Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways

BACKGROUND: Recent clinical studies have suggested that γ-glutamyltransferase (γ-GT) can trigger oxidative stress within the plaque. This study aimed to investigate whether serum γ-GT might be as a risk factor of coronary heart disease (CHD), and measure the associations of serum γ-GT with high sensitive C-Reactive Protein (hs-CRP), Oxidized LDL (Ox-LDL) and Glutathione Peroxidase (GPx).METHODS: This study recruited 48 patients aged 30-70 year who underwent coronary angiography at Haji Adam Malik Medical Center at Medan between February and April 2008 and who presented at least one coronary stenosis of > 50% of the luminar diameter. The sample subjects were consecutively selected.RESULTS: γ-Glutamyltransferase was positively associated (r = 0.546) with hs-CRP as a marker of chronic inflammation after careful adjustment for other established risk factors in CHD patient. But, there was no significant difference between γ-GT in male and female patients. Further, there were no correlations between γ-GT and Ox-LDL and GPx. Ratio of γ-GT/GPx was measured as well, and it was associated with hs-CRP.CONCLUSIONS: Ratio of γ-GT/GPx was associated with inflammation process in coronary heart disease patients.KEYWORDS: γ-glutamyltransferase (γ-GT), inflammation, oxidative stress, coronary heart disease

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The Role of Traditional Chinese Medicine in the Regulation of Oxidative Stress in Treating Coronary Heart Disease

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/3231424 ◽

2019 ◽

Vol 2019 ◽

pp. 1-13 ◽

Cited By ~ 15

Author(s):

Xinyu Yang ◽

Tianmai He ◽

Songjie Han ◽

Xiaoyu Zhang ◽

Yang Sun ◽

...

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Antioxidant Treatment ◽

Molecular Systems ◽

Artery Disease ◽

Signal Activation

Oxidative stress has been closely related with coronary artery disease. In coronary heart disease (CHD), an excess of reactive oxygen species (ROS) production generates endothelial cell and smooth muscle functional disorders, leading to a disequilibrium between the antioxidant capacity and prooxidants. ROS also leads to inflammatory signal activation and mitochondria-mediated apoptosis, which can promote and increase the occurrence and development of CHD. There are several kinds of antioxidative and small molecular systems of antioxidants, such as β-carotene, ascorbic acid, α-tocopherol, and reduced glutathione (GSH). Studies have shown that antioxidant treatment was effective and decreased the risk of CHD, but the effect of the treatment varies greatly. Traditional Chinese medicine (TCM) has been utilized for thousands of years in China and is becoming increasingly popular all over the world, especially for the treatments of cardiovascular diseases. This review will concentrate on the evidence of the action mechanism of TCM in preventing CHD by modulating oxidative stress-related signaling pathways.

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Enhanced oxidative stress in coronary heart disease and chronic heart failure as indicated by an increased 8-epi-PGF2α

European Journal of Heart Failure ◽

10.1016/j.ejheart.2004.05.007 ◽

2005 ◽

Vol 7 (2) ◽

pp. 167-172 ◽

Cited By ~ 40

Author(s):

Roswitha Wolfram ◽

Anthony Oguogho ◽

Barbara Palumbo ◽

Helmut Sinzinger

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Coronary Heart Disease ◽

Heart Disease ◽

Chronic Heart Failure

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Effect of smoking on the state of vascular endothelium, the severity of oxidative stress and inflammatory activation in patients with a combination of bronchial asthma and coronary heart disease

Profilakticheskaya meditsina ◽

10.17116/profmed202023011100 ◽

2020 ◽

Vol 23 (1) ◽

pp. 100

Author(s):

L.P. Voronina ◽

I.V. Sevost'yanova ◽

E.A. Polunina ◽

O.S. Polunina

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Bronchial Asthma ◽

Vascular Endothelium ◽

The State ◽

Inflammatory Activation

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Increased Plasma Markers of Oxidative Stress Are Associated with Coronary Heart Disease in Males with Diabetes Mellitus and with 10-Year Risk in a Prospective Sample of Males

Clinical Chemistry ◽

10.1373/clinchem.2005.060194 ◽

2006 ◽

Vol 52 (3) ◽

pp. 446-452 ◽

Cited By ~ 61

Author(s):

Jeffrey W Stephens ◽

David R Gable ◽

Steven J Hurel ◽

George J Miller ◽

Jackie A Cooper ◽

...

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Coronary Heart Disease ◽

Heart Disease ◽

Oxidized Ldl ◽

Total Antioxidant Status ◽

Cross Sectional ◽

Chd Risk ◽

Markers Of Oxidative Stress ◽

Plasma Markers

Abstract Background: Increased oxidative stress is associated with coronary heart disease (CHD). We examined the association between plasma markers of oxidative stress and CHD in a cross-sectional sample of patients with diabetes and prospective CHD risk in a sample of men predominantly without diabetes. Methods: Plasma total antioxidant status (TAOS) and the ratio of oxidized LDL (Ox-LDL) to LDL-cholesterol (LDL-C) were determined in a cross-section of 761 Caucasian individuals with diabetes (UDACS study). Plasma TAOS was also determined in 310 baseline samples from a 10-year prospective cohort of 3012 healthy males (NPHSII). Results: Within UDACS, males with CHD had lower mean (SD) plasma TAOS [no CHD, 43.4 (13.2)%; CHD, 40.3 (13.8)%; P = 0.04]. The prevalence of CHD was higher in the lowest compared with the upper quartiles (32.7% vs 19.7%; P = 0.004). We observed a significant association between plasma Ox-LDL:LDL-C and CHD status [no CHD vs CHD, 16.9 (3.1) vs 19.3 (5.0) units/mmol; P = 0.04], with the prevalence of CHD being higher among men in the upper compared with lower quartiles (18.4% vs 35.1%; P = 0.003). No association was observed in females. In NPHSII, TAOS was lower in those who developed CHD [35.1 (8.0)% vs 37.1 (7.9)%; P = 0.04]. The odds ratio for CHD in the lowest compared with the upper quartile was 1.91 (95% confidence interval, 0.99–3.70; P = 0.04). This remained unchanged after adjustment for classic risk factors. Conclusions: A cross-sectional and prospective association exists between baseline plasma measures of oxidative stress and CHD risk. The association with prospective CHD risk remained after adjustment for “traditional” risk factors, implying an independent role for oxidative stress in CHD risk.

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Oxidized LDL and the Risk of Coronary Heart Disease: Results from the MONICA/KORA Augsburg Study

Clinical Chemistry ◽

10.1373/clinchem.2011.165134 ◽

2011 ◽

Vol 57 (8) ◽

pp. 1196-1200 ◽

Cited By ~ 50

Author(s):

Wolfgang Koenig ◽

Mahir Karakas ◽

Astrid Zierer ◽

Christian Herder ◽

Jens Baumert ◽

...

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Smoking Status ◽

Oxidized Ldl ◽

Critical Role ◽

Source Population ◽

Parental History ◽

Increased Risk ◽

Lipid Parameters

BACKGROUND Oxidative stress plays a critical role in the initiation and progression of atherosclerosis. Oxidized LDL (oxLDL) is a marker of oxidative stress. We prospectively investigated whether increased serum oxLDL concentrations are associated with incident coronary heart disease (CHD). METHODS We conducted a prospective population-based case–cohort study within the MONICA/KORA Augsburg studies. Serum oxLDL concentrations were measured in 333 case individuals with incident CHD and in 1727 noncase individuals selected from a source population of 9300 middle-aged, healthy men and women. The mean (SD) follow-up time was 10.8 (4.6) years. RESULTS Baseline oxLDL concentrations were higher in case individuals than in noncase individuals (P < 0.001). After adjustment for age, sex, survey, smoking status, systolic blood pressure, physical activity, diabetes, body mass index, parental history of myocardial infarction, and alcohol consumption, the hazard ratio (HR) for comparing the first and third tertiles was 1.87 (95% CI, 1.33–2.64; P < 0.001). Additional adjustment for lipid parameters, inflammatory markers, and markers of endothelial dysfunction attenuated the association (HR, 1.29; 95% CI, 0.88–1.89; P = 0.087). We observed no significant interactions between oxLDL and sex or being overweight. CONCLUSIONS Increased oxLDL concentrations were associated with an increased risk for incident CHD. Nevertheless, because this effect became nonsignificant after adjustment for covariates, particularly the ratio of total cholesterol to HDL cholesterol, it may be mediated primarily by lipid parameters. Further studies are warranted to clarify this issue.

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Lipid Peroxidation Product and Glutathione Levels in Patients with Coronary Heart Disease Before and After Surgery

Galen Medical Journal ◽

10.31661/gmj.v4i2.316 ◽

2015 ◽

Vol 4 (2) ◽

pp. 78-82

Author(s):

Rahman Khansha ◽

Behnoosh Miladpour ◽

Zohreh Mostafavi-Pour ◽

Fatemeh Zal

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Ischemia Reperfusion ◽

Artery Bypass ◽

Bypass Graft ◽

Lipid Peroxidation Product ◽

Cabg Surgery ◽

Significant Difference ◽

Before And After

Background: It has been reported that ischemia-reperfusion is associated with augmentation of oxidative stress and its specific and sensitive markers. Oxidative stress may cause atrial fibrillation (AF) which is a common consequence after cardiac surgery. Dietary supplementation with antioxidants might lower the incidence of AF following coronary artery bypass graft (CABG) surgery. Materials and Methods: Fifty patients with coronary heart disease (CHD) referred to Namazi and Faghihi Hospitals in Shiraz, undergone elective CABG, were enrolled in this study. For evaluation of oxidative stress, whole blood was taken before and 24 hours after surgery and malondialdehyde (MDA) as an oxidative marker and glutathione (GSH) as an antioxidant marker were measured. Results: Results showed a significant difference between the mean concentration of GSH before and after CABG surgery (P <0.05); however, the difference in plasma MDA levels before and after CABG was insignificant. Conclusion: CABG surgery results in oxidative stress and reduces GSH 24h after surgery and administration of antioxidants may attenuate post-operative oxidative stress. [GMJ.2015;4(2):78-82]

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Genderspecific differences of homocysteinemia and its influence on oxidative stress parameters and endothelial function in patients with stable forms of coronary heart disease

Clinical Medicine (Russian Journal) ◽

10.18821/0023-2149-2017-95-8-705-712 ◽

2017 ◽

Vol 95 (8) ◽

pp. 705-712

Author(s):

Olga L. Belaya ◽

K. Yu. Bondar ◽

L. I. Markova ◽

Z. V. Kuropteva ◽

L. M. Baider ◽

...

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Coronary Heart Disease ◽

Heart Disease ◽

Endothelial Dysfunction ◽

Endothelial Function ◽

Gas Liquid Chromatography ◽

Men And Women ◽

Stable Forms ◽

Gender Specific

One of the early manifestations of atherosclerotic lesions is endothelial dysfunction developing under conditions of reduced nitric oxide production, hyperhomocysteinemia, and oxidative stress. Bearing in mind high interest shown to gender-specific peculiarities of cardiovascular diseases, it appears important to study the relationship between these features in men and women with stable forms of coronary heart disease (CHD). Material and methods. The study included 102 patients with sable COPD divided into 2 groups (men and women) and 40 practically healthy subjects. Plasma homocysteine levels were measured by high-resolution gas-liquid chromatography with fluorescent detector with the use of Eko-Novo Milikhrom A-02 apparatus (Russia). Standard methods were used to measure plasma lipids, products of their peroxidation (dienic conjugates and products reacting with 2-thibarbituric acid), antioxidant enzymes (glutathioneperoxidase, and superoxide dismutase in erythrocytes), activity of the ceruloplasmin-transferrin system (by electron paramagnetic resonance method), final metabolites of nitric oxide using the Gries reaction. The endothelial function was studies by ultrasound with the evaluation of endothelium-dependent vasodilation. Results. The mean levels of homocystein and final NO metabolites in men with stable CHD were 1.5 times higher (р=0,01) and 12% lower (р = 0,03) than in women. Endothelial dysfunction was more pronounced in men (р< 0,05). Conclusion. Patients with CHD exhibit significant gender-specific differences in blood levels of of homocystein and final NO metabolites as well as in endothelium-dependent vasoreactivity associated with intensification of lipid peroxidation and impairment of antioxidative protection.

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