scholarly journals Psychological traumatic events in the recent past and association with diagnosis of cancer

2021 ◽  
Vol 3 (4) ◽  
pp. 96-102
Author(s):  
Fasiha Shah ◽  
Faisal Hyder Shah
Keyword(s):  
Cancer Patients ◽  
Psychological Trauma ◽  
High Rate ◽  
Close Relative ◽  
Snowball Sampling ◽  
Immune System Dysfunction ◽  
Diagnosis Of Cancer ◽  
One Year ◽  
Risk Of Cancer

Emotional stress due to psychological trauma  causes immune system dysfunction resulting in high risk of development of cancer. The study aimed to correlation psychological trauma in the past five years of cancer diagnosis. This study was a community based survey including cancer patients diagnosed with different cancers undergoing treatment or follow-up by using snowball sampling and questionnaire based technique.  The study was conducted during a period of one year from December 2019 till December 2020. All recruited patients were requested for an interview. The results of the study showed a high rate of major psychological trauma among cancer patients. Sudden death of a close relative with and without trauma of natural disaster were high. The study conclude that risk of cancer development rises with major emotional trauma specially death of a close relative.  

Interleukin-10 Levels are Associated with Doxorubicin-Related Cardiotoxicity in Breast Cancer Patients in a One-Year Follow-Up Study

2021 ◽  
pp. 1-16
Author(s):  
Michelle Teodoro Alves ◽  
Ricardo Simões ◽  
Rodrigo Mendonça Cardoso Pestana ◽  
Angélica Navarro de Oliveira ◽  
Heloísa Helena Marques Oliveira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Interleukin 10 ◽  
Breast Cancer Patients ◽  
Follow Up Study ◽  
One Year

scholarly journals Arm lymphoedema and upper limb impairments in sentinel node-negative breast cancer patients: A one year follow-up study

The Breast ◽  
2016 ◽  
Vol 29 ◽  
pp. 102-108 ◽  
Author(s):  
An De Groef ◽  
Marijke Van Kampen ◽  
Elena Tieto ◽  
Petra Schönweger ◽  
Marie-Rose Christiaens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Upper Limb ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Follow Up Study ◽  
Node Negative Breast Cancer ◽  
Arm Lymphoedema ◽  
One Year

What Kinds of Care Do New Cancer Patients Need? A One-Year Follow-Up Study of Patients Diagnosed in a Dutch General Hospital

1997 ◽  
Vol 30 (2) ◽  
pp. 131-145 ◽  
Author(s):  
Fred C.J. Stevens ◽  
Annemie M. Courtens ◽  
Luc P. De Witte ◽  
Harry F.J.M. Crebolder ◽  
Hans Philipsen
Keyword(s):  
Cancer Patients ◽  
General Hospital ◽  
Follow Up Study ◽  
One Year

One-year follow-up of the ‘Starting Again’ Group rehabilitation programme for cancer patients

1994 ◽  
Vol 30 (12) ◽  
pp. 1744-1751 ◽  
Author(s):  
G. Berglund ◽  
C. Bolund ◽  
U.-L. Gustafsson ◽  
P.-O. Sjödén
Keyword(s):  
Cancer Patients ◽  
Rehabilitation Programme ◽  
Group Rehabilitation ◽  
One Year

Depression among Elderly Residents of Local-Authority Residential Homes

1990 ◽  
Vol 156 (5) ◽  
pp. 667-675 ◽  
Author(s):  
David Ames
Keyword(s):  
Local Authority ◽  
Social Activity ◽  
The Elderly ◽  
High Rate ◽  
Homes For The Elderly ◽  
Organic Mental Disorder ◽  
Psychiatric Intervention ◽  
One Year ◽  
Study Participants

Of 390 residents in 12 local-authority homes for the elderly, 93 had evidence of depression on screening and underwent standard clinical assessment. Half had an affective disorder, and a further third had depressive symptoms in the setting of an organic mental disorder. The 93 residents had a high rate of physical illness and disability, undertook little social activity, and were visited infrequently. A range of interventions for depressed residents, the majority social in type, mostly proved difficult to implement. There was no evidence of efficacy of psychiatric intervention at three months; at one-year follow-up a quarter of study participants had died, and 28% of those who were reassessed for depression showed evidence of recovery.

scholarly journals Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population

2007 ◽  
Vol 204 (6) ◽  
pp. 1295-1301 ◽  
Author(s):  
David Dynnes Ørsted ◽  
Stig Egil Bojesen ◽  
Anne Tybjærg-Hansen ◽  
Børge Grønne Nordestgaard
Keyword(s):  
Tumor Suppressor ◽  
General Population ◽  
Cancer Survival ◽  
P53 Protein ◽  
Tumor Suppressor P53 ◽  
Life Threatening ◽  
Diagnosis Of Cancer ◽  
Functional Single Nucleotide Polymorphism ◽  
Risk Of Cancer

p53 is an important tumor suppressor, normally preventing cancer development via apoptosis. A genomic Arg72Pro substitution in the p53 protein has important influence on cell death via apoptosis, which could be beneficial. We therefore tested the hypotheses that this polymorphism influences longevity, survival after a cancer diagnosis, and risk of cancer in the general population. We examined a cohort of 9,219 participants ages 20–95 from the Danish general population with 100% follow-up. The overall 12-yr survival was increased in p53 Arg/Pro heterozygotes with 3% (P = 0.003) and in Pro/Pro homozygotes with 6% (P = 0.002) versus Arg/Arg homozygotes, corresponding to an increase in median survival of 3 yr for Pro/Pro versus Arg/Arg homozygotes. We also demonstrated an increased survival after the development of cancer, or even after the development of other life-threatening diseases, for Pro/Pro versus Arg/Arg homozygotes. The Arg72Pro substitution did not associate with decreased risk of cancer. In conclusion, in this large cohort from the general population, we show that a well-known functional single nucleotide polymorphism in the tumor suppressor p53 protein leads to increased longevity, but not to decreased risk of cancer. The increased longevity may be due to increased survival after a diagnosis of cancer or other life-threatening diseases.

scholarly journals Effect of Anxiety and Depression on Survival of Cancer Patients, a 13 Year Follow-up

2021 ◽  
Vol 6 (1) ◽  
pp. 9-13
Author(s):  
Suriati Mohamed Saini ◽  
Susan Tan Mooi Koon ◽  
Mohamad Adam Bujang ◽  
Gerard Lim Chin Chye ◽  
Shalisah Sharip ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Cancer Patients ◽  
Depression Scale ◽  
Cox Proportional Hazards ◽  
Anxiety Symptoms ◽  
High Rate ◽  
Anxiety And Depression ◽  
Risk Of Death ◽  
Increased Risk

Introduction: Anxiety and depression occur at a high rate in cancer patients. However, debate remains regarding the effect of anxiety and depression on cancer survival. Objective: This study aimed to determine the effect of anxiety and depressive symptoms on the survival of cancer patients. Methods: The subjects consisted of 112 cancer patients who attended the Oncology and Radiotherapy outpatient clinic Hospital Kuala Lumpur, Malaysia, in 1999. Anxiety and depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS) questionnaire at inception. Information on patients’ mortality status for extended 13 years follow-up (in 2011) was obtained from the National Registration Department death records. Overall survival for each anxiety and depressive symptoms scores in HADS at 13 years was calculated using Cox proportional hazards regression analysis. Results: Cancer patients experienced more anxiety (83%) compared to depressive symptoms (40.2%). The mean (S.D.) HADS scores for depressive symptoms were 9.9 (2.5), and the anxiety symptoms score was 12.6 (2.1). At 13 years, half of the patients (50.9%) had died. No significant effect of anxiety (p=0.399, 95% C.I.= 6.2-8.4) or depressive symptoms at inception (p=0.749, 95% C.I.= 5.9-8.4) towards cancer patients’ survival was found at 13 years follow-up. Conclusion: The occurrence of anxiety symptoms among cancer patients in this study was 2-folds higher than depressive symptoms. However, no significant increased risk of death was found in cancer patients with anxiety or depressive symptoms at 13 years follow-up. It may imply that as time extended, survival in cancer patients may be related to various interacting elements, and intervening health factors are of importance.

scholarly journals Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: A case report

2013 ◽  
Vol 7 (3) ◽  
pp. 308-311 ◽  
Author(s):  
Sara Mota Borges Bottino ◽  
Célia Petrossi Gallo Garcia ◽  
Bernardo de Mattos Viana ◽  
Cássio Machado de Campos Bottino
Keyword(s):  
Case Report ◽  
Depressive Symptoms ◽  
Cancer Patients ◽  
Cognitive Deficits ◽  
Rectal Adenocarcinoma ◽  
Cancer Therapies ◽  
Elderly Cancer Patients ◽  
Brain Changes ◽  
One Year

ABSTRACT Cognitive deficits in cancer patients can be related to depression, anxiety, and the side effects of treatments such as fatigue. In this case report, we described an elderly patient with rectal adenocarcinoma, which presented depressive symptoms and memory complaints after treatment with 5-Fluoracil and Leucovorin. Depressive symptoms improved after two months but cognitive and functional impairment worsened suggesting the diagnosis of mild dementia. Structural and functional brain changes were seen on neuroimaging exams. Rivastigmine was introduced up to 12 mg/day, and after a one-year follow up the patient remained stable. Cognitive deficits can be a consequence of cancer therapies and a protocol to investigate deficits cognitive could be useful to the diferential diagnosis and management of elderly cancer patients submitted to chemotherapy.

Disparities in COVID-19 severity and risk of death in cancer patients: Experiences from a U.K. cancer center.

2020 ◽  
Vol 38 (29_suppl) ◽  
pp. 285-285
Author(s):  
Beth Russell ◽  
Charlotte L Moss ◽  
Sophie Papa ◽  
Harriet Wylie ◽  
Anna Haire ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Severe Disease ◽  
Ethnic Disparities ◽  
Cox Proportional Hazards ◽  
Initial Diagnosis ◽  
Cancer Center ◽  
Asian Ethnicity ◽  
Risk Of Death ◽  
Diagnosis Of Cancer

285 Background: There has been widespread evidence emerging regarding disparities between COVID-19 outcomes in patients of varying ethnicities and background. It is, however, unclear how various patient characteristics affect COVID-19 severity and risk of death in a cancer population. Methods: Our Cancer Centre was at the epicentre of the COVID-19 outbreak in the UK. A total of 156 cancer patients had a confirmed COVID-19 diagnosis between the 29th of February through the 12th of May 2020. Logistic/Cox proportional hazards models were used to identify which demographic and/or clinical characteristics were associated with COVID-19 severity/death. The regression models were defined through a directed acyclic graph (DAG) to decide upon the minimal adjustments required for each statistical model. Results: Of the 156 COVID-19 positive cancer patients, the most frequently reported tumour types were urological/gynaecological (29%), followed by haematological (18%) and breast (15%). 128 (82%) presented with mild/moderate COVID-19 and 28 (18%) with severe disease. Initial diagnosis of cancer >24m before COVID-19 (OR:1.74 (95%CI: 0.71-4.26)), presenting with fever (6.21 (1.76-21.99)), dyspnoea (2.60 (1.00-6.76)), gastro-intestinal symptoms (7.38 (2.71-20.16)), or higher levels of CRP (9.43 (0.73-121.12)) were linked with greater COVID-19 severity. During median follow-up of 37 days, 34 patients had died of COVID-19 (22%). Asian ethnicity (3.73 (1.28-10.91), palliative treatment (5.74 (1.15-28.79), initial diagnosis of cancer >24m before (2.14 (1.04-4.44), dyspnoea (4.94 (1.99-12.25), and increased CRP levels (10.35 (1.05-52.21)) were positively associated with COVID-19 death. Socioeconomic status (SES) was not found to be associated with either COVID-19 severity or risk of death. We will present updated data with more mature follow-up. Conclusions: In cancer patients, Asian ethnicity was found to be positively associated with COVID-19 death compared to Caucasian patients. However, SES was not associated with COVID-19 severity or risk of death thereby implying this was not due to poor access to healthcare. Future studies hence need to identify the underlying biological and/or societal reasons explaining these ethnic disparities in COVID-19 outcomes for cancer patients.

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