Potential Risk Factors of Developmental Cognitive Delay in the First Two Years of Life

BACKGROUND: The first two years of life constitute a critical period of rapid change. The events during this phase prepare the child for subsequent developmental competency.AIM: To determine the potential risk factors that affect an infant’s cognitive development in the first two years of life in a sample of Egyptian infantsSUBJECTS AND METHODS: A cross-sectional comparative study included 655 male and female infants. Their age ranged from 3 – 24 months. Bayley Scales of Infant and Toddler Development (Bayley III) were used for cognitive assessment. Perinatal and nutritional data were recorded. Levels of serum Zinc, Copper, Iron, vitamin B12 and complete blood count (CBC) were assessed in a subsample of 193 infants.RESULTS: Infants having below the average cognitive composite score (CCS) represented 38.47% of the whole sample. The risk of having a low average (CCS) was determined by multiple factors. Poor maternal education and low family income were the most significant social risk factors (OR = 2.19, p = 0.0003; OR = 1.64, p = 0.002 respectively). Prematurity and complicated labor represented significant perinatal risks (OR = 1.22, p = 0.005; OR = 2.39, p =0.001respectively). Bottle feeding versus breastfeeding in the first six months of life was the most significant nutritional predictor of low average (CCS) (OR = 1.79, p = 0.001). Infants with low average (CCS) had significantly lower levels of serum zinc and vitamin B12 than those with average scores. CONCLUSION: Multiple factors appear to interact affecting the early cognitive development of Egyptian infants. Prematurity, complicated labour, poor maternal education, low family income and micronutrient deficiency are the main risk factors. Studying these factors is of great value in directing governmental intervention efforts.

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Assessment of potential risk factors associated with early childhood caries in a subpopulation of children from Thrace region of Turkey

Folia Medica ◽

10.3897/folmed.63.e57845 ◽

2021 ◽

Vol 63 (4) ◽

pp. 546-556

Author(s):

Sirin Guner Onur ◽

Betul Kargul

Keyword(s):

Risk Factors ◽

Early Childhood ◽

Early Childhood Caries ◽

Family Income ◽

Bottle Feeding ◽

Health Concern ◽

Caries Experience ◽

Night Time ◽

Potential Risk Factors ◽

Childhood Caries

Introduction: Early childhood caries (ECC) is considered a global health concern due to its high prevalence and effect on the overall health of children. Aim: The present study aimed to investigate prevalence of ECC and associated risk factors in a Turkish subpopulation of children. Materials and methods: Five hundred forty-two (299 boys, 243 girls) children were enrolled in this study. Caries experience on primary teeth was measured using decayed or filled teeth (dft) index and the presence of caries was diagnosed if dft >0. A structured questionnaire was employed to mothers through interview. Results: ECC was significantly associated with increased age (OR=1.032; 95% CI, 1.018–1.047; p<0.001), low level of family income (OR=2.91; 95% CI, 1.567–5.404; p=0.001), low educational level of mother (OR=2.602; 95% CI, 1.509–4.485), night-time frequent breastfeeding (OR=1.695; CI, 1.07–2.685; p=0.024) and bottle feeding with sugary beverages (OR=1.689; CI, 1.002–2.847; p=0.049). First dental visit age (OR=1.482; 95% CI, 1.254–1.753; p<0.001) and initial age of tooth brushing (OR=2.062; 95% CI, 1.324–3.209; p=0.001) were found to be protective against ECC development. Conclusions: The current study highlights potential factors that are commonly associated with the risk of developing ECC. From the perspective of public health, a better understanding of socioeconomic, environmental, maternal and behavioural risks factors for ECC will aid improving maternal and child-based health promotion and preventive programmes.

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Enteric viral infections as potential risk factors for intussusception

The Journal of Infection in Developing Countries ◽

10.3855/jidc.2321 ◽

2013 ◽

Vol 7 (01) ◽

pp. 028-035 ◽

Cited By ~ 15

Author(s):

Adel M Mansour ◽

Montasser El Koutby ◽

Mohamed M El Barbary ◽

Wissam Mohamed ◽

Sameh Shehata ◽

...

Keyword(s):

Risk Factors ◽

Potential Risk ◽

Maternal Education ◽

Viral Infections ◽

Enteric Bacteria ◽

Rotavirus Infection ◽

Increased Risk ◽

Potential Risk Factors ◽

History Of ◽

And Gender

Introduction: We aimed to identify potential risk factors for intussusception (ISS) among children presenting to two pediatric hospitals in Egypt. Methodology: In this case-control study, enrolled children < 3 years old with ISS (confirmed radiologically and/or surgically) were matched by age and gender to controls admitted with acute non-abdominal surgical illnesses. Stool samples were collected and tested for various enteric bacteria, rotavirus, enteric adenoviruses (EA, 40 and 41) and astroviruses using commercially available ELISA diagnostic kits. Results: From December 2004 to May 2009, 158 cases and 425 matched controls were enrolled. A history of diarrhoea and cough over the preceding four weeks of interview were more common in cases than controls, respectively. Children with mothers who had secondary education and above were 2.2 times more likely to have ISS than those whose mothers had a lower level of education. In spite of the low detection rate of EA infection (regardless of diarrhoea history) and asymptomatic rotavirus infection, they were detected in higher frequencies in cases than controls; however, infection with astrovirus and bacterial pathogens did not appear to be associated with increased risk of ISS. Conclusions: History of diarrhoea and cough over the four weeks preceding the study and maternal education above secondary level were potential risk factors for ISS. EA and asymptomatic rotavirus infection were detected in higher frequencies among cases than controls; however, association with ISS cannot be confirmed. Additional research is needed to confirm these findings and evaluate the pathogenesis which may link such infections with ISS.

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Potential Risk Factor for Malaria Infection in Banjarnegara, Indonesia: A Matched Case-control Study

International Journal of TROPICAL DISEASE & Health ◽

10.9734/ijtdh/2020/v41i530276 ◽

2020 ◽

pp. 28-35

Author(s):

Sulistyawati Sulistyawati ◽

Rokhmayanti Rokhmayanti ◽

Maririn Devi Pradita

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Potential Risk ◽

Family Income ◽

Case Control Study ◽

Case Control ◽

Potential Risk Factor ◽

Health Seeking ◽

Potential Risk Factors ◽

Control Study

Context: This research is performed in Banjarnegara, an endemic malaria area in Indonesia. Considering the incidence of malaria in Indonesia in the last ten years, it is essential to assess the potential risk factors to maintain the cases and to accelerate malaria elimination. Aims: This study examined the potential risk factors from the human socio-economic aspect and human behavior for malaria cases. Settings and Design: This is a match case-control study conducted in 34 cases and 34 controls in Banjarmangu Subdistrict, Banjarnegara, Indonesia. The subjects for the two groups were based on the routine report of Banjarmangu I public health center from July 2017–March 2018. Inclusion and exclusion criteria were applied to select the subject. Statistical Analysis: Logistic regression was used to seek the association among the variables. Results: This research found that installing wire netting, not sleeping under a bed net, and consuming higher transportation costs were significant protective factors for malaria cases. Having lower family income was significant as a potential risk factor for malaria cases (OR=10.68, CI = 1.01-112.59). Conclusions: This study may explain that economic income was the essential aspect of malaria prevention as it contributed to the other health issues, such as health-seeking behavior.

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Premature Arterial Disease Associated with Familial Antithrombin III Deficiency

Thrombosis and Haemostasis ◽

10.1055/s-0038-1645677 ◽

1990 ◽

Vol 63 (01) ◽

pp. 013-015 ◽

Cited By ~ 15

Author(s):

E J Johnson ◽

C R M Prentice ◽

L A Parapia

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Potential Risk ◽

Antithrombin Iii ◽

Arterial Disease ◽

Coagulation System ◽

Early Age ◽

Arterial Thromboembolism ◽

Potential Risk Factors ◽

Antithrombin Iii Deficiency

SummaryAntithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early age. Both patients had other potential risk factors, though these would normally be considered unlikely to lead to such catastrophic events at such an age. Thrombosis due to ATIII deficiency is potentially preventable, and this diagnosis should be sought more frequently in patients with arterial thromboembolism, particularly if occurring at a young age. In addition, in patients with known ATIII deficiency, other risk factors for arterial disease should be eliminated, if possible. In particular, these patients should be counselled against smoking.

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