scholarly journals THE ROLE OF UNDIFFERENTIATED DYSPLASIA OF THE CONNECTIVE TISSUE IN THE DEVELOPMENT OF THE ENTEROCUTANEOUS FISTULA

2019 ◽  
pp. 5-10
Author(s):  
O.Yu. Usenko ◽  
Ya.Yu. Voitiv
Keyword(s):  
Connective Tissue ◽  
Biochemical Markers ◽  
Enterocutaneous Fistula ◽  
Prospective Trial ◽  
Prognostic Sign ◽  
Colocutaneous Fistula ◽  
Surgical Tactics ◽  
Severe Degree

Summary. Retro- and prospective trial was based on data about 30 patients, suffering entero-colocutaneous fistula, who were treated in the Shalimov National Institute of Surgery and Transplantology during 2016-2019.  There was revealed, that the most informative phenotypical markers of undifferentiated dysplasia of the connective tissue (UDCT) in patients, with entero-colocutaneous fistula, are visceral (83,3%), vascular (70%), arrhythmic (70%) syndromes. There was founded, that direct correlation between the level of biochemical markers of the collagen biodegradation and the UDCT degree may be applied for prognostication of development and course of complications in patients, suffering entero-colocutaneous fistula. Severe degree of UDCT in the patients, entero-colocutaneous fistula, constitutes unfavorable prognostic sign and enhances the mortality by 62.5%. The presence of UDCT in the patients winh entero-colocutaneous fistula is an aggravating comorbid factor that is difficult to be treated and accompanied by high rates of lethality, which must be taken into account, choosing the adequate surgical tactics and complex pathogenetically substantiated treatment.

scholarly journals Undifferentiated dysplasia of connective tissue in patients with insufficiency of anastomotic sutures of the gut hollow organs

2019 ◽  
Vol 86 (6) ◽  
pp. 3-7
Author(s):  
О. Yu. Usenko ◽  
Ya. Yu. Voitiv
Keyword(s):  
Connective Tissue ◽  
Blood Serum ◽  
Prospective Trial ◽  
Reactive Protein ◽  
Results Of Treatment ◽  
The Status ◽  
Connective Tissue Metabolism ◽  
Surgical Tactics ◽  
And Gender ◽  
Severe Degree

Objective. Improvement of results of treatment in patients, suffering insufficiency of anastomotic sutures in the gut hollow organs, using determination of role for the connective tissue undifferentiated dysplasia (CTUD) in development of this complication, estimation of the phenomena spreading and elaboration of informative criteria for the CTUD diagnosis. Маterials and methods. Retro- and prospective trial was based on data about 42 patients, suffering insufficiency of anastomotic sutures, who were treated in the National Institute of Surgery and Transplantology named after О. О. Shalimov of NAMS of Ukraine, and 20 practically healthy persons (the comparison group), comparable for age and gender with the investigated patients. The procalcitonin of the blood serum and C-reactive protein analysis were used for special laboratory investigation. The status of the connective tissue metabolism was estimated in accordance to content of free oxyprolene in the blood serum and the level of glycosaminoglycans in urine. Results. There was revealed, that the most informative phenotypical markers of CTUD in patients, suffering insufficiency of anastomotic sutures of the gut hollow organs, are visceral (78.6%), vascular (73.8%) and arythmical (54.7%) syndromes. There was established, that direct correlation between the level of biochemical markers of the collagen biodegradation and the CTUD degree may be applied for prognostication of development and course of complications in patients, suffering insufficiency of the anastomotic sutures of the gut hollow organs. Severe degree of CTUD in the patients, suffering insufficiency of interintestinal anastomoses, complicated by extended peritonitis, constitutes unfavorable prognostic sign and enhances the mortality by 87.5%. Conclusion. The presence of CTUD in the patients, suffering insufficiency of anastomotic sutures of the gut hollow organs constitutes the unfavorable factor of comorbidity, which must be taken into account, choosing the adequate surgical tactics and complex pathogenetically substantiated treatment.

scholarly journals AB0026 DECREASE OF ANGIOGENIC T CELLS IN CONNECTIVE TISSUE DISEASE-ASSOCIATED INTERSTITIAL LUNG DISEASE

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1046.3-1047
Author(s):  
V. Pulito-Cueto ◽  
S. Remuzgo Martinez ◽  
F. Genre ◽  
B. Atienza-Mateo ◽  
V. M. Mora-Cuesta ◽  
...  
Keyword(s):  
T Cells ◽  
Interstitial Lung Disease ◽  
Connective Tissue ◽  
Lung Disease ◽  
Cell Subset ◽  
Vascular Damage ◽  
Type I ◽  
Research Support ◽  
Angiogenic T Cells

Background:Interstitial lung disease (ILD) is one of the most significant complications of connective tissue diseases (CTD), leading to an increase of the morbidity and mortality in patients with CTD [1]. A specific T cell subset termed angiogenic T cells (TAng), that promote endothelial repair and revascularization, have been involved in the pathogenesis of CTD [2-4]. However, to the best of our knowledge, no information regarding the role of TAng in CTD-ILD+ is available.Objectives:To study, for the first time, the potential role of TAng related to vascular damage in CTD-ILD+.Methods:Peripheral venous blood was collected from 40 patients with CTD-ILD+ and three comparative groups: 44 CTD-ILD- patients, 21 idiopathic pulmonary fibrosis (IPF) patients and 20 healthy controls (HC). All subjects were recruited from the Rheumatology and Pneumology departments of Hospital Universitario Marqués de Valdecilla, Santander, Spain. Quantification of TAng was performed by flow cytometry. TAng were considered as triple-positive for CD3, CD31 and CXCR4.Results:Patients with CTD-ILD+ exhibited a significantly lower TAng frequency than CTD-ILD- patients (p<0.001). Similar results were obtained when patients with CTD-ILD+ were compared with HC (p=0.004) although no difference was observed between CTD-ILD+ and IPF. In addition, a significant increase of TAng frequency was shown in patients with CTD-ILD- in relation to IPF patients (p<0.001), while no difference was observed between CTD-ILD- and HC.Conclusion:Our results reveal a decrease of TAng frequency related to vascular damage in CTD-ILD+. Furthermore, we disclose that the presence of ILD is associated with lower TAng frequency.References:[1]Expert Rev Clin Immunol 2018;14(1):69-82.[2]Circulation 2007;116(15):1671-82.[3]Ann Rheum Dis 2015 74(5):921-7.[4]PLoS One 2017;12(8):e0183102.Acknowledgements:Personal funds, VP-C: PREVAL18/01 (IDIVAL); SR-M: RD16/0012/0009 (ISCIII-ERDF); LL-G: INNVAL20/06 (IDIVAL); RP-F: START PROJECT (FOREUM); RL-M: Miguel Servet type I CP16/00033 (ISCIII-ESF).Disclosure of Interests:Verónica Pulito-Cueto: None declared, Sara Remuzgo Martinez: None declared, Fernanda Genre: None declared, Belén Atienza-Mateo: None declared, Victor Manuel Mora-Cuesta: None declared, David Iturbe-Fernández: None declared, Leticia Lera-Gómez: None declared, Raquel Pérez-Fernández: None declared, Pilar Alonso Lecue: None declared, Javier Rodriguez Carrio: None declared, Diana Prieto-Peña: None declared, Virginia Portilla: None declared, Ricardo Blanco Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Grant/research support from: Abbvie, MSD and Roche, Alfonso Corrales: None declared, Jose Manuel Cifrián-Martínez: None declared, Raquel López-Mejías: None declared, Miguel A González-Gay Speakers bureau: Pfizer, Abbvie, MSD, Grant/research support from: Pfizer, Abbvie, MSD

scholarly journals Does the Interaction between Local and Systemic Inflammation Provide a Link from Psychology and Lifestyle to Tissue Health in Musculoskeletal Conditions?

2021 ◽  
Vol 22 (14) ◽  
pp. 7299
Author(s):  
David M. Klyne ◽  
Mary F. Barbe ◽  
Greg James ◽  
Paul W. Hodges
Keyword(s):  
Connective Tissue ◽  
Systemic Inflammation ◽  
Molecular Basis ◽  
Tissue Level ◽  
Lifestyle Factors ◽  
Local Inflammation ◽  
Musculoskeletal Conditions ◽  
Tissue Biology ◽  
Mind And Body

Musculoskeletal conditions are known to involve biological, psychological, social and, often, lifestyle elements. However, these domains are generally considered in isolation from each other. This siloed approach is unlikely to be adequate to understand the complexity of these conditions and likely explains a major component of the disappointing effects of treatment. This paper presents a hypothesis that aims to provide a foundation to understand the interaction and integration between these domains. We propose a hypothesis that provides a plausible link between psychology and lifestyle factors with tissue level effects (such as connective tissue dysregulation/accumulation) in musculoskeletal conditions that is founded on understanding the molecular basis for interaction between systemic and local inflammation. The hypothesis provides plausible and testable links between mind and body, for which empirical evidence can be found for many aspects. We present this hypothesis from the perspective of connective tissue biology and pathology (fibrosis), the role of inflammation locally (tissue level), and how this inflammation is shaped by systemic inflammation through bidirectional pathways, and various psychological and lifestyle factors via their influence on systemic inflammation. This hypothesis provides a foundation for new consideration of the development and refinement of personalized multidimensional treatments for individuals with musculoskeletal conditions.

Mast cell heterogeneity

1984 ◽  
Vol 62 (6) ◽  
pp. 734-737 ◽  
Author(s):  
F. Shanahan ◽  
J. A. Denburg ◽  
J. Bienenstock ◽  
A. D. Befus
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Regulatory Peptides ◽  
Cell Heterogeneity ◽  
Cell Secretion ◽  
Biochemical Basis ◽  
Mucosal Mast Cells ◽  
Mast Cell Heterogeneity

Increasing evidence for the existence of inter- and intra-species mast cell heterogeneity has expanded the potential biological role of this cell. Early studies suggesting that mast cells at mucosal sites differ morphologically and histochemically from connective tissue mast cells have been confirmed using isolated intestinal mucosal mast cells in the rat and more recently in man. These studies also established that mucosal mast cells are functionally distinct from connective tissue mast cells. Thus, mucosal and connective tissue mast cells differ in their responsiveness to a variety of mast cell secretagogues and antiallergic agents. Speculation about the therapeutic use of antiallergic drugs in disorders involving intestinal mast cells cannot, therefore, be based on extrapolation from studies of their effects on mast cells from other sites. Regulatory mechanisms for mast cell secretion may also be heterogeneous since mucosal mast cells differ from connective tissue mast cells in their response to a variety of physiologically occurring regulatory peptides. The development of techniques to purify isolated mast cell sub-populations will facilitate future analysis of the biochemical basis of the functional heterogeneity of mast cells.

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