OESOPHAGEAL STENTING IN MALIGNANT DYSPHAGIA - FACTORS ASSOCIATED WITH DIFFERENT COMPLICATIONS AND THEIR EFFECT ON LONG-TERM PROGNOSIS

ObjectiveBenign multiple sclerosis (BMS) is often defined by the Expanded Disability Status Scale (EDSS) score of ≤3.0 after ≥15 years of disease duration. This classification’s clinical relevance remains unclear as benign patients may suffer other impairments and advance towards a progressive course, prompting our objective to holistically investigate factors associated with BMS and its long-term prognosis.MethodsBenign cases were identified in the Swedish Multiple Sclerosis registry. Baseline clinical data, demographic features and influence of multiple sclerosis (MS) major risk alleles on likelihood of benign course were investigated. Physical disability (EDSS), cognitive function (Symbol Digit Modalities Test; SDMT) and self-reported and socioeconomic differences between benign and non-benign patients were evaluated using generalised estimation equations models.Results11222 patients (2420 benign/8802 non-benign) were included. Benign patients were more likely to be female and younger at MS onset, have fewer relapses within the first two and 5 years from onset and fully recover from the first relapse (p<0.001). No association between human leucocyte antigen (HLA) DRB1*15:01 carriership (OR: 0.97, 95% CI: 0.86 to 1.09) or HLA-A*02:01 lacking (OR: 0.99, 95% CI: 0.87 to 1.11) and benign/non-benign was found. Non-benign patients accumulated an extra 0.04 (95% CI 0.03 to 0.04, p<0.001) EDSS score/year, lost an extra 0.3 (95% CI − 0.39 to − 0.18, p<0.001) SDMT score/year and deteriorated faster in self-reported impact and socioeconomic measures (p<0.001).ConclusionPatients with BMS have a better disease course as they progress more slowly at the group level in all respects. Lack of an association with major genetic risk factors indicates that MS course is most likely influenced by either environmental factor(s) or genetic factors outside the HLA region.

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Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer

World Journal of Gastroenterology ◽

10.3748/wjg.v23.i34.6212 ◽

2017 ◽

Vol 23 (34) ◽

pp. 6212 ◽

Cited By ~ 15

Author(s):

Renate S Olsen ◽

Johnny Nijm ◽

Roland E Andersson ◽

Jan Dimberg ◽

Dick Wågsäter

Keyword(s):

Colorectal Cancer ◽

Inflammatory Factors ◽

Factors Associated ◽

Long Term Prognosis

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Sa1197 Factors Associated With Treatment Outcome, and Long-Term Prognosis of Patients With Ulcerative Colitis Undergoing Adsorptive Granulocyte/Monocyte Apheresis: A Prospective Multicentre Investigation

Gastroenterology ◽

10.1016/s0016-5085(15)30837-4 ◽

2015 ◽

Vol 148 (4) ◽

pp. S-254

Author(s):

Yoko Yokoyama ◽

Kenji Watanabe ◽

Hiroaki Ito ◽

Koji Sawada ◽

Yusuke Okuyama ◽

...

Keyword(s):

Ulcerative Colitis ◽

Treatment Outcome ◽

Factors Associated ◽

Long Term Prognosis

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Epidemiology of Asthma

Journal of Pharmacy Practice ◽

10.1177/089719009701000307 ◽

1997 ◽

Vol 10 (3) ◽

pp. 165-175

Author(s):

Nancy A. Letassy

Keyword(s):

Risk Factors ◽

Inner City ◽

Life Style ◽

Economic Status ◽

Morbidity And Mortality ◽

Contributing Factors ◽

Factors Associated ◽

Long Term Prognosis ◽

Severity Of The Disease

Epidemiology of asthma is discussed in terms of the prevalence, risk factors associated with increasing morbidity and mortality, impact on life-style, long-term prognosis, and economic impact. Those most at risk for development of asthma are young children, African Americans, and those in lower economic status and inner-city communities. The primary contributing factor to increasing morbidity and mortality is undertreatment. Contributing factors may be restricted access to continuing medical care, unstable family situations, cultural and language barriers, failure to recognize severity of the disease, and inability to afford care.

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Current Evidence on Long-Term Prognostic Factors in Vasospastic Angina

Journal of Clinical Medicine ◽

10.3390/jcm10184270 ◽

2021 ◽

Vol 10 (18) ◽

pp. 4270

Author(s):

Hack-Lyoung Kim ◽

Sang-Ho Jo

Keyword(s):

Vasospastic Angina ◽

Current Evidence ◽

Channel Blockers ◽

Clinical Factors ◽

Factors Associated ◽

Clinical Events ◽

Risk Patients ◽

Long Term Prognosis ◽

Better Than

Vasospastic angina (VSA) is characterized by a reversible spasm of the coronary arteries and is more prevalent in Asians. Vasodilators, such as calcium channel blockers, are effective in relieving coronary spasms and preventing clinical events. Therefore, the prognosis of VSA is generally known to be better than for significant organic stenosis caused by atherosclerosis. However, coronary vasospasm is sometimes associated with fatal complications such as sudden death, ventricular arrhythmia, and myocardial infarction. Thus, it is very important to identify and actively treat high-risk patients to prevent VSA complications. Here, we will review clinical factors associated with long-term prognosis in patients with VSA.

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