Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems

This paper aims to improve medical strategies regarding cancer treatment, by developing new targeted cancer therapy nanostructured systems, based on magnetite and natural catabolism products as coating agents (glutamic acid, tartaric acid), with induced cellular internalization. In order to create hydrophilic, biocompatible systems, suitable for targeted cancer therapy, and minimize the negative side effects of current approaches, a one-pot synthesis by co-precipitation technique, starting from Fe2+ and Fe3+ inorganic precursors and multifunctional organic compounds, carefully controlling the reaction parameters (concentration of precursors, pH, temperature etc.) was performed. The obtained Fe3O4 stabilised nanoparticles were subjected to morphological and structural characterization. The formation of inorganic-organic hybrid systems was evaluated using FTIR spectroscopy and complex thermal analysis (TG / DSC) for determining the content of the organic component, while X-ray Diffractometry and Scanning and Transmission Electron Microscopy were used to characterize the crystallinity and particle dimensions and distribution. The magnetic properties at room temperature were also evaluated, recording the magnetic susceptibility relative to the applied magnetic field.

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Conducting polymer nanoparticles for targeted cancer therapy

RSC Advances ◽

10.1039/c5ra05125h ◽

2015 ◽

Vol 5 (47) ◽

pp. 37943-37956 ◽

Cited By ~ 13

Author(s):

Mona Doshi ◽

Marissa Krienke ◽

Saeid Khederzadeh ◽

Henry Sanchez ◽

Alicja Copik ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Cancer Therapy ◽

Conducting Polymer ◽

Targeted Delivery ◽

Reactive Oxygen ◽

Polymer Nanoparticles ◽

Oxygen Species ◽

Targeted Cancer Therapy ◽

Fluorescence Bioimaging

Functionalized conducting polymer nanoparticles allow for targeted delivery, tracking by fluorescence bioimaging, and therapeutics through formation of reactive oxygen species.

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In Situ One-Pot Synthesis of MOF-Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy

Advanced Science ◽

10.1002/advs.201800287 ◽

2018 ◽

Vol 5 (6) ◽

pp. 1800287 ◽

Cited By ~ 50

Author(s):

Dongdong Wang ◽

Huihui Wu ◽

Jiajia Zhou ◽

Pengping Xu ◽

Changlai Wang ◽

...

Keyword(s):

Cancer Therapy ◽

Photothermal Effect ◽

Targeted Cancer Therapy ◽

One Pot ◽

One Pot Synthesis

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Chemotherapeutic, Toxin, and Therapeutic Protein Delivery via Nucleolin Aptamer-functionalized Nanoplatforms for Targeted Cancer Therapy

Trends in Medical Sciences ◽

10.5812/tms.113773 ◽

2021 ◽

Vol 1 (1) ◽

Author(s):

Pouya Safarzadeh Kozani ◽

Pooria Safarzadeh Kozani ◽

Fatemeh Rahbarizadeh

Keyword(s):

Cancer Therapy ◽

Targeted Delivery ◽

Protein Delivery ◽

Therapeutic Potential ◽

Therapeutic Protein ◽

Targeted Cancer Therapy ◽

Chemotherapeutic Drugs ◽

Different Types ◽

As1411 Aptamer ◽

Targeting Peptide

: Nucleolin is a protein abundantly present in the nucleolus, but its expression on the surface of cells is potentially associated with various types of malignancies. So far, several nucleolin-targeting strategies, including the nucleolin-targeting peptide, anti-nucleolin pseudopeptides, anti-nucleolin antibodies, and the anti-nucleolin aptamer, AS1411, have been developed and investigated in different types of studies. The AS1411 aptamer has been known as the outstanding approach for targeting nucleolin with superior specificity and therapeutic potential in comparison with other targeting strategies. In this review, we highlight different nucleolin-targeting strategies for the targeted delivery of chemotherapeutic drugs, proteins with therapeutic potential, and toxins.

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Synthesis of Li4Ti5O12/V2O5 Nanocomposites for Lithium-ion Batteries by a One-pot co-precipitation Method

10.21203/rs.3.rs-190031/v1 ◽

2021 ◽

Author(s):

liu zhenjie ◽

Yudai Huang ◽

xingchao Wang ◽

Yue Zhang ◽

juan Ding ◽

...

Keyword(s):

Lithium Ion ◽

Precipitation Method ◽

X Ray Diffraction ◽

One Pot ◽

High Discharge ◽

X Ray ◽

High Discharge Capacity ◽

Transmission Electron ◽

Co Precipitation ◽

Nano Size

Abstract Li4Ti5O12/V2O5 nanocomposites were synthesized by a one-pot co-precipitation method. The structure and morphology of the as-prepared materials were analyzed by X-ray diffraction and transmission electron microscopy. The results show that Li4Ti5O12/V2O5 composites with different nano size were successfully synthesized. The Li4Ti5O12/V2O5 sample (2 wt.% V2O5 addition of Li4Ti5O12) keep at a high discharge capacity of 169.9 mAh g− 1 after 150 cycles at 1 C. The existence of the V2O5 reduces the size of Li4Ti5O12, which improve the electrochemical activity of the sample.

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Synthesis, characterization of Co1-xNixAl2O4 Spinel system and catalytic role in the synthesis of dihydropyrimidinone

10.21203/rs.3.rs-605742/v1 ◽

2021 ◽

Author(s):

Teotone Vaz ◽

Pranav P. Naik ◽

Janesline Fernandes ◽

Lalitprabha Salgaonkar ◽

Snehal S. Hasolkar

Keyword(s):

Fourier Transforms ◽

Magnetic Behavior ◽

Size Estimation ◽

One Pot ◽

Transmission Electron ◽

Catalytic Role ◽

The One ◽

Co Precipitation ◽

Citrate Precursor

Abstract In the present investigation, Spinel systems with chemical composition Co1 − xNixAl2O4 (x = 0.0, 0.25, 0.5, and 0.75) have been successfully synthesized by the co-precipitation citrate precursor technique. The phase formation, crystal structure, and impurity check were confirmed by X-ray powdered diffraction (XRD) and Fourier transforms infrared (FTIR) spectroscopy technique. The particle size estimation was done using a transmission electron microscope (TEM). Investigation of magnetic behavior and parameters such as saturation magnetization (MS), coercivity (HR), and retentivity (MR) was done using a vibrating sample magnetometer (VSM). The catalytic activity of prepared spinel systems was explored for the one-pot synthesis of dihydropyrimidinone derivatives. The catalytic product was identified by comparison of melting point and the spectral data (FTIR).

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One-Pot, Low-Temperature Preparation of Pyrochlore-Like Na2Ta2O6 Nanocrystals by Solvothermal Synthesis

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.703.267 ◽

2016 ◽

Vol 703 ◽

pp. 267-272 ◽

Cited By ~ 1

Author(s):

Qing Song Jiang ◽

Jian Gao ◽

Hai Feng Yuan ◽

Lu Rong Ding ◽

Lin Yi

Keyword(s):

Low Temperature ◽

Sodium Hydroxide ◽

Mixed Solvents ◽

Single Step ◽

Synthesis Process ◽

X Ray Diffraction ◽

One Pot ◽

Transmission Electron ◽

Low Temperature Preparation ◽

Temperature Preparation

In this paper, pyrochlore-like Na2Ta2O6 nanocrystals have been successfully synthesized in mixed solvents (water-ethanol) by a single-step and low-temperature solvothermal method. During the synthesis process, tantalum chloride and sodium hydroxide are used as starting materials; diethanolamine is acted as a stabilizer. The influence of alkaline concentration, reaction temperature and time on the crystallinity and morphology of Na2Ta2O6 nanocrystals is investigated in detail. The samples are characterized by X-ray diffraction and transmission electron microscope. The results show that the pure-phase pyrochlore-like Na2Ta2O6 nanocrystals can be formed with 10.5 mmol sodium hydroxide at 353K for 12 h.

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Magnetic and dielectric properties of BiFeO3 nanoparticles

JOURNAL OF ADVANCES IN PHYSICS ◽

10.24297/jap.v7i2.1697 ◽

2015 ◽

Vol 7 (2) ◽

pp. 1393-1403

Author(s):

Dr R.P VIJAYALAKSHMI ◽

N. Manjula ◽

S. Ramu ◽

Amaranatha Reddy

Keyword(s):

Diffuse Reflectance Spectrum ◽

Precipitation Method ◽

Secondary Phases ◽

X Ray Diffraction ◽

Bifeo3 Nanoparticles ◽

Transmission Electron ◽

Multiferroic Bifeo3 ◽

Pure Phase ◽

Simple Chemical ◽

Co Precipitation

Single crystalline nano-sized multiferroic BiFeO3 (BFO) powders were synthesized through simple chemical co-precipitation method using polyethylene glycol (PEG) as capping agent. We obtained pure phase BiFeO3 powder by controlling pHand calcination temperature. From X-ray diffraction studies the nanoparticles were unambiguously identified to have a rhombohedrally distorted perovskite structure belonging to the space group of R3c. No secondary phases were detected. It indicates single phase structure. EDX spectra indicated the appearance of three elements Bi, Fe, O in 1:1:3. From the UV-Vis diffuse reflectance spectrum, the absorption cut-off wavelength of the BFO sample is around 558nm corresponding to the energy band gap of 2.2 eV. The size (60-70 nm) and morphology of the nanoparticles have been analyzed using transmission electron microscopy (TEM). Â Â Linear Mâˆ’H behaviour and slight hysteresis at lower magnetic field is observed for BiFeO3 nanoparticles from Vibrating sample magnetometer studies. It indicates weak ferromagnetic behaviour at room temperature. From dielectric studies, the conductivity value is calculated from the relation s = L/RbA Sm-1 and it is around 7.2 x 10-9 S/m.

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Focused Ion Beam Analysis of Low-K Dielectrics

ISTFA 2000: Conference Proceedings from the 26th International Symposium for Testing and Failure Analysis ◽

10.31399/asm.cp.istfa2000p0397 ◽

2000 ◽

Author(s):

H. J. Bender ◽

R. A. Donaton

Keyword(s):

Electron Microscope ◽

Cross Section ◽

Focused Ion Beam ◽

Ion Beam ◽

Single Step ◽

Specimen Preparation ◽

Transmission Electron ◽

Beam Analysis ◽

Low K ◽

Scanning Electron

Abstract The characteristics of an organic low-k dielectric during investigation by focused ion beam (FIB) are discussed for the different FIB application modes: cross-section imaging, specimen preparation for transmission electron microscopy, and via milling for device modification. It is shown that the material is more stable under the ion beam than under the electron beam in the scanning electron microscope (SEM) or in the transmission electron microscope (TEM). The milling of the material by H2O vapor assistance is strongly enhanced. Also by applying XeF2 etching an enhanced milling rate can be obtained so that both the polymer layer and the intermediate oxides can be etched in a single step.

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