Investigating the effects of negative-calorie diet compared with low-calorie diet under exercise conditions on weight loss and lipid profile in overweight/obese middle-aged and older men

A randomized controlled clinical trial in 196 obese subjects was performed to examine the effectiveness of body acupuncture on body weight loss, lipid profile and immunogenic and inflammatory markers. Subjects received authentic (cases) or sham (controls) acupuncture for 6 weeks in combination with a low-calorie diet. In the following 6 weeks, they received the low-calorie diet alone. Subjects were assessed at the beginning, 6 and 12 weeks later. Heat shock protein (Hsps)-27, 60, 65, 70 antibody titers and high sensitivity C-reactive protein (hs-CRP) levels were also assessed. A significant reduction in measures of adiposity and improvement in lipid profile were observed in both groups, but the levels of anti-Hsp-antibodies decreased in cases only. A reduction in anthropometric and lipid profile in cases were sustained in the second period, however, only changes in lipid profile were observed in the control group. Anti-Hsp-antibodies and hs-CRP levels continued to be reduced in cases but in controls only the reduction in hs-CRP remained. Changes in anthropometric parameters, lipid profile, and anti-Hsp-antibodies were more evident in cases. Body acupuncture in combination with diet restriction was effective in enhancing weight loss and improving dyslipidemia.

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sRAGE as a potential biomarker to predict weight loss and improvement of insulin sensitivity by a very low calorie diet of obese human subjects

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0035-1547693 ◽

2015 ◽

Vol 122 (03) ◽

Author(s):

I Hagen ◽

D Schulte ◽

N Mueller ◽

J Martinsen ◽

K Türk ◽

...

Keyword(s):

Weight Loss ◽

Insulin Sensitivity ◽

Human Subjects ◽

Very Low Calorie Diet ◽

Low Calorie ◽

Low Calorie Diet ◽

Potential Biomarker ◽

Calorie Diet ◽

Predict Weight Loss ◽

Obese Human

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A Moderate Low-Carbohydrate Low-Calorie Diet Improves Lipid Profile, Insulin Sensitivity and Adiponectin Expression in Rats

Nutrients ◽

10.3390/nu7064724 ◽

2015 ◽

Vol 7 (6) ◽

pp. 4724-4738 ◽

Cited By ~ 20

Author(s):

Jie-Hua Chen ◽

Caiqun Ouyang ◽

Qiang Ding ◽

Jia Song ◽

Wenhong Cao ◽

...

Keyword(s):

Insulin Sensitivity ◽

Lipid Profile ◽

Low Calorie ◽

Low Calorie Diet ◽

Low Carbohydrate ◽

Calorie Diet

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Low-calorie diet induced weight loss may alter regulatory hormones and contribute to rebound visceral adiposity in obese persons with a family history of type-2 diabetes

Journal of the American Association of Nurse Practitioners ◽

10.1111/j.1745-7599.2012.00808.x ◽

2012 ◽

Vol 25 (8) ◽

pp. 440-448 ◽

Cited By ~ 4

Author(s):

Jacquelyn L. Banasik ◽

Marilee K. Walker ◽

Judith M. Randall ◽

Robert B. Netjes ◽

Mary S. Foutz

Keyword(s):

Type 2 Diabetes ◽

Weight Loss ◽

Family History ◽

Visceral Adiposity ◽

Low Calorie ◽

Low Calorie Diet ◽

Calorie Diet ◽

History Of

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Effectiveness, Compliance, and Acceptability of Preoperative Weight Loss with a Liquid Very Low-Calorie Diet Before Bariatric Surgery in Real Practice

Obesity Surgery ◽

10.1007/s11695-018-3444-0 ◽

2018 ◽

Vol 29 (1) ◽

pp. 54-60 ◽

Cited By ~ 3

Author(s):

Kamthorn Yolsuriyanwong ◽

Komdej Thanavachirasin ◽

Kimberly Sasso ◽

Lauren Zuro ◽

Jessica Bartfield ◽

...

Keyword(s):

Bariatric Surgery ◽

Weight Loss ◽

Preoperative Weight Loss ◽

Very Low Calorie Diet ◽

Low Calorie ◽

Low Calorie Diet ◽

Calorie Diet ◽

Preoperative Weight ◽

Real Practice

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Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet

BMJ Open ◽

10.1136/bmjopen-2019-031431 ◽

2019 ◽

Vol 9 (11) ◽

pp. e031431

Author(s):

Simon Birk Kjær Jensen ◽

Julie Rehné Lundgren ◽

Charlotte Janus ◽

Christian Rimer Juhl ◽

Lisa Møller Olsen ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Receptor Agonist ◽

Controlled Trial ◽

Good Clinical Practice ◽

Study Groups ◽

Very Low Calorie Diet ◽

Low Calorie ◽

Low Calorie Diet ◽

Calorie Diet

IntroductionThe success rate of weight loss maintenance is limited. Therefore, the purpose of this study is to investigate the maintenance of weight loss and immunometabolic health outcomes after diet-induced weight loss followed by 1-year treatment with a glucagon-like peptide-1 receptor agonist (liraglutide), physical exercise or the combination of both treatments as compared with placebo in individuals with obesity.Methods and analysisThis is an investigator-initiated, randomised, placebo-controlled, parallel group trial. We will enrol expectedly 200 women and men (age 18–65 years) with obesity (body mass index 32–43 kg/m2) to adhere to a very low-calorie diet (800 kcal/day) for 8 weeks in order to lose at least 5% of body weight. Subsequently, participants will be randomised in a 1:1:1:1 ratio to one of four study groups for 52 weeks: (1) placebo, (2) exercise 150 min/week+placebo, (3) liraglutide 3.0 mg/day and (4) exercise 150 min/week+liraglutide 3.0 mg/day. The primary endpoint is change in body weight from randomisation to end-of-treatment.Ethics and disseminationThe trial has been approved by the ethical committee of the Capital Region of Denmark and the Danish Medicines Agency. The trial will be conducted in agreement with the Declaration of Helsinki and monitored to follow the guidelines for good clinical practice. Results will be submitted for publication in international peer-reviewed scientific journals.Trial registration number2015-005585-32

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Lutein supplementation combined with a low calorie diet in the middle-aged obese individuals: effects on anthropometric indices, body composition, and metabolic parameters

British Journal Of Nutrition ◽

10.1017/s0007114520004997 ◽

2020 ◽

pp. 1-32

Author(s):

Fatemeh Hajizadeh-Sharafabad ◽

Ali Tarighat-Esfanjani ◽

Zohreh Ghoreishi ◽

Mehrnoosh Sarreshtedari

Keyword(s):

Body Composition ◽

Placebo Group ◽

Lipid Profile ◽

Glucose Homeostasis ◽

Density Lipoprotein ◽

Metabolic Parameters ◽

Middle Aged ◽

Anthropometric Indices ◽

Low Calorie Diet ◽

Calorie Diet

Abstract Lutein is considered as a major biologically active carotenoid, with potential benefits for obesity and cardiometabolic health. This double-blind, randomized controlled trial aimed to assess whether the consumption of lutein along with a low calorie diet (LCD) can influence anthropometric indices, body composition, and metabolic parameters in obese middle-aged individuals. After a 2-week run-in period with an LCD, 48 participants aged 45–65 y were randomly assigned to consume 20 mg/d lutein or placebo along with LCD for 10 weeks. Dietary intake, anthropometric indices, body composition, lipid profile, glucose homeostasis parameters, non-esterified fatty acids (NEFAs), and appetite sensations were assessed at the beginning and end of the study. After 10 weeks, body weight, and waist circumference significantly decreased in both groups, although between-group differences were not significant. There was a more decrease in the percentage of body fat in the lutein group vs. the placebo group. Moreover, the placebo group experienced a significant reduction in fat free mass (FFM), whereas lutein group preserved FFM during calorie restriction, although between-group difference did not reach statistical significance. Visceral fat and serum levels of total cholesterol (TC) and low-density lipoprotein-cholesterol were significantly decreased only in the lutein group, with a statistically significant difference between two arms only for TC. No significant changes were observed in the triglyceride, high-density lipoprotein-cholesterol, glucose homeostasis parameters, NEFAs, and appetite sensations. Lutein supplementation in combination with an LCD could improve body composition and lipid profile in obese middle-aged individuals.

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