scholarly journals Chemical constituents of Chaenomeles sinensis twigs and their biological activity

2020 ◽  
Vol 16 ◽  
pp. 3078-3085
Author(s):  
Joon Min Cha ◽  
Dong Hyun Kim ◽  
Lalita Subedi ◽  
Zahra Khan ◽  
Sang Un Choi ◽  
...  
Keyword(s):  
Biological Activity ◽  
Data Analysis ◽  
Cell Lines ◽  
Chemical Structure ◽  
Biological Effects ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Nmr Data ◽  
Chaenomeles Sinensis ◽  
Modified Mosher’S Method

A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher’s method, and LC–MS analysis. The characterized compounds’ biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.

scholarly journals α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nguyen Phuong Thao ◽  
Pham Thanh Binh ◽  
Nguyen Thi Luyen ◽  
Ta Manh Hung ◽  
Nguyen Hai Dang ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Inhibitory Effects ◽  
Meoh Extract ◽  
Inhibitory Activities ◽  
Isolated Compound ◽  
New Compounds ◽  
Modified Mosher’S Method

As part of an ongoing search for new natural products from medicinal plants to treat type 2 diabetes, two new compounds, a megastigmane sesquiterpenoid sulfonic acid (1) and a new cyclohexylethanoid derivative (2), and seven related known compounds (3–9) were isolated from the leaves of Wedelia chinensis (Osbeck.) Merr. The structures of the compounds were conducted via interpretation of their spectroscopic data (1D and 2D NMR, IR, and MS), and the absolute configurations of compound 1 were determined by the modified Mosher’s method. The MeOH extract of W. chinensis was found to inhibit α-amylase and α-glucosidase inhibitory activities as well as by the compounds isolated from this extract. Furthermore, compound 7 showed the strongest effect with IC50 values of 112.8 ± 15.1 μg/mL (against α-amylase) and 785.9 ± 12.7 μg/mL (against α-glucosidase). Compounds 1, 8, and 9 showed moderate α-amylase and α-glucosidase inhibitory effects. Other compounds showed weak or did not show any effect on both enzymes. The results suggested that the antidiabetic properties from the leaves of W. chinensis are not simply a result of each isolated compound but are due to other components such as the accessibility of polyphenolic groups to α-amylase and α-glucosidase activities.

scholarly journals Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2577 ◽  
Author(s):  
Hongjing Dong ◽  
Yanling Geng ◽  
Xueyong Wang ◽  
Xiangyun Song ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
2D Nmr ◽  
No Production ◽  
Inhibitory Effects ◽  
Nmr Data ◽  
Extensive Analysis ◽  
Ic50 Values ◽  
Monoterpene Glycoside ◽  
Anti Inflammatory

One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especially 2D NMR data and comparison with literatures. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production in vitro. Compounds 3 and 7 exhibited moderate inhibitory effects on NO production with IC50 values of 12.2 ± 0.8 and 18.9 ± 0.3 μM, respectively.

Dammarane and Ceanothane Triterpenes from Zizyphus glabrata

2006 ◽  
Vol 61 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Seru Ganapaty ◽  
Pannakal S. Thomas ◽  
Kancharalapalli V. Ramana ◽  
Gloria Karagianis ◽  
Peter G. Waterman
Keyword(s):  
Bactericidal Activity ◽  
Chemical Constituents ◽  
2D Nmr ◽  
First Report ◽  
Nmr Data ◽  
C Nmr ◽  
Dammarane Glycoside

From the leaves of Zizyphus glabrata, a new dammarane-type triterpene, pseudojujubogenin -3-O- β -D-glucopyranoside, along with the known ceanothane triterpenes, granulosic acid, ceanothic acid and daucosterol were isolated. The structures of the compounds were fully characterized by detailed NMR investigations including 1H and 13C NMR, HSQC, COSY, HMBC and NOESY experiments. In addition, the dammarane glycoside was tested for its potential to inhibit various bacteria and was found to possess significant bactericidal activity. The 1H, 13C and full 2D-NMR data on granulosic acid has also been presented. This is the first report on the chemical constituents of the leaves of Z. glabrata.

scholarly journals Chemical Constituents from an Endophytic Fungus Chaetomium Globosum Z1

2013 ◽  
Vol 8 (9) ◽  
pp. 1934578X1300800
Author(s):  
Chun-Yan Zhang ◽  
Xiao Ji ◽  
Xuan Gui ◽  
Bao-Kang Huang
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Endophytic Fungus ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Chaetomium Globosum ◽  
Spectroscopic Methods ◽  
Esi Ms

A new ergosterol, 15β-hydroxyl-(22 E,24 R)-ergosta-3,5,8,22-tetraen-one (1), along with three known ergosterols, two known cytochalasins, and two known azapholines were isolated from Chaetomium globosum Z1. The structures of these compounds were elucidated on the basis of spectroscopic methods (HR-ESI-MS, 1D NMR, and 2D NMR). Compound 6 showed significant cytotoxic activity against A-549 and MG-63 cell lines with IC50 values of 6.96 and 1.73 μg/mL, respectively.

scholarly journals Root Extracts of Two Cultivars of Paeonia Species: Lipid Composition and Biological Effects on Different Cell Lines: Preliminary Results

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 655
Author(s):  
Natalia Calonghi ◽  
Giovanna Farruggia ◽  
Carla Boga ◽  
Gabriele Micheletti ◽  
Elena Fini ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Flow Cytometry ◽  
Biological Activity ◽  
Cell Lines ◽  
Doubling Time ◽  
Biological Effects ◽  
Lipid Fraction ◽  
Phase Imaging ◽  
Oxygen Species ◽  
Root Extracts

The roots of two cultivars of Paeonia, namely Paeonia officinalis “Rubra Plena” and Paeonia “Pink Hawaiian Coral”, have been extracted with chloroform. The composition of the lipid fraction, analyzed by GC–MS technique, revealed the absence of paeonol and the presence of phenol, benzoic acid, fatty acid—and some sterol—derivatives. The chloroformic extracts have been tested on normal and several cancer cell lines but showed antiproliferative activity only on the ovarian carcinoma and the osteosarcoma. The biological activity of extracts was investigated mainly by confocal microscopy, flow cytometry and quantum phase imaging. The results indicated that the root extracts induced a hyperpolarization of mitochondria and an increase in reactive oxygen species levels, without inducing cell death. These effects are associated to an increased doubling time and a retarded confluence.

scholarly journals Chemical constituents from the ethyl acetate and n-butanol extracts of the stems of Buchanania lucida Blume (Anacardiaceae)

2018 ◽  
Vol 1 (T5) ◽  
pp. 167-171
Author(s):  
Tung Thanh Nguyen ◽  
Thuong Thi Nguyen ◽  
Phu Hoang Dang ◽  
Trong Nguyen Huu Phan ◽  
Nhan Trung Nguyen
Keyword(s):  
Phenolic Compounds ◽  
Methyl Ester ◽  
Ethyl Acetate ◽  
Nmr Spectra ◽  
Chemical Structure ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Published Data ◽  
2D Nmr Spectra ◽  
Aloe Emodin

There is no research on the chemical constituents investigation and bioactivity evaluation of Buchanania lucida Blume (Anacardiaceae). From the stems of Buchanania lucida collected at Dong Nai province, the ethyl acetate and n-butanol extracts were prepared. Four phenolic compounds: protocatechuic methyl ester (1), aloe-emodin (2), naringenin (3), and glucosyringic acid (4) were isolated from these extracts. The chemical structure of these compounds were elucidated by 1D and 2D NMR spectra and comparison with published data. These compounds were first reported in Buchanania lucida.

scholarly journals STIMULATING AND INHIBITING EFFECTS ON PLANTS OF SOME ACETYLENIC AMINO ALCOHOLS AND SALTS GUIDAMONACI

2021 ◽  
Vol 56 (1) ◽  
pp. 33-40
Author(s):  
E. Turgunov ◽  
◽  
M.F. Faizullaeva ◽  
K.Kh. Darmaganbet ◽  
L.A. Zhusupova ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Chemical Structure ◽  
Biological Effects ◽  
Amino Alcohols ◽  
Herbicidal Activity ◽  
Ammonium Salts ◽  
Wheat Coleoptile ◽  
High Biological Activity

The herbicidal effects of aminopentinols, aminohexinols and some synthesized acetylene aminospirths, hydrochloride compounds, as well as the biological activity of their effects in relation to such important crops as cotton and corn were studied. During pretreatment of seeds and weeds, it was found that the studied drugs show different herbicidal activity in relation to annual dicotyledonous and annual grain weeds, depending on their chemical composition and dosage. It has been established that many ammonium salts of acetylene amino alcohols have high biological activity and that their use, depending on the chemical structure and quantity, has biological effects. To determine the biological activity of the studied drugs, the authors used a well-known method of biotestylation in wheat coleoptile. Preemergence treatment by solutions of abovementioned preparates in dependence on their chemical structure and dose have rendered different action on the growth leguminous (nut) and cereals (wheat, sorghum) plants.

scholarly journals CHEMICAL CONSTITUENTS FROM THE ROOTS OF MYXOPYRUM SMILACIFOLIUM

2021 ◽  
Vol 59 (4) ◽  
pp. 498
Author(s):  
Nguyễn Quốc Vượng ◽  
Vu Van Chien ◽  
Nguyễn Thị Huế ◽  
Phạm Thị Hằng ◽  
Tran Van Hieu ◽  
...  
Keyword(s):  
Data Analysis ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Esi Ms ◽  
Hydroxymethyl Furfural ◽  
Chemical Structures

 From the roots of Myxopyrum smilacifolium Blume, five known compounds, verbascoside (1), arenarioside (2), myxopyroside (3), 3-formylindole (4), and 5-hydroxymethyl furfural (5) were isolated. Their chemical structures were determined by  ESI-MS, 1D, 2D-NMR spectrascopic data analysis as well as in comparison with those reported in the literatures.   

scholarly journals Structural Characterization and Biological Effects of Constituents of the Seeds of Alpinia katsumadai (Alpina Katsumadai Seed)

2012 ◽  
Vol 7 (6) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Joo-Won Nam ◽  
Eun-Kyoung Seo
Keyword(s):  
Biological Activity ◽  
Structural Characterization ◽  
Plant Material ◽  
Review Paper ◽  
Biological Effects ◽  
Chemical Constituents ◽  
Oriental Medicine

Alpinia katsumadai Hayata (Zingiberaceae) has been used as an anti-emetic medicine and to treat gastric disorders in Oriental Medicine. Previous phytochemical investigations of this plant have resulted in the isolation of various diarylheptanoids, kavalactones, flavonoids, stilbenes, monoterpenes, and sesquiterpenes. Some of these compounds have antioxidant, anti-emetic, antiviral, and cytoprotective effects. This review paper discusses the structural characterization of the chemical constituents of A. katsumadai, as well as the biological activity of pure constituents of this plant material.

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