scholarly journals RESEARCH OF UPPER LIMB BIOMECHANICS OF SUBJECTS WITH PARKINSON‘S DISEASE AND ESSENTIAL TREMMOR / SERGANČIŲJŲ PARKINSONO IR ESENCIALINIO TREMORO LIGA VIRŠUTINĖS GALŪNĖS BIOMECHANIKOS TYRIMAS

2013 ◽  
Vol 5 (6) ◽  
pp. 587-590
Author(s):  
Julius Griškevičius ◽  
Jurgita Žižienė
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Disease Progression ◽  
Upper Limb ◽  
Symptom Severity ◽  
Clinical Symptoms ◽  
Physical Exam ◽  
Rest Tremor ◽  
Biomechanical Evaluation

Parkinson’s disease (PD) is a common neurodegenerative diseasewith symptoms of bradykinesia, rest tremor, rigidity and posturalinstability. PL is diagnosed by a clinician who qualitativelyevaluates patient’s visible symptoms during a physical exam. Inaddition, differentiating PD from essential tremor (ET) can bechallenging because their clinical symptoms are similar. Oncediagnosed, only qualitative tools such as the UPDRS are availableto monitor symptom severity and disease progression. Thepurpose of this study is to evaluate the changes of biomechanicalparameters of upper limb of subjects diagnosed either PD or ET,estimate differences and compare them with healthy subjectsin facilitate a creation of an additional instrumental clinical assessmentof PD subjects via biomechanical evaluation of motorfunction tool and develop methods and indices for differentiatingPD from ET. Santrauka Parkinsono liga (PL) yra lėtinė progresuojanti neurologinė liga, kuri išoriškai pasireiškia galvos bei galūnių drebėjimu, judesių sulėtėjimu, sukaustymu ir eisenos pasikeitimu. Esencialinis tremoras – laipsniškai progresuojanti liga, kuriai būdingas nevalingas kūno dalies drebėjimas. Tai daug dažnesnė būklė negu PL judėjimo sutrikimas. Neretai ankstyvoje ligos stadijoje šios abi patologinės būklės yra painiojamos. Šio straipsnio tikslas yra įvertinti žmonių, sergančių Parkinsono liga ir esencialiniu tremoru, viršutinės galūnės biomechanikos parametrų pokyčius, skirtumus ir palyginti juos su sveiko žmogaus viršutinės galūnės biomechanika.

scholarly journals Clinical Differentiation of Essential Tremor and Parkinson's Disease

2013 ◽  
Vol 6 ◽  
pp. CCRep.S11903 ◽  
Author(s):  
Robert Fekete ◽  
Jin Li
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Postural Tremor ◽  
Arm Swing ◽  
Rest Tremor ◽  
Dopaminergic Terminal

We present clinical features and tremor characterization in a patient with Parkinson's disease (PD) as well as in two cases of essential tremor (ET) with some parkinsonian features but no evidence of dopaminergic terminal loss on 123I-FP-CIT Single Photon Emission Computed Tomography (SPECT). Relatively slow frequency rest tremor and bilateral upper extremity bradykinesia without decrementing amplitude were observed in the ET cases, with unilaterally decreased arm swing in case 3. Alternating rest tremor and re-emergent tremor with 13 second latency was confirmed in the PD case. Re-emergent tremor had alternating characteristics, which to our knowledge has not been previously reported. The ET cases had synchronous postural tremor. Alternating re-emergent tremor in PD provides further evidence for re-emergent tremor as an analogue of rest tremor in PD. Two cases of ET with synchronous postural tremor and one to two year history of parkinsonian features had no evidence of dopaminergic terminal loss up to 40 years after the initial onset of ET. Tremor synchronicity characterization can assist in differential diagnosis between the two disorders.

Wearable Tremor Reduction Device (TRD) for Human Hands and Arms

2018 ◽  
Author(s):  
Sreekanth Rudraraju ◽  
The Nguyen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Upper Limb ◽  
Movement Disorders ◽  
Normal Life ◽  
Human Hands

Parkinson’s disease (PD) and essential tremor (ET) are two common but unrelated diseases that cause movement disorders often involving with severe tremor. The two diseases affects tens of millions of people worldwide, but there is no known cure for them. The tremor not only pose difficulty in completing daily tasks but also impair patients’ social confidence. The objective of this project is to develop a wearable tremor reduction device for the upper limb. The device is obviously different from any previous devices because it is compact, lightweight, comfortable to wear and effective. It is expected to help patients manage the tremor symptoms and regain their normal life.

Objective Quantitative Assessment of Movement Disorders Through Analysis of Static Handwritten Characters

2015 ◽  
Author(s):  
Naiqian Zhi ◽  
Beverly K. Jaeger ◽  
Andrew Gouldstone ◽  
Samuel Frank ◽  
Rifat Sipahi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Upper Limb ◽  
Movement Disorders ◽  
Healthy Subjects ◽  
Quantitative Assessment ◽  
Clinical Tests ◽  
Assessment Approach

Movement disorders associated with Essential Tremor (ET) and Parkinson’s disease (PD) can negatively impact use of the upper limb for many precision tasks, including handwriting. Both ET and PD can be assessed through clinical tests which are, however, relatively subjective. This assessment approach possesses inherent logistical and resolution limitations. To address this, here we present objective computerized metrics intended to assess and quantify the extent to which static writing samples display the effects of ET and PD. Specifically, these metrics are tested in their ability to measure tremor by comparing unaffected writing samples with those affected by artificially induced tremor on healthy subjects, and also by comparing healthy writing samples with symptomatic writing samples collected from PD patients reporting micrographia. Our findings indicate that the presented metrics can be utilized for assessment, leading to a toolset capable of objectively monitoring static handwriting changes associated with symptom variations in ET and/or PD patients.

scholarly journals Transitioning from Unilateral to Bilateral Upper Limb Tremor Therapy for Parkinson’s Disease and Essential Tremor Using Botulinum Toxin: Case Series

Toxins ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 394 ◽  
Author(s):  
Olivia Samotus ◽  
Jack Lee ◽  
Mandar Jog
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Botulinum Toxin ◽  
Essential Tremor ◽  
Upper Limb ◽  
Kinematic Analysis ◽  
Rating Scale ◽  
Pilot Trial ◽  
Case Series ◽  
Preliminary Finding

Botulinum toxin type A (BoNT-A) injections guided by kinematic analysis for unilateral upper limb essential tremor (ET) and Parkinson’s disease (PD) tremor therapy has demonstrated efficacy, improvements in quality of life (QoL) and arm functionality. In this open-label pilot trial, 5 ET and 2 PD participants decided to switch from receiving long-term unilateral arm treatment to now bilateral BoNT-A arm therapy in their other tremulous arm which worsened over time. Injection patterns were based on kinematic analysis. Efficacy endpoints including kinematic analysis, Fahn-Tolosa-Marin tremor rating scale, QoL questionnaire, and maximal grip strength were collected over 2 treatments and 2 follow-up visits totaling 18-weeks. BoNT-A decreased wrist tremor amplitude by 84.6% and 89.6% 6-weeks following the 1st injection in the newly-treated limb in ET and PD participants, respectively. PD participants started with worse QoL but demonstrated an additional improvement in QoL by 29.9% for switching to bilateral treatment, whereas ET participants did not. Left and right arm tremor also did not share commonalities in severity or dose. This preliminary finding suggests trends for transitioning to bilateral therapy and warrants further studies to evaluate efficacy of bilateral tremor BoNT-A therapy in a larger cohort of PD and ET patients.

scholarly journals Circulating CircRNAs Panel Acts as a Biomarker for the Early Diagnosis and Severity of Parkinson’s Disease

2021 ◽  
Vol 13 ◽  
Author(s):  
Lingling Zhong ◽  
KeJu Ju ◽  
Ainian Chen ◽  
Hua Cao
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Diagnosis ◽  
Disease Progression ◽  
Clinical Symptoms ◽  
Early Stage ◽  
Healthy Controls ◽  
Training Set ◽  
The Central Nervous System

Parkinson’s disease (PD) is a chronic and progressive degenerative disease of the central nervous system. Degenerative neuropathy can occur in patients with PD even before typical clinical symptoms appear in the preclinical stage. Therefore, if the early diagnosis of degenerative diseases can be timely and the correlation with the disease progression can be explored, the disease progression will be slowed down and the quality of life of patients will be improved. In this study, the circRNA microarray was employed to screen the dysregulated circRNA in plasma samples of PD. Four circRNAs (circ_0085869, circ_0004381, circ_0017204, and circ_0090668) were obtained with increased levels in PD patients by cross comparison and preliminary verification in PD comparing with healthy controls. Further validation found the circRNA panel was consistent with the training set. The ROC curve also revealed a high diagnostic ability of circ_0004381 and circ_0017204 in predicting the early stage of PD from healthy controls. circ_0085869, circ_0004381, circ_0017204, and circ_0090668 also presented a high ability to distinguish the late stage of PD from early stage. In conclusion, circulating circRNA panel might be a potential fingerprint for predicting the early diagnosis of PD and may act as a biomarker for disease progression.

scholarly journals Electrophysiologic characteristics of tremor in Parkinson?s disease and essential tremor

2014 ◽  
Vol 72 (4) ◽  
pp. 301-306 ◽  
Author(s):  
Ederson Cichaczewski ◽  
Renato P. Munhoz ◽  
Joaquim M. Maia ◽  
Percy Nohama ◽  
Edison M. Nóvak ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Average Frequency ◽  
Rest Tremor ◽  
Kinetic Tremor ◽  
Tremor Analysis ◽  
Rest Posture ◽  
Similar Intensity

Tremor in essential tremor (ET) and Parkinson’s disease (PD) usually present specific electrophysiologic profiles, however amplitude and frequency may have wide variations. Objective: To present the electrophysiologic findings in PD and ET. Method: Patients were assessed at rest, with posture and action. Seventeen patients with ET and 62 with PD were included. PD cases were clustered into three groups: predominant rest tremor; tremor with similar intensity at rest, posture and during kinetic task; and predominant kinetic tremor. Results: Patients with PD presented tremors with average frequency of 5.29±1.18 Hz at rest, 5.79±1.39 Hz with posture and 6.48±1.34 Hz with the kinetic task. Tremor in ET presented with an average frequency of 5.97±1.1 Hz at rest, 6.18±1 Hz with posture and 6.53±1.2 Hz with kinetic task. Seven (41.2%) also showed rest tremor. Conclusion: The tremor analysis alone using the methodology described here, is not sufficient to differentiate tremor in ET and PD.

scholarly journals Association between positive history of essential tremor and disease progression in patients with Parkinson's disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ruwei Ou ◽  
Qianqian Wei ◽  
Yanbing Hou ◽  
Lingyu Zhang ◽  
Kuncheng Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Disease Progression ◽  
Rating Scale ◽  
Cox Regression ◽  
Cox Proportional Hazards ◽  
Yahr Stage ◽  
Point Increase ◽  
History Of

AbstractThis study aimed to explore the effect of pre-existing essential tremor (ET) history on the disease progression of Parkinson’s disease (PD). We recruited and followed-up a group of PD patients from March 2009 to July 2020. The ET history of each patient was obtained by retrospective interviews or past medical records. Cox proportional hazards models with inverse probability of treatment weighting (IPTW) were used to estimate the hazard ratio (HR) with 95% confidence intervals (CIs). Of 785 patients who completed the followed-up visits, 61 patients (7.8%) reported a history of pre-existing ET. Cox regression models after IPTW indicated that the positive ET history in patients with PD was protective against time to United PD Rating Scale III 14-point increase (HR = 0.301, 95% CI = 0.134–0.678, P = 0.004), time to akinesia and rigidity 8-point increase (HR = 0.417, 95% CI = 0.218–0.796, P = 0.008), time to conversion to Hoehn and Yahr stage 3 (HR = 0.356, 95% CI = 0.131–0.969, P = 0.043), time to develop dyskinesia (HR = 0.160, 95% CI = 0.037–0.698, P = 0.015), and time to Montreal Cognitive Assessment 3-point decrease (HR = 0.389, 95% CI = 0.160–0.946, P = 0.037), but had no relationship with time to tremor 4-point increase (HR = 1.638, 95% CI = 0.822–3.266, P = 0.161) and time to death (HR = 0.713, 95% CI = 0.219–2.319, P = 0.574). Our study indicated that ET history in patients with PD is associated with a benign prognosis with slower motor and non-motor progression.

Evaluation of rest tremor in different positions in Parkinson’s disease and essential tremor plus

2022 ◽  
Author(s):  
Rita Nisticò ◽  
Andrea Quattrone ◽  
Marianna Crasà ◽  
Marida De Maria ◽  
Basilio Vescio ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Rest Tremor

scholarly journals 123-I ioflupane (Datscan®) presynaptic nigrostriatal imaging in patients with movement disorders

2005 ◽  
Vol 48 (spe2) ◽  
pp. 115-126 ◽  
Author(s):  
Angel Soriano Castrejón ◽  
Ana María García Vicente ◽  
Montserrat Cortés Romera ◽  
Julia Vaamonde Cano ◽  
Sonia Rodado Marina ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Movement Disorder ◽  
Essential Tremor ◽  
Disease Progression ◽  
Movement Disorders ◽  
Neurodegenerative Disorders ◽  
Nigrostriatal Pathway

123-I Ioflupane (Datscan®) presynaptic imaging has been shown to have a significant utility in the assessment of patients with movement disorders 123-I Ioflupane SPECT is able to distinguish between Parkinson’s disease (PD) and other forms of parkinsonism without degeneration of the nigrostriatal pathway, including a common movement disorder such as essential tremor, and to assess disease progression in PD and other neurodegenerative disorders involving the substantia nigra.

Synchronous pattern distinguishes resting tremor associated with essential tremor from rest tremor of Parkinson’s disease

2011 ◽  
Vol 17 (1) ◽  
pp. 30-33 ◽  
Author(s):  
R. Nisticò ◽  
D. Pirritano ◽  
M. Salsone ◽  
F. Novellino ◽  
F. Del Giudice ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Rest Tremor ◽  
Resting Tremor
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