Naringenin: a potential bioactive compound and pathways of biosynthesis – a review

2021 ◽  
pp. 13-20
Keyword(s):  
Secondary Metabolites ◽  
Natural Compound ◽  
Higher Plants ◽  
Bioactive Compound ◽  
Effective Drug ◽  
Pharmacological Effects ◽  
Human Diet ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Plant Metabolite

Naringenin is a member of the flavonoid family. This natural compound represents a large proportion of secondary metabolites produced by higher plants and is a rich part of the human diet. Naringenin also has been used in the pharmaceutical and medical fields as an effective drug for anti-oxidative, anti-cancer, anti-obesity, and anti-inflammatory activities. Naringenin is also a typical plant metabolite, that has never been reported to be produced in prokaryotes. Recently, many papers reported that various members of the Streptomyces family, a genus of actinobacteria, had a novel pathway to produce naringenin. As a result, this review focuses on some clinical pharmacological effects and promising applications in the medical of naringenin, also its pathways of biosynthesis.

Pharmacology Research Progress of Phenolic Alkaloids from Menisphermum dauricum

2014 ◽  
Vol 636 ◽  
pp. 157-162
Author(s):  
Qi Guo ◽  
Qi Jiang ◽  
Zhi Guo Wang
Keyword(s):  
Blood Pressure ◽  
Cerebral Ischemia ◽  
Respiratory Depression ◽  
Research Progress ◽  
Pharmacological Effects ◽  
Learning Disorder ◽  
Anti Cancer ◽  
Rhizoma Menispermi ◽  
Heart Electrophysiology ◽  
Anti Inflammatory

Phenolic alkaloids from Menisphermum dauricum (PAMD) was a compound of multiple fat soluble alkaloid extracted from Rhizoma Menispermi. PAMD had wide pharmacological effects including of anti-arrhythmia, anti-MI, anti-thrombosis, anti-dementia, anti-cancer, anti-inflammatory, inhibiting respiratory depression, influencing on heart electrophysiology, ptotecting heart and nerve after cerebral ischemia, suppressing pain, lowering blood pressure, improving learning disorder and so on.

EXTRACTION AND EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF SPATHIPHYLLUM CANNIFOLIUM

2015 ◽  
Vol 77 (24) ◽  
Author(s):  
Raha Ahmad Raus ◽  
Norhayati Abdullah ◽  
Nurul Fakhriah Ismail ◽  
Munira Shahbuddin
Keyword(s):  
Optimum Condition ◽  
Bioactive Compounds ◽  
Bioactive Compound ◽  
Inflammatory Activity ◽  
Chloroform Fraction ◽  
Landscape Plant ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Face Centered ◽  
Central Composite

Sphathiphyllum cannifolium is abundantly planted in Malaysia as a landscape plant. However, this plant also has medical benefit to human as it was previously found to possess anti-bacteria and anti-cancer activities. In the present study, the plant was evaluated for its anti inflammatory activity and the optimum condition for the extraction of bioactive compounds with anti inflammatory activity was determined. Semi purification of the compounds possessing anti inflammatory activity was conducted as well. To extract the bioactive compound, sonication with methanol as a solvent extraction was carried out. Face-Centered Central Composite Design (FCCCD) and Response Surface Methodology (RSM) were used to design and identify the optimum condition to extract the compound, respectively. The results showed that the plant was positive for the anti inflammatory activity with IC50 6.3 µg/ml. Sonication for 60 min at 40°C using medium frequency was the optimum condition to carry out the extraction for bioactive compounds. After semi purification of the initial crude extract by solvent partitioning, chloroform fraction was found to be positive for anti inflammatory activity. In conclusion, this study suggested that S. cannifolium possess anti inflammatory activity and should be further analyzed to identify the specific compounds that responsible for this activity.   

MEKANISME KERJA ANDROGRAFOLIDA DARI SAMBILOTO SEBAGAI SENYAWA ANTIOKSIDAN

2021 ◽  
Vol 4 (1) ◽  
pp. 43
Author(s):  
Elvira Yunita
Keyword(s):  
Free Radicals ◽  
Mechanism Of Action ◽  
Superoxide Anion ◽  
Bioactive Compound ◽  
Ester Group ◽  
Superoxide Anions ◽  
Chemical Profile ◽  
Chain Reaction ◽  
Anti Cancer ◽  
Anti Inflammatory

Andrographolide is the main bioactive compound derived from sambiloto, Andrographis paniculata. Andrographolide compounds can potentially be used as phytopharmaca substances. Andrographolide has very broad pharmacological aspects, including anti-inflammatory, anticancer and anti-diabetic. The pharmacological aspects possessed by andrographolide are probably closely related to the chemical profile and the mechanism of action of andrographolide as an antioxidant in counteracting free radicals. Therefore, it is important to know the chemical profile and mechanism of action of andrographolide compounds as antioxidants to understand the mechanism of action of these compounds in dealing with various diseases. This study is based on a review of related literature. Based on the literature review, it was found that the mechanism of action of andrographolide as anti-cancer, anti-inflammatory and anti-dyslipidemia is closely related to the mechanism of action of this compound as an antioxidant. The unsaturated γ- lactone structure at C13 and C14 of andrographolide can neutralize superoxide anions. The double bond in this carbonyl ester group will affect the deprotonization of the H atone located at C15 so that the H atoms on C15 will be easily extracted by the highly reactive superoxide anion. Thus, andrographolide can stop the chain reaction of a radical molecule. This mechanism can cause andrographolide compounds to play a role in reducing the effects of free radicals in various diseases.

TERPENOIDS AS SOURCE OF ANTI-INFLAMMATORY COMPOUNDS

2017 ◽  
Vol 10 (3) ◽  
pp. 68 ◽  
Author(s):  
Ved Prakash
Keyword(s):  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Environmental Stress ◽  
Mechanism Of Action ◽  
Bioactive Compound ◽  
Natural Source ◽  
Major Class ◽  
Inflammatory Mechanism ◽  
Source Plant ◽  
Anti Inflammatory

ABSTRACTTerpenoids accounts for the major class of secondary metabolites produced by plants. It shows defense activity against environmental stress and helpto heal injuries. Medicinal plants are rich in monoterpenoids, diterpenoids, sesquiterpenes, triterpenes, tetraterpenes, and ceramide. A number oftherapeutic applications such as antibacterial, antimicrobial, antitumor, anti-inflammatory activity have been identified. Terpenoids are compoundssimilar to terpenes derived from 5-carbon monomer isoprene units. The review puts and detail insight on different class of compounds isolated fromnatural source from 2000 to 2016 showing anti-inflammatory potential of pharmacologically interesting agent and their mechanism of action.Keywords: Anti-inflammatory, Mechanism of action, Natural source, Plant, Terpenoid, Bioactive compound.

scholarly journals The Multifaced Actions of Curcumin in Pregnancy Outcome

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 126
Author(s):  
Giovanni Tossetta ◽  
Sonia Fantone ◽  
Stefano Raffaele Giannubilo ◽  
Daniela Marzioni
Keyword(s):  
Natural Compound ◽  
Curcuma Longa ◽  
Human Diet ◽  
Beneficial Effects ◽  
Toxic Agents ◽  
Anti Oxidant ◽  
Ancient Times ◽  
Anti Inflammatory ◽  
Pleiotropic Functions

Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in the rhizomes of Curcuma longa L. This plant showed many beneficial effects and has been used since ancient times for both food and pharmaceutical purposes. Due to its pleiotropic functions, curcumin consumption in the human diet has become very common thanks also to the fact that this natural compound is considered quite safe as it does not have serious side effects. Its functions as an anti-inflammatory, anti-oxidant, neuroprotective, immunomodulatory, anti-toxicant, anti-apoptotic, and anti-diabetic compound are already known and widely demonstrated. There are numerous studies concerning its effects on various human pathologies including cancer, diabetes and arthritis while the studies on curcumin during pregnancy have been performed only in animal models. Data concerning the role of curcumin as anti-inflammatory compound suggest a possible use of curcumin in managing pregnancy complications such as Preeclampsia (PE), Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), PreTerm Birth (PTB), and exposure to toxic agents and pathogens. The aim of this review is to present data to support the possible use of curcumin in clinical trials on human gestation complications.

A Review of Various Pharmacological Effects of Quercetin with its Barriers and Approaches for Solubility and Permeability Enhancement

2021 ◽  
Vol 11 ◽  
Author(s):  
Rakesh Mishra ◽  
Shweta Kulkarni
Keyword(s):  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Human Diet ◽  
Permeability Enhancement ◽  
Current Review ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Novel Approaches

Background: Quercetin, one of the most beneficial flavonoids, has been included in the human diet due to its therapeutic effect on health. Recently, Quercetin is gaining scientific attraction for its multifarious activities, including anti-oxidant, anti-inflammatory, antiviral, anti-diabetic, anti-cancer, anti-arthritic, as well as function to ease some cardiovascular diseases. However, these applications of quercetin in the pharmaceutical field are limited due to its poor aqueous solubility and poor permeability. Objective: The present review summarizes various pharmacological activities of quercetin, analyses the barriers like solubility and permeability, which restrict the therapeutic efficiency of quercetin, and also discusses novel approaches to enhance aqueous solubility and permeability of quercetin for its effective clinical use. Methods: The current review information sources were peer-reviewed relevant scientific articles of recognized journals from scientific engines and databases (Scopus, Web of Science, PubMed, Science Direct, Google Scholar) using different key words related to quercetin pharmacological effects, mechanism, solubility, permeability, absorption barriers, and formulation approaches. Results: Various novel approaches, including solid dispersions, inclusion complex, pro-drugs, nanoemulsion, micelles, liposomes, SNEEDS, and microspheres, have been developed to overcome the solubility and permeability barriers for efficient quercetin delivery. Conclusion: This review revealed that the multifaceted pharmacological activities of quercetin for management of various disease are enormously dependent on the development of novel and safe drug delivery systems of quercetin.

Isolation and Identification of Andrographolide Compounds from the Leaves of Sambiloto Plant (Andrographis paniculata Ness)

2021 ◽  
Vol 4 (1) ◽  
pp. 108
Author(s):  
Devi Ayu Septiani ◽  
Aliefman Hakim ◽  
Lalu Raftha Patech ◽  
Zulhalifah Zulhalifah ◽  
Siswadi Siswadi
Keyword(s):  
Infrared Spectroscopy ◽  
Respiratory Tract ◽  
Bioactive Compounds ◽  
Bioactive Compound ◽  
Andrographis Paniculata ◽  
Pharmacological Effects ◽  
Isolation And Identification ◽  
Qualitative Test ◽  
Ft Ir ◽  
Anti Inflammatory

Sambiloto plant (Andrographis paniculata Ness) is a plant that has been used as medicine from generation to generation. Bioactive compounds in Sambiloto have pharmacological effects such as immunostimulants (increase immunity), antibiotic diuretics (facilitate urine), antipyretics, anti-inflammatory (anti-inflammatory), hepatoprotective, hypotensive, hypoglycemic, antibacterial, anti-inflammatory, respiratory tract, and heart and lung meridians - lungs. The bioactive compound in Sambiloto which is mostly found in the leaves is Andrographolide. In this study, the isolation of Andrographolide from the leaves of the sambiloto plant (Andrographis paniculata Ness) was carried out using purification and crystallization methods aimed at obtaining pure Andrographolide isolates more efficiently and identifying the results of Andrographolide isolates. The results showed that the isolates obtained using the purification and crystallization methods obtained a yield of 0.47%. In the qualitative test of Andrographolide isolates using eluent and acetate: n-hexane (3: 2), the Rf value was 0.38. The results obtained from Andrographolide isolates using infrared spectroscopy (FT-IR) were identical to the literature on Andrographolide. The absorption peaks at the wavenumbers obtained includes 3400,41 cm-1, 1979,68 cm-1, 1959,46 cm-1, 2928,22 cm-1, 1727,56 cm-1, 1646,98 cm-1, and 907,53 cm-1.

Natural Fused Heterocyclic Flavonoids: Potent Candidates As Anti-Inflammatory And Anti-Allergic Agents In The Treatment Of Asthma

2019 ◽  
Vol 15 ◽  
Author(s):  
Rajwinder Kaur ◽  
Kirandeep Kaur ◽  
Rashmi Arora ◽  
Balraj Saini ◽  
Sandeep Arora
Keyword(s):  
Clinical Trials ◽  
Mast Cells ◽  
Human Neutrophil ◽  
Chemical Structure ◽  
Polyphenolic Compounds ◽  
The Other ◽  
Human Neutrophil Elastase ◽  
Pharmacological Effects ◽  
Anti Cancer ◽  
Anti Inflammatory

: In the last two decades, the flavanoids containing fused heterocyclic nucleus in their chemical structure have emerged to display a variety of pharmacological effects including anti-allergic and anti-inflammatory the most recent to the list. These polyphenolic compounds exert their pharmacological effect by various mechanisms including inhibition of human neutrophil elastase, cytokines (Interleukins- IL-3 and IL-4) and mast cells. Quercetin, Pycnogenol, Rutin and Kampferol are the few bio-flavonols out of hundreds of other compounds still under clinical trials that have been studied most. These flavonoids have been also reported to the other pharmacological effects like anti-cancer, anti-oxidants, anti-hypertensive, anti-viral, anti-ulcerogenic, anti-platelet, anti-hypotensive and anti-hepatotoxic. With all these versatile properties heterocyclic containing flavonoids may be a powerful candidate for the discovery of their utilization in other ailments like asthma.

scholarly journals Phaeophytin and Triterpenoids from Brachystelma togoense Schltr, a Nigerian Medicinal Herb

2019 ◽  
pp. 1-5 ◽  
Author(s):  
Abiche Ekalu ◽  
Rachael Gbekele-Oluwa Ayo ◽  
James D. Habila ◽  
Ibrahim Hamisu
Keyword(s):  
Secondary Metabolites ◽  
Biological Activities ◽  
2D Nmr ◽  
Medicinal Herb ◽  
Medicinal Purpose ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Anti Fungal

The medicinal herb Brachystelma togoense schtlr (Apocynaceae) is used traditionally for treatment of ailments.   The secondary metabolites, phaeophytin a, α-amyrin and lupeol were isolated from the CH2Cl2 and MeOH extracts of Brachystelma togoense.  The structures were elucidated using 1H, 13C and 2D NMR. These phytochemicals have previously being reported to have various biological activities such as anti-inflammatory, anti-fungal and anti-cancer. The presence of phaeophytin a, α-amyrin and lupeol in Brachystelma togoense justified the use of the plant for medicinal purpose in Nigeria.

scholarly journals Assessment of a developed HPLC-MS/MS approach for determining plasma eupatorin in rats and its application in pharmacokinetics analysis

RSC Advances ◽  
2020 ◽  
Vol 10 (53) ◽  
pp. 32020-32026
Author(s):  
Rui Feng ◽  
Luya Li ◽  
Xiaowei Zhang ◽  
Yuqian Zhang ◽  
Yuting Chen ◽  
...  
Keyword(s):  
Bioactive Compound ◽  
Orthosiphon Stamineus ◽  
Anti Cancer ◽  
Anti Inflammatory

Eupatorin, a bioactive compound extracted from Java tea (Orthosiphon stamineus), possesses potent anti-cancer, anti-inflammatory and vasodilation activities.

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