ANTICYTOKINE ACTIVITY OF THE PROTOZOA BLASTOCYSTIS SPP

2020 ◽  
pp. 44-48
Author(s):  
Bugero N.V. ◽  
Ilyina N.A. ◽  
Aleksandrova S.M.
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Ulcer Disease ◽  
Cytokine Balance ◽  
High Prevalence ◽  
Blastocystis Spp ◽  
High Level ◽  
Eukaryotic Organisms ◽  
High Degree

In addition to the classical pathogens, which are well understood and well identified, new pathogens with the potential to spread epidemiologically are being identified. Some of these little-known organisms are the simplest Blastocystis spp. blastocystostosis. The clinical significance of Blastocystis spp. and its pathogenicity are still under discussion. This parasite belongs to a group of single-celled eukaryotic organisms living in the colon of the human intestine. Blastocystis spp. is known to be found both in people with reduced immune status and in individuals without any clinical manifestation. It has been established that a sufficiently high degree of invasiveness is observed in persons with gastrointestinal tract diseases, dermatosis, allergic reactions, in patients with carriers of the human immunodeficiency virus, etc. Possessing persistence factors, protozoa blastocysts contribute to the inactivation of host defensive mechanisms, providing a stable anthogonistic effect. In recent years, many works have been devoted to the characteristics of the persistent properties of Blastocystis spr., however, individual properties of blastocysts, in particular, anticytokine activity (ACA), have not yet been studied. In this regard, the work studied the anticytokine activity of microorganisms isolated from healthy subjects and patients with gastrointestinal tract diseases. A high prevalence of the studied characteristic in the subjects was shown. The expression of anticytokine activity in the obtained isolates of blastocysts was the highest in the group of persons with gastric ulcer disease, which decreased in the order of duodenal ulcer, chronic cholecystitis, chronic gastritis, etc. The data obtained in this work on the high level of ACA expression in blastocyst isolates obtained from individuals with gastrointestinal diseases as compared with the control group enables to conclude that their exometabolites may influence the local cytokine balance [1], which supports the inflammatory process.

Disorders of mineral bone density and vitamin D deficiency in chronic diseases of the gastrointestinal tract

2015 ◽  
Vol 21 (31) ◽  
pp. 28-32
Author(s):  
Тотров ◽  
Igor Totrov ◽  
Слохова ◽  
N. Slokhova ◽  
Медоева ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gastrointestinal Tract ◽  
Bone Density ◽  
Blood Serum ◽  
Vitamin D Deficiency ◽  
Chronic Diseases ◽  
Gastrointestinal Diseases ◽  
High Prevalence ◽  
Mineral Bone Density ◽  
Different Parts

This article presents the results of a study of mineral bone density, and vitamin D 25(OH)D3 in serum of 100 patients with chronic diseases of the stomach and duodenum. The results osteodensitometry studies have demonstrated a high prevalence of osteopenia and osteoporosis in different parts of the skeleton among the patients with diseases of the gastrointestinal tract. The decrease of vitamin D level in the blood serum of patients with diseases of the stomach and duodenum. The existing disorders of bone metabolism in patients with gastrointestinal diseases are connected with deficiency of vitamin D.

scholarly journals Peptic Ulcer Does Not Increase the Risk of Stroke: a Longitudinal Follow-up Study Using a National Sample Cohort

2021 ◽  
Author(s):  
Hyo Geun Choi ◽  
Jae Seung Soh ◽  
Jae Sung Lim ◽  
Song Yong Sim ◽  
Suk Woo Lee
Keyword(s):  
Peptic Ulcer ◽  
Ischemic Stroke ◽  
Subgroup Analysis ◽  
Gastrointestinal Diseases ◽  
National Sample ◽  
Control Group ◽  
Ulcer Disease ◽  
Hazard Ratios ◽  
Korean National Health Insurance ◽  
Age And Sex

Abstract Background: Studies have reported that several gastrointestinal diseases increase the risk of stroke. We aimed to evaluate the risk of stroke in patients with peptic ulcer disease (PUD) using a national sample cohort from South Korea. Methods: We extracted data entered into the Korean National Health Insurance Service for patients with PUD (n = 129,531) and for 1:1 matched control participants (n = 129,531) and analyzed the risk of stroke using Cox proportional hazard model. Subgroup analyses were performed based on age and sex.Results: The rates of hemorrhagic and ischemic stroke were lower in the PUD group than in the control group. In a subgroup analysis according to age, the adjusted hazard ratios (HRs) of PUD for hemorrhagic and ischemic stroke were 0.76 (95% CI = 0.63-0.90) and 0.85 (95% CI = 0.73-0.98) in the < 50-year-old group and 0.72 (95% CI = 0.65-0.80) and 0.84 (95% CI = 0.80-0.89) in the ≥ 50-year-old group, respectively (each p < 0.05). In a subgroup analysis according to sex, the adjusted HRs of PUD were 0.71 (95% CI = 0.63-0.81) and 0.81 (95% CI = 0.5-0.87) in men and 0.75 (95% CI = 0.66-0.86) and 0.88 (95% CI = 0.82-0.95) in women, respectively (each p < 0.05).Conclusions: Our study concluded that PUD does not increase the risk of ischemic or hemorrhagic stroke regardless of age and sex.

scholarly journals Asymptomatic Bacteriuria amongst Menopausal women in Calabar, Nigeria

2018 ◽  
Vol 9 (4) ◽  
pp. 51-56
Author(s):  
Paul Columba Inyang-Etoh ◽  
Abasiodiong Udom Akpan ◽  
Victor Udo Usanga ◽  
Gabriel Chuks Ejezie
Keyword(s):  
Postmenopausal Women ◽  
Prevalence Rate ◽  
Asymptomatic Bacteriuria ◽  
Test Group ◽  
Early Morning ◽  
Control Group ◽  
Menopausal Women ◽  
High Prevalence ◽  
Post Menopausal ◽  
High Level

Background: Bacteriuria is considered a common bacterial infection in women particularly in postmenopausal women which consequently may warrant the need to treat the disease for prevention of bacteriuria developing complications.Aims and Objectives: This work was to investigate the prevalence of asymptomatic bacteriuria among menopausal women in Calabar, the incriminating bacterial pathogens and their antibiotic susceptibility pattern. Materials and Methods: Early morning mid stream urine samples from randomly selected 200 women (comprising of 50 premenopausal, 50 menopausal, 50 postmenopausal women and 50 apparently healthy young ladies of menstruating age (control subjects)) between the ages of 50 to 90 years were cultured by Leigh and Williams’s method. Questionnaires were also administered.Results: 24 (16%) of the test group while 3 (6%) of the control group had infection (p=0.008). Subjects aged 35-40 years had the highest prevalence of infection 6 (18.5%), while age group 66-70yrs had the lowest infection rate 0(0%)( P = 0.841). Post-menopausal women had the highest prevalence of asymptomatic bacteriuria 10(20%) while pre-menopausal and menopausal women had a lower prevalence rate of 7 (14%) each (p=0.0687). The most frequently isolated organism was Staphylococcus aureus (33%) and Ciprofloxacin was the most sensitive antibiotic observed.Conclusion: This work has revealed a high prevalence rate of asymptomatic bacteriuria high level of asymptomatic bacteriuria among menopausal women and the need for routine screening of this category of women for a standard healthy living.Asian Journal of Medical Sciences Vol.9(4) 2018 51-56

The Prevalence of Thyroid Dysfunction in PCOS Women in Comparison with A Control Group

2021 ◽  
Author(s):  
Suad M. Ghazi ◽  
Nadia khaleil ismail
Keyword(s):  
Thyroid Dysfunction ◽  
High Body Mass Index ◽  
Thyroid Stimulating Hormone ◽  
Reproductive Age ◽  
Control Group ◽  
High Prevalence ◽  
The Common ◽  
High Level ◽  
Ovarian Syndrome ◽  
Healthy Females

Abstract Background One of the common disorders that affect females of reproductive age is the Poly-Cystic Ovarian Syndrome (PCOS). Thyroid dysfunction is also more prevalent in this age group. This study aimed to evaluate the prevalence of thyroid dysfunction in women with PCOS in comparison with control and to investigate the association between hypothyroidism and PCOS in women of ovulatory age. Patients and Methods: Eighty female subjects of fertility age were selected and divided into two equal groups. The first 40 subjects are healthy females as a control group. The second 40 group are patients with PCOS. The PCOS women were diagnosed by Rotterdam criteria and performed thyroid tests, sex hormones and lipid profile tests. Results The results show that PCOS women with hypothyroidism are tending have a high body mass index (BMI). Forty-five percent of PCOS patients had hypothyroidism which was investigated in TSH and T4 tests by 35% and 10%, respectively. A high level of testosterone was found in females with PCOS. The cholesterol shows a significant correlation with the alteration in Thyroid Stimulating Hormone (TSH). Conclusion There is a correlation between thyroid dysfunction especially hypothyroidism with the polycystic ovarian syndrome because both of them lead in features to metabolic syndrome and there is a high prevalence of hypothyroidism in women with PCOS

scholarly journals Effectiveness of a feed additive with a high degree of protein protection in feeding fresh cows

2021 ◽  
pp. 134-141
Author(s):  
E. G. Chupurina ◽  
D. A. Iurin ◽  
A. B. Vlasov ◽  
N. A. Iurina
Keyword(s):  
Feed Additive ◽  
Control Group ◽  
Group Feeding ◽  
High Level ◽  
Daily Milk Yield ◽  
High Degree ◽  
To Receive ◽  
Experimental Group ◽  
Daily Milk ◽  
Degradable Protein

Intensive dairy farming in modern conditions is impossible without a solid forage base and the use of high-quality forage resources. A high level of cow productivity presupposes adequate nutrition for the animal at all physiological periods of its life. Due to the fact that cows consume relatively little feed during the first period of lactation, the primary task of livestock breeders is to provide the body of highly productive animals with the necessary amount of energy, protein and other nutrients. The article presents the data of a scientific experiment on the use of non-degradable protein in the rumen PassPro Balance in diets for fresh cows. The feed additive under study contributes to an increase in the level of dry matter consumption by animals. The average daily milk yield of the experimental group, which received the studied supplement, significantly increased by 12.0% (P <0.05) in comparison with the control group. There was also established a tendency to an increase in the fat content in the milk of cows from the experimental group. According to the biochemical analysis of the blood serum of cows, the level of albumin in all animals was within the physiological norm. The content of globulins was below the norm in animals of all groups without significantly significant differences. The activity of the AST and ALT enzymes between the groups did not differ significantly. However, it should be noted that in both groups these indicators were within the normal range. The level of alkaline phosphatase tended to increase in the experimental group by 20.8% in comparison with the control group. Feeding PassPro Supplements Balance in the diets for the experimental group made it possible to receive 2565,00 rubles of additional profit, while the level of profitability of milk production increased by 2.02% relative to control.

scholarly journals Effect of quercetin on histamine induced gastric ulcers in male guinea pigs

2019 ◽  
Vol 8 (9) ◽  
pp. 2018 ◽  
Author(s):  
Uma Narayanamurthy ◽  
Ranjani Jayachandran ◽  
Sudar Codi Ramarajan ◽  
Manimekalai Kumarappan
Keyword(s):  
Gastric Ulcer ◽  
Guinea Pigs ◽  
Gastrointestinal Diseases ◽  
Gastric Ulcers ◽  
Control Group ◽  
Ulcer Disease ◽  
Group I ◽  
Permanent Cure ◽  
Group 3 ◽  
Group 2

Background: Peptic ulcer disease is the most prevalent gastrointestinal diseases caused by an imbalance between gastric stimulant or aggressive factors and the mucosal defensive factors. The defence of flavonoids against the tissue oxidative stress is being proved in various animal models for wide pharmacological effects. The aim of the present study is to evaluate the anti-oxidant effect of quercetin in histamine induced gastric ulcers.Methods: Male guinea pigs were divided into 4 groups (n=6). Group I includes normal control. Group 2, 3 and 4 were induced gastric ulcers with histamine as intraperitoneal (IP) injection. Group 2 serves as the gastric ulcer control. Group 3 and Group 4 are pre-treated with quercetin 200 mg/kg per orally (PO) and ranitidine 100 mg/kg PO respectively 45mins before histamine injection. After 4 hours of histamine injection, the animals were sacrificed to collect blood samples and stomach tissue for estimation of plasma and tissue antioxidant levels.Results: On estimation of antioxidant levels both in plasma and stomach tissues the SOD and CAT levels increased in the Group 3 and 4 significantly and also a significant reduction in MDA levels were noted in the Group 3 and 4 compared to the gastric ulcer control group.Conclusions: Hence, with flavonoids quercetin utilization in histamine induced gastric ulcers, the antioxidants showed comparative levels with ranitidine treatment groups. So a permanent cure for the chronic gastric ulcers could be proved in further studies as this is the milestone, tough to achieve in general clinical practice.

The features of the pollen sensitization in seasonal allergic rhinitis patients with gastrointestinal tract inflammatory diseases comorbidity

2020 ◽  
Vol 17 (3) ◽  
pp. 57-63
Author(s):  
Natalia S. Iraklionova ◽  
Eleonora B. Belan ◽  
Svetlana V. Turkina ◽  
Anna A. Panina ◽  
Tatiana L. Sadchikova ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Gastrointestinal Tract ◽  
Seasonal Allergic Rhinitis ◽  
Inflammatory Diseases ◽  
Skin Prick Testing ◽  
Birch Pollen ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Pollen Allergens ◽  
H Pylori

BACKGROUND:Allergic diseases and gastrointestinal tract diseases can influence on the natural course of each other. AIM:To study the sensitization profile in patients with comorbidity of seasonal allergic rhinitis (SAR) and upper gastrointestinal tract inflammatory diseases (UGITID). MATERIALS AND METHODS:112 adult residents of Volgograd city suffering from SAR but without perennial symptoms and sensitization to indoor allergens have been included in the study. 31/112 patients hadH. pylori-negative and 38/112 H. pylori-positive UGITID. Control group consisted of 43/112 patients without gastrointestinal diseases. Skin prick-testing with 3 groups of pollen allergens have been carried out. RESULTS:75.9% of patients were sensitized to weed pollen; sensitization to grass pollen was in 1.53 times less, and 10.5% of patients (4/38) had positive tests with birch pollen. The sensitization to quinoa and ragweed in SAR and H. pylori-UGITID patients was comparable with control group but less common with wormwood, sumpfweed allergens. The sensitization in SAR patients andH. pylori+-UGITID was similar to the control group, but positive SPT with sunflower and corn allergens were rare then in control group. CONCLUSION:Weed pollen allergens prevail in sensitization spectrum of adult Volgograd residents with SAR. Sensitization to goose-foot and ragweed is common less in SAR patients andH. pylori-UGITID but to graminea grass and birch pollen is more often. It may be supposed that the UGITID are predisposing factors to the sensitization to cross-reacting plant food allergens. At the same time supposed immunomodulating action ofH. pylorimake the differences between AR patients withH. pylori+-UGITID orH. pylori-UGITID minor.

scholarly journals Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19

2021 ◽  
Vol 12 ◽  
Author(s):  
Alessandra Oliva ◽  
Maria Claudia Miele ◽  
Federica Di Timoteo ◽  
Massimiliano De Angelis ◽  
Vera Mauro ◽  
...  
Keyword(s):  
Binding Protein ◽  
Microbial Translocation ◽  
Control Group ◽  
Intestinal Damage ◽  
Cell Integrity ◽  
Gut Permeability ◽  
Fatty Acid Binding ◽  
And Gender ◽  
High Level ◽  
High Degree

Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19. Aims were to assess whether alteration of gut permeability and cell integrity characterize COVID-19 patients, whether it is more pronounced in severe infections and whether it influences the development of subsequent bloodstream infection (BSI). Furthermore, we looked at the potential predictive role of TM and ID markers on Intensive Care Unit (ICU) admission and in-hospital mortality. Over March–July 2020, 45 COVID-19 patients were enrolled. Markers of MT [LPB (Lipopolysacharide Binding Protein) and EndoCab IgM] and ID [I-FABP (Intestinal Fatty Acid Binding Protein)] were evaluated at COVID-19 diagnosis and after 7 days. As a control group, age- and gender-matched healthy donors (HDs) enrolled during the same study period were included. Median age was 66 (56-71) years. Twenty-one (46.6%) were admitted to ICU and mortality was 22% (10/45). Compared to HD, a high degree of MT and ID was observed. ICU patients had higher levels of MT, but not of ID, than non-ICU ones. Likewise, patients with BSI had lower EndoCab IgM than non-BSI. Interestingly, patients with high degree of MT and low ID were likely to be admitted to ICU (AUC 0.822). Patients with COVID-19 exhibited high level of MT, especially subjects admitted to ICU. COVID-19 is associated with gut permeability.

scholarly journals DIAGNOSTIC SIGNIFICANCE OF SOME REPRESENTATIVES OF NORMAL MICROBIOME OF THE ORAL CAVITY IN THE DEVELOPMENT OF RECOVERABLE ACTS OF THE ORAL CAVITY IN PATIENTS WITH ACID-DEPENDENT GASTROINTESTINAL DISEASES

2020 ◽  
Vol 15 (4) ◽  
pp. 31-37
Author(s):  
Irina Galimova ◽  
Irina Usmanova ◽  
Larisa Gerasimova ◽  
Marsel Tuigunov ◽  
Yigal Granot ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Cavity ◽  
Clinical Manifestations ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Candida Spp ◽  
Diagnostic Significance ◽  
Detection Frequency ◽  
Enterococcus Spp ◽  
Staphylococcus Spp

Subject. The results of a comprehensive microbiological study of the state of the normobioma of the oral cavity in individuals with recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract are considered. The goal is to determine the diagnostic significance of individual representatives of the oral normobioma in patients with recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract. Methodology. The study involved 83 patients who were divided into two main and control groups depending on the clinical manifestations of recurrent aphthae of the oral cavity on the background of hypersecretory syndrome. Results. The results of the study showed that in patients of the first and second main groups, in which the manifestations of recurrent aphthae in the oral cavity were accompanied by diseases of the gastrointestinal tract with hypersecretory syndrome, the frequency of allocation of staphylococcal flora was 1.3—1.5 times higher compared to control (p≤0.05), an increase in the proportion of S. aureus — 2.5 times. The detection frequency of S. epidermidis in the control and both clinical groups was 28.0, 27.6 and 31.0 % of cases, respectively, the proportion of hemolytic forms in the control group was 4.0 %, in the first 10.3 % (an increase of 2 5 times), in the second — 17.2 % (4.3 times). The observed changes in the species composition may indicate dysbiosis in the oral cavity, caused not only by the presence of recurrent aphthae, but also by acid-dependent diseases of the gastrointestinal tract. Conclusions. In recurrent aphthae of the oral cavity in patients with acid-dependent diseases of the gastrointestinal tract in the microbiome of the oral cavity against the background of reduced titers of lactobacilli, an increase in representatives of Staphylococcus spp., Enterococcus spp is most often observed. and Candida spp. (1.2 times average), Enterococcus spp. (1.4 times), Staphylococcus spp. and Enterobacteriaceae spp. (1.2 times), Actinobacillus spp. (1.1 times).

Statistical analysis of distribution, dynamics and etiological structure of bovine diseases in Vologda region

2020 ◽  
pp. 3-4
Author(s):  
Oksana B. Badeeva ◽  
Keyword(s):  
Respiratory Diseases ◽  
Birth Rate ◽  
Statistical Data ◽  
Delayed Diagnosis ◽  
Specific Weight ◽  
Gastrointestinal Diseases ◽  
Vologda Region ◽  
High Incidence ◽  
Young Cattle ◽  
High Level

Statistical data of livestock for 30 years is reflected in the article. Author used the materials of the state veterinary reporting. A comparative analysis of the number, incidence and death rate of adult animals and young cattle for two five-year periods (2001-2005 and 2014-2018). the data of the analysis of veterinary statistical reports for 2018 on the specific weight of the large horned cattle and age dynamics of calves in farms of the Vologda region are shown. A significant decrease in livestock of the large horned cattle by 56.3% (from 1990 to 2018) is shown in the analysis of the data. Over the five years 2014-2018, there was a decrease in the number of the large horned cattle by 31.3%, the birth rate of calves - by 26.2%, and the incidence of calves - by 12.3% and the mortality rate decreased by 3.3%. Despite the decline in the number of livestock, in 2018 there is a high incidence of animal diseases (49.6%). The highest incidence rate was observed among calves under 10 days of age 43.3%, 31.7% - from 11 to 30 days, 15.8% - from one to three months, 6.5% - from three to six months and 2.7% - from 6 to 12 months. Of the total number of sick calves in 2018, 63.2% had gastrointestinal diseases, and death for this reason is 49.6% of the total number of victims. Respiratory diseases affect 21.8% of young animals, and death due to respiratory diseases is 18.2%. Analysis of statistical data showed that, despite the complex of veterinary and sanitary measures, the incidence and death of calves remain at a high level. This can be explained by delayed diagnosis and low therapeutic effectiveness in gastrointestinal and respiratory diseases of cattle.

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