The enhanced antitumour response of pimozide combined with the IDO inhibitor L‑MT in melanoma

Introduction. Autologous haematopoietic stem cell transplantation (auto-HSCT) is a highly effective treatment for multiple myeloma (MM). Auto-HSCT allows a signifi cant improvement of haematological response leading to higher overall survival and quality of life in MM patients. Nonetheless, the majority of patients develop relapse.Aim — a comparison of clinical MM relapses developing at variant terms after auto-HSCT.Patients and methods. A retrospective study enrolled 65 MM patients aged between 39 and 64 years. All patients had auto-HSCT during 2009–2019, all had achieved complete response (CR) or very good partial response (VGPR) and all since developed immunochemical MM relapse in laboratory evidence. Patients were divided in two cohorts by relapse term, the early (within 12 months of auto-HSCT) and late relapse.Results. Early immunochemical relapse was diagnosed in 13 (20 %), late relapse — in 52 (80 %) patients. The dependence between relapse term and depth of post-auto-HSCT antitumour response has been determined. The proportion of CR patients was signifi cantly higher in late than in early relapse (55.8 vs. 23 %). In follow-up, 60 patients (92.3 %) were initiated on antirelapse therapy, all early relapse and 90.3 % late relapse patients. On day +100 of auto-HSCT, CR patients had later relapse vs. VGPR individuals (median 24 vs. 19.9 months, p = 0.08) with signifi cantly weaker paraprotein secretion resembling the clinical course of monoclonal gammopathy of unclear signifi cance (MGUS).Conclusion. Auto-HSCT allows long-term control of the disease. A signifi cant prognostic factor is antitumour response on +100 day of auto-HSCT. Patients attaining CR have later relapse progressing in a MGUS-like manner. Patients with late indolent relapse can be managed long-term without antitumour therapy.

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Whole-body magnetic resonance imaging for diagnosis and treatment monitoring in multiple myeloma

Hematology and Transfusiology ◽

10.35754/0234-5730-2020-65-4-431-443 ◽

2020 ◽

Vol 65 (4) ◽

pp. 431-443

Author(s):

N. S. Lutsik ◽

L. P. Mendeleeva ◽

M. V. Solovev ◽

S. M. Kulikov ◽

Yu. A. Chabaeva ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Multiple Myeloma ◽

Bone Marrow ◽

Magnetic Resonance ◽

Whole Body ◽

Relative Reduction ◽

Resonance Imaging ◽

Whole Body Mri ◽

Adc Values ◽

Antitumour Response

Introduction. Whole-body diffusion-weighted magnetic resonance imaging (MRI) is an informative method for bone marrow inﬁltration diagnosis in patients with multiple myeloma (MM) and post-monitoring in autologous haematopoietic stem cell transplantation (auto-HSCT).Aim: to study bone marrow lesions in MM patients using whole-body MRI prior to and after chemotherapy with subsequent auto-HSCT.Materials and methods. Forty patients with MM were included in a prospective study of whole-body MRI before and after high-dose chemotherapy with auto-HSCT. All patients had whole-body MRI prior to and at +100 day of auto-HSCT. Antitumour response was assessed after induction and at +100 day. The number and volume of bone marrow lesions prior to and at +100 day of auto-HSCT were determined, along with apparent diffusion coefﬁcient (ADC) in the lesions.Results. We observed a signiﬁcant reduction of 29 % in the number of lesions, 40 % — in their volume and 33 % — in ADC. A signiﬁcant correlation was revealed between relative reduction in the number and volume of foci (r = 0.52, p = 0.0017). A correlation was found between relative reduction in the foci number and ADC (r = 0.47, p = 0.016). Patients with lesions > 7 cm3 in MRI data exhibited a lesser reduction in the foci number and volume and ADC values after auto-HSCT compared to patients with lesions < 7 cm3.Conclusion. Whole-body MRI with diffusion-weighted imaging and subsequent estimation of the number and volume of lesions and their ADC values prior to and after auto-HSCT add power to assessing antitumour response in MM patients with auto-HSCT.

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Dendritic Cell Immunotherapy Induces Antitumour Response in Parathyroid Carcinoma and Neuroendocrine Pancreas Carcinoma

Hormone and Metabolic Research ◽

10.1055/s-2007-978817 ◽

1999 ◽

Vol 31 (12) ◽

pp. 662-664 ◽

Cited By ~ 9

Author(s):

M. Schott ◽

J. Seissler ◽

J. Feldkamp ◽

C. von Schilling ◽

W. Scherbaum

Keyword(s):

Dendritic Cell ◽

Parathyroid Carcinoma ◽

Pancreas Carcinoma ◽

Cell Immunotherapy ◽

Antitumour Response

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Faculty Opinions recommendation of Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726220978.793518500 ◽

2016 ◽

Author(s):

Vincenzo Cerundolo ◽

Uzi Gileadi

Keyword(s):

T Cells ◽

Cd8 T Cells ◽

Cholesterol Metabolism ◽

Antitumour Response

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Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer

Journal of Oncology ◽

10.1155/2017/5035371 ◽

2017 ◽

Vol 2017 ◽

pp. 1-15 ◽

Cited By ~ 43

Author(s):

Rea Bingula ◽

Marc Filaire ◽

Nina Radosevic-Robin ◽

Mathieu Bey ◽

Jean-Yves Berthon ◽

...

Keyword(s):

Lung Cancer ◽

Immune System ◽

Innate Immune ◽

The Other ◽

Microbial Composition ◽

Central Nervous Systems ◽

Altered Immune Response ◽

Insight Into ◽

Antitumour Response ◽

Stimulation Of

The microbiota includes different microorganisms consisting of bacteria, fungi, viruses, and protozoa distributed over many human body surfaces including the skin, vagina, gut, and airways, with the highest density found in the intestine. The gut microbiota strongly influences our metabolic, endocrine, and immune systems, as well as both the peripheral and central nervous systems. Recently, a dialogue between the gut and lung microbiota has been discovered, suggesting that changes in one compartment could impact the other compartment, whether in relation to microbial composition or function. Further, this bidirectional axis is evidenced in an, either beneficial or malignant, altered immune response in one compartment following changes in the other compartment. Stimulation of the immune system arises from the microbial cells themselves, but also from their metabolites. It can be either direct or mediated by stimulated immune cells in one site impacting the other site. Additionally, this interaction may lead to immunological boost, assisting the innate immune system in its antitumour response. Thus, this review offers an insight into the composition of these sites, the gut and the lung, their role in shaping the immune system, and, finally, their role in the response to lung cancer.

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