scholarly journals Current guidelines for the management of celiac disease: A systematic review with comparative analysis

2022 ◽  
Vol 28 (1) ◽  
pp. 154-176
Author(s):  
Alberto Raiteri ◽  
Alessandro Granito ◽  
Alice Giamperoli ◽  
Teresa Catenaro ◽  
Giulia Negrini ◽  
...  
BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e047980
Author(s):  
Oliseneku Damien Uyagu ◽  
Cosmas Ofoegbu ◽  
Joseph Ikhidero ◽  
Emeka Chukwuka ◽  
Okezie Enwere ◽  
...  

IntroductionPeripheral arterial disease (PAD) is the third leading atherosclerotic arterial disease. There is evidence that there is a high variation in the quality and recommendations of clinical practice guidelines for PAD, leading to the possibility of confusion among clinicians and patients. This study aims to conduct a quality assessment and comparative analysis of the clinical practice guidelines on PAD written between 2010 and 2020.Method and analysisWe aim to perform a systematic review of clinical practice guidelines written between 2010 and 2020. A search for guidelines will be conducted through medical databases Scope, Pubmed, TRIP, Guideline Clearinghouses and specialist international organisations’ specific websites. Guidelines that meet the inclusion criteria will be extracted from the search result. The Appraisal of Guidelines for Research and Evaluation II (AGREE-II instrument) will assess the quality of the selected guidelines. The recommendations, level of evidence and other relevant information will be extracted in a datasheet for qualitative analysis. The score for each guideline’s quality will be represented using charts and central tendency measures for comparison. The summary of recommendations will also be represented in tables for easy comparison for similarities and variations across sections. Finally, the level of evidence on which the recommendations are based will also be noted along with other significant characteristics such as the authors’ financial relationship to the biomedical community. We aim to point out deficiencies present in current guidelines and elucidate areas where recommendations are made with low-level evidence. The results will enable the scientific community to design future research to fill in PAD management knowledge gaps.Ethics and disseminationNo ethical approval was sought. Dissemination will be via journal articles and conference presentations.PROSPERO registration numberCRD42020219176.


2017 ◽  
Vol 153 (2) ◽  
pp. 395-409.e3 ◽  
Author(s):  
María Inés Pinto-Sánchez ◽  
Natalia Causada-Calo ◽  
Premysl Bercik ◽  
Alexander C. Ford ◽  
Joseph A. Murray ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0241156
Author(s):  
Fazel Isapanah Amlashi ◽  
Zahra Norouzi ◽  
Ahmad Sohrabi ◽  
Hesamaddin Shirzad-Aski ◽  
Alireza Norouzi ◽  
...  

Background and objectives Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization. Data sources Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated. Synthesis methods Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed. Results Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45–0.70; P < 0.001), with no publication bias (P = 0.825). The L’Abbé plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity. Conclusions According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients. Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=167730.


2020 ◽  
Vol 115 (10) ◽  
pp. 1584-1595 ◽  
Author(s):  
Caroline L. Seiler ◽  
Michel Kiflen ◽  
Juan Pablo Stefanolo ◽  
Julio César Bai ◽  
Premysl Bercik ◽  
...  

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