Analysis of invasion-metastasis mechanism in pancreatic cancer: involvement of tight junction transmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation

2004 ◽  
Author(s):  
Xiaodong Tan ◽  
Yasuhiro Tamori ◽  
Hiroshi Egami ◽  
Shinji Ishikawa ◽  
Takashi Kurizaki ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Signal Transduction ◽  
Tight Junction ◽  
Cancer Cell ◽  
Transmembrane Protein ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Cell Dissociation

Analysis of the signal transduction pathway in relation to invasion and metastasis in pancreatic cancer

2003 ◽  
Vol 1255 ◽  
pp. 307-311
Author(s):  
H. Egami ◽  
X. Tan ◽  
T. Kurizaki ◽  
S. Ishikawa ◽  
N. Hayashi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Signal Transduction ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Invasion And Metastasis

scholarly journals A Genetic Analysis of Glucocorticoid Receptor Signaling: Identification and Characterization of Ligand-Effect Modulators in Saccharomyces cerevisiae

Genetics ◽  
2000 ◽  
Vol 156 (3) ◽  
pp. 963-972
Author(s):  
Raquel Sitcheran ◽  
Roger Emter ◽  
Anastasia Kralli ◽  
Keith R Yamamoto
Keyword(s):  
Signal Transduction ◽  
Glucocorticoid Receptor ◽  
Cellular Response ◽  
Transmembrane Protein ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Ligand Effect ◽  
Yeast Genetic ◽  
Identification And Characterization

Abstract To find novel components in the glucocorticoid signal transduction pathway, we performed a yeast genetic screen to identify ligand-effect modulators (LEMs), proteins that modulate the cellular response to hormone. We isolated several mutants that conferred increased glucocorticoid receptor (GR) activity in response to dexamethasone and analyzed two of them in detail. These studies identify two genes, LEM3 and LEM4, which correspond to YNL323w and ERG6, respectively. LEM3 is a putative transmembrane protein of unknown function, and ERG6 is a methyltransferase in the ergosterol biosynthetic pathway. Analysis of null mutants indicates that LEM3 and ERG6 act at different steps in the GR signal transduction pathway.

Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway

2011 ◽  
Vol 308 (2) ◽  
pp. 162-171 ◽  
Author(s):  
Mei-Chuan Tang ◽  
Li-Chuan Chan ◽  
Yi-Chen Yeh ◽  
Cheng-Yu Chen ◽  
Teh-Ying Chou ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Signal Transduction Pathway ◽  
Colon Cancer Cell ◽  
Cancer Cell Migration ◽  
Transduction Pathway ◽  
Thymosin Beta 4

scholarly journals Correlation of tight junction protein-2 expression and localization with pancreatic cancer cell dissociation

2010 ◽  
Vol 18 (15) ◽  
pp. 1537
Author(s):  
Xiao-Dong Tan ◽  
Lei Zhou ◽  
Wei Wang ◽  
Bao-Sheng Wang ◽  
Jin-Gang Liu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tight Junction ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Tight Junction Protein ◽  
Cell Dissociation ◽  
Junction Protein
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