In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake

2018 ◽  
Vol 69 (5) ◽  
pp. 1229-1232
Author(s):  
Eugeniu Mihalas ◽  
Adriana Balan ◽  
Ana Petcu (Sirghe) ◽  
Laura Gavrila ◽  
Carmen Savin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Water Intake ◽  
Fasting Blood Glucose ◽  
Chronic Administration ◽  
Short Term Treatment ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Daily Water Intake ◽  
Daily Water

Amoxicillin it is the most commonly prescribed antibiotic agent and the first intention in the short-term treatment of infections in children. The aim of this study was to assess the effects of amoxicillin/clavulanic acid (AMC) chronic administration on the laboratory mice�s body weight (BW), water intake and values of non-fasting blood glucose levels (n-FBG). Thus, twenty-eight C57BL/6 male mice, of similar age, randomly divided into a control and 3 treatment groups (n = 7) received subcutaneous injection, once per day, for 60 days. During the experiment the n-FBG, daily water intake, and BW changes were recorded every 10 days. The results of our study revealed that the chronic administration of AMC, at a concentration of 100 and 150 mg/kg BW/day, increased capillary n-FGB, and can be associated with a significant increase in the BW and daily water intake in mice.

scholarly journals Effect of Increased Daily Water Intake and Hydration on Health in Japanese Adults

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1191 ◽  
Author(s):  
Yumi Nakamura ◽  
Hiroshi Watanabe ◽  
Aiko Tanaka ◽  
Masato Yasui ◽  
Jun Nishihira ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Body Temperature ◽  
Water Intake ◽  
Fasting Blood Glucose ◽  
Intervention Group ◽  
Glucose Levels ◽  
Daily Water Intake ◽  
Daily Water ◽  
Water Supplementation

Increased hydration is recommended as healthy habit with several merits. However, supportive data are sparse. To assess the efficacy of increased daily water intake, we tested the effect of water supplementation on biomarkers in blood, urine, and saliva. Twenty-four healthy Japanese men and 31 healthy Japanese women with fasting blood glucose levels ranging from 90–125 mg/dL were included. An open-label, two-arm, randomized controlled trial was conducted for 12 weeks. Two additional 550 mL bottles of water on top of habitual fluid intake were consumed in the intervention group. The subjects drank one bottle of water (550 mL) within 2 h of waking, and one bottle (550 mL) 2 h before bedtime. Subjects increased mean fluid intake from 1.3 L/day to 2.0 L/day, without changes in total energy intake. Total body water rate increased with associated water supplementation. There were no significant changes in fasting blood glucose and arginine vasopressin levels, but systolic blood pressure was significantly decreased in the intervention group. Furthermore, water supplementation increased body temperature, reduced blood urea nitrogen concentration, and suppressed estimated glomerular filtration rate reduction. Additionally, existence of an intestinal microbiome correlated with decreased systolic blood pressure and increased body temperature. Habitual water supplementation after waking up and before bedtime in healthy subjects with slightly elevated fasting blood glucose levels is not effective in lowering these levels. However, it represents a safe and promising intervention with the potential for lowering blood pressure, increasing body temperature, diluting blood waste materials, and protecting kidney function. Thus, increasing daily water intake could provide several health benefits.

scholarly journals HYPOGLYCEMIC EFFECT OF ANDROGRAPHIS ECHIOIDES ON STREPTOZOTOCIN INDUCED EXPERIMENTAL RATS

2015 ◽  
Vol 7 ◽  
pp. 55
Author(s):  
Mani Rupeshkumar ◽  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Fasting Blood Glucose ◽  
Hypoglycemic Effect ◽  
Reference Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Single Intraperitoneal Injection

The present study aims to study the hypoglycemic effect of methanol extract of Andrographisechioides (MEAE) in streptozotocin (STZ)-induced diabetic Wistar rats. Hyperglycemia was induced in rats by single intraperitoneal injection of STZ (55 mg/kg bodyweight). Three days after STZ induction, the hyperglycemic rats were treated with MEAE orally at the doses of 200, 500, and 800 mg/kg body weight daily for 21 days. Glibenclamide (1 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on each 7th day during the 21 days of treatment.

scholarly journals BLOOD GLUCOSE LEVEL AND PANCREAS HISTOLOGICAL SECTION OF MICE ( Mus musculus L.) INDUCED BY ALLOXAN AFTER TREATMENT OF Curcuma mangga Val. RHIZOME EXTRACT

2016 ◽  
Vol 20 (2) ◽  
pp. 64 ◽  
Author(s):  
Madihah Madihah ◽  
Fitriani Alfina ◽  
Yetti Yusri Gani
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mus Musculus ◽  
Fasting Blood Glucose ◽  
Histological Section ◽  
Tolerance Test ◽  
Endocrine Gland ◽  
Synthetic Drugs ◽  
Glucose Levels ◽  
Blood Glucose Levels

Herbal-based drug development for diabetes mellitus continues to grow in order to find alternatives of theuse of synthetic drugs which is relatively expensive. The present study examined the potency of temu mangga(Curcuma mangga Val.) rhizome extract in decreasing blood glucose levels and repairing histological damage ofpancreas endocrine gland in male mice (Mus musculus L.) Swiss-Webster that has been induced by alloxan. Theexperimental method with 5 treatments and 5 replications were used. The dose of alloxan was 200 mg/kg bw,while the dose of temu mangga extract were 100, 200, 400 and 800 mg/kg bw. The measured parameters werethe body weight, fasting blood glucose levels by using blood glucose tolerance test, and the percentage of pancreatic? cells that undergo necrosis. Data were analyzed by ANOVA with 95% confidence level and continued withDuncan’s multiple range tests. The results showed no difference on body weight of test animals in all treatments.The reduction percentage of fasting blood glucose levels from temu mangga rhizome extract by dosage of 400mg/kg bw (48.712%) was significantly different from the treatment of alloxan (0.588%) (p<0.05). The percentageof ? cells that undergo necrosis from temu mangga rhizome by dosages of 200, 400, and 800 mg/kg bw weresignificantly different with alloxan (22.75±3.68 %) (p<0.05). In conclusion, temu mangga rhizome extract bydosage of 400 mg/kg was optimum to decrease blood glucose levels and repair the pancreas histological damagein mice that were induced by alloxan.

scholarly journals Effect of Sorghum-tigernut Ibyer (A Traditional Gruel) on the Fasting Blood Glucose Levels of Alloxan-induced Diabetic Rats

2019 ◽  
pp. 260-268
Author(s):  
Shalem Shiekuma ◽  
Moses Ukeyima ◽  
Msendoo, Janet Ahuah ◽  
Idoko Blessing ◽  
Terzungwe Tughgba
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Saline Water ◽  
Fasting Blood Glucose ◽  
Sensory Attributes ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Sorghum Flour ◽  
Blood Glucose Levels ◽  
Alloxan Monohydrate

Background: There is growing interest in the use of natural foods in the management of chronic diseases like diabetes. Ibyer is a fibre rich gruel consumed amongst the Tiv people of Benue State made from whole sorghum or millet flours. Aim: The aim of the study was to evaluate the effect of sorghum-tigernut ibyer on the fasting blood glucose levels and body weight of alloxan monohydrate-induced diabetic rats. Methods: Sorghum flour (SF) and tigernut flour (TNF) were blended at different proportions (100:00; 90:10; 80:20; 70:30) for the purpose of ibyer production. The flour samples were subjected to proximate analysis using standard analytical procedures, the sensory attributes of ibyer produced from the different flour samples was evaluated on a 9-point hedonic scale. Thirty (30) male Wistar rats (100–180 g body weight) were grouped into five (1-5) each group containing six rats. They were induced with diabetes by injecting them with 150ml/kg of body weight with alloxan monohydrate dissolved in saline water (0.9% NaCl) except for group 1. Blood samples were collected from the tail of the rats, prior to induction, 48hrs after induction and 72 hrs after three days of continuous feeding with test diet. Fasting blood glucose was measured using a standard glucometer and test strips. Results: The sensory attributes indicated that ibyer produced from the flour samples were generally acceptable. Fasting blood glucose levels after 72 hrs of feeding were found to be lowered more in groups giving flours with a higher proportion of Tigernut. Conclusion: The results indicated that sorghum-tigernut ibyer exerted hypoglycaemic effect on the experimental animals.

scholarly journals Effects of synbiotic supplement on body weight and fasting blood glucose levels in obesity: A randomized placebo-controlled trial

2021 ◽  
pp. 102548
Author(s):  
Andi Salsa Anggeraini ◽  
Muhammad Nasrum Massi ◽  
Firdaus Hamid ◽  
Ahyar Ahmad ◽  
Suryani As'ad ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Controlled Trial ◽  
Fasting Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals Analysis on Soy-Yamgurt Potential as Antidiabetic in Streptozotocin-Nicotinamide Induced Rats

2018 ◽  
Vol 1 (1) ◽  
pp. 58-70
Author(s):  
Jessica Kwanariesta ◽  
Herla Rusmarilin ◽  
Ismed Suhaidi
Keyword(s):  
Body Weight ◽  
Lactic Acid ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Average Weight ◽  
In Vivo Test ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Male Wistar Rats

This study was conducted to determine the potential of soy-yamgurt probiotics drink from the mixture of yam and soy extract with a ratio of 1: 1 in reducing the fasting blood glucose level of rats induced by streptozotocin-nicotinamide. Based on the analysis of chemical and phytochemical characteristics of soy-yamgurt, it was found that it has water content (80.97%), total solids (18.85%), protein content (11.95%), total lactic acid (1.03%), viscosity (20.56 Pa.s), lactic acid bacteria (10.22 log CFU/g), fiber content (0.98%), IC50 value (44.99 μg/ml), total phenol (711.90 μgGAE/g) and total flavonoids (1345.73 μgQE/g). The in vivo test used thirty 10-16 week old male Wistar rats with an average weight of 160-200 g divided into 5 groups: P1 (control), P2 (streptozotocin-nicotinamide), P3 (glibenclamide of 0.45 mg/kg body weight), P4 (3 ml of soy-yamgurt) and P5 (3.5 ml of soy-yamgurt).The results showed that the soy-yamgurt at the doses of 3 ml/160 g body weight and 3.5 ml/160 g body weight for 4 weeks in streptozotocin-nicotinamide-induced rats had significantly (P<0.01) lowered blood glucose levels and increased their weight.

scholarly journals Diabetogenic effect of gluten in Wistar albino rats: a preliminary preclinical screening

2020 ◽  
Author(s):  
Robin Shetty ◽  
Mohandas Rai ◽  
Rajan Chandrashekar ◽  
Bhuvanesh Sukhlal Kalal
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Albino Rats ◽  
The Public ◽  
Glucose Levels ◽  
Special Diet ◽  
Blood Glucose Levels ◽  
Wistar Albino Rats

Background and objectives. Gluten-related disease affects less than 1% population and is not considered of relevance at the public health level. However, the consumption of a gluten-free diet has been most commonly adopted as a special diet worldwide in the recent past. In the present study, we investigated the association of gluten intake and diabetic Wistar albino rats. Methods. Thirty adult Wistar rats were randomly divided into five groups: control, diabetic, and test treated with pure gluten (100, 200 and 400 mg/kg body weight). Diabetes was induced in rats by intraperitoneal injection of Streptozotocin (65 mg/kg) after a dose of nicotinamide (110 mg/kg). Body weight, fasting blood glucose levels, postprandial blood glucose levels and histopathology of the pancreas were compared. Results. Fasting blood glucose levels and postprandial blood glucose were significantly higher in diabetes animals but there were no significant changes in gluten treated groups. Other parameters were not significantly changed among different groups. Conclusions. Gluten at doses 100 mg/kg, 200 mg/kg and 400 mg/kg is not a diabetogenic diet and hence it needs not be excluded from diet for the prevention and management of Type 2 diabetes mellitus.

scholarly journals Prophylactic Effect of Ethanol Extract of Azadirachta indica Leaf in Streptozotocin-induced Diabetic Rats

2020 ◽  
pp. 15-27
Author(s):  
O. C. Ezeigwe ◽  
C. J. Ononamadu ◽  
M. E. Onuegbu ◽  
O. R. Ikpeogu ◽  
I. C. Agugom ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Control Group ◽  
Prophylactic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pre Treatment

Background: Medicinal plants are now becoming indispensable in the treatment and management of many ailments. The unaffordability, unavailability and adverse effects of conventional therapy in the treatment and management of many diseases have geared keen interest in the use of herbal medicine. This work was carried out to investigate the prophylactic effect of the ethanol extract of Azadirachta indica leaf in streptozotocin-induced diabetic rats.   Methods: A total of one hundred (100) rats were randomized into four (4) groups (n=25) and used for the study. Each group of 25 rats was sub-divided into five (5) groups (n=5). The sub-groups comprise: Group A-normal control that was not treated, group B-100 mg/kg body weight of metformin and groups C to E - graded doses (100 mg/kg, 200 mg/kg and 400 mg/kg body weight) of the ethanol leaf extracts of A. indica leaves. The standard drug and the extracts were consecutively administered to groups B-E for 7, 14, 21 and 28 days before the induction of diabetes. Diabetes was induced intraperitoneally using 50 mg/kg bodyweight of streptozotocin. Results: The groups that were administered 100, 200 and 400 mg/kg bw of ethanol extract of A. indica showed a significant (p<0.05) increase in their weight after 21 and 28 days of pre-treatment compared with the control group that was not treated. The graded doses of the extract also have a remarkable effect in the fasting blood glucose levels which was made visible by the significant (p<0.05) reduction recorded in the fasting blood glucose levels compared with the control group that was not pre-treated and the group pre-treated with metformin. Conclusion: The results obtained in this research suggest that ethanol extract of A. indica has the potential to protect against diabetes by delaying its onset. However, the longer the period of pre-treatment, the better the condition of the animals pre-treated as well as the protection as can be seen from the results of the weight and fasting blood glucose levels.

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