scholarly journals Met Metabolismo intermediario de Blastocystis spp

2021 ◽  
Vol 15 (2) ◽  
pp. 115-136
Keyword(s):  
Blastocystis Spp

Blastocystis es un stramenopile o cromista, pleomórfico no móvil. Se han identificado diecinueve subtipos de este organismo (ST1-ST19). Tiene una presencia a nivel mundial. Este microorganismo tiene un metabolismo intermediario anaeróbico. Un aspecto interesante de la bioquímica de este stramenopile está dado por la presencia de organelas similares a mitocondrias con un conjunto de rutas: cadena de fosforilación oxidativa incompleta, ciclo de Krebs parcial, metabolismo de ácidos grasos (anabolismo y catabolismo), metabolismo de aminoácidos y ensamblaje de proteínas con centros hierro/azufre. El tratamiento se ha basado tradicionalmente en metronidazol y otros imidazoles. Sin embargo, hay un número creciente de cepas resistentes a esos medicamentos. La reciente obtención del genoma nuclear y los estudios bioquímicos, proteómicos, metabolómicos, interactómicos permitirán el desarrollo racional de nuevos fármacos curativos. El objetivo de esta revisión es describir el metabolismo de Blastocystis spp.

ANTICYTOKINE ACTIVITY OF THE PROTOZOA BLASTOCYSTIS SPP

2020 ◽  
pp. 44-48
Author(s):  
Bugero N.V. ◽  
Ilyina N.A. ◽  
Aleksandrova S.M.
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Ulcer Disease ◽  
Cytokine Balance ◽  
High Prevalence ◽  
Blastocystis Spp ◽  
High Level ◽  
Eukaryotic Organisms ◽  
High Degree

In addition to the classical pathogens, which are well understood and well identified, new pathogens with the potential to spread epidemiologically are being identified. Some of these little-known organisms are the simplest Blastocystis spp. blastocystostosis. The clinical significance of Blastocystis spp. and its pathogenicity are still under discussion. This parasite belongs to a group of single-celled eukaryotic organisms living in the colon of the human intestine. Blastocystis spp. is known to be found both in people with reduced immune status and in individuals without any clinical manifestation. It has been established that a sufficiently high degree of invasiveness is observed in persons with gastrointestinal tract diseases, dermatosis, allergic reactions, in patients with carriers of the human immunodeficiency virus, etc. Possessing persistence factors, protozoa blastocysts contribute to the inactivation of host defensive mechanisms, providing a stable anthogonistic effect. In recent years, many works have been devoted to the characteristics of the persistent properties of Blastocystis spr., however, individual properties of blastocysts, in particular, anticytokine activity (ACA), have not yet been studied. In this regard, the work studied the anticytokine activity of microorganisms isolated from healthy subjects and patients with gastrointestinal tract diseases. A high prevalence of the studied characteristic in the subjects was shown. The expression of anticytokine activity in the obtained isolates of blastocysts was the highest in the group of persons with gastric ulcer disease, which decreased in the order of duodenal ulcer, chronic cholecystitis, chronic gastritis, etc. The data obtained in this work on the high level of ACA expression in blastocyst isolates obtained from individuals with gastrointestinal diseases as compared with the control group enables to conclude that their exometabolites may influence the local cytokine balance [1], which supports the inflammatory process.

scholarly journals Pathogenicity and non-opportunistic character of Blastocystis spp.: a hospital-based survey in Central Cameroon

2018 ◽  
Vol 12 (05) ◽  
pp. 373-379 ◽  
Author(s):  
Stéphanie Jupsa-Mbiandou ◽  
Samuel Fosso ◽  
Edimo Billé ◽  
Tito T Mélachio-Tanekou ◽  
Gideon Ajeagah-Aghaindum ◽  
...  
Keyword(s):  
Rural Areas ◽  
Urban Areas ◽  
Age Groups ◽  
Clinical Signs ◽  
Hiv Positive ◽  
Cross Sectional ◽  
Significant Difference ◽  
Blastocystis Spp ◽  
Stool Samples ◽  
Hiv Negative

Introduction: Blastocystis spp. is a protist found in humans. Although usually the most frequent protozoa found in stool samples of both symptomatic and healthy subjects, its pathogenic or rather opportunistic role is yet to be clearly elucidated. To attempt to fill this gap, a cross-sectional study was conducted to compare the frequency of Blastocystis spp. in HIV positive (HIV+) versus HIV negative (HIV-) individuals in four health facilities of the Center Region of Cameroon. Methodology: Stool samples were collected from 283 HIV positive and 245 HIV negative subjects and analyzed using direct diagnostic tests. Results: A total of 46 (8.7%) individuals were found infected with Blastocystis spp., including 6.7% HIV positive and 11.0% HIV negative. This species was more frequent in urban and semi-urban areas than in rural areas, but evenly distributed among genders and age groups as well as among all sectors of activity. The prevalence of Blastocystis spp. (11.3%) was higher in HIV+ patients with a CD4 count ≥ 500 cells / mm3, but no significant difference was found among HIV clinical stages. Likewise prevalence, the mean number of cysts per gram of stool was similar between HIV positive and HIV negative individuals. People infected with Blastocystis spp. showed diverse clinical signs, but only flatulence was significantly more prevalent. The frequencies of these clinical signs were not related to HIV status. Conclusion: No clear relationship links the infection with Blastocystis spp. to HIV, although its presence was associated with digestive disorder, suggesting that this parasite might not be opportunist.

scholarly journals THE RELEVANCE OF THE DEFINITION OF BLASTOCYSTIS SPP. IN ENVIRONMENTAL OBJECTS AS POTENTIAL RISK FACTORS FOR THE OCCURRENCE OF PROTOZOAL HUMAN INFECTION

2018 ◽  
Vol 97 (11) ◽  
pp. 1043-1045
Author(s):  
Olga V. Gritsyuk ◽  
K. Yu. Kuznetsova ◽  
A. V. Zagainova
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
Practical Importance ◽  
Human Infection ◽  
Survival Duration ◽  
Environmental Objects ◽  
Blastocystis Spp ◽  
Potential Risk Factors ◽  
Infection Risk Factors ◽  
Protozoal Infection

The most abundant protozoan Blastocystis spp. from human and animal intestines is one of the poor-studied pathogens causing the occurrence of a protozoal infection of the human gastrointestinal tract. In Russia, no Blastocyst invasion is recorded and neither included in the forms of state statistical reporting. The manifestations of the epidemic process of blastocyst can be judged based on a small number of studies. Analysis of clinical observations and literature data indicates a variety of forms, localization, and nature of the infection manifestation. This article is devoted to substantiating the need to detect blastocysts in environmental objects (water, soil, surfaces) as potential risk factors for the occurrence of a protozoal infection. At the same time, the studies both of the survival duration in the external environment and influence of various factors the Blastocystis survival have both the theoretical and practical importance. This information can be used in problems of epidemiology and epizootiology, for developing new methods for Blastocystis elimination, and identifying ways of spreading these parasites. Infection risk factors are sanitary and hygienic problems of environmental objects (geographical, environmental and social factors), profession features, contact with animals, use of contaminated water and food, immigration and travel to tropical countries, as well as people with weakened immune status.

scholarly journals Laboratory diagnosis of Blastocystis spp

2015 ◽  
Vol 5 (1) ◽  
pp. 3 ◽  
Author(s):  
ChristenRune Stensvold
Keyword(s):  
Laboratory Diagnosis ◽  
Blastocystis Spp

scholarly journals Clarifying the Cryptic Host Specificity of Blastocystis spp. Isolates from Alouatta palliata and A. pigra Howler Monkeys

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169637 ◽  
Author(s):  
Claudia Villanueva-Garcia ◽  
Elias Jose Gordillo-Chavez ◽  
Eduardo Lopez-Escamilla ◽  
Emilio Rendon-Franco ◽  
Claudia Irais Muñoz-Garcia ◽  
...  
Keyword(s):  
Host Specificity ◽  
Alouatta Palliata ◽  
Howler Monkeys ◽  
Blastocystis Spp
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