New Clinical findings on the Longevity Gene in Disease, Health, & Longevity: Sirtuin 1 Often Decreases with Advanced Age & Serious Diseases in Most Parts of the Human Body, While Relatively High & Constant Sirtuin 1 Regardless of Age was First Found in the Hippocampus of Supercentenarians

2011 ◽  
Vol 36 (3) ◽  
pp. 287-309 ◽  
Author(s):  
Yoshiaki Omura ◽  
Dominic P. Lu ◽  
Marilyn Jones ◽  
Brian O'Young ◽  
Harsha Duvvi ◽  
...  
Keyword(s):  
Human Body ◽  
Clinical Findings ◽  
Sirtuin 1 ◽  
Advanced Age ◽  
Longevity Gene

Involvement of longevity gene sirtuin-1 in switch of white/brown adipocytes

2010 ◽  
Vol 34 (8) ◽  
pp. S29-S29
Author(s):  
Zhichun Yang ◽  
Kuansong Wang ◽  
Yuanjian Li
Keyword(s):  
Sirtuin 1 ◽  
Brown Adipocytes ◽  
Longevity Gene

scholarly journals The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Tingdong Yan ◽  
Jinlong Huang ◽  
Muhammad Farrukh Nisar ◽  
Chunpeng Wan ◽  
Weifeng Huang
Keyword(s):  
Liver Injury ◽  
Er Stress ◽  
Human Body ◽  
Critical Role ◽  
Sirtuin 1 ◽  
Potential Candidate ◽  
Nuclear Factor ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Toxic Agents

Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) as a result of accumulated drugs in the human body metabolized into toxic agents and helps generate heavy oxidative stress, inflammation, and apoptosis, which induces necrosis in hepatocytes and ultimately damages the liver. Sirtuin 1 (SIRT1) is said to have multiple vital roles in cell proliferation, aging, and antistress systems of the human body. The levels of SIRT1 and its activation precisely modulate its critical role in the interaction between multiple step procedures of DILI. The nuclear factor kappa-light-chain-enhancer of activated B cell- (NF-κB-) mediated inflammation signaling pathway, reactive oxygen species (ROS), DNA damage, mitochondrial membrane potential collapse, and endoplasmic reticulum (ER) stress also contribute to aggravate DILI. Apoptosis is regarded as the terminal reaction followed by multiple signaling cascades including caspases, p53, and mitochondrial dysfunction which have been said to contribute in DILI. The SIRT1 activator is regarded as a potential candidate for DILI, because the former could inhibit signaling of p53, NF-κB, and ER stress. On the other hand, overexpression of SIRT1 also enhances the activation of antioxidant responses via Kelch-like ECH-associated protein 1- (Keap1-) nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) signaling. The current manuscript will highlight the mechanism of DILI and the interaction of SIRT1 with various cytoplasmic factors leading to DILI along with the summary of potent SIRT1 agonists.

scholarly journals Management of craniosynostosis at an advanced age: Clinical findings and interdisciplinary treatment in a 17 year-old with pan-suture synostosis

2015 ◽  
Vol 2 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Rajiv J. Iyengar ◽  
Petra M. Klinge ◽  
Wendy Chen ◽  
Stephen R. Sullivan ◽  
Helena O. Taylor
Keyword(s):  
Clinical Findings ◽  
Advanced Age ◽  
Interdisciplinary Treatment

scholarly journals ADJUVANT AND BENEFICIAL PROBIOTIC THERAPY FOR WOMEN HEALTH

2021 ◽  
Vol 80 (2) ◽  
pp. 151-163
Author(s):  
Igori Balta ◽  
Eugenia Butucel ◽  
Valentyn Mohylyuk
Keyword(s):  
Human Body ◽  
Infant Development ◽  
Well Being ◽  
Complementary Therapy ◽  
Clinical Findings ◽  
Lactobacillus Species ◽  
Vaginal Infections ◽  
Women Health ◽  
Normal Microflora ◽  
Beneficial Impact

Probiotics are living microbial strains, also considered functional foods, that improve the human intestine and mucosal sites' functionality and normalize the immune system balance. This symbiosis between the human body and microorganisms has attracted scientists and showed a notable role in maintaining human health. The microbiota composition within different sites of the organs can change rapidly and unfavorably, leading to the development of infections or abnormal conditions. The treatments with antibiotics affect and disturb the overall normal microflora, and specifically to the vaginal tract, by inhibiting the spread of the normal microflora of Lactobacillus species. In this sense, probiotics have shown to be an integrative and complementary therapy for the amelioration and prevention of vaginal infections in women. The main objective of the current review is to highlight the importance of probiotics to prevent and treat antibiotic-associated acute and chronic diseases and highlight their possible beneficial impact on women reproductive health. Moreover, the review discusses the recent clinical findings of probiotic therapy concerning protection against vaginal diseases, well-being, infant development, and human body detoxification from the chemical compounds.

Microstructural comparison of synthetic bioceramics with natural bioceramics

1991 ◽  
Vol 49 ◽  
pp. 38-39
Author(s):  
Shulin Wen ◽  
Jingwei Feng ◽  
A. Krajewski ◽  
A. Ravaglioli
Keyword(s):  
Recent Work ◽  
Human Body ◽  
Human Tissues ◽  
Main Constituent ◽  
Laboratory Furnace ◽  
Chinese Adult ◽  
Human Enamel ◽  
Biological Compatibility ◽  
Synthetic Hydroxyapatite ◽  
Synthetic Work

Hydroxyapatite bioceramics has attracted many material scientists as it is the main constituent of the bone and the teeth in human body. The synthesis of the bioceramics has been performed for years. Nowadays, the synthetic work is not only focused on the hydroapatite but also on the fluorapatite and chlorapatite bioceramics since later materials have also biological compatibility with human tissues; and they may also be very promising for clinic purpose. However, in comparison of the synthetic bioceramics with natural one on microstructure, a great differences were observed according to our previous results. We have investigated these differences further in this work since they are very important to appraise the synthetic bioceramics for their clinic application.The synthetic hydroxyapatite and chlorapatite were prepared according to A. Krajewski and A. Ravaglioli and their recent work. The briquettes from different hydroxyapatite or chlorapatite powders were fired in a laboratory furnace at the temperature of 900-1300°C. The samples of human enamel selected for the comparison with synthetic bioceramics were from Chinese adult teeth.

Study on erythrocytes by SEM photogrammetry (SEMP) technique

1990 ◽  
Vol 48 (3) ◽  
pp. 724-725
Author(s):  
Tong Wensheng ◽  
Lu Lianhuang ◽  
Zhang Zhijun
Keyword(s):  
Quantitative Analysis ◽  
Cell Membrane ◽  
Clinical Diagnosis ◽  
Human Body ◽  
Blood Cells ◽  
Three Dimensional ◽  
Normal Person ◽  
Blood Disease ◽  
Computation Technique ◽  
Important Basis

This is a combined study of two diffirent branches, photogrammetry and morphology of blood cells. The three dimensional quantitative analysis of erythrocytes using SEMP technique, electron computation technique and photogrammetry theory has made it possible to push the study of mophology of blood cells from LM, TEM, SEM to a higher stage, that of SEM P. A new path has been broken for deeply study of morphology of blood cells.In medical view, the abnormality of the quality and quantity of erythrocytes is one of the important changes of blood disease. It shows the abnormal blood—making function of the human body. Therefore, the study of the change of shape on erythrocytes is the indispensable and important basis of reference in the clinical diagnosis and research of blood disease.The erythrocytes of one normal person, three PNH Patients and one AA patient were used in this experiment. This research determines the following items: Height;Length of two axes (long and short), ratio; Crevice in depth and width of cell membrane; Circumference of erythrocytes; Isoline map of erythrocytes; Section map of erythrocytes.

Clinical Findings with SAL Audiometry: Some Further Observations

1965 ◽  
Vol 30 (4) ◽  
pp. 325-335
Author(s):  
George E. Lynn ◽  
Jack A. Willeford
Keyword(s):  
Clinical Findings

Partial characterization and post-feeding activity of midgut aminopeptidase in the human body louse,Pediculus humanus humanus

1998 ◽  
Vol 23 (4) ◽  
pp. 382-387 ◽  
Author(s):  
James O. Ochanda ◽  
Eva A. C. Oduor ◽  
Rachel Galun ◽  
Mabel O. Imbuga ◽  
Kosta Y. Mumcuoglu
Keyword(s):  
Human Body ◽  
Feeding Activity ◽  
Partial Characterization ◽  
Body Louse ◽  
Pediculus Humanus ◽  
Post Feeding ◽  
Human Body Louse

Spinal Impairment Evaluation: Fifth Edition Changes

2001 ◽  
Vol 6 (1) ◽  
pp. 1-3
Author(s):  
Robert H. Haralson
Keyword(s):  
Spinal Cord ◽  
Lower Extremity ◽  
Range Of Motion ◽  
Upper Extremity ◽  
Spinal Cord Injuries ◽  
Clinical Findings ◽  
Fourth Edition ◽  
Treatment Results ◽  
Standard Terminology ◽  
Made In

Abstract The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fifth Edition, was published in November 2000 and contains major changes from its predecessor. In the Fourth Edition, all musculoskeletal evaluation and rating was described in a single chapter. In the Fifth Edition, this information has been divided into three separate chapters: Upper Extremity (13), Lower Extremity (14), and Spine (15). This article discusses changes in the spine chapter. The Models for rating spinal impairment now are called Methods. The AMA Guides, Fifth Edition, has reverted to standard terminology for spinal regions in the Diagnosis-related estimates (DRE) Method, and both it and the Range of Motion (ROM) Method now reference cervical, thoracic, and lumbar. Also, the language requiring the use of the DRE, rather than the ROM Method has been strengthened. The biggest change in the DRE Method is that evaluation should include the treatment results. Unfortunately, the Fourth Edition's philosophy regarding when and how to rate impairment using the DRE Model led to a number of problems, including the same rating of all patients with radiculopathy despite some true differences in outcomes. The term differentiator was abandoned and replaced with clinical findings. Significant changes were made in evaluation of patients with spinal cord injuries, and evaluators should become familiar with these and other changes in the Fifth Edition.

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