scholarly journals The Role of Atorvastatin in Management of Eruptive Xanthoma on a Boy: A Case Report

2021 ◽  
Vol 9 (C) ◽  
pp. 151-153
Author(s):  
Harapan Parlindungan Ringoringo
Keyword(s):  
Body Weight ◽  
Case Report ◽  
Clinical Presentation ◽  
Skin Lesions ◽  
Chief Complaint ◽  
Laboratory Examination ◽  
Cutaneous Lesions ◽  
Early Therapy ◽  
Intense Pruritus

Background: Eruptive xanthoma is a benign skin lesion caused by the accumulation of cholesterol and triglycerides in the skin's dermis. Xanthoma can be an early clinical manifestation of systemic diseases such as dyslipidemia, cardiovascular disease, diabetes mellitus. Clinical presentation varies from asymptomatic skin lesions to intense pruritus and tenderness. Aim: This study aims that oral atorvastatin is effective in treating a child with eruptive xanthoma. Case report: A three-year-old boy with an 8.4 kg body weight and 82.5 cm height came to the hospital with the chief complaint of small yellowish-white papules and nodes, discrete, 2-5 mm in size, painless on pressing, itchy, scattered, mainly in the lower extremity around the buttocks. On laboratory examination, Hb 11.5 g/dL, leukocyte 9,900/ul, platelet 413,000/uL, blood glucose 66 mg/dL. Further evaluation revealed total cholesterol 814 mg/dL, LDL 970 mg/dL, HDL 341 mg/dl, triglycerides 621 mg/dL; there is no evidence of familial hypercholesterolemia. The diagnosis is eruptive xanthoma.  After starting treatment with atorvastatin 0.2 mg/kg body weight/day in one dose for six months, his cutaneous lesions gradually subsided and significantly decreased cholesterol, LDL, HDL, and triglyceride levels. Conclusion: Early therapy with atorvastatin will reduce the morbidity and mortality of eruptive xanthoma.

scholarly journals Case Report: Mastocytosis: The Long Road to Diagnosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Tiago Azenha Rama ◽  
Diana Martins ◽  
Nuno Gomes ◽  
Jorge Pinheiro ◽  
Ana Nogueira ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Case Report ◽  
Mast Cells ◽  
Allergic Sensitization ◽  
Skin Lesions ◽  
Normal Serum ◽  
Cutaneous Lesions ◽  
History Of ◽  
Exercise Induced ◽  
Low Prevalence

Mastocytosis is a heterogeneous group of disorders characterized by expansion and accumulation of clonal mast cells. Patients mainly present with either cutaneous lesions, anaphylaxis, or both. Its low prevalence and unusual features often hinder its diagnosis for several years. We report the case of an 18-year-old male who was referred to our department with a long-standing history of atypical skin lesions, allergic rhinitis, exercise-induced bronchoconstriction and what was believed to be food-related flushing and anaphylaxis, that was later diagnosed with mastocytosis. This case illustrates the need to consider investigating for mastocytosis when recurrent anaphylaxis is present, especially in the presence of atypical skin lesions, even if normal serum basal tryptase levels and allergic sensitization are present.

scholarly journals Isolation of Rhodotorula mucilaginosa from skin lesions in a Southern sea lion (Otaria flavescens): a case report

2010 ◽  
Vol 55 (No. 6) ◽  
pp. 297-301 ◽  
Author(s):  
S. Alvarez-Perez ◽  
A. Mateos ◽  
L. Dominguez ◽  
E. Martinez-Nevado ◽  
JL Blanco ◽  
...  
Keyword(s):  
Case Report ◽  
Topical Treatment ◽  
Skin Lesions ◽  
Rhodotorula Mucilaginosa ◽  
Sea Lion ◽  
Cutaneous Lesions ◽  
Repeat Testing ◽  
Otaria Flavescens ◽  
Clinical Recovery

This paper reports the isolation of Rhodotorula mucilaginosa from skin lesions in a Southern sea lion (Otaria flavescens). The microorganism was isolated from cutaneous lesions, identified by the commercial API 20 C AUX system, and confirmed by sequencing. Topical treatment with sertaconazol resulted in complete clinical recovery of the animal and repeat testing did not result in the recovery of the yeast from the healed lesion sites.

scholarly journals New-onset cutaneous sarcoidosis under tocilizumab treatment for giant cell arteritis: a quasi-paradoxical adverse drug reaction. Case report and literature review

2019 ◽  
Vol 11 ◽  
pp. 1759720X1984179 ◽  
Author(s):  
Rosaria Del Giorno ◽  
Alfonso Iodice ◽  
Cristina Mangas ◽  
Luca Gabutti
Keyword(s):  
Case Report ◽  
Clinical Response ◽  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Case Reports ◽  
Skin Lesions ◽  
Cutaneous Sarcoidosis ◽  
Cutaneous Lesions ◽  
Topical Corticosteroids ◽  
New Onset

Background: New-onset sarcoidosis has been previously described in three case reports in patients affected by rheumatoid arthritis treated with tocilizumab (TCZ). The existence of a cause–effect mechanism between the biological treatment and the onset of the illness is still being debated. Patient concerns: A 74-year-old woman was diagnosed with giant cell arteritis (GCA). The first-line treatment with glucocorticoids; and the second-line with methotrexate and low-dose glucocorticoids were stopped due to multiple pathological vertebral fractures and insufficient biological and clinical response. The cytotoxic agent, cyclophosphamide, was then introduced and in turn stopped, because of gastrointestinal side effects. Thereafter a treatment with TCZ was begun. The patient experienced good clinical response; however, 8 months later she developed painful hyper-pigmented reddish cutaneous micronodular lesions localized to the abdomen and thorax. A cutaneous biopsy was performed, and histological analysis showed noncaseating epithelioid granulomas in the hypodermis. The diagnosis of cutaneous sarcoidosis was made. Interventions: Topical corticosteroids were administered and, as requested by the patient, TCZ was discontinued with slow but complete resolution of the skin lesions. After TCZ discontinuation however, the GCA flared and the patient’s symptoms and biological abnormalities reappeared. Thus, after a 6-month suspension, TCZ was re-administered. At 2 months later the skin lesions compatible with cutaneous sarcoidosis reappeared. Topical corticosteroids were once again prescribed and as suggested by the patient the TCZ posology was reduced. The patient’s symptoms disappeared, and the cutaneous lesions resolved. Lessons: The time elapsed from TCZ treatment start and the onset of cutaneous sarcoidosis, as well as its recurrence after TCZ suspension and rechallenge supported the diagnosis of a drug-induced reaction. To the best of our knowledge, this case report represents the first instance of cutaneous sarcoidosis most likely induced by TCZ in patients affected by GCA. In addition, our case emphasizes that although TCZ in monotherapy confirms to be an effective treatment for GCA, further immunological disorders could be unmasked, and the discussed side effect of the drug could be dose-dependent.

Bacillary Angiomatosis in a Patient with AIDS

1993 ◽  
Vol 27 (11) ◽  
pp. 1378-1382 ◽  
Author(s):  
A. Christine Teague ◽  
Sharon K. Parks
Keyword(s):  
Case Report ◽  
Antibiotic Therapy ◽  
Antimicrobial Therapy ◽  
Clinical Presentation ◽  
Single Case ◽  
Skin Lesions ◽  
University Teaching ◽  
Hiv Positive ◽  
Single Case Report ◽  
Bacillary Angiomatosis

OBJECTIVE: To report the clinical presentation and response to antimicrobial therapy of presumed bacillary angiomatosis in an AIDS patient. DESIGN: Single case report. SETTING: A 1058-bed, university teaching hospital. PATIENT: 28-year-old HIV-positive man (T4 lymphocyte count <3/mm3), who was diagnosed with AIDS in 1984. RESULTS: The skin lesions responded promptly to treatment with doxycycline and erythromycin. CONCLUSIONS: Bacillary angiomatosis is an infection that occurs with endstage AIDS. Skin lesions have recognizable characteristics and respond promptly to appropriate antibiotic therapy.

scholarly journals Neglected Tropical Diseases: Treatment of Dermatological Manifestation of Filariasis with Combination Regimen of Albendazole, Ivermectin, and Loratadine: A Case Report from a Suburban Community in Nigeria

2017 ◽  
Vol 03 ◽  
pp. 29
Author(s):  
Osede Ignis Iribhogbe ◽  
Keyword(s):  
Case Report ◽  
Neglected Tropical Diseases ◽  
Skin Lesions ◽  
Lower Limbs ◽  
Combination Regimen ◽  
Uncommon Presentation ◽  
Laboratory Confirmation ◽  
Filarial Nematodes ◽  
Intense Pruritus ◽  
Dose Combination

Threadlike filarial nematodes have been identified as the causative agent of filariasis. Cutaneous filariasis is caused primarily by Loa loa, Onchocerca volvulus, and Mansonella streptocerca. These parasites occupy the subcutaneous layer of the skin. However, other filarial parasites are usually associated with varying degrees of dermatological manifestations. In the present discourse, two cases of cutaneous filariasis were diagnosed in two female patients (21 and 40 years old, respectively) in Remitch Clinic and Maternity located in a nonriverine community in Ekpoma, Edo State, Nigeria. In this report, patients with body mass index (BMI) of 18.97 and 23.45 kg/m2, respectively, presented on two different occasions at least 6 months apart with hyperpigmented skin lesions in the upper and lower limbs, respectively. There was associated intense pruritus with no evidence of lymphadenopathy and lymphoedema. Following laboratory confirmation of filariasis, the patients were placed on a single oral dose combination of albendazole (400 mg) + ivermectin (200 mcg/kg), while oral doses of loratadine 10 mg were administered daily for 5 days. Patients were carefully followed up for 6 weeks during which recession of the lesion and untoward reactions were monitored. It was observed that within 6 weeks of treatment, there was a dramatic recession of skin lesion. Adverse effect reported from use of the combination was mild. This case report revealed that cutaneous filariasis is not an uncommon presentation of filariasis infestation in Nigeria. The report also validates the safety and efficacy of the combination in the management of cutaneous manifestation of the disease.

scholarly journals Cutaneous Sarcoidosis in a patient with left Hilar calcification of the lungs - A Case Report

2016 ◽  
Vol 8 (3) ◽  
pp. 161-170
Author(s):  
Mirjana Paravina ◽  
Milanka Ljubenović ◽  
Milenko Stanojević ◽  
Milica Stepanović ◽  
Dragica Marković
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Female Patient ◽  
Skin Lesions ◽  
Granulomatous Disease ◽  
Cutaneous Sarcoidosis ◽  
Cutaneous Lesions ◽  
Antimalarial Therapy ◽  
Cutaneous Granuloma ◽  
Systemic Manifestations

Abstract Sarcoidosis is an acquired idiopathic granulomatous disease, which is characterized by noncaseating epithelioid granulomas in organs and tissues. Most frequently it affects the lungs, liver, lymph nodes, skin, eyes and other organs. The cutaneous lesions appear in 20 - 30% of patients with systemic manifestations, and in 25% of them they appear without systemic manifestations. Based on the histopathological characteristics, cutaneous lesions are divided into specific, characterized by cutaneous granuloma, and non-specific, which are not granulomatous. Moreover, they can be classified as typical and atypical. We are presenting a female patient with unilateral hilar calcification of the lungs, who exhibited plaque skin lesions typical for sarcoidosis, with a specific granulomatous histology and a favorable response to corticosteroid and antimalarial therapy.

scholarly journals Role of systemic steroids in acute hemorrhagic edema of infancy: report of two cases

2019 ◽  
Vol 6 (2) ◽  
pp. 537
Author(s):  
Mohammed S. Alharbi
Keyword(s):  
Clinical Presentation ◽  
Leukocytoclastic Vasculitis ◽  
Skin Lesions ◽  
Histological Evaluation ◽  
Conservative Approach ◽  
Systemic Steroids ◽  
Unusual Form ◽  
Clinical Cases

Acute hemorrhagic edema of infancy (AHEI) is an unusual form of leukocytoclastic vasculitis with dramatic distinguishing skin lesions that occurs in infants who age 4 to 24 months old. Clinical presentation at onset requires clinical and, less often, histological evaluation to distinguish it from more serious diseases and other vasculitis. Treatment of AHEI remains controversial; and since it is a self-limiting disease, a conservative approach should be considered first. Although some authors have reported that the use of steroids may be beneficial if started early on, we think their use, based on our presented cases here, may accelerate the healing and improves the color of preexisting skin lesions but does not significantly alter the course of the disease. Authors reported here two clinical Cases of AHEI (Diagnosed based on characteristic skin lesions and confirmed with Histological evaluation) who were treated initially with systemic steroids, besides we reviewed the role of systemic steroids in the treatment of AHEI.

Role of Radiotherapy in a Recurrent Aneurysmal Bone Cyst of the Temporal Bone: Case Report

Neurosurgery ◽  
2006 ◽  
Vol 58 (3) ◽  
pp. E584-E584 ◽  
Author(s):  
Piyush Kumar ◽  
Shalini Singh ◽  
Rajendra V. Phadke ◽  
Himanshu Diwakar ◽  
Tanu Agarawal ◽  
...  
Keyword(s):  
Case Report ◽  
Temporal Bone ◽  
Aneurysmal Bone Cyst ◽  
Rare Case ◽  
Clinical Presentation ◽  
Bone Cyst ◽  
Temporal Region ◽  
Radiological Images

Abstract OBJECTIVE AND IMPORTANCE: A rare case of aneurysmal bone cyst (ABC) of the temporal bone is presented which, following recurrence after surgery, was successfully treated with radiotherapy. The role of radiotherapy in such cases is reviewed. CLINICAL PRESENTATION: A 30-year-old man presented with a recurrent swelling and pain in right temporal region following surgery for ABC at that site. INTERVENTION: Local radiotherapy to a dose of 31.5 Gy in 18 fractions over 3.5 weeks was delivered to the site of recurrence. The patient had a near total regression of the ABC as evident clinically and on radiological images. CONCLUSION: To the best of our knowledge, radiation for the recurrent ABC at the temporal bone has not been described in the literature. However, in view of the response evident in this patient, radiotherapy seems to be effective for recurrent cases of ABC at the temporal bone and a dose of around 30 to 36 Gy could be effectively delivered with satisfactory results.

scholarly journals Pernio as the clinical presentation of celiac disease: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2094044
Author(s):  
Alexandre Lemieux ◽  
Natasha Emily Sanchez Vivas ◽  
Julie Powell ◽  
Prévost Jantchou ◽  
Marie-Paule Morin
Keyword(s):  
Celiac Disease ◽  
Case Report ◽  
Pharmacological Treatment ◽  
Clinical Remission ◽  
Clinical Presentation ◽  
Gastrointestinal Symptoms ◽  
Skin Lesions ◽  
Gluten Free Diet ◽  
Gluten Free

We present the case of a 12-year-old girl with severe pernio as the sole clinical presentation of celiac disease (CD), without associated gastrointestinal symptoms. Lesions greatly improved once a gluten free diet was initiated. At 5-year follow-up, she remains in clinical remission throughout the year with no pharmacological treatment, without skin lesions flare-up in the winter months.

scholarly journals Clinically Amyopathic Dermatomyositis Caused by a Tattoo

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Bing Han ◽  
Qiang Guo
Keyword(s):  
Immune Response ◽  
Case Report ◽  
Interstitial Lung Disease ◽  
Laboratory Test ◽  
Clinical Presentation ◽  
Unknown Origin ◽  
Skin Lesions ◽  
Amyopathic Dermatomyositis ◽  
Clinically Amyopathic Dermatomyositis ◽  
Left Chest

Introduction. Clinically amyopathic dermatomyositis (CADM) is a rare disease with unknown origin. It is characterized by the specific skin lesions of dermatomyositis (DM) without clinical or laboratory evidence of myopathy. Previous studies indicated that tattoo may induce immune response. Case Report. A 22-year-old male who tattooed butterfly on the left chest with blue and red ink. Then, he gradually had typical Gottron rash and interstitial lung disease (ILD) without weakness of the muscle. The clinical presentation and laboratory test represent the diagnosis of CADM. According to the history, CADM was induced by the tattoo five months before admission. Discussion. We first reported the CADM induced by a tattoo. However, further studies are still needed to approach the specific substances within the tattoo that trigger immune response.

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