Dual roles of Nemo-like kinase in tumor development and progression

2015 ◽  
Vol 36 (1) ◽  
pp. 69
Author(s):  
Jian HE ◽  
Wei ZHANG
Keyword(s):  
Tumor Development ◽  
Dual Roles

scholarly journals Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)

2021 ◽  
Vol 21 (6) ◽  
Author(s):  
Zhangming Chen ◽  
Jie Hu ◽  
Songcheng Ying ◽  
Aman Xu
Keyword(s):  
Anticancer Drugs ◽  
Tumor Development ◽  
Dual Roles

scholarly journals Dual Roles ofMETCAMin the Progression of Different Cancers

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Guang-Jer Wu
Keyword(s):  
Intracellular Signaling ◽  
Tumor Development ◽  
Malignant Progression ◽  
Dual Roles ◽  
Aberrant Expression ◽  
Intrinsic Factors ◽  
Stromal Microenvironment ◽  
Early Tumor

METCAM, an integral membrane cell adhesion molecule (CAM) in theIg-like gene superfamily, is capable of performing typical functions ofCAMs, such as mediating cell-cell and cell-extracellular interactions, crosstalk with intracellular signaling pathways, and modulating social behaviors of cells.METCAMis expressed in about nine normal cells/tissues. Aberrant expression ofMETCAMhas been associated with the progression of several epithelial tumors. Furtherin vitroandin vivostudies show thatMETCAMplays a dual role in the progression of different tumors. It can promote the malignant progression of several tumors. On the other hand, it can suppress the malignant progression of other tumors. We suggest that the role ofMETCAMin the progression of different cancer types may be modulated by different intrinsic factors present in different cancer cells and also in different stromal microenvironment. Many possible mechanisms mediated by thisCAMduring early tumor development and metastasis are suggested.

scholarly journals SALL Proteins; Common and Antagonistic Roles in Cancer

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6292
Author(s):  
Claudia Álvarez ◽  
Aracelly Quiroz ◽  
Diego Benítez-Riquelme ◽  
Elizabeth Riffo ◽  
Ariel F. Castro ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Progression ◽  
Cancer Biology ◽  
Genetic Disorders ◽  
Family Members ◽  
Tumor Development ◽  
Cancer Biomarkers ◽  
Regulatory Mechanisms ◽  
Dual Roles ◽  
Human Genetic Disorders

SALL proteins are a family of four conserved C2H2 zinc finger transcription factors that play critical roles in organogenesis during embryonic development. They regulate cell proliferation, survival, migration, and stemness; consequently, they are involved in various human genetic disorders and cancer. SALL4 is a well-recognized oncogene; however, SALL1–3 play dual roles depending on the cancer context and stage of the disease. Current reviews of SALLs have focused only on SALL2 or SALL4, lacking an integrated view of the SALL family members in cancer. Here, we update the recent advances of the SALL members in tumor development, cancer progression, and therapy, highlighting the synergistic and/or antagonistic functions they perform in similar cancer contexts. We identified common regulatory mechanisms, targets, and signaling pathways in breast, brain, liver, colon, blood, and HPV-related cancers. In addition, we discuss the potential of the SALL family members as cancer biomarkers and in the cancer cells’ response to therapies. Understanding SALL proteins’ function and relationship will open new cancer biology, clinical research, and therapy perspectives.

Altered thymic epithelial cells may be decisive for Moloney virus-induced lymphoma development

1983 ◽  
Vol 41 ◽  
pp. 784-785
Author(s):  
U.I. Heine ◽  
G.R.F. Krueger ◽  
E. Munoz ◽  
A. Karpinski
Keyword(s):  
Epithelial Cells ◽  
Leukemia Virus ◽  
Light And Electron Microscopy ◽  
Tumor Development ◽  
Current Evidence ◽  
Thymic Epithelial Cells ◽  
Thymic Tissue ◽  
Newborn Mice ◽  
Moloney Leukemia Virus ◽  
Differentiation Block

Infection of newborn mice with Moloney leukemia virus (M-MuLV) causes a T-cell differentiation block in the thymic cortex accompanied by proliferation and accumulation of prethymic lymphoblasts in the thymus and subsequent spreading of these cells to generate systemic lymphoma. Current evidence shows that thymic reticular epithelial cells (REC) provide a microenvironment necessary for the maturation of prethymic lymphoblasts to mature T-lymphocytes by secretion of various thymic factors. A change in that environment due to infection of REC by virus could be decisive for the failure of lymphoblasts to mature and thus contribute to lymphoma development.We have studied the morphology and distribution of the major thymic cell populations at different stages of tumorigenesis in Balb/c mice infected when newborn with 0.2ml M-MuLV suspension, 6.8 log FFU/ml. Thymic tissue taken at 1-2 weekly intervals up to tumor development was processed for light and electron microscopy, using glutaraldehyde-OsO4fixation and Epon-Araldite embedding.

Stage-Dependent Expression of an Angiogenic Agent and Vascular Organization in Experimental Skin Tumor Development

2003 ◽  
Vol 31 (5) ◽  
pp. 539-548 ◽  
Author(s):  
Veera Näyhä ◽  
Jaakko Laitakari ◽  
Frej Stenbäck
Keyword(s):  
Tumor Development ◽  
Skin Tumor

Magnetic Properties of xCeO2•(50 − x) PbO•50B2O3 Glasses and Glass Ceramics

2017 ◽  
Vol 13 (1) ◽  
pp. 4486-4494 ◽  
Author(s):  
G.El Damrawi ◽  
F. Gharghar
Keyword(s):  
Magnetic Properties ◽  
Large Scale ◽  
Glass Ceramics ◽  
Magnetic Behavior ◽  
Crystal Formation ◽  
Dual Roles ◽  
Effective Agent ◽  
Ordered Structures ◽  
Essential Change

Cerium oxide in borate glasses of composition xCeO2·(50 − x)PbO·50B2O3 plays an important role in changing both microstructure and magnetic behaviors of the system. The structural role of CeO2 as an effective agent for cluster and crystal formation in borate network is clearly evidenced by XRD technique. Both structure and size of well-formed cerium separated clusters have an effective influence on the structural properties. The cluster aggregations are documented to be found in different range ordered structures, intermediate and long range orders are the most structures in which cerium phases are involved. The nano-sized crystallized cerium species in lead borate phase are evidenced to have magnetic behavior.  The criteria of building new specific borate phase enriched with cerium as ferrimagnetism has been found to keep the magnetization in large scale even at extremely high temperature. Treating the glass thermally or exposing it to an effective dose of ionized radiation is evidenced to have an essential change in magnetic properties. Thermal heat treatment for some of investigated materials is observed to play dual roles in the glass matrix. It can not only enhance alignment processes of the magnetic moment but also increases the capacity of the crystallite species in the magnetic phases. On the other hand, reverse processes are remarked under the effect of irradiation. The magnetization was found to be lowered, since several types of the trap centers which are regarded as defective states can be produced by effect of ionized radiation. 

Morphological Characteristics of the Stroma in Malignat Epithelial Neoplasms with Short Review of Skin Squamous Cell Carcinoma

2014 ◽  
Vol 68 (1) ◽  
pp. 8-15
Author(s):  
Lena Kakasheva-Mazhenkovska ◽  
Vesna Janevska ◽  
Gordana Petrushevska ◽  
Liljana Spasevska ◽  
Neli Basheska
Keyword(s):  
Immune Cells ◽  
Complex Structure ◽  
Tumor Development ◽  
Morphological Characteristics ◽  
Basal Membrane ◽  
Short Review ◽  
Invasion And Metastasis ◽  
Genetic Changes ◽  
Cancer Associated Fibroblast ◽  
Skin Squamous Cell Carcinoma

Abstract The stroma of the neoplasm is a highly complex structure built by: specialized mesenchymal cells typical for each tissue surroundings, cancer associated fibroblast/myofibroblast, congenital or acquired immune cells, vascular network with endothelial cells and pericytes, mastocytes, macrophages, leukocytes and adipocytes, all together incorporated in the extracellular matrix. Each neoplasm produces its own unique microenvironment where the tumor grows and modifies. Although most of the cells of the host in the stroma have compulsory tumor suppressor ability, the stroma is changing during the malignant process and it even promotes growth, invasion and metastasis. Genetic changes that occur during the development of the cancer, which are guided by the malignant cells lead to changes in the stroma of the host that will overtake it and adjust it to their own needs. In the early stages of the tumor development and invasion, the basal membrane is degraded and the stroma becomes active and contains an increased number of fibroblasts, inflammatory infiltrate and newly composed capillaries which come into direct contact with the tumor cells. These changes lead to cancer invasion.

Sign in / Sign up

Export Citation Format

Share Document