scholarly journals Melatonin and Epilepsy

Folia Medica ◽  
2021 ◽  
Vol 63 (6) ◽  
pp. 827-833
Author(s):  
Zdravka Vasileva
Keyword(s):  
Neurological Disease ◽  
Experimental Models ◽  
Glutamate Excitotoxicity ◽  
Anticonvulsant Effect ◽  
Social Significance ◽  
Melatonin Concentration ◽  
Medical Risk ◽  
The Social ◽  
Growth And Aging ◽  
Patients With Epilepsy

Epilepsy is a chronic neurological disease with recurrent seizures. Its incidence, the social and psychological aspects of epilepsy-associated stigmatization in society, the medical risk of severe seizures, and the challenges in treatment confirm its medical and social significance. The pathogenesis of the diseases is associated with abnormal activity of a population of neurons due to various mechanisms, the most frequent being oxidative stress, glutamate excitotoxicity, and mitochondrial dysfunction. In the last 3-4 decades, the possible connection between epilepsy and melatonin – a neurohormone secreted by the pineal gland – has been sought and studied. Various physiological functions of melatonin in humans have been proven – regulation of circadian rhythms (diurnal, seasonal), sleep and wakefulness, participation in the processes of thermoregulation, tumour growth and aging, sexual activity and reproductive functions. It also has immunomodulatory, cytoprotective and antioxidant activity. The results from the studies with experimental models with animals conducted so far in search of a correlation between melatonin and epileptogenesis are mainly in support of the hypothesis of its anticonvulsant effect. The studies with humans are diverse in design, with a smaller number of participants, and the results are not always in explicit support of this hypothesis. The correlation between melatonin concentration and the course of the disease in patients with epilepsy has been discussed. The possibility of adding melatonin to anti-epileptic therapy has also been studied recently.

V.V. Rozanov Among Parties and Politicians

2019 ◽  
Vol 60 ◽  
pp. 165-170
Author(s):  
Aleksey V.  Lomonosov
Keyword(s):  
The Political ◽  
Editorial Office ◽  
Social Significance ◽  
Political Ideas ◽  
Political Journalism ◽  
Political Views ◽  
The Social ◽  
The Press ◽  
Journal Editorial ◽  
Political Essays

The article reveals the social significance of determining the political views of V.V. Rozanov in the system of the thinker’s worldview. The correlation of these views with his political journalism is shown. The genesis of social and political ideas of V.V. Rozanov is revealed. The author specifies his ideological predecessors in the sphere of public thought of the late 19th century and the thinker’s affiliation with the conservative political camp of Russian writers. The author of the article also gives coverage of the V.V. Rozanov’s polemical publications in the press. He outlines the circle of political sympathies and determinative constants in the political views of Rozanov-publicist and proves his commitment to the centrist political parties. The author examines the process of Rozanov’s socio-political views evolution at the turn of the 19th–20th centuries, and the related changes in his political journalism. The evaluations are based on the large layer of Rozanov’s newspaper publicism in the years of 1905–1917. To determine the Rozanov’s position in the “New time” journal editorial office and to reveal the motives of his political essays the author of the article used epistola

LEGAL ESSENCE OF ANCIENT PROVERBS AND SAYS AND THEIR SOCIAL SIGNIFICANCE

2020 ◽  
Author(s):  
Angela Dranishnikova ◽  
Ivan Semenov
Keyword(s):  
Public Sphere ◽  
Rule Of Law ◽  
Social Significance ◽  
The Rule Of Law ◽  
The Public ◽  
Moral Standards ◽  
The Social ◽  
The Law ◽  
The Public Sphere ◽  
Status Position

The national legal system is determined by traditional elements characterizing the culture and customs that exist in the social environment in the form of moral standards and the law. However, the attitude of the population to the letter of the law, as a rule, initially contains negative properties in order to preserve personal freedom, status, position. Therefore, to solve pressing problems of rooting in the minds of society of the elementary foundations of the initial order, and then the rule of law in the public sphere, proverbs and sayings were developed that in essence contained legal educational criteria.

The Social Significance of Mobility: An Omaha Study

1950 ◽  
Vol 55 (6) ◽  
pp. 559-564 ◽  
Author(s):  
T. Earl Sullenger
Keyword(s):  
Social Significance ◽  
The Social

Citizen sociolinguists scaling back

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Betsy Rymes ◽  
Gareth Smail
Keyword(s):  
Social Meaning ◽  
Social Significance ◽  
Communicative Practices ◽  
Everyday Language ◽  
Fine Grained ◽  
Multilingual Communication ◽  
The Social ◽  
Linguistic Practices ◽  
Over Time

AbstractThis paper examines the different ways that professional experts and everyday language users engage in scaling practices to claim authority when they talk about multilingual practices and the social significance they assign to them. Specifically, we compare sociolinguists’ use of the term translanguaging to describe multilingual and multimodal practices to the diverse observations of amateur online commentators, or citizen sociolinguists. Our analysis focuses on commentary on cross-linguistic communicative practices in Wales, or “things Welsh people say.” We ultimately argue that by calling practices “translanguaging” and defaulting to scaled-up interpretations of multilingual communication, sociolinguists are increasingly missing out on analyses of how the social meaning of (cross)linguistic practices accrues and evolves within specific communities over time. By contrast, the fine-grained perceptions of “citizen sociolinguists” as they discuss their own communicative practices in context may have something unique and underexamined to offer us as researchers of communicative diversity.

Two Social Environments in a Working Day: Occupation and Spatial Segregation in Metropolitan Tel Aviv

10.1068/a3452 ◽  
2001 ◽  
Vol 33 (10) ◽  
pp. 1765-1784 ◽  
Author(s):  
Orna Blumen ◽  
Iris Zamir
Keyword(s):  
Social Environment ◽  
Spatial Segregation ◽  
Social Environments ◽  
Social Significance ◽  
Tel Aviv ◽  
Blue Collar Workers ◽  
The Social ◽  
White Collar Workers ◽  
Working Day ◽  
And Gender

The concepts of segregation and social distance have long been used to explain the social environment of stratified residential space. However, the social significance of occupation, though acknowledged, has rarely been applied spatially. In this study, we employed these three concepts to examine the social environment of the entire metropolitan employment space as defined by job location. Smallest space analysis was used to identify and compare the sociospatial segregation produced by workers' occupational distribution in employment and residential spheres. This empirical study focused on metropolitan Tel Aviv, Israel's largest urban area, using the latest available national census. Our findings show that the social milieu of employment differed from that of residence: blue-collar workers were segregated from white-collar workers; managers, clerks, and salespersons formed the core group; and gender and ethnic divisions characterised the sociospatial realm of employment. Overall, most employees changed their social environment when they went to work. The study indicates that spatial segregation, within each sphere and between the two spheres, is intrinsic to the capitalist – patriarchal order.

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