scholarly journals Effect of esomeprazole on lipid profile in patients with peptic ulcer

Pharmacia ◽  
2021 ◽  
Vol 68 (3) ◽  
pp. 613-617
Author(s):  
Eman Abdullah ◽  
Sarraa Dhiaa ◽  
Khalaf Saleh ◽  
Marwan Merkhan
Keyword(s):  
Peptic Ulcer ◽  
Lipid Metabolism ◽  
Side Effects ◽  
Lipid Profile ◽  
Total Cholesterol Level ◽  
Healthcare Providers ◽  
Pharmacokinetic Profile ◽  
Healthy Individuals ◽  
The Impact

Esomeprazole; a newly introduced PPI has been widely prescribed by healthcare providers due to its improved pharmacokinetic profile. Most users could have other diseases and the PPIs are indicated as acid-suppressor to minimize gastric side effects of polypharmacy. A high percentage of users could suffer from cardiovascular diseases and lipid dysmetabolism. Hence, this study was designed to determine the impact of long-term use of esomeprazole on lipid profile in a normal subject other than having peptic ulcer for which esomeprazole has been indicated. Results confirmed that esomeprazole reduced triglyceride and HDL levels and elevated total cholesterol level and correspondingly LDL level was elevated, however, no effect was noticed with VLDL. To sum up, esomeprazole impaired lipid metabolism in apparently normal healthy individuals apart from having peptic ulcer for which the esomeprazole was indicated, this finding rise a caution during prescribing esomeprazole for the patient with multiple diseases and polypharmacy including cardiovascular ailments.

scholarly journals Clinical Investigations of the Effect of Citrus unshiu Peel Pellet on Obesity and Lipid Profile

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Seongil Kang ◽  
Sangyeol Song ◽  
Joosang Lee ◽  
Hyekyung Chang ◽  
Sanghun Lee
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Weight Control ◽  
Large Scale ◽  
Total Cholesterol Level ◽  
Experimental Studies ◽  
Density Lipoprotein ◽  
Citrus Unshiu ◽  
The Impact

Objectives. Several experimental studies have reported antiobesity and lipid-improving effects of Citrus unshiu. However, clinical studies on its effects are lacking. This study was designed to evaluate the impact of Citrus unshiu peel pellet (CUPP) on obesity and lipid profile. Methods. For 118 patients with body mass index (BMI) > 23 who took Citrus unshiu peel pellet (CUPP) for 4 weeks in a Public Health Center, laboratory and biometric readings before and after CUPP administration were analyzed. Results. Mean age of these subjects was 53.8±10.6 years (range: 18-75 years). There were 88 (74.6%) females in the study sample (n = 118). A significant (p < 0.01) decrease in BMI from 27.47±2.24 to 27.27±2.22 was observed in all subjects after CUPP treatment and 65.3% (N = 77) of them lost 1.03±0.83 kg of weight after 4 weeks of treatment. Total cholesterol level was significantly (p < 0.01) decreased from 204.0±37.4 mg/dL to 193.5±36.5 mg/dL. Significant (p < 0.05) decreases in levels of low-density lipoprotein, cholesterol, and triglyceride were also observed. Conclusions. These results suggest that CUPP in practice could help weight control and improve total cholesterol level. Findings of this study provide clinical foundation for future large-scale trials to establish clinical benefits of CUPP.

scholarly journals Coronavirus Pandemic: Coping with the Psychological Outcomes, Mental Changes, and the “New Normal” During and After COVID-19

2020 ◽  
pp. 07-19
Author(s):  
Hiba Takieddine ◽  
Samaa AL Tabbah
Keyword(s):  
Healthcare Providers ◽  
Well Being ◽  
World Health ◽  
Vulnerable Groups ◽  
Public Health Response ◽  
New Normal ◽  
The World ◽  
Health Organization ◽  
The Impact

Coronavirus disease 2019 (COVID-19) is a highly infectious disease that has rapidly swept across the world, inducing a considerable degree of fear, worry and concern in the population at large and among certain groups in particular, such as older adults, healthcare providers and people with underlying health conditions. Authorities around the world tried to prevent the virus spread by imposing social distancing measures, quarantining citizens and isolating infected persons. Apart from its physical impact, COVID-19 pandemic has brought numerous changes to people’s lives. It changed daily routines, caused worldwide economic crisis, increased unemployment, and placed people under emotional and financial pressures. It affected people psychologically and mentally especially in terms of emotions and cognition. During the acute crisis, everyone to varying degrees experienced fear of infection, somatic concerns, worries about the pandemic’s consequences, loneliness, depression, stress, as well as increased alcohol and drug use. As part of its public health response, the World Health Organization (WHO) has worked with partners to develop a set of new guidelines and messages that can be used to prevent, manage, and support mental and psychological well-being in different vulnerable target groups during the outbreak. Whether people like it or not, the psychological sequela of this pandemic will emerge and persist for months and years to come leading to long-term consequences. New lifestyles and “New Normals” will surely emerge. The main purpose of this review is to summarize the impact of coronavirus pandemic on the psychological and mental health of people around the world especially vulnerable groups. It also presents the relevant intervention actions and recommendations to cope efficiently and effectively with the psychological short-term and long-term outcomes, mental changes, and the “New Normal” during and after COVID-19. Keywords: COVID-19; Coronavirus, Psychological; Mental; New Normal

Manipulation of fishing effort in Australia's penaeid Prawn Fisheries

1990 ◽  
Vol 41 (1) ◽  
pp. 1 ◽  
Author(s):  
IF Somers
Keyword(s):  
Side Effects ◽  
Great Barrier Reef ◽  
Simulation Model ◽  
Fishing Effort ◽  
Regulatory Mechanisms ◽  
Barrier Reef ◽  
Restrictive Measures ◽  
The Impact ◽  
Term Management

The potentially detrimental side-effects of prawn trawling are coming under increasing scrutiny in Australian waters, particularly in such ecologically sensitive areas as Queensland's Great Barrier Reef, and various restrictive measures are being suggested. Before changes are imposed on the prawning industry, the effects of trawling on the target prawn species and the long-term management of these effects need to be fully understood. Using a simulation model of a simplified prawn fishery, this paper describes the basis for the current regulatory mechanisms for Australian's prawn fisheries, in particular the manipulation of both the level and pattern of fishing effort. It is shown that even in moderately fished stocks, the fishery manager has several options, such as seasonal and nursery area closures, that are consistent with the goal of minimizing the impact of prawn trawling, while in no way penalizing the industry economically. With these in mind, possible ways of resolving or reducing the conflict with groups outside the prawning industry are discussed.

Impact of Extracorporeal Photochemotherapy on the Clinical and Economical Management of Patients Affected with GVHD.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 5293-5293
Author(s):  
Cesare Perotti ◽  
Paola Isernia ◽  
Claudia Del Fante ◽  
Gianluca Viarengo ◽  
Daniela Bressan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Cost Analysis ◽  
Short Form ◽  
Extracorporeal Photochemotherapy ◽  
Short Period ◽  
The Impact ◽  
Economical Advantage

Abstract Extracorporeal photochemotherapy (ECP) is an effective, relatively new technique, FDA approved for cutaneous T-cell lymphoma, employed as second-third line treatment in patients affected with GVHD not or poorely responsive to standard immunosuppressive drugs. Both aGVHD and cGVHD are the major complications after stem cell transplantation (till to 50% and 80% of the patients, respectively). Corticosteroids, cyclosporine, micofenolate, tacrolimus and various experimental monoclonal antibodies (anti CD40 ligand, anti TNFα etc) are the drugs employed to control GVHD and are burdened with important short and long term side effects. Recently we revised our data about 102 pts (children and adults) treated by ECP in our Institution. The overall response was 75%, permitting to taper or suspend the immunosuppressive therapy (IST) in 67.6% of the pts. The economical and social impact (cost analysis and quality of life) of ECP vs standard IST was calculated basing on the National Price List and on Short Form Quality of Life (QoL) Scoring System. The cost of ECP comprehensive of the leukapheresis procedure, waste matherials and dedicated personnel was estimated as 684.51 Euro/procedure. On the other side, when the solely costs of the most common IST drugs (corticosteroids, cyclosporine) were considered for 5 months of treatment, an evident and obvious economical advantage emerged (120,3 E). On the contrary, when the costs of hospitalisation and day hospital regimen derived from the most common side effects related to the solely use of IST were included in our cost analysis studies, an economical advantage for long term ECP treatment (calculated on 16 procedures) was demonstrated (14952.16 E vs 17553 E). Moreover, when the “real life implication” calculated on the QoL parameters were considered, the advantages were more evident. In conclusion, the tie of respecting strictly an imposed program of budget calculated on the short period may exert an inhibitory effect in introducing new diagnostic or therapeutic procedures ignoring that the improvement or the cure of the patient has always a positive economical counterpart, expecially when the impact of a new technology is considered in a long term view.

An Assessment of the Impact That Chemotherapy Treatment Has on Employment Status in Individuals with Lymphoma.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5492-5492
Author(s):  
Jeff Horn ◽  
Ann T. Shaw
Keyword(s):  
Side Effects ◽  
Hodgkin’S Lymphoma ◽  
Significant Proportion ◽  
Hodgkin's Lymphoma ◽  
Small Scale ◽  
Main Theme ◽  
Chemotherapy Treatment ◽  
Working Age ◽  
The Impact

Abstract A significant proportion of individuals undergoing treatment for lymphoma are of working age and are in employment prior to diagnosis and during subsequent chemotherapy treatment. This small-scale study seeks to explore the impact that chemotherapy treatments have on employment. Specifically, the reasons for the decision to continue to work or not, and any perceived benefits or disadvantages encountered as a result are explored. Methods: All individuals presenting with newly diagnosed lymphoma, over a 12 month period, were identified retrospectively. Individuals of official working age, and who were receiving out-patient chemotherapy (i.e. who had the ability to be working at the time) were invited to participate. Participants were asked to complete a questionnaire that was designed to explore their experiences of employment during this time. Results: A total of 33 patients were invited to participate. A return rate of 70% was achieved. Of those who responded, 5 (22%) had already retired prior to diagnosis. A total of 12 patients (52%) continued to work during their chemotherapy treatment. Of these, 6 (50%) continued to work the same hours in the same conditions, whereas 6 (50%) worked an altered or flexible pattern. 6 patients (26%) stopped working for the duration of treatment, one of whom has not returned since. There were no obvious differences in patients with Hodgkin’s Lymphoma as opposed to Non-Hodgkin’s Lymphoma. The response rate was much higher in those who had received intravenous chemotherapy than oral preparations, preventing analysis of any potential variation in experiences. The qualitative data obtained gives a clearer insight into the many issues faced by the patient when undergoing chemotherapy treatment. Familiar themes were identified in many cases, and these were grouped into 5 main theme categories: Diversion from the reality of diagnosis and treatment Psychological Issues Issues of retained normality Practical Issues Physical or medical issues. Difficulty in coping with the side-effects of treatment, particularly fatigue, were commonly cited. Emotional effects such as stress and anxiety were also alluded to. Despite this, those who continued to work reported benefit from retaining a normal lifestyle, gained support from co-workers and experienced a diversion of focus from treatment. Several of those who continued to work cited financial reasons for this decision. Feedback suggested that advice given by the health-care team was often lacking or inconsistent. This did not reflect our perception of current practice, so it may suggest that it is the way that information is given that is ineffective. Conclusion: The majority of patients continued to work during their treatment and there appear to be many benefits to this. Difficulties encountered related mainly to treatment side-effects, logistical and practical problems associated with undergoing chemotherapy. It is envisaged that a greater understanding of the impact that lymphoma and its treatment has on employment may improve the level of support that can be offered by the multi-disciplinary team. The curative nature of many Lymphomas demands that long-term complications of the disease and treatment are fully addressed at the time of diagnosis. Social, economic and employment welfare are integral aspects to be considered, especially in a group of individuals who are likely to be long-term survivors.

Treatment of Post-operative Inflammation following Cataract Surgery – A Review

2012 ◽  
Vol 06 (02) ◽  
pp. 98 ◽  
Author(s):  
Harminder S Dua ◽  
Richa Attre ◽  
◽  
Keyword(s):  
Side Effects ◽  
Adverse Events ◽  
Cataract Surgery ◽  
Healthcare Providers ◽  
Surgical Techniques ◽  
Ocular Inflammation ◽  
Effective Control ◽  
Loteprednol Etabonate ◽  
Design Modification

Inflammation after cataract surgery, which can be persistent, remains an undesirable consequence despite many advances in surgical techniques. Although corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) have traditionally been used to treat inflammation, prophylactically as well as post-operatively, there are no established guidelines for the treatment of inflammation induced by cataract surgery. The long-term use of corticosteroids has raised safety concerns, especially with regard to elevated intraocular pressure (IOP). This limitation of traditional corticosteroids led to the development of C-20 ester corticosteroids through retrometabolic drug design. This design modification allows the corticosteroid to be active at its site of action and then undergo predictable hydrolysis to inactive metabolites, resulting in reduced side effects. A review of studies published in the last 10 years indicates that C-20 ester corticosteroids provide effective control of post-cataract surgery inflammation without the elevation of IOP. Loteprednol etabonate ophthalmic suspension 0.5 % is the only topical C-20 ester corticosteroid approved for use in the treatment of corticosteroid-responsive inflammatory conditions including post-operative ocular inflammation. This corticosteroid, alone or in combination with NSAIDs, may provide effective and safe inflammation control, especially for high-risk patients, and may overcome concerns regarding side effects associated with traditional C-20 ketone corticosteroids. Ocular inflammation after cataract surgery presents healthcare providers with a treatment dilemma. While corticosteroids are traditionally the therapy of choice for inflammation, their long-term use for managing ocular inflammation can produce significant adverse events. This article discusses whether C-20 ester corticosteroids, alone or in combination with NSAIDs, offer effective treatment of post-cataract surgery inflammation while minimising adverse events.

scholarly journals The impact of side effects on long-term retention in three new antiepileptic drugs

Seizure ◽  
2009 ◽  
Vol 18 (5) ◽  
pp. 327-331 ◽  
Author(s):  
Hans P. Bootsma ◽  
Lukas Ricker ◽  
Yechiel A. Hekster ◽  
Jacques Hulsman ◽  
Danielle Lambrechts ◽  
...  
Keyword(s):  
Side Effects ◽  
Antiepileptic Drugs ◽  
New Antiepileptic Drugs ◽  
Term Retention ◽  
Long Term Retention ◽  
The Impact

scholarly journals Impact Of Pragya Yoga Exercise On Lipid Profile Among Overweight Women

2017 ◽  
Vol 9 ◽  
pp. 11-17
Author(s):  
Riddhi Sahu
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol Level ◽  
Low Density Lipoprotein ◽  
Age Groups ◽  
Density Lipoprotein ◽  
Significant Elevation ◽  
Overweight Women ◽  
The World ◽  
The Impact ◽  
Total Triglyceride

Obesity is defined as abnormal or excessive fat accumulation that presents risks for many other disorders. It is affecting populations across the world in all age groups which may be caused due to unhealthy lifestyles or genetic predisposition. The present study was conducted to assess the impact of pragya-yoga exercise (a defined set of 16 yogic postures) on lipid profile among overweight women. 30 overweight women (BMI>25kg/m) were selected from the polyclinic of Dev Sanskriti university Haridwar, with their ages ranging from 30 to 50 years (group average age ±S.D., 38.37±5.52 years). All participants practiced Pragya Yoga exercise for 40 minutes on each day for eight weeks under supervision of a female yoga therapist. Data was analyzed using paired sample t-test. There were statistically significant reduction in total cholesterol level(df=28, p<0.01), total triglyceride level(df=28, p<0.01), low density lipoprotein(df=29,p<0.01) and significant elevation in high density lipoprotein(df=29, p<0.01). The result suggests that Pragya-yoga practices are beneficial for the management of lipid profile among overweight women.

scholarly journals A genome-wide association study to identify candidate genes for metabolic disorders in offspring by in vitro fertilization

2021 ◽  
Author(s):  
Lihong Liu ◽  
Siyao Ha ◽  
Zhiling Li ◽  
MingQing Li
Keyword(s):  
Lipid Metabolism ◽  
In Vitro Fertilization ◽  
Health Risks ◽  
Genome Wide Association Study ◽  
Vitro Fertilization ◽  
A Genome ◽  
Offspring Health ◽  
The Impact

Abstract In vitro fertilization (IVF) processes increase offspring's short-term and long-term health risks, but their mechanisms remain unclear. We conducted a bibliometric analysis to determine the landscape of IVF offspring health. Subsequently, a bioinformatics method was utilized to identify the co-genes properties and biological function mechanisms of IVF and type 2 diabetes mellitus (T2DM). Finally, we predicted compounds against key targets and performed multiple validations of the mechanisms underlying IVF offspring health risks. We identified 15 genes associated with T2DM, and their biological functions are primarily associated with lipid metabolism. We also identified the properties of co-genes, modified characteristics, confirmed a conserved motif, identified 3 SNPs sites, and determined the three core genes, APOA1, APOB, and APOE, which were mainly correlated with metabolic and cardiovascular diseases. In addition, we predicted drugs that may improve metabolic abnormalities in IVF offspring. The impact of aberrant lipid metabolism in offspring after IVF therapy warrants additional investigation, particularly in terms of long-term health consequences and possible mechanisms.

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