scholarly journals Correlation of Leukocyte Subtypes, Neutrophil-to-Lymphocyte Ratio, and Functional Outcome in Brain Metastasis

2018 ◽  
Vol 6 (12) ◽  
pp. 2333-2336 ◽  
Author(s):  
Kiking Ritarwan ◽  
Irina Keumala Nasution ◽  
Iswandi Erwin ◽  
Nerdy Nerdy
Keyword(s):  
Brain Metastasis ◽  
Functional Outcome ◽  
General Hospital ◽  
Ethylenediaminetetraacetic Acid ◽  
Venous Blood ◽  
Karnofsky Performance Scale ◽  
Pathology Laboratory ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Performance Scale

BACKGROUND: As the most cause of death in patients with solid extracranial malignancy, brain metastasis (BM) nowadays being studied extensively especially on how to find a reliable laboratory marker that can correlate with its clinical outcome. Leukocyte subtypes, primarily neutrophils and lymphocytes and its ratio known as Neutrophils-Lymphocyte Ratio (NLR) have been known before its relationship with progressivity of BM from other solid tumours. AIM: The objectives of this research to study the correlation of leukocyte subtypes, neutrophil-lymphocyte ratio & functional outcome in brain metastasis. METHODS: The study subjects were recruited consecutively from the study population. Venous blood was taken 5 ml of venous blood samples done in the first day of admission on emergency department and neurology clinic of Neurology Department of Adam Malik General Hospital before any drug injections. Samples were kept in vacutainer tubes containing ethylenediaminetetraacetic acid (EDTA) and sent to Department of Clinical Pathology laboratory of Adam Malik General Hospital, immediately centrifuged at 3100 rpm for 10 minutes in -20°C temperature and analysed using Sysmex XT-2000i. Functional outcome of the patient assessed using Karnofsky performance scale (KPS) in a cross-sectional manner with laboratory analysis. RESULTS: We conduct a mean differences and correlational leukocytes and its subsets analysis of 72 BM patients resulting on significant positive correlation on lymphocyte percentage (r = 0.383, p = 0.001) and lymphocyte absolute (r = 0.265, p = 0.024), also significant negative correlation on neutrophils (r = -0.240, p = 0.042) and NLR (r = -0.432, p < 0.001) with Karnofsky Performance Scale (KPS). CONCLUSION: Increased lymphocyte absolute and lymphocyte percentage correlated significantly (p < 0.05) with better KPS, while elevated neutrophils percentage and increased NLR show significant correlation with worse outcome of BM patients.

scholarly journals Monocyte Lymphocyte Ratio, Platelet Lymphocyte Ratio, Neutrophil Lymphocyte Ratio as Prognostic Markers in Patients with Multidrugs Resistant Tuberculosis Treated at Ulin General Hospital Banjarmasin

2018 ◽  
Vol 14 (2) ◽  
pp. 165
Author(s):  
Bagus Wicaksono
Keyword(s):  
General Hospital ◽  
Prognostic Biomarker ◽  
Laboratory Evaluation ◽  
Treatment Progress ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Tb Treatment ◽  
Resistant Tuberculosis ◽  
Mdr Tb

Abstract: Multi Drugs Resistant Tuberculosis (MDR TB) is tubercolusis with the least resistance to rifampicin and isoniazid. The progresivity and side effects of MDR TB treatment can be monitored through clinical, imaging, and laboratory evaluation. Monocyte Lymphocyte Ratio (MLR), Neutrophil Lymphocyte Ratio (NLR), and Platelet Lymphocyte Ratio (PLR) are the inflammatory markers used as biomarkers of treatment progress in MDR TB. The purpose of this research was to determine the difference of MLR, NLR, and PLR value pre and post MDR TB therapy and to determine the best prognostic biomarker in the evaluation of MDR TB treatment progress at Ulin General Hospital in January-December 2017. This research was an analytic observational study with a cross-sectional design. The sample was 17 patients selected based on the inclusion and exclusion criteria. Results obtained from paired T-tests showed the decreasing of MLR, NLR, PLR value in MDR TB patients receiving TB therapy. PLR had a more role as inflammatory biomarker of MDR TB treatment with p = 0.000, compared to MLR (ρ = 0.01), and NLR ( ρ = 0.006). The conclusion is PLR was significantly the best prognostic biomarker for MDR TB treatment.  Keywords: MDR TB, Monocyte Lymphocyte Ratio, Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio

Evaluation of Functional Outcome Following Resection of Supratentorial Lesions at Eloquent Brain Areas

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ashraf Al-Abyad ◽  
Hasan Jalalod’din ◽  
Mohamed Nosseir ◽  
Omar El Farouk Ahmed ◽  
Fathi Alahwal
Keyword(s):  
Functional Outcome ◽  
Seizure Control ◽  
Surgical Excision ◽  
Extent Of Resection ◽  
Karnofsky Performance Scale ◽  
Pathology Report ◽  
Karnofsky Performance Score ◽  
Brain Areas ◽  
Performance Scale ◽  
Seizure Attacks

Abstract Objectives Microsurgical management of intrinsic brain tumors aims to maximize the extent of resection and to minimize the postoperative morbidity. The purpose of this study is to evaluate the functional outcome following surgical excision of supratentorial lesions at eloquent brain areas such as language, motor and sensory cortex, regarding the extent of resection, the karnofsky performance scale, the neurological deficit and seizure control. Methods A prospective study of 25 patients aged 15-55 years, 15 females and 10 males underwent surgical excision of supra-tentorial lesions at eloquent brain, The Karnofsky Performance Score (KPS), seizure attacks and neurological deficits were analyzed before and after resection. Functional resection was implemented using preoperative functional magnetic resonance image (fMRI), intraoperative image guidance and electrophysiological monitoring under total intravenous anesthesia (TIVA) or awake craniotomy and the extent of resection was quantified postoperatively. Results Preoperative median KPS was 76.8%. It improved one year post-operatively to 89.2%. One patient died 3 weeks postoperatively due to neurological, cardiac and chest complications. The pathology report revealed recurrent metastatic adenocarcinoma GIII. Preoperatively, twenty-three patients had seizure attacks, 10 were controlled and 13 were uncontrolled on medication. Postoperatively seven patients were Engels classification IC and 17 patients were controlled on anti-epileptics (Engels classification ID). Preoperatively 19 patients had hemiparesis/ hemiplegia, while immediate (one week) postoperatively 13 patients improved, 8 patients experienced initial worsening of the preoperative deficits and 4 patients had the same deficit as preoperatively while at 1-year postoperatively, 24 patients improved. Gross total resection (&gt;95%) was achieved in 19 patients, subtotal resection (&gt;75%) in 4 patients and partial resection (&gt;65%) in 2 patients. Conclusion Functional resection is believed to be a key prognostic factor in supratentorial lesions at eloquent brain regarding improving of karnofsky performance scale, neurological outcome and seizure control.

Neutrophil-Lymphocyte Ratio Predicts Functional and Safety Outcomes after Endovascular Treatment for Acute Ischemic Stroke

2018 ◽  
Vol 45 (5-6) ◽  
pp. 221-227 ◽  
Author(s):  
Zhenhui Duan ◽  
Huaiming Wang ◽  
Zhen Wang ◽  
Yonggang Hao ◽  
Wenjie Zi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Endovascular Treatment ◽  
Functional Outcome ◽  
Laboratory Data ◽  
Poor Functional Outcome ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Relationship

Background and Objective: Endovascular treatment (EVT) is proven to be safe and effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of treating ischemic stroke. This study aims to explore the relationship between NLR and the clinical outcomes of LVOS patients undergoing EVT. Methods: Patients were selected from the EVT for acUte Anterior circuLation (ACTUAL) ischemic stroke registry. The laboratory data (neutrophil count, lymphocyte count) before EVT were collected. Poor functional outcome was defined as modified Rankin Scale (mRS) of 3–6 at 3 months. Multivariable logistic regression analyses were performed to explore the relationship of NLR with functional outcome, symptomatic intracranial hemorrhage (sICH), and mortality. Results: We eventually included 616 patients (median of age, 66 years; 40.3% female). There were 350 (56.7%) patients achieving mRS of 3–6 at 3 months, 98 (15.9%) patients with sICH, and the mortality at 3 months was 24.8% (153/616). Baseline NLR was independently associated with poor functional outcome (OR 1.58; 95% CI 1.02–2.45; p = 0.039) and sICH (OR 1.84; 95% CI 1.09–3.11; p = 0.023) but showed a trend for predicting 3-month mortality (OR 1.57; 95% CI 0.94–2.65; p = 0.088). Conclusions: NLR independently predicts 3-month functional outcome and sICH but the existence of a trend association with mortality after EVT for acute anterior circulation LVOS patients.

Gamma Knife radiosurgery to the surgical cavity following resection of brain metastases

2009 ◽  
Vol 111 (3) ◽  
pp. 431-438 ◽  
Author(s):  
Jay Jagannathan ◽  
Chun-Po Yen ◽  
Dibyendu Kumar Ray ◽  
David Schlesinger ◽  
Rod J. Oskouian ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Local Tumor Control ◽  
Gross Total Resection ◽  
Tumor Control ◽  
Karnofsky Performance Scale ◽  
Total Resection ◽  
Resection Cavity ◽  
The Mean ◽  
Performance Scale

Object This study evaluated the efficacy of postoperative Gamma Knife surgery (GKS) to the tumor cavity following gross-total resection of a brain metastasis. Methods A retrospective review was conducted of 700 patients who were treated for brain metastases using GKS. Forty-seven patients with pathologically confirmed metastatic disease underwent GKS to the postoperative resection cavity following gross-total resection of the tumor. Patients who underwent subtotal resection or who had visible tumor in the resection cavity on the postresection neuroimaging study (either CT or MR imaging with and without contrast administration) were excluded. Radiographic and clinical follow-up was assessed using clinic visits and MR imaging. The radiographic end point was defined as tumor growth control (no tumor growth regarding the resection cavity, and stable or decreasing tumor size for the other metastatic targets). Clinical end points were defined as functional status (assessed prospectively using the Karnofsky Performance Scale) and survival. Primary tumor pathology was consistent with lung cancer in 19 cases (40%), melanoma in 10 cases (21%), renal cell carcinoma in 7 cases (15%), breast cancer in 7 cases (15%), and gastrointestinal malignancies in 4 cases (9%). The mean duration between resection and radiosurgery was 15 days (range 2–115 days). The mean volume of the treated cavity was 10.5 cm3 (range 1.75–35.45 cm3), and the mean dose to the cavity margin was 19 Gy. In addition to the resection cavity, 34 patients (72%) underwent GKS for 116 synchronous metastases observed at the time of the initial radiosurgery. Results The mean radiographic follow-up duration was 14 months (median 10 months, range 4–37 months). Local tumor control at the site of the surgical cavity was achieved in 44 patients (94%), and tumor recurrence at the surgical site was statistically related to the volume of the surgical cavity (p = 0.04). During follow-up, 34 patients (72%) underwent additional radiosurgery for 140 new (metachronous) metastases. At the most recent follow-up evaluation, 11 patients (23%) were alive, whereas 36 patients had died (mean duration until death 12 months, median 10 months). Patients who showed good systemic control of their primary tumor tended to have longer survival durations than those who did not (p = 0.004). At the last clinical follow-up evaluation, the mean Karnofsky Performance Scale score for the overall group was 78 (median 80, range 40–100). Conclusion: Radiosurgery appears to be effective in terms of providing local tumor control at the resection cavity following resection of a brain metastasis, and in the treatment of synchronous and metachronous tumors. These data suggest that radiosurgery can be used to prevent recurrence following gross-total resection of a brain metastasis.

scholarly journals Evaluation of Neutrophil, Lymphocyte, Platelet, Mean Platelet Volume, Neutrophil-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio in Prostate Cancer Patients Treated with Radiotherapy

2020 ◽  
Vol 7 (5) ◽  
pp. 482-488 ◽  
Author(s):  
Nurten Bahtiyar ◽  
Özlem Mermut
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Mean Platelet Volume ◽  
Venous Blood ◽  
Control Group ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Radiotherapy Group ◽  
Platelet Lymphocyte Ratio

Objective: Radiotherapy is a one cura­tive method for prostate cancer. Ionizing radiation can cause inflammation of tissues in and around the irradiated sites. But it is also suggested that low-dose radiation has anti-inflammatory effects. The present study was aimed at investigating the effects of radiotherapy on some inflammatory markers in prostate cancer patients. Material and Methods: A total of 42 patients with prostate cancer and 30 healthy subjects were included in the present study. The day prior to radiotherapy (pre radiotherapy group) and the day radiotherapy was completed (post radiotherapy group) venous blood samples were collected. Neutrophil, lymphocyte, platelet, mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) levels were detected. Results: Neutrophil values of the pre radiotherapy group were higher than the control group (p<0.05), and values of the post radiotherapy group were lower than the pre radiotherapy group (p<0.001). Lymphocyte values of the post radiotherapy group were lower than the control, and the pre radiotherapy groups (p <0.001 for both). Platelet values were decreased in the post radiotherapy group compared to the pre radiotherapy group (p <0.01). MPV values of the pre radiotherapy group were higher than the control group (p<0.05), and were lower in the post radiotherapy group than the pre radiotherapy group (p <0.001). NLR and PLR values were decreased in the post radiotherapy group compared to the control group (p <0.001 for both), and were increased in post radiotherapy group compared to the pre radiotherapy group (p<0.001 for both). Conclusion: Our findings showed that neutrophil, and MPV were increased in the pre radiotherapy group compared to the control group. Neutrophil, lymphocyte, platelet, and MPV were decreased, NLR and PLR were increased in the post radiotherapy group compared to the pre radiotherapy group.

Correlation between Ferritin Levels with Malondialdehyde and Neutrophil Lymphocyte Ratio on Iron Overload

2021 ◽  
Vol 27 (2) ◽  
pp. 147
Author(s):  
Imam Budiwiyono ◽  
Purwanto AP ◽  
Nyoman Suci Widyastiti ◽  
Hadian Hadian ◽  
Kusmiyati DK
Keyword(s):  
Iron Overload ◽  
General Hospital ◽  
Cell Damage ◽  
Ferritin Level ◽  
The Body ◽  
Blood Transfusions ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Spearman Test

Thalassemia major is one of the types of thalassemia that need a routine blood transfusion. If not treated immediately, the patient will only last for 1-8 months. Blood transfusions performed at least or more than 10 times causes iron overload. Excess levels of Fe ions in the body will be stored in the form of ferritin. If the ferritin level is high, cell damage will occur in the presence of a fat peroxidation reaction or Malondialdehyde (MDA). Cell damage can trigger proinflammation, which increases neutrophil counts and decreases lymphocyte counts. The Neutrophil-Lymphocyte Ratio (NLR), which measures the ratio between Absolute Neutrophil Count (ANC) divided by Absolute Lymphocyte Count (ALC) with a manual peripheral blood picture. This study aimed to determine the correlation of ferritin levels with MDA and NLR in iron overload. This study used an analytical observational design with a cross-sectional approach, with samples were thalassemia patients who received repeated blood transfusions at the General Hospital Dr. R Soetrasno, Rembang City and Regional General Hospital Dr. R Soedjati, Grobogan Purwodadi. Inclusion criteria were age 10-18 years, transfusion 10-20 times, normal body temperature. Exclusion criteria were Fe therapy orally, leukocytosis, chronic kidney disease. In the MDA levels, there was no significant difference where p=0.25 by Spearman test. In the NLR there was no significant difference where p=0.91 by Spearman test. There is no correlation between ferritin levels with MDA and NLR in iron overload.

scholarly journals Adult quality of life in congenital hydrocephalus operated cases. A twenty years retrospective study

2015 ◽  
Vol 29 (3) ◽  
pp. 235-238
Author(s):  
A. Tascu ◽  
A. Iliescu ◽  
R.E. Rizea ◽  
Irina Tudose ◽  
St.M. Iencean
Keyword(s):  
Quality Of Life ◽  
Retrospective Study ◽  
Functional Outcome ◽  
Congenital Hydrocephalus ◽  
Karnofsky Performance Scale ◽  
Outcome Questionnaire ◽  
Neurosurgical Department ◽  
Emergency Hospital ◽  
Performance Scale

Abstract Congenital hydrocephalus is a health problem in many countries and in Romania the pediatric neurosurgical department of the Emergency Hospital “Bagdasar-Arseni” has a large number of such patients. This is a retrospective study and it includes the patients with congenital hydrocephalus operated between 1992 and 2012 in the pediatric neurosurgical department of the Emergency Hospital “Bagdasar-Arseni”. The functional outcome was assessed using Karnofsky Performance Scale, Hydrocephalus Outcome Questionnaire and Glasgow outcome scale. The total number of the patients was 372, with a predominance of boys (212 boys versus 160 girls) and at the time of our study 168 patients were over 16 years old. Functional outcome of the children over 16 years old assessed using Karnofsky Performance Scale, showed that 73 patients were above 80 and leading independent lives, and 95 were less than 80 points. The results would be better if all these patients would benefit from schooling for children with special needs.

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