scholarly journals Anticancer Activities of Sesewanua Leaf Extracts (Clerodendrum fragrans (Vent.) Willd) Against A549 Lung Cancer Cell

2021 ◽  
Vol 9 (A) ◽  
pp. 1226-1230
Author(s):  
Elisabeth Natalia Barung ◽  
Donald Emilio Kalonio ◽  
Yos Banne ◽  
Norma Tiku Kambuno
Keyword(s):  
Lung Cancer ◽  
Ethyl Acetate ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Ethyl Acetate Fraction ◽  
Water Soluble ◽  
Lung Cancer Cells ◽  
Assay Method ◽  
Anticancer Activities ◽  
A549 Lung

BACKGROUND: Cancer is one of the leading causes of non-communicable diseases in the world, with about 10 million deaths worldwide in 2020. Lung cancer was the most common type of cancer and the highest cause of death. Therapy for lung cancer can be either conventional therapy or molecular targeted therapy that has many limitations. AIM: It is, therefore, important to explore new sources of anticancer activity, including those from plants. One plant that is thought to have anticancer activity is Sesewanua (Clerodendrum fragrans [Vent.] Willd. Syn. Clerodendrum chinense [Osbeck] Mabb., Family Lamiaceae). METHODS: This research is a laboratory experiment. The sample used is the C. fragrans leaves obtained in Malalayang I Timur Village, Malalayang District, Manado City, North Sulawesi Province, while the subjects in this study were A549 lung cancer cells from Cell-Culture Laboratory, Faculty of Pharmacy, Universitas Padjadjaran Bandung. Anticancer activity test was using the MTT tetrazolium assay method. Data in the form of a percentage (%) inhibition of cell proliferation, then determined the value the concentration of 50% proliferation inhibition (IC50) using a computer program online. RESULTS: The results showed that ethanol extract, hexane fraction, ethyl acetate fraction, and water-soluble fraction of C. fragrans had anticancer activity on A549 lung cancer cells. The smallest IC50 value is indicated by ethyl acetate fraction (191, 165 ppm), which is categorized as moderately active.

scholarly journals Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides

MedChemComm ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 116-119 ◽  
Author(s):  
Fabrizio Olivito ◽  
Nicola Amodio ◽  
Maria Luisa Di Gioia ◽  
Monica Nardi ◽  
Manuela Oliverio ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Preliminary Evaluation ◽  
Natural Analogue ◽  
Anti Cancer ◽  
A549 Lung ◽  
Cancer Activity

In this work we synthesized and tested a series of unsaturated disulfides. Two compounds showed a promising anticancer activity in vitro on A549 lung cancer cells compared to the natural analogue.

scholarly journals Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3733 ◽  
Author(s):  
Zhenhua Yin ◽  
Wei Zhang ◽  
Juanjuan Zhang ◽  
Huili Liu ◽  
Qingfeng Guo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Monosaccharide Composition ◽  
Water Soluble ◽  
Lung Cancer Cells ◽  
Psoralea Corylifolia ◽  
Scanning Calorimetry ◽  
Good Thermal Stability ◽  
A549 Lung

Two novel water soluble heteroglycan (PCp-I and PCp-II) with anti-A549 lung cancer cells activity were isolated from Psoralea corylifolia L. Their average molecular weights were 2.721 × 104 and 2.850 × 104. PCp-I and PCp-II had the same monosaccharide composition, but their molar ratios were different. Based on methylation and NMR spectroscopy, the part structure of PCp-I was identified. The results of scanning electron microscope (SEM) showed that PCp-I had an irregular porous structure and PCp-II was flaky and irregularly curved. The results of thermogravimetry-differential scanning calorimetry (TG-DSC) showed that PCp-I and PCp-II had good thermal stability. Furthermore, PCp-I and PCp-II exhibited significant anti-A549 lung cancer cells activity (IC50 = 64.84 and 126.30 μM) in vitro.

Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase

2017 ◽  
Vol 40 (2) ◽  
pp. 249-256 ◽  
Author(s):  
Arunachalam Kalaiarasi ◽  
Renu Sankar ◽  
Chidambaram Anusha ◽  
Kandasamy Saravanan ◽  
Kalyanasundaram Aarthy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Copper Oxide ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Copper Oxide Nanoparticles ◽  
Lung Cancer Cells ◽  
Oxide Nanoparticles ◽  
A549 Lung

scholarly journals A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity

Pharmacia ◽  
2021 ◽  
Vol 68 (3) ◽  
pp. 679-692
Author(s):  
Ali H. Abbas ◽  
Ammar A. Razzak Mahmood ◽  
Lubna H. Tahtamouni ◽  
Zainab A. Al-Mazaydeh ◽  
Majdoleen S. Rammaha ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Endoplasmic Reticulum ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Picolinic Acid ◽  
Docking Study ◽  
Lung Cancer Cells ◽  
A549 Lung ◽  
Egfr Kinase ◽  
Mcf 7

Thirteen new derivatives of picolinic acid (4–7) were designed and synthesized from the starting parent molecule, picolinic acid. The new compounds were characterized by ATR-FTIR, 1HNMR, and CHNS analysis. A molecular docking study was performed to evaluate the binding affinity of the synthesized compounds toward EGFR kinase domain that indicated occupation of the critical site of EGFR kinase pocket and excellent positioning of the compounds in the pocket. The cytotoxic activity of the compounds against two human cancer cell lines (A549 and MCF-7), the non-tumorigenic MCF10A cell line, and white blood cells (WBC) was evaluated using the MTT assay. Compound 5 showed anticancer activity against A549 lung cancer cells (IC50 = 99.93 µM) but not against MCF-7 breast cancer cells or normal cells. Compound 5 mediated cytotoxicity in A549 lung cancer cells by inducing apoptotic cell death, as suggested by fragmented nuclei after DAPI staining, and agarose gel electrophoresis. Moreover, compound 5 triggered the activation of caspases 3, 4 and 9. However, compound 5 treatment did not affect the release of cytochrome c from the mitochondria to the cytosol, as compared to the vehicle-treated control cells. Nevertheless, compound 5-treated cells reported greater release of smac/DIABLO to the cytosol. In the same context, both compound 5 and thapsigargin (specific inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA)) enhanced eIF2 phosphorylation, reflecting the activation of the atypical ER stress pathway and the potential applicability of compound 5 in lung cancer treatment.

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