scholarly journals Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer

2017 ◽  
Vol 23 (34) ◽  
pp. 6212 ◽  
Author(s):  
Renate S Olsen ◽  
Johnny Nijm ◽  
Roland E Andersson ◽  
Jan Dimberg ◽  
Dick Wågsäter
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Factors ◽  
Factors Associated ◽  
Long Term Prognosis

scholarly journals Examination of main lymph node (No.253) metastasis in left colorectal cancer: A retrospective analysis of a single-institution cohort

2021 ◽  
Author(s):  
Takefumi Yoshida ◽  
Fumihiko Fujita ◽  
Dai Shida ◽  
Kenichi Koushi ◽  
Kenji Fujiyoshi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Poor Prognosis ◽  
Advanced Colorectal Cancer ◽  
D3 Lymphadenectomy ◽  
Positive Group ◽  
Factors Associated

Abstract Background. The extent of lymph node dissection in advanced colorectal cancer varies according to regional guidelines. D3 lymphadenectomy is routinely performed in Japan but is associated with several risk factors. Metastases of the main lymph nodes (No.253 lymph nodes), which are located at the root of the inferior mesenteric artery, are rare in left-sided colorectal cancer. Tumor depth (T4) is an identifier of No.253 lymph node metastasis (LNM) risk, but other risk factors associated with No.253 LNM are unclear. This study was undertaken to investigate the frequency of No.253 LNM and to identify other clinicopathological risk factors associated with No.253 LNM in left-sided colorectal cancer. In this study, we aimed to evaluate the clinical benefit of routine D3 lymphadenectomy in surgically treated advanced colorectal cancer. Methods. A retrospective database of patients with colorectal cancer who underwent D3 dissection and R0 resection at Kurume University Hospital from 1978 to 2017 was constructed and used to search for the frequency and risk factors of No.253 LNM to investigate long-term prognosis. Clinicopathological factors associated with No.253 LNM, including age, sex, tumor location, T stage, tumor diameter, carcinoembryonic antigen levels, and various dissected lymph nodes, were analyzed. Results. Among 1,614 consecutive patients, No.253 LNM was observed in 23 cases (1.4%). The presence of three or more regional LNMs was an independent risk factor for No.253 LNM (odds ratio: 26.8). The 5-year overall survival rate was 49.1% in the No.253 LNM-positive group and 78.4% in the No.253 LNM-negative group (p=0.002). Conclusion. In left-sided colorectal cancer, No.253 LNM was a poor prognosis factor, and three or more regional LNMs were a risk factor for No.253 LNM. The No.253 LNM-positive group had a poor prognosis, but there are cases of long-term survival, with a 5-year survival rate of 49%. D3 lymphadenectomy is suitable when three or more metastatic LNs are identified prior to surgery.

scholarly journals Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Luis de la Cruz-Merino ◽  
Fernando Henao Carrasco ◽  
David Vicente Baz ◽  
Esteban Nogales Fernández ◽  
Juan José Reina Zoilo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Colorectal Carcinoma ◽  
Tumor Cells ◽  
Immune Reaction ◽  
Current Knowledge ◽  
Immune Microenvironment ◽  
Long Term Prognosis ◽  
Infiltrating Lymphocytes

Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells.

scholarly journals OESOPHAGEAL STENTING IN MALIGNANT DYSPHAGIA - FACTORS ASSOCIATED WITH DIFFERENT COMPLICATIONS AND THEIR EFFECT ON LONG-TERM PROGNOSIS

2016 ◽  
Vol 5 (101) ◽  
pp. 7413-7417
Author(s):  
Parvinder Singh ◽  
Ghansham Sharma ◽  
Abhitesh Singh ◽  
Anantbir Singh ◽  
Parmod Kumar Bhatia ◽  
...  
Keyword(s):  
Factors Associated ◽  
Malignant Dysphagia ◽  
Long Term Prognosis

scholarly journals Long-term trends in colorectal cancer: incidence, localization, and presentation

2020 ◽  
Author(s):  
Øystein Høydahl ◽  
Tom-Harald Edna ◽  
Athanasios Xanthoulis ◽  
Stian Lydersen ◽  
Birger Henning Endreseth
Keyword(s):  
Colorectal Cancer ◽  
Sex Distribution ◽  
Observational Period ◽  
Colorectal Obstruction ◽  
Factors Associated ◽  
Future Burden ◽  
Long Term Trends ◽  
Colorectal Cancer Incidence ◽  
Descending Colon

Abstract Background The purpose of this study was to assess trends in incidence and presentation of colorectal cancer (CRC) over a period of 37 years in a stable population in Mid-Norway. Secondarily, we wanted to predict the future burden of CRC in the same catchment area.Methods All 2268 patients diagnosed with CRC at Levanger Hospital between 1980 and 2016 were included in this study. We used Poisson regression to calculate the incidence rate ratio (IRR) and analyse factors associated with incidence.Results The incidence of CRC increased from 43/100,000 person-years during 1980–1984 to 84/100,000 person-years during 2012–2016. Unadjusted IRR increased by 1.8% per year, corresponding to an overall increase in incidence of 94.5%. Changes in population (ageing and sex distribution) contributed to 28% of this increase, whereas 72% must be attributed to primary preventable factors associated with lifestyle. Compared with the last observational period, we predict a further 40% increase by 2030, and a 70% increase by 2040. Acute colorectal obstruction was associated with tumours in the left flexure and descending colon. Spontaneous colorectal perforation was associated with tumours in the descending colon, caecum, and sigmoid colon. The incidence of obstruction remained stable, while the incidence of perforation decreased throughout the observational period. The proportion of earlier stages at diagnosis increased significantly in recent decades.Conclusion CRC incidence increased substantially from 1980 to 2016, mainly due to primary preventable factors. The incidence will continue to increase during the next two decades, mainly due to further ageing of the population.

scholarly journals Characterisation of long-term cancer survivors and application of statistical cure models: a protocol for an observational follow-up study in patients with colorectal cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sonia Pértega-Díaz ◽  
Vanesa Balboa-Barreiro ◽  
Rocío Seijo-Bestilleiro ◽  
Cristina González-Martín ◽  
Remedios Pardeiro-Pértega ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Term Survival ◽  
Long Term Survival ◽  
Follow Up Study ◽  
Cure Models ◽  
Long Term Prognosis ◽  
Clinical Records ◽  
Long Term Survivors

Abstract Background Improved colorectal cancer (CRC) survival rates have been reported over the last years, with more than half of these patients surviving more than 5 years after the initial diagnosis. Better understanding these so-called long-term survivors could be very useful to further improve their prognosis as well as to detect other problems that may cause a significant deterioration in their health-related quality of life (HRQoL). Cure models provide novel statistical tools to better estimate the long-term survival rate for cancer and to identify characteristics that are differentially associated with a short or long-term prognosis. The aim of this study will be to investigate the long-term prognosis of CRC patients, characterise long-term CRC survivors and their HRQoL, and demonstrate the utility of statistical cure models to analyse survival and other associated factors in these patients. Methods This is a single-centre, ambispective, observational follow-up study in a cohort of n = 1945 patients with CRC diagnosed between 2006 and 2013. A HRQoL sub-study will be performed in the survivors of a subset of n = 485 CRC patients for which baseline HRQoL data from the time of their diagnosis is already available. Information obtained from interviews and the clinical records for each patient in the cohort is already available in a computerised database from previous studies. This data includes sociodemographic characteristics, family history of cancer, comorbidities, perceived symptoms, tumour characteristics at diagnosis, type of treatment, and diagnosis and treatment delay intervals. For the follow-up, information regarding local recurrences, development of metastases, new tumours, and mortality will be updated using hospital records. The HRQoL for long-term survivors will be assessed with the EORTC QLQ-C30 and QLQ-CR29 questionnaires. An analysis of global and specific survival (competitive risk models) will be performed. Relative survival will be estimated and mixture cure models will be applied. Finally, HRQoL will be analysed through multivariate regression models. Discussion We expect the results from this study to help us to more accurately determine the long-term survival of CRC, identify the needs and clinical situation of long-term CRC survivors, and could be used to propose new models of care for the follow-up of CRC patients.

Clinical impact of non-predominant histopathological subtypes on the long-term prognosis of colorectal cancer patients in Japan

2020 ◽  
Vol 35 (12) ◽  
pp. 2257-2266
Author(s):  
Heita Ozawa ◽  
Shinichi Yamauchi ◽  
Hiroki Nakanishi ◽  
Junichi Sakamoto ◽  
Shin Fujita ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Clinical Impact ◽  
Long Term Prognosis ◽  
Colorectal Cancer Patients
Sign in / Sign up

Export Citation Format

Share Document