scholarly journals Prognostic possibilities of molecular genetic testing for assessing the risk of recurrence of papillary thyroid cancer in children

2021 ◽  
Vol 67 (4) ◽  
pp. 511-517
Author(s):  
S Sergiiko ◽  
Sergei Lukianov ◽  
Sergey Titov ◽  
Iuliia Veriaskina ◽  
Anatolii Romanchishen ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Braf Mutation ◽  
Molecular Genetic ◽  
Molecular Genetic Testing ◽  
Papillary Thyroid ◽  
Clinical Criteria ◽  
Risk Of Death ◽  
New Criteria ◽  
Cancer In Children

The assessment of aggressiveness and risk of death in papillary thyroid cancer in children is currently based on clinical criteria. To ensure a more accurate risk stratification, new criteria and various molecular genetic markers are constantly being sought. The article studied the dependence of the clinical and pathological manifestations of papillary thyroid cancer in children on the level of expression of various microRNAs and the presence of the BRAF mutation. It was found that the BRAF mutation was present in 20.4% of cases, while the dependence of the clinical behavior of cancer on the BRAF mutation was not established. Of the 14 microRNAs studied, statistical differences were obtained for oncogenic miR-146b, -221, -31, and oncosuppressive miR-144, which correlated with signs such as extrathyroid tumor growth, multi-focus, and metastasis to the neck lymph nodes.

scholarly journals INFLUENCE OF BRAF MUTATION ON CLINICAL AND PATHOLOGICAL MANIFESTATIONS OF PAPILLARY THYROID CANCER

2020 ◽  
Vol 23 (2) ◽  
pp. 92-99
Author(s):  
S. A. Lukyanov ◽  
S. V. Sergiyko ◽  
S. E. Titov ◽  
G. O. Shcherbakov
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Braf Mutation ◽  
Clinical Stage ◽  
Molecular Genetic ◽  
Papillary Thyroid ◽  
Regional Lymph Nodes ◽  
Clinical Criteria ◽  
Increased Risk ◽  
Risk Of Relapse

Stratifications of the risk of recurrence and mortality in papillary thyroid cancer (PTC) are currently based on clinical criteria. In order to provide a more accurate assessment of the risk of relapse, new criteria, such as molecular genetic markers, are constantly being sought. The most studied of these markers is the BRAF mutation. The aim of the work was to study the dependence of clinical and pathological manifestations of papillary thyroid cancer on the presence of a BRAF mutation. The retrospective study included 212 patients with PTC. The dependence of the BRAF mutation on the patient’s gender, age, multifocality, presence of regional and remote metastases, extrathyroid invasion, clinical stage, and risk of relapse was studied. A single tumor was found in 196 (92.4%) cases, and a multifocal one in 16 (7.6%). Macroscopic extrathyroid invasion was observed in 80 (37.7%) patients. Metastases in regional lymph nodes were found in 83 (39.2%) patients, in 12 (5.7%) cases, the presence of distant metastases was detected. It was found that the BRAF mutation was present in 128 (60.4%) patients. There was no statistically significant association between the presence of the mutation and clinical and pathological manifestations of PTC, except for age. The incidence of the BRAF mutation in patients with PTC in young, middle, elderly and senile age was 3.8-35 times higher than in children and young men. It was found that the frequency of detection of the BRAF mutation increases with the age of the patient and has a linear relationship. It was concluded that the BRAF mutation can’t be used as an isolated marker of aggressive flow and a criterion indicating an increased risk of relapse of PTC.

QUANTITATIVE AND QUALITATIVE CHARACTERISTICS OF METASTASES IN REGIONAL LYMPH NODES - RISK FACTORS FOR THE RECURRENCE OF PAPILLARY THYROID CANCER IN CHILDREN AND ADOLESCENTS

2018 ◽  
Vol 64 (2) ◽  
pp. 159-165
Author(s):  
Mikhail Fridman ◽  
Svetlana Mankovskaya ◽  
Olga Krasko
Keyword(s):  
Risk Factors ◽  
Thyroid Cancer ◽  
Lymph Nodes ◽  
Children And Adolescents ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Regional Lymph Nodes ◽  
Cancer In Children ◽  
Qualitative Characteristics

Among the factors determining the relapse/persistence of papillary thyroid cancer in children and adolescents the most important are the age of the patient (p= 0.003), the presence of concomitant background pathology (p

Accuracy of the Lymph Node Yield in Surgery for Papillary Thyroid Cancer in Children

2021 ◽  
Author(s):  
Ava Yap ◽  
Amy Shui ◽  
Jessica Gosnell ◽  
Chiung-Yu Huang ◽  
Julie Ann Sosa ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Lymph Node Yield ◽  
Cancer In Children ◽  
Node Yield

scholarly journals Elastography as a Potential Modality for Screening Cervical Lymph Nodes in Patients with Papillary Thyroid Cancer: A Review of Literature

2018 ◽  
Vol 97 (1-2) ◽  
pp. 31-39 ◽  
Author(s):  
Robert Saadi ◽  
Salvatore LaRusso ◽  
Kanupriya Vijay ◽  
David Goldenberg
Keyword(s):  
Thyroid Cancer ◽  
Lymph Nodes ◽  
Papillary Thyroid Cancer ◽  
Clinical Utility ◽  
Lymph Node Involvement ◽  
Papillary Thyroid ◽  
Ultrasound Technique ◽  
Cervical Lymph Nodes ◽  
Specific Patient ◽  
Clinical Criteria

Papillary thyroid cancer often presents with cervical lymph node involvement and has a high incidence of recurrence, which requires routine follow-up with ultrasound imaging. Elastography is a novel ultrasound technique that has been demonstrated to be effective clinically in detecting tissue pathology in areas such as the liver and breast. Preliminary data suggest that it may be effective in screening tissues in the neck for malignancy, specifically cervical lymph nodes. However, diagnostic criteria and elastographic techniques vary significantly among the studies we have reviewed, which all tend to focus on populations of patients with many different types of primary malignancies. Further research is required on the feasibility of creating standardized and reproducible clinical criteria in a specific patient population. To study the clinical utility of elastography in cervical lymph nodes, patients with diagnosed papillary thyroid carcinoma may serve as an ideal population because of their need for ultrasound surveillance and the propensity of papillary thyroid cancer to metastasize to and recur in cervical lymph nodes. We will review the limitations, techniques, and reported clinical utility of elastography on cervical lymph nodes and its potential as a screening modality for papillary thyroid cancer.

Papillary Thyroid Cancer in Children and Adolescents Does Not Differ in Growth Pattern and Metastatic Behavior

2010 ◽  
Vol 157 (4) ◽  
pp. 648-652 ◽  
Author(s):  
Andreas Machens ◽  
Kerstin Lorenz ◽  
Phuong Nguyen Thanh ◽  
Michael Brauckhoff ◽  
Henning Dralle
Keyword(s):  
Thyroid Cancer ◽  
Children And Adolescents ◽  
Papillary Thyroid Cancer ◽  
Growth Pattern ◽  
Papillary Thyroid ◽  
Metastatic Behavior ◽  
Cancer In Children

Molecular genetic factors in the development of papillary thyroid cancer in the Kazakh population

2018 ◽  
Vol 64 (3) ◽  
Author(s):  
Mayra Zhaksimanovna Espenbetova ◽  
Natalya Egorovna Glushkova ◽  
Ainur Serikovna Krykpayeva
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Case Control Study ◽  
Effective Means ◽  
Molecular Genetic ◽  
Control Group ◽  
Papillary Thyroid ◽  
Similar Work ◽  
Kazakh Population ◽  
Control Study

Introduction. In the last decade several population studies on the association of the genes NKX2-1 and FOXE1 with sporadic papillary thyroid cancer were conducted. In the Kazakh population of similar work to date were not conducted. The aim of this study was to study the genetic association of the FOXE1 (rs9655313) and NKX2-1 (rs944289) oncomarkers with papillary thyroid cancer in the Kazakh population. Materials and methods. We conducted a case-control study that allows us to retrospectively evaluate the association of NKX2-1 and FOXE1 genes and papillary thyroid cancer. Results. The frequency distribution of FOXE1 rs965513 polymorphism in the group of papillary thyroid cancer and the control group detected by healthy individuals was significantly different (χ2 = 100.09, D.f. = 2, p = 0.000). In the group of cases, the AA genotype (17.5%) was in three times more often compared with the control group (5.1%). The GG variant had a lower frequency in the group of persons of papillary thyroid cancer (37.9%) against the control group (61.4%), the odds ratio (OR) in the FOXE1 rs965513 group was 2.367. The distribution of the NKX2-1 (rs944289) polymorphism frequencies in the compared groups of values were significantly different (χ2 = 100.09, D.f. = 2, p = 0.000). In the group of cases, the genotype of TT (30.5%) against the control group (20.7%) was 1.5 times more common. The SS variant had a lower frequency of occurrence in the group of persons of papillary thyroid cancer (19.8%) against the control group (28.9%), OR in NKX2-1 (rs944289) group was 1.46. Conclusion. Carrying out screening for carriers of FOXE1 rs965513 and NKX2-1 (rs944289) can become an effective means of early diagnosis with a high frequency of its spread and associations with cases of papillary thyroid cancer in the Kazakh population.

scholarly journals The ret/PTC Mutations are Common in Sporadic Papillary Thyroid Cancer in Children

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 89A-89A
Author(s):  
Cydney L Fenton ◽  
Yvonne Lukes ◽  
Catherine A Dinauer ◽  
R Michael Tuttle ◽  
Gary L Francis
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Cancer In Children
Sign in / Sign up

Export Citation Format

Share Document