scholarly journals CHARACTERISTICS OF THE LIPID PROFIL YOUNG ADULTS WITH ISCHEMIC HEART DISEASE IN GEORGIAN POPULATION

2021 ◽  
Vol 11 (01) ◽  
pp. 47-52
Author(s):  
Giorgi Gogishvili Giorgi Gogishvili ◽  
Shalva Petriashvili Shalva Petriashvili ◽  
Nino Nanobashvili Nino Nanobashvili ◽  
Nino Megrelishvili Nino Megrelishvili ◽  
Iamze Taboridze Iamze Taboridze
Keyword(s):  
Young Adults ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Ischemic Heart ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Georgian Population

Objective: Impaired lipoprotein metabolism is a significant and modifiable risk factor for atherosclerotic cardiovascular disease. Aim: The aim of our study was to determine the diagnostic accuracy of lipid profile indices in young adults in Georgian population. Methods: Under our observation were 107 patients with ischemic heart disease, aged 18-45 years, From the St. John The Merciful Private Clinic contingent. Examination: anamnesis, cardiography, echocardiography, coronography, blood lipid metabolism. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), Triglycerides (TG), mmol/L) and lipid indices -TC-HDL/HDL, TG /HDL, and LDL/HDL Results: With IHD for young adults, TC-HDL/HDL distinguished by good sensitivity and sufficient specificity, TG /HDL - bad sensitivity and very excellent specificity, LDL/HDL - sufficient sensitivity and good specificity, With IHD, for TC-HDL/HDL Cut off=2.29, for TG /HDL, cut off=2.76 and for LDL/HDL - 2.17 High lipid indices on these data indicate a high risk of ischemic heart disease. Conclusion: lipid indices TC-HDL/HDL, TG /HDL, and LDL/HDL can be used for the primary diagnosis of ischemic heart disease in young adults. Keywords: risk factors IHD, dyslipidemia.

Abstract 14116: Effects of Statin Intensity and Low-density Lipoprotein Cholesterol Lowering in Korean Patients With Chronic Ischemic Heart Disease and Very Low Low-density Lipoprotein Cholesterol

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Soo Youn Lee ◽  
Jong-Chan Youn ◽  
Sungha Park ◽  
Seok-Min Kang ◽  
Donghoon Choi ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ischemic Heart ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Low Density ◽  
Chronic Ischemic Heart Disease ◽  
Low Density Lipoprotein Cholesterol

Introduction: Current guidelines on lipid management emphasize LDL-C lowering >50% of baseline levels with intensive statin regimens in patients with coronary artery disease. However, whether this strategy is beneficial also in patients with very low LDL-C has not been proven. Furthermore, controversy remains on the optimal statin intensity for Asians in whom outcome data of lipid therapy are highly limited. Methods and Results: Totally, 3867 patients with chronic ischemic heart disease were initially screened. Among them, 393 subjects(age: 66 years; males: 68%) who showed baseline LDL-C <80 mg/dL without lipid lowering medications were finally included. Patients were retrospectively classified to 4 groups according to statin intensity they received : no (n=35), Moderate-low (atorvastatin 10mg or similar, n=135), moderate-high (atorvastatin 20 mg or similar, n=177), or high (atorvastatin 40-80 mg or similar, n=46) intensity. Patients took blood tests every 3-6 months and were clinically followed-up for major adverse cardiac events (MACE). During the mean follow-up of 3.8 years, 41 patients (10.4%) experienced MACE. The event-free survival was higher in patients receiving higher dose statins (Figure, p=0.03). In the univariate analysis, age (p=0.05), the % change of LDL-C (p=0.01), and the statin intensity (p=0.03) were associated with MACE. In the multivariate analysis, the statin intensity was found to be an only independent predictor of clinical outcome (p=0.05). Interestingly, the beneficial effect of statins became significant at the moderate-high dose. The predictive value of the % change of LDL-C was not significant after controlling other variables. Conclusions: Our study demonstrated that higher dose statins (at least moderate-high intensity) were more beneficial in Asian patients with chronic ischemic heart disease even if their LDL-C is <80 mg/dL. This effect was independent of % change of LDL-C.

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