scholarly journals Fertility following treatment of high-grade malignant bone and soft tissue tumors in young adults

2014 ◽  
Vol 3 (2) ◽  
pp. 367-374 ◽  
Author(s):  
MANABU HOSHI ◽  
MASATSUGU TAKAMI ◽  
MAKOTO IEGUCHI ◽  
MASANARI AONO ◽  
JUN TAKADA ◽  
...  
Keyword(s):  
Young Adults ◽  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
High Grade

scholarly journals The First Case Treated with Larotrectinib of a Novel TMTC2-NTRK3 Fusion Undifferentiated High-Grade Pleomorphic Sarcoma of the Chest

2021 ◽  
Author(s):  
Chujie Bai ◽  
Lu Zhang ◽  
Yaohui Wang ◽  
Taiyan Guo ◽  
Xia You ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Clinical Manifestations ◽  
Soft Tissue Tumors ◽  
The Body ◽  
High Grade ◽  
Pleomorphic Sarcoma ◽  
First Case ◽  
Painless Mass ◽  
Almost All ◽  
Next Generation Sequencing Ngs

Abstract Undifferentiated high-grade pleomorphic sarcoma (UPS) is a rare soft tissue sarcoma (STS) of mesenchymal origin, particularly the extremities and retroperitoneum, meanwhile it has been reported in almost all parts of the body. UPS is highly invasive and has a poor prognosis due to its clinical manifestations of painless mass and deep tumor site, which are usually found at an advanced stage. Patients with UPS tend to have a lower 5-year survival rate than patients with other types of STS. Recently, NTRK fusions were detected in many cancer types, such as thyroid cancer, colorectal cancer, non-small cell lung cancer, soft tissue tumors, uterine sarcomas, and melanomas. However, the mutation frequency of NTRK fusion in all cancers is only 0.1-1%. Targeted therapy with NTRK inhibitors, such as Larotrectinib and Entrectinib, leads to a response in most patients with NTRK1/2/3 gene fusion-positive tumors. Herein, we present a 68-years old man diagnosed with stage IIIA (T2N0M0G3) UPS. Next-generation sequencing (NGS) revealed a novel TMTC2-NTRK3 fusion. The NTRK3 positivity was also detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). He had a response to Larotrectinib. This report broadens the spectrum of NTRK fusions in UPS and highlights a new target for treatment.

Percutaneous Image-Guided Treatment of Benign Musculoskeletal Tumors in Children

2018 ◽  
Vol 22 (01) ◽  
pp. 003-011 ◽  
Author(s):  
Anne Gill ◽  
C. Hawkins ◽  
Matthew O'Dell
Keyword(s):  
Young Adults ◽  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
Research Interest ◽  
Percutaneous Ablation ◽  
Image Guided ◽  
Musculoskeletal Tumors ◽  
Children And Young Adults

AbstractPercutaneous ablation of benign musculoskeletal tumors in children has become an area of significant clinical growth over the last decade. With growing research interest, the technologies available and techniques used are becoming increasingly safe and effective. We review some of the more common ablation technologies and their utility in several common benign bone and soft tissue tumors that occur in children and young adults.

scholarly journals Pre-chemotherapy preservation of fertility in male patients with high-grade malignant bone and soft tissue tumors

2014 ◽  
Vol 2 (6) ◽  
pp. 1111-1114 ◽  
Author(s):  
MANABU HOSHI ◽  
NAOTO OEBISU ◽  
JUN TAKADA ◽  
TADASHI IWAI ◽  
RIE TSURUTA ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
High Grade ◽  
Preservation Of Fertility ◽  
Male Patients

A Malignant Neoplasm From the Jejunum With a MALAT1-GLI1 Fusion and 26-Year Survival History

2020 ◽  
Vol 28 (5) ◽  
pp. 553-562
Author(s):  
Owen William John Prall ◽  
Christopher Robert Edward McEvoy ◽  
David John Byrne ◽  
Amir Iravani ◽  
Judy Browning ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
S100 Protein ◽  
Malignant Neoplasm ◽  
Soft Tissue Tumors ◽  
High Grade ◽  
Metastatic Tumors ◽  
Term Survival ◽  
Pathway Gene ◽  
Mutation Burden

The transcription factor GLI1 is a critical effector of the sonic hedgehog pathway. Gene fusions that activate GLI1 have recently been reported in several tumor types including gastroblastoma, plexiform fibromyxoma, a subset of pericytomas, and other soft tissue tumors. These tumors arise in a wide variety of anatomical origins and have variable malignant potentials, morphologies, and immunohistochemistry profiles. In this case report, we describe a malignant tumor from the jejunum with a MALAT1-GLI1 gene fusion that expressed a truncated constitutively active GLI1 protein and GLI1 targets that were detectable by immunohistochemistry. The tumor showed high-grade epithelioid and spindle cell morphology, strongly expressed CD56, and focally expressed other neuroendocrine markers and cytokeratins, but not S100 protein or SMA. The tumor recurred multiple times in liver, soft tissue, and lung over the course of 26 years, the longest reported follow-up for a GLI1 fusion-associated tumor. These metastatic tumors were also composed of epithelioid and spindle cells, but showed lower morphological grade than the primary tumor. The metastatic tumors resembled the recently reported “malignant epithelioid neoplasms with GLI1 rearrangements.” The tumor also had a relatively high tumor mutation burden for a sarcoma. This case report expands the sites of origin for GLI1 rearranged neoplasms and shows that despite being associated with high-grade morphology, these malignancies can be associated with very long-term survival.

scholarly journals Low-Grade Uterine Epithelioid Hemangioendothelioma Presented as a Submucosal Leiomyoma during Labor

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Anastasios V. Koutsopoulos ◽  
Efthimios Sivridis ◽  
Panagiotis Tsikouras ◽  
Vasileios Liberis ◽  
Georgia Karpathiou ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Pregnant Woman ◽  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
Epithelioid Hemangioendothelioma ◽  
Low Grade ◽  
High Grade ◽  
Unique Case ◽  
Uterine Corpus ◽  
Vascular Neoplasms

With the exception of leiomyomas, soft tissue tumors of the uterine corpus are not common. This is particularly true for vascular neoplasms, with the epithelioid hemangioendothelioma being a curiosity; not more than twenty-two cases of malignant hemangioendotheliomas have been reported in the literature so far, all of which were high-grade hemangioendotheliomas (hemangiosarcomas). We present herewith a unique case of low-grade epithelioid hemangioendothelioma of the uterus in a pregnant woman aged 29 years. The clinical, histological, and immunohistochemical characteristics of this entity, together with its differential diagnosis, are discussed.

scholarly journals Undifferentiated pleomorphic sarcoma: Diagnosis of exclusion

2017 ◽  
Vol 03 (02) ◽  
pp. 133-135
Author(s):  
Pragati S. Upasham ◽  
Sharayu P. Dighavkar ◽  
Prakash M. Roplekar
Keyword(s):  
Soft Tissue ◽  
Lower Extremity ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Soft Tissue Tumors ◽  
High Grade ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Malignant Soft Tissue Tumors ◽  
Pleomorphic Sarcoma ◽  
Malignant Soft Tissue

AbstractMalignant soft-tissue tumors which were designated as malignant fibrous histiocytoma are regrouped by the WHO (in 2002) under the new entity termed as “undifferentiated pleomorphic sarcoma.”1 It accounts for less than 5% of all adult soft-tissue sarcomas. Here, we report the lesion in a 70-year-old man who presented with high-grade undifferentiated pleomorphic sarcoma in the lower extremity.

Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

1973 ◽  
Vol 31 ◽  
pp. 404-405
Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Tumor Tissue ◽  
Soft Tissue Tumors ◽  
Clinical Usefulness ◽  
Electron Microscopic ◽  
Normal Cells ◽  
Electron Microscopic Autoradiography ◽  
Peritoneal Cells ◽  
Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

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