NDMA, the same impurity. Safety of ARBs is a major concern among healthcare professionals after the recalls of valsartan in the recent years. Periodic quality assessment of the manufacturing process and the drugs is key to ensure safe, effective and high-quality drugs for the global population. Additionally, practising physicians need to be vigilant in reporting adverse events in their patients receiving treatments.

scholarly journals Perception and Information Behaviour of Institutional Repository End-Users Provides Valuable Insight for Future Development

2012 ◽  
Vol 7 (2) ◽  
pp. 81
Author(s):  
Lisa Shen
Keyword(s):  
Information Source ◽  
Research Process ◽  
End Users ◽  
The Other ◽  
Original Research ◽  
Valuable Insight ◽  
Host Institution ◽  
Institutional Repository ◽  
Structured Interviews ◽  
Google Search

Objective – To determine the perceptions and information behavior of institutional repository (IR) end-users. Design – Semi-structured interviews. Setting – The interviews were conducted over the telephone. Subjects – Twenty end-users of five different IRs were interviewed for the study. Seventeen of the interviewees were recruited via recruitment forms the researchers placed on IR homepages and the other three interviewees were referred to researchers by IR managers. The interviewees’ academic backgrounds varied, including six undergraduates, four masters’ students, three doctorial students, five faculty, and two library or museum staff members. They represented disciplines in Arts and Humanities (5), Science and Health Sciences (10), and Social Sciences (5). Fifteen of the 20 interviewees were recruited through their own institution’s IR. All except two of the interviewees had used the IR for which they were recruited less than six times. Methods – Forty-three potential interviewees were recruited using web recruitment forms and IR manager recommendations. Researchers subsequently excluded 23 (53.5%) of the interviewees because they were primarily IR contributors rather than end-users, or could not be reached by phone. Twenty interviews ranging from 17 to 60 minutes were conducted between January and June 2008. The average interview time was 34 minutes. The recordings were transcribed then analyzed using qualitative data analysis software NVivo7. Coding categories were developed using both the original research questions and emerging themes from the actual transcripts. The final coding scheme had a Holsi Coefficient of Reliability of 0.732 for inter-coder reliability. Main Results – Researchers identified six common themes from the results: How do end-users characterize IRs? While most interviewees recognized that there is a relationship between the IR and its host institution, their understandings of the function and content of IRs varied widely. Interviewees likened the IRs they used to a varying array of information resources and tools, including databases, interface, server, online forums, and “static Wikipedia” (p. 27). Furthermore, six of the interviewees had never heard of the actual term “Institutional Repository” (p. 27). How do end-users access and use IRs? The most common methods of accessing IRs included selecting the link on their institution library’s website and Google searches. Many interviewees found out about the IRs they are using through recommendations from professors, peers, or library workshops. Other interviewees found out about particular IRs “simply because a Google search had landed them there” (p. 29). Interviewees’ preferred method of interacting with an IR were divided between browsing and keyword searching. However, these preferences may have been the result of an IR’s content or interface limitations. For instance, some interviewees expressed difficulties with browsing a particular IR, while another interviewee preferred browsing because “there wasn’t much going on” when searching for a specific topic of interest (p. 30). For what purposes do end-users use IRs? Interviewees commonly cited keeping abreast with research projects from their own university as a reason to access their institutions’ IRs. Student interviewees also used IRs to find examples of theses and dissertations they would be expected to complete. Identifying people doing similar work across different departments in the same institution for collaboration and networking opportunities was another unique purpose for using IRs. How do end-users perceive the credibility of information from IRs? Many interviewees perceived IRs to be more “trustworthy” than Google Scholar (p. 33). In their view, an IR’s credibility was assured by the reputation of its affiliated institution. On the other hand, many interviewees viewed a lack of comprehensiveness in content negatively when judging the credibility of an information source, which placed most IRs in a less favorable light. Additionally, researchers noted conflicting assumptions made by interviewees about IRs in the evaluation process for their content. Some interviewees believed all the content of an IR has been vetted through an approval process, while others distrusted all IR content that was not peer-reviewed. To what extent are end-users willing to return to an IR or recommend it to their peers? The great majority of interviews indicated they were likely to use IRs again in the future, and nearly all indicated they would recommend IRs to their peers. However, most interviewees did not know of any people using IRs. The few interviewees who did often knew of IR contributors rather than end-users. How do IRs fit into end-users’ information seeking behavior? Many interviewees noted that IRs provided them with content that was not commonly available through traditional publishing channels, including conference papers and dissertations. Others felt IRs made content available more quickly than other information sources. However, the results also suggested that most interviewees did not include IRs in their routine research process. Conclusion – This study identified current end-users’ perceptions of IRs and highlighted several areas for future IR development. Areas of improvement for IRs included intensifying publicity efforts; increasing content recruitment; making content recruitment policies more transparent; and improving appearance and navigation functionalities. The findings also suggested new directions for IR marketing, such as emphasizing on the networking and collaborating benefits of using IR.

scholarly journals Avaliação e intervenção do equilíbrio em idosos

2018 ◽  
Vol 12 (9) ◽  
pp. 2479
Author(s):  
Jéssica Resende Del’Olmo Bennett ◽  
Ivânia Vêra ◽  
Kamylla Guedes De Sena ◽  
Moisés Fernandes Lemos ◽  
Roselma Lucchese ◽  
...  
Keyword(s):  
Risk Factors ◽  
Activities Of Daily Living ◽  
Postural Balance ◽  
Daily Living ◽  
The Elderly ◽  
Original Research ◽  
Assessment Instruments ◽  
Level Of Evidence ◽  
Factores De Riesgo ◽  
Method Of Evaluation

RESUMOObjetivo: apresentar quais instrumentos e técnicas são utilizados em idosos com vistas à melhoria do equilíbrio e da postura. Método: revisão integrativa com pesquisas originais publicadas nos últimos dez anos. Utilizaram-se, para as buscas, os descritores “Aged”, “Postural Balance” e “Activities of Daily Living” nas bases de dados LILACS, PubMed/MEDLINE e na biblioteca virtual SciELO. Sintetizaram-se os artigos selecionados após preencherem os critérios de inclusão   classificando-os por meio do nível de evidência em um total de 36 estudos. Resultados: identificaram-se 75 instrumentos de avaliação. Destes, o Mini Exame do Estado Mental, a Escala de Equilíbrio de Berg e o Teste Time up and Go foram os mais utilizados e com melhores indicações de seu uso. Conclusão: inúmeros são os instrumentos utilizados para avaliar o equilíbrio e a mobilidade de idosos revelando que apenas um meio de avaliação não é eficaz para avaliar todas as vertentes que envolvem o deficit de equilíbrio. Necessita-se associar dois ou mais instrumentos de avaliação, a fim de proporcionar um resultado mais fidedigno, com vistas a serem traçados objetivos e intervenções adequados na identificação dos fatores de risco e proposição de intervenções preventivas e de promoção à saúde. Descritores: Idoso; Equilíbrio Postural; Atividades Cotidianas; Limitação da Mobilidade; Fatores de Risco; Saúde Pública.ABSTRACT Objective: to present which instruments and techniques are used in the elderly to improve balance and posture. Method: integrative review, with original research published over the last ten years. The descriptors "Aged", "Postural Balance" and "Activities of Daily Living" were used in the searches: LILACS, PubMed / MEDLINE and SciELO virtual library. The selected articles were synthesized after fulfilling the inclusion criteria and were classified through the level of evidence, totaling 36 studies. Results: in the face of the research, 75 assessment instruments were identified, of which the Mini Mental State Exam, Berg Balance Scale and Time Up and Go Test were the most used and with better indications of their use. Conclusion: a number of instruments are used to assess the balance and mobility of the elderly, revealing that only one method of evaluation is not effective in assessing all aspects of equilibrium deficits. It is necessary to associate two or more assessment instruments in order to provide a more reliable result, with a view to establishing appropriate objectives and interventions, identifying risk factors and proposing preventive and health promotion interventions. Descriptors: Aged; Postural Balance; Activities of Daily Living; Mobility Limitation; Risk Factors; Public Health.RESUMEN Objetivo: presentar cuales instrumentos y técnicas se utilizan en ancianos con miras a mejora del equilibrio y de la postura. Método: revisión integrativa, con investigaciones originales publicadas en los últimos 10 años. Se utilizó para las búsquedas los descriptores "Aged", "Postural Balance" y "Actividades del Daily Living" en las bases de datos: LILACS, PubMed / MEDLINE y biblioteca virtual SciELO. Se sintetizaron los artículos seleccionados después de llenar los criterios de inclusión y se clasificaron a través del nivel de evidencia, totalizando 36 estudios. Resultados: en la investigación se identificaron 75 instrumentos de evaluación, de los cuales el Mini Examen del Estado Mental, Escala de Equilibrio de Berg y la Prueba Time up and Go fueron los más utilizados y con mejores indicaciones de su uso. Conclusión: numerosos son los instrumentos utilizados para evaluar el equilibrio y la movilidad de ancianos, revelando que sólo un medio de evaluación no es eficaz para evaluar todos los aspectos que implican el déficit de equilibrio. Se requiere asociar dos o más instrumentos de evaluación a fin de proporcionar un resultado más fidedigno, con miras a ser trazados objetivos e intervenciones adecuadas, en la identificación de los factores de riesgo y proposición de intervenciones preventivas y de promoción a la salud. Descriptores: Anciano; Balance Postural; Actividades Cotidianas; Limitación de la Movilidad; Factores de Riesgo; Salud Pública.

Tsunami!

2005 ◽  
Author(s):  
Susan Elizabeth Hough ◽  
Roger G. Bilham
Keyword(s):  
New York ◽  
Sea Level ◽  
Urban Life ◽  
Trade Routes ◽  
Unusual Event ◽  
Moonless Night ◽  
Ancient Times ◽  
The City ◽  
Global Population

The 1867 tsunami described in the previous chapter was, as the world has recently witnessed, scarcely an unusual event. Nor was the scene of destruction that followed. Elsewhere in this book we emphasize how the world’s rush, since the 1950s, to expand the size of cities has been driven by an increase in global population. Like a box with flexible sides, the city expands to embrace all those who favor the convenience, bustle, and economic opportunities of urban life. When lateral expansion is no longer feasible, as in the walled holy city of Bhaktipur in Nepal, or the confined economic and cultural island powerhouse of Manhattan, the city expands upward. When both lateral and upward expansion are confined, the size of dwelling units inevitably contracts. Few citizens leave these urban black holes, and when they do, they invariably choose to swell the ranks of another city. Yet one other type of place on our planet has beckoned since ancient times—coastlines of continents, especially the earth’s temperate and tropical shores. It has been estimated that 400 million people live within 20 meters of sea level and within 20 kilometers of a coast, many of them within a few kilometers of the beach. Precise numbers are difficult to pin down because census compilations rarely list a household’s height above sea level or its distance from the sea. Some idea of mankind’s curious predilection to gravitate shoreward can be obtained by viewing the earth from space on a moonless night. Seen from above, the coastlines of continents and islands are illuminated festively by electric light bulbs. The attraction here is not so much the views nor even the fish: coastlines are trade routes and, being the termini for the world’s rivers, streams, and subsurface aquifers, are nearly always endowed with a bountiful supply of freshwater for agriculture, as well as for thirsty populations and industries. This, of course, is why many of the world’s largest cities are seaports: London, New York, Karachi, Calcutta, Hong Kong.

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