Plasma Levels of Heat Shock Protein 70 in Patients with Prostate Cancer: A Potential Biomarker for Prostate Cancer

2004 ◽  
Vol 3 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Miyako Abe ◽  
Judith B. Manola ◽  
William K. Oh ◽  
Diane L. Parslow ◽  
Daniel J. George ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Plasma Levels ◽  
Heat Shock Protein 70 ◽  
Potential Biomarker

The role of heat shock protein 70 in the thermoresistance of prostate cancer cell line spheroids

FEBS Letters ◽  
2004 ◽  
Vol 561 (1-3) ◽  
pp. 144-148 ◽  
Author(s):  
Samideh Khoei ◽  
Bahram Goliaei ◽  
Ali Neshasteh-Riz ◽  
Abdolkhalegh Deizadji
Keyword(s):  
Prostate Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Line ◽  
Cancer Cell ◽  
Heat Shock Protein 70 ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line

scholarly journals Heat shock protein 70 inhibitors suppress androgen receptor expression in LNC aP95 prostate cancer cells

2017 ◽  
Vol 108 (9) ◽  
pp. 1820-1827 ◽  
Author(s):  
Kazuaki Kita ◽  
Masayuki Shiota ◽  
Masako Tanaka ◽  
Asuka Otsuka ◽  
Masaki Matsumoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Heat Shock Protein 70 ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells

scholarly journals Heat Shock Protein 70 Acts as a Potential Biomarker for Early Diagnosis of Heart Failure

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67964 ◽  
Author(s):  
Zongshi Li ◽  
Yao Song ◽  
Rui Xing ◽  
Haiyi Yu ◽  
Youyi Zhang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heat Shock ◽  
Early Diagnosis ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Potential Biomarker

scholarly journals Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis

2018 ◽  
Vol 4 (2) ◽  
pp. 205521731876719 ◽  
Author(s):  
Patricia Lechner ◽  
Dorothea Buck ◽  
Lisa Sick ◽  
Bernhard Hemmer ◽  
Gabriele Multhoff
Keyword(s):  
Multiple Sclerosis ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Neurological Diseases ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Potential Biomarker ◽  
Inflammatory Processes

Background Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation. Objective The purpose of this study is to determine whether Hsp70 in serum can serve as a potential biomarker to distinguish inflammatory and neurodegenerative processes in MS. Methods Serum was obtained from 94 patients: 26 clinically isolated syndrome (CIS), 40 relapsing–remitting MS (RRMS), 19 secondary progressive MS (SPMS), and nine primary progressive MS (PPMS). As controls, serum samples were collected from patients with non-inflammatory neurological diseases (NINDs, n = 41), other inflammatory neurological diseases (OINDs, n = 28) and healthy donors (HDs, n = 114). Serum levels of Hsp70 were quantified using the enzyme-linked immunosorbent assay detecting free and liposomal Hsp70 (lipHsp70 ELISA). Results Patients with MS displayed significantly higher Hsp70 serum levels than HDs ( p < 0.001) and significantly lower levels than OINDs ( p = 0.001). A subgroup analysis revealed that Hsp70 serum levels of CIS/RRMS patients are significantly higher than those of patients with progressive MS (SPMS/PPMS) ( p < 0.05). Conclusion Inflammation causes the release of Hsp70 into the blood. As CIS/RRMS are associated with higher Hsp70 serum levels than progressive MS, serum Hsp70 levels might provide a marker for inflammatory processes.

Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity

2005 ◽  
Vol 55 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Kai S. Lipinski ◽  
Steven Pelech ◽  
Andrew Mountain ◽  
Alistair S. Irvine ◽  
Robert Kraaij ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Tumour Immunity
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