CLINICOPATHOLOGICAL FEATURE AND PROGNOSIS OF AGED PATIENTS OVER 75 YEARS WITH COLORECTAL CANCER

AimsThe relationship between cancer and schizophrenia requires re-examination. We investigated the cancer risk among young and middle-aged patients with schizophrenia.MethodsRecords of newly admitted patients with schizophrenia (n = 32.731) from January 2000 through December 2008 were retrieved from the Psychiatric Inpatient Medical Claims database in Taiwan, and the first psychiatric admission of each patient during the same period was defined as the baseline. Five hundred and fourteen incident cancer cases were identified and standardized incidence ratios (SIRs) were calculated to compare the risk of cancer between those with schizophrenia and the general population. Stratified analyses of cancer incidences were performed by gender, site of cancers, and duration since baseline.ResultsThe incidence of cancer for all sites was slightly higher than that of the general population for the period (SIR = 1.15 [95% CI 1.06–1.26], P = 001). Men had a significantly higher incidence of colorectal cancer (SIR = 1.48 [95% CI 1.06–2.06], P = 0.019). Women had a higher incidence of breast cancer (SIR = 1.47 [95% CI 1.22–1.78], P < .001). Intriguingly, the risk for colorectal cancer was more pronounced 5 years after the first psychiatric admission rather than earlier (SIR = 1.94 [1.36–2.75], P < .001), and so was the risk for breast cancer (SIR = 1.85 [1.38–2.48], P < .001). The cancer incidence was higher in schizophrenic patients contradicting the belief that schizophrenia was protective of cancers.ConclusionsMen and women with schizophrenia were more vulnerable to certain types of cancers, which indicate the need for gender-specific cancer screening programs.Disclosure of interestThe author has not supplied his declaration of competing interest.

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Misleading Presentation of Colorectal Cancer in an Otherwise Healthy Patient

Journal of the Faculty of Medicine Baghdad ◽

10.32007/jfacmedbagdad.6241800 ◽

2021 ◽

Vol 62 (4) ◽

pp. 132-138

Author(s):

Mustafa Aljarshawi ◽

Haitham Albadree ◽

Hasan Bahar ◽

Ahmed Al-Imam

Keyword(s):

Colorectal Cancer ◽

Case Report ◽

Anal Fissure ◽

Clinical Features ◽

Clinical Assessment ◽

Aged Patients ◽

Medical City ◽

Bowel Motion ◽

Life Threatening ◽

History Of

Background: Colorectal cancer (CRC) represents the second most common malignancy and the fourth most common cause of cancer deaths. CRC can manifest early with bright red bleeding per rectum, tenesmus, and altered bowel habits. These symptoms are often attributed to benign lesions, including anal fissure. Our objective is to highlight the alarming scenario of an anal fissure masking the clinical features of an underlying colorectal cancer in healthy middle-aged patients. Case Report Our case report aims to discuss how congruent clinical features of benign-looking anal fissure can delay the diagnosis of rectal cancer. In January 2019, a healthy forty-four years old Iraqi male with no family history of colorectal neoplasms presented to Baghdad Medical City. He suffered from a long-standing peri-anal pain and infrequent bowel motion that was initially diagnosed as an anal fissure. Subsequent clinical assessment, with endoscopy, confirmed the presence of colorectal adenocarcinoma. We also carried out analytics, using Google Trends, to assess the spatiotemporal mapping of web users interested in case scenarios similar to our patient. Conclusion Anal fissure could coexist with colorectal cancer, even in younger patients. Therefore, it is essential to consider anal fissure and colorectal cancer on clinical assessment. Follow-up visits are paramount to exclude underlying life-threatening aetiology at secondary care.

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Clinicopathological studies of colorectal cancer in the aged patients

Progress of Digestive Endoscopy ◽

10.11641/pde.74.2_36 ◽

2009 ◽

Vol 74 (2) ◽

pp. 36-39

Author(s):

Masashi Misawa ◽

Hiroshi Kashida ◽

Orie Takemura ◽

Hideyuki Miyachi ◽

Yoshiki Wada ◽

...

Keyword(s):

Colorectal Cancer ◽

Aged Patients

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SOME NOTES ON OPERATED CASES OF COLORECTAL CANCER IN AGED PATIENTS OVER 80 YEARS OLD

The journal of the Japanese Practical Surgeon Society ◽

10.3919/ringe1963.53.2066 ◽

1992 ◽

Vol 53 (9) ◽

pp. 2066-2070

Author(s):

Sengai TANAKA ◽

Hiromi TANEMURA ◽

Hiroo OSHITA

Keyword(s):

Colorectal Cancer ◽

Aged Patients

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Familial and non-familial risk factors associated with colorectal cancer survival in young and middle-aged patients

International Journal of Colorectal Disease ◽

10.1007/s00384-019-03380-5 ◽

2019 ◽

Vol 34 (10) ◽

pp. 1673-1680 ◽

Cited By ~ 1

Author(s):

Erin Kelty ◽

Sarah V. Ward ◽

Gemma Cadby ◽

Nina S. McCarthy ◽

Peter O’Leary ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Cancer Survival ◽

Familial Risk ◽

Middle Aged ◽

Aged Patients ◽

Factors Associated ◽

Colorectal Cancer Survival ◽

Familial Risk Factors

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Clinicopathological Feaure and Prognosis of Colorectal Cancer in Aged Patients.

Nippon Daicho Komonbyo Gakkai Zasshi ◽

10.3862/jcoloproctology.48.206 ◽

1995 ◽

Vol 48 (3) ◽

pp. 206-211

Author(s):

K. Kawahori ◽

M. Okajima ◽

M. Arita ◽

R. Kobayashi ◽

M. Nakahara ◽

...

Keyword(s):

Colorectal Cancer ◽

Aged Patients

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Prognostic implications of metabolism-associated gene signatures in colorectal cancer

PeerJ ◽

10.7717/peerj.9847 ◽

2020 ◽

Vol 8 ◽

pp. e9847

Author(s):

Yandong Miao ◽

Qiutian Li ◽

Jiangtao Wang ◽

Wuxia Quan ◽

Chen Li ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Score ◽

Expression Profiles ◽

Enrichment Analysis ◽

Gene Set Enrichment Analysis ◽

The Cancer Genome Atlas ◽

Functional Enrichment ◽

Clinicopathological Feature ◽

Metabolic Genes ◽

Cox Analysis

Colorectal cancer (CRC) is one of the most common and deadly malignancies. Novel biomarkers for the diagnosis and prognosis of this disease must be identified. Besides, metabolism plays an essential role in the occurrence and development of CRC. This article aims to identify some critical prognosis-related metabolic genes (PRMGs) and construct a prognosis model of CRC patients for clinical use. We obtained the expression profiles of CRC from The Cancer Genome Atlas database (TCGA), then identified differentially expressed PRMGs by R and Perl software. Hub genes were filtered out by univariate Cox analysis and least absolute shrinkage and selection operator Cox analysis. We used functional enrichment analysis methods, such as Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis, to identify involved signaling pathways of PRMGs. The nomogram predicted overall survival (OS). Calibration traces were used to evaluate the consistency between the actual and the predicted survival rate. Finally, a prognostic model was constructed based on six metabolic genes (NAT2, XDH, GPX3, AKR1C4, SPHK1, and ADCY5), and the risk score was an independent prognostic prognosticator. Genetic expression and risk score were significantly correlated with clinicopathologic characteristics of CRC. A nomogram based on the clinicopathological feature of CRC and risk score accurately predicted the OS of individual CRC cancer patients. We also validated the results in the independent colorectal cancer cohorts GSE39582 and GSE87211. Our study demonstrates that the risk score is an independent prognostic biomarker and is closely correlated with the malignant clinicopathological characteristics of CRC patients. We also determined some metabolic genes associated with the survival and clinical stage of CRC as potential biomarkers for CRC diagnosis and treatment.

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