Instruments Measuring Physical Function for Psoriatic Arthritis Endorsed at GRAPPA 2020 Annual Meeting: Updates of the GRAPPA-OMERACT Working Group

2021 ◽  
pp. jrheum.201679
Author(s):  
Ying Ying Leung ◽  
Ana-Maria Orbai ◽  
William Tillett ◽  
Alexis Ogdie ◽  
Lihi Eder ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Physical Function ◽  
Annual Meeting ◽  
Working Group ◽  
Structural Damage ◽  
Short Form ◽  
Core Outcome Set ◽  
Health Assessment ◽  
Working Groups ◽  
Set Up

The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)–Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis (PsA) Working Group provided updates at the 2020 GRAPPA annual meeting on its work toward developing a core outcome set for PsA. Working groups were set up for the 4 prioritized domains: enthesitis, fatigue, structural damage, and physical function. Two instruments for measurement of physical function were provisionally endorsed: (1) the Health Assessment Questionnaire–Disability Index and (2) the physical functioning domain in the Medical Outcomes Study 36-item Short Form survey.

Appraisal of Candidate Instruments for Assessment of the Physical Function Domain in Patients with Psoriatic Arthritis

2020 ◽  
Vol 48 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Ying Ying Leung ◽  
Ana-Maria Orbai ◽  
Alexis Ogdie ◽  
Pil Hojgaard ◽  
Richard Holland ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Physical Function ◽  
Outcome Measures ◽  
Physical Functioning ◽  
Working Group ◽  
Short Form ◽  
Outcome Measurement ◽  
Patient Reported Outcome Measures ◽  
Measurement Information ◽  
Patient Reported

Objective.Numerous patient-reported outcome measures (PROM) exist for the measurement of physical function for psoriatic arthritis (PsA), but only a few are validated comprehensively. The objective of this project was to prioritize PROM for measuring physical function for potential incorporation into a standardized outcome measurement set for PsA.Methods.A working group of 13 members including 2 patient research partners was formed. PROM measuring physical function in PsA were identified through a systematic literature review and recommendations by the working group. The rationale for inclusion and exclusion from the original list of existing PROM was thoroughly discussed and 2 rounds of Delphi exercises were conducted to achieve consensus.Results.Twelve PROM were reviewed and discussed. Six PROM were prioritized: Health Assessment Questionnaire (HAQ) and 4 modifications (HAQ-Disability Index, HAQ-Spondyloarthritis, modified HAQ, multidimensional HAQ), Medical Outcomes Study 36-item Short Form survey physical functioning domain, and the Patient-Reported Outcomes Measurement Information System (PROMIS) physical functioning module.Conclusion.Through discussion and Delphi exercises, we achieved consensus to prioritize 6 physical function PROM for PsA. These 6 PROM will undergo further appraisal using the Outcome Measures in Rheumatology (OMERACT) Filter 2.1.

scholarly journals Report of the Skin Research Working Groups From the GRAPPA 2020 Annual Meeting

2021 ◽  
pp. jrheum.201668
Author(s):  
Lourdes M. Perez-Chada ◽  
Alison Kohn ◽  
Alice B. Gottlieb ◽  
April W. Armstrong ◽  
Lihi Eder ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Annual Meeting ◽  
Outcome Measures ◽  
Working Group ◽  
Treatment Satisfaction ◽  
Panel Discussion ◽  
Musculoskeletal Symptoms ◽  
Working Groups ◽  
Feasible Outcome ◽  
Longitudinal Observational Studies

At the 2020 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), the International Dermatology Outcome Measures (IDEOM) Initiative Psoriasis (PsO) Working Group presented an update on its work to agree on meaningful, valid, and feasible outcome measures for PsO randomized controlled trials and longitudinal observational studies. The Treatment Satisfaction Working Group presented the development of a treatment satisfaction instrument to be utilized in PsO clinical trials. The Musculoskeletal Symptoms Working Group presented an overview of their work conducted to date to define how to best measure musculoskeletal symptoms in PsO clinical studies, and discussed next steps during an open-panel discussion, which included PsO and psoriatic arthritis experts.

Measuring physical function in psoriatic arthritis: comparing the Multi-Dimensional Health Assessment Questionnaire to the Health Assessment Questionnaire Disability Index

2021 ◽  
pp. jrheum.200927
Author(s):  
Weiyu Ye ◽  
Simon Hackett ◽  
Claire Vandevelde ◽  
Sarah Twigg ◽  
Philip S. Helliwell ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Physical Function ◽  
Health Assessment Questionnaire ◽  
Health Assessment ◽  
Clinic Visit ◽  
Retest Reliability ◽  
Floor Effects ◽  
Test Retest Reliability ◽  
Assessment Questionnaire ◽  
Questionnaire Disability

Objective To compare physical function scales of the Multi-Dimensional Health Assessment Questionnaire (MDHAQ) to the Health Assessment Questionnaire Disability Index (HAQDI) in patients with psoriatic arthritis (PsA), and examine whether either questionnaire is less prone to ‘floor effects’. Methods Data were collected prospectively from 2018 to 2019 across three UK hospitals. All patients completed physical function scales within the MDHAQ and HAQDI in a single clinic visit. Agreement was assessed using medians and the Bland-Altman method. Intraclass correlation coefficients (ICCs) were used to assess test-retest reliability. Results 210 patients completed the clinic visit; one withdrew consent thus 209 were analysed. 60.0% were male, with mean age of 51.7 years and median disease duration of 7 years. In clinic, median MDHAQ and HAQDI including/excluding aids scores were 0.30, 0.50 and 0.50 respectively. Although the median score for HAQDI is higher than MDHAQ, the difference between the two mostly lies within 1.96 standard deviations from the mean suggesting good agreement. The ICCs demonstrated excellent test-retest reliability for both HAQ questionnaires.Similar numbers of patients scored ‘0’ on the MDHAQ and HAQDI including/excluding aids (48, 47, and 49 respectively). Using a score of ≤0.5 as a cut-off for minor functional impairment, 23 patients had a MDHAQ ≤0.5 when their HAQDI including aids >0.5. Conversely, 4 patients had a MDHAQ > 0.5 when the HAQDI including aids ≤0.5. ConclusionBoth HAQ questionnaires appear to be similar in detecting floor effects in patients with PsA.

Biomarkers of Radiographic Progression in Psoriatic Arthritis: A Report from the GRAPPA 2011 Annual Meeting

2012 ◽  
Vol 39 (11) ◽  
pp. 2189-2192 ◽  
Author(s):  
OLIVER FITZGERALD ◽  
CHRISTOPHER T. RITCHLIN ◽  
PHILIP J. MEASE
Keyword(s):  
Psoriatic Arthritis ◽  
Annual Meeting ◽  
Structural Damage ◽  
Radiographic Progression ◽  
Clinical Markers ◽  
Sample Collection ◽  
Critical Research ◽  
Specific Protocol ◽  
Radiographic Scoring Methods ◽  
Selection Of

Clinical markers of radiographic progression have been studied in patients with psoriatic arthritis (PsA), and results have clearly confirmed the progression of radiographic damage over a 2-year period. Biomarkers of radiographic progression damage (erosion and new bone formation) have also been identified as a critical research issue in these patients. At the 2011 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members discussed development of a pivotal observational study (PsA Biodam study) to determine the validity of several soluble biomarkers in predicting structural damage in patients with PsA receiving standard therapies. Specific protocol issues discussed were the inclusion criteria, selection of candidate biomarkers, timing of sample collection, the primary radiographic outcome measure, radiographic scoring methods, possible substudies, and funding strategies.

scholarly journals Committee for managing the risk by Faults and Cracks due to subsidence in Aguascalientes State, México

2020 ◽  
Vol 382 ◽  
pp. 791-795
Author(s):  
Jesús Pacheco-Martínez ◽  
Martín Hernández-Marín ◽  
Mario E. Zermeño-de-León ◽  
Norma González-Cervantes ◽  
José A. Ortiz-Lozano ◽  
...  
Keyword(s):  
State Government ◽  
Land Subsidence ◽  
Working Group ◽  
The State ◽  
Public Works ◽  
Federal State ◽  
Main Concern ◽  
Public And Private ◽  
Working Groups ◽  
Set Up

Abstract. Land subsidence due to groundwater withdrawal has been developing in the Aguascalientes Valley since the 1980's. Even though the affected area is close to 900 km2, and the sinking velocity is up to 10 cm yr−1 in some zones, the main concern for valley inhabitants and local government is the occurrence of subsidence-related cracks and failures, which are developed in the surface terrain and damage buildings and infrastructure. In order to face this problem, the state government of Aguascalientes set up in 1994 an interinstitutional committee which is integrated by four working groups: (1) technical studies, (2) equilibrium of the aquifer, (3) normativity and cartography, and (4) attention to damaged infrastructure. Each working group integrates several public and private agencies whose activities are influenced by the in-progress subsidence process. Federal, state and municipal water management agencies, as well as government bureaus of urban planning and public works are included in the committee. Also, the state university and some professional state associations such as civil engineers and earth sciences engineers are actively involved in the committee, along with the National Institute of Statistics, Geography and Informatics, which is the federal agency addressed to produce official cartography in Mexico. Some agencies participate not only in one working group but in those that fall in their interest, therefore, many agencies are contributing to several working groups objectives. In this work, we present a summarize of the work developed for the committee since its creation, and about its evolution and current organization. It is presented an analysis and discussion of the changes that the committee has experienced in their objectives and applied methods to address the evolution of the fissuring problem, and how their results have helped to prevent and to mitigate the land subsidence effects. Also, the mechanisms implemented to inform to the general public about the subsidence process and its effects; besides of the expected challenges that the committee will enfaces in the near and far future. This work intends to share the experiences of the committee hoping to be useful to other government agencies and earth scientists dealing with the land subsidence problem.

scholarly journals The GRAPPA-OMERACT Psoriatic Arthritis Working Group at the 2018 Annual Meeting: Report and Plan for Completing the Core Outcome Measurement Set

2019 ◽  
Vol 95 ◽  
pp. 33-37
Author(s):  
Ying Ying Leung ◽  
Ana-Maria Orbai ◽  
Alexis Ogdie ◽  
Laura C. Coates ◽  
Maarten de Wit ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Annual Meeting ◽  
Working Group ◽  
Outcome Measurement ◽  
Meeting Report ◽  
Core Outcome ◽  
The Core

scholarly journals Test-retest reliability for HAQ-DI and SF-36 PF for the measurement of physical function in psoriatic arthritis

2021 ◽  
pp. jrheum.210175
Author(s):  
Ying Ying Leung ◽  
William Tillett ◽  
Pil Hojgaard ◽  
Ana-Maria Orbai ◽  
Richard Holland ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Short Form ◽  
Health Assessment ◽  
Correlation Coefficients ◽  
Intra Class Correlation ◽  
Retest Reliability ◽  
Sf 36 ◽  
Reliability Performance ◽  
Test Retest Reliability

Objective Due to no existing data, we aimed to derive evidence to support test-retest reliability for the Health Assessment Questionnaire-Disability Index (HAQ-DI) and Medical Outcome Survey Short-Form-36 item physical functioning domain (SF-36 PF) in psoriatic arthritis (PsA). Methods We identified datasets that collected relevant data for test-retest reliability for HAQ-DI and SF-36 PF; and evaluated them using OMERACT Filter 2.1 methodology. We calculated intra-class correlation coefficients (ICC) as a measure of test-retest reliability. We then conducted a quality assessment and evaluated the adequacy of test-retest reliability performance. Results Two datasets were identified for HAQ-DI and one for SF-36 PF in PsA. The quality of the datasets was good. The ICCs for HAQ-DI were excellent in both datasets: 0.94 (95% CI: 0.88 to 0.97) and 0.94 (95% CI: 0.89 to 0.97). The ICC of SF-36 PF was good (0.89, 95% CI: 0.76 to 0.95). The performance of test-retest reliability for both instruments was judged to be adequate. Conclusion The new data derived support good and reasonable test-retest reliability for HAQ-DI and SF-36 PF in PsA.

Building Bridges between Researchers and Patient Research Partners: A Report from the GRAPPA 2014 Annual Meeting

2015 ◽  
Vol 42 (6) ◽  
pp. 1021-1026 ◽  
Author(s):  
Maarten de Wit ◽  
Willemina Campbell ◽  
Ana-Maria Orbai ◽  
William Tillett ◽  
Oliver FitzGerald ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Annual Meeting ◽  
Outcomes Research ◽  
Patient Perspective ◽  
Mutual Understanding ◽  
Roles And Responsibilities ◽  
Working Groups ◽  
Governance Arrangements

Concurring with a worldwide trend to include the patient perspective in outcomes research, the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) recently engaged patients as collaborative partners in psoriatic arthritis (PsA) research. We summarize Building Bridges, a session held at the GRAPPA 2014 annual meeting, where interactive dialogue was encouraged between all participants regarding GRAPPA’s vision for patient research partner (PRP) involvement, including the mutual understanding of the roles and responsibilities of PRP and researchers in GRAPPA’s working groups, meetings, and governance arrangements. We conclude that involving PRP in GRAPPA projects is pivotal to optimizing incorporation of the patient perspective in psoriasis and PsA research.

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