Lipid Profiles and Blood Pressure among Worker Women, Its Correlation with Risk Factor of Coronary Heart Disease

2013 ◽  
Vol 12 (9) ◽  
pp. 806-810 ◽  
Author(s):  
Betty Yosephin ◽  
Ali Khomsan ◽  
Dodik Briawan ◽  
Rimbawan .
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Lipid Profiles

scholarly journals High Blood Pressure and Cardiovascular Disease

Hypertension ◽  
2020 ◽  
Vol 75 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Flávio D. Fuchs ◽  
Paul K. Whelton
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Cohort Studies ◽  
High Blood Pressure ◽  
Population Distribution ◽  
Meta Analysis ◽  
Age Related

Fragmented investigation has masked the overall picture for causes of cardiovascular disease (CVD). Among the risk factors for CVD, high blood pressure (BP) is associated with the strongest evidence for causation and it has a high prevalence of exposure. Biologically, normal levels of BP are considerably lower than what has typically been characterized as normal in research and clinical practice. We propose that CVD is primarily caused by a right-sided shift in the population distribution of BP. Our view that BP is the predominant risk factor for CVD is based on conceptual postulates that have been tested in observational investigations and clinical trials. Large cohort studies have demonstrated that high BP is an important risk factor for heart failure, atrial fibrillation, chronic kidney disease, heart valve diseases, aortic syndromes, and dementia, in addition to coronary heart disease and stroke. In multivariate modeling, the presumed attributable risk of high BP for stroke and coronary heart disease has increased steadily with progressive use of lower values for normal BP. Meta-analysis of BP-lowering randomized controlled trials has demonstrated a benefit which is almost identical to that predicted from BP risk relationships in cohort studies. Prevention of age-related increases in BP would, in large part, reduce the vascular consequences usually attributed to aging, and together with intensive treatment of established hypertension would eliminate a large proportion of the population burden of BP-related CVD.

Abstract P448: Exploring Socioeconomic Inequalities In Coronary Heart Disease Prevention

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
R Ahmed ◽  
Martin O'Flaherty ◽  
N Hawkins ◽  
J Lucy ◽  
Simon Capewell
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Primary Prevention ◽  
Systolic Blood Pressure ◽  
Population Based ◽  
Policy Model ◽  
English Population ◽  
Asymptomatic Individuals

Background: Between 2000 and 2007, coronary heart disease (CHD) mortality rates in England plummeted by one third. An important part of this substantial CHD mortality decline was achieved through reductions in major cardiovascular risk factors (primary prevention). However, the relative contributions from medications and from population-wide changes remains unclear, particularly the effects on health inequalities. Methods: Using a previously validated policy model, the fall in CHD mortality in England was analysed. The contributions from risk factor declines in asymptomatic individuals through medications and through population-wide changes were quantified. Data were stratified using the Index of Multiple Deprivation (IMD). Model outputs were quantified as deaths prevented or postponed (DPPs). Results: Between 2000 and 2007, approximately 21,900 fewer CHD deaths were attributable to risk factor declines in systolic blood pressure and cholesterol in the English population. Some 7,100 of these 21,900 fewer deaths (DPPs) were attributed to medications (32%) and approximately 14,800 DPPs were attributed to secular changes in asymptomatic individuals (68%). Substantial declines in systolic blood pressure were responsible for approximately 14,300 fewer deaths. This comprised approximately 12,500 DPPs attributable to population-wide changes and some 1,800 DPPs attributable to hypertension medications. The hypertension medications resulted in approximately 350 fewer deaths in the most affluent quintile compared with 270 DPP in the most deprived. In contrast, the population-wide (secular) falls in blood pressure resulted in approximately 2400 fewer deaths in the most deprived quintile compared with only 1900 DPPs in the most affluent. Cholesterol falls resulted in approximately 7,700 fewer deaths. This comprised some 5,300 fewer deaths attributable to statin medications and approximately 2,400 fewer deaths attributable to population-wide changes (mostly diet). Statin medications prevented more deaths in the most affluent quintile (1050 DPPs) compared with the most deprived (770 DPPs). Population-wide changes in cholesterol prevented substantially more deaths in the most deprived quintile (820 DPPs) compared with the most affluent (260 DPPs). Conclusions: Population-based declines in blood pressure and cholesterol resulted in much greater reductions in CHD deaths than did primary prevention medications. Mortality falls were greatest in the most deprived quintiles, mainly reflecting their bigger initial burden of disease. Future CHD prevention policies should prioritise healthier diets ahead of medications.

PREVALENCE OF HYPERTENSION AND TREATMENT OUTCOME IN TERTIARY CARE

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Dr. Rajendra Prasad Gupta ◽  
Dr. Satish Chandra Arya
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
High Blood Pressure ◽  
Resistant Hypertension ◽  
Tertiary Care ◽  
Hypertensive Crisis ◽  
Normal Weight ◽  
Age Group

INTRODUCTION: High blood pressure (BP) is ranked as the third most important risk factor for attributable burden of disease in south Asia. Raised blood pressure is a major risk factor for chronic heart disease, stroke, and coronary heart disease. WHO rates hypertension as one of the most important causes of premature death worldwide[i].  In India 57% of all stroke deaths and 24% of all coronary heart disease (CHD) deaths are due to hypertension. Other than coronary heart disease and stroke, complications include peripheral vascular disease, heart failure, renal impairment, retinal hemorrhage, and visual impairment. MATERIAL AND METHODS: Study population was adult patients who had been receiving anti-hypertensive treatment at hospital for at least 6 months. Interviews were conducted with all the participants and the questionnaires were filled. Demographic and anthropometric data were obtained for the patient who includes height and weight, BMI (Body Mass Index), personal medical history was obtained, and diagnosis of hypertension and other co-morbid conditions were recorded. RESULTS: A total of 200 patients were included in this study were observed and traced up to 6 month period of the study. 200 patients were included in the study of which 117 (58.50%) were male and 83 (41.50%) were female. Mean age of male patients was 52 ± 18.29 while in female it was 53 ± 17.88. We have divided our patients into four groups in <20 years only one male patient (0.85%) was having hypertension. In 20 – 39 years age group 16 (13.67%) male and 8 (9.63%) female were observed. In 40 to 59 age group 47 (35.04%) male and 31 (37.35%) female were observed. In >60 age group there were 53(45.30%) male and 44 (53.01%) female were observed. Maximum number of cases were observed in the >60 age group in both the sexes. 46 male (39.32%) and 35(42.17%) female had history of hypertension with Less than 5 years. while 71 (60.68%) male and 48 (57.83%) female had hypertension for more than five years. Out of 117 male 13 (11.11%) were normal weight, 85 (72.65%) were overweight and 19 (16.24%) were obese. In female 4 (4.82%) were normal weight, 69 (85.13%) were overweight and 10 (12.50%) were obese. Hypertension was most prevalent in overweight group in both the sexes. Diabetes was observed in 71 (60.68%) male and 56 (67.47%) female. 46 (39.32%) male and 27(32.53%) of female had myocardial infarction.   Before start of the study 68 (58.12%) had controlled blood pressure, 42 (35.90%) had uncontrolled BP, Hypertensive crisis was seen in 5 (4.27%) patients and Resistant hypertension was seen in 2 (1.71%) cases. After study period 58 (49.57%) had controlled blood pressure, 22 (18.80%) had uncontrolled BP, Hypertensive crisis was seen in 2 (1.71%) patients and Resistant hypertension was seen in 1 (0.85%) case. CONCLUSION:  Chronic uncontrolled high blood pressure which can be reduced by proper management, counselling and lifestyle modification. Prevalence of hypertension in males was slightly higher than female counterparts .Control of hypertension was more in female patients. Also patient assessment should be improved in order to increase the identification and management of hypertension KEYWORDS: Hypertension, Diabetes, coronary heart disease (CHD), management.

A Randomised Controlled Trial of Counseling in a Workplace Setting for Coronary Heart Disease Risk Factor Modification: Effects on Blood Pressure

1990 ◽  
Vol 4 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Michael S Frommer ◽  
John A Mandryk ◽  
Beryl V Edye ◽  
Sandra Healey ◽  
Geoffrey Berry ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Controlled Trial ◽  
Counseling Program ◽  
Randomised Controlled ◽  
Heart Disease Risk

This paper reviews a prospective study of occupational factors in coronary heart disease risk incorporated in a randomised controlled trial of a worksite based occupational health nurse counseling program for reducing coronary heart disease risk factors. The aim of the trial was to evaluate the longterm effectiveness of the counseling program in persons with mildly elevated risk factor levels. Of the 2, 489 Australian government employees with mildly elevated risk factor levels who entered the intervention trial, 1, 937 (78%) attended a followup examination three years later. This paper reports on changes in systolic and diastolic blood pressure. Multiple linear regression models were used with three-year blood pressure reduction as the dependent variable, intervention status as the main determinant, and sex, age, initial risk level and initial blood pressure as covariates. Although systolic and diastolic blood pressure fell in both the intervention and control groups, intervention was significantly associated with systolic blood pressure change only.

scholarly journals Bayesian variable selection with a pleiotropic loss function in Mendelian randomization

2019 ◽  
Author(s):  
Apostolos Gkatzionis ◽  
Stephen Burgess ◽  
David V Conti ◽  
Paul J Newcombe
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Variable Selection ◽  
Diastolic Blood Pressure ◽  
Loss Function ◽  
Genetic Variants ◽  
Mendelian Randomization ◽  
Bayesian Variable Selection

AbstractMendelian randomization is the use of genetic variants as instruments to assess the existence of a causal relationship between a risk factor and an outcome. A Mendelian randomization analysis requires a set of genetic variants that are strongly associated with the risk factor and only associated with the outcome through their effect on the risk factor. We describe a novel variable selection algorithm for Mendelian randomization that can identify sets of genetic variants which are suitable in both these respects. Our algorithm is applicable in the context of two-sample summary-data Mendelian randomization and employs a recently proposed theoretical extension of the traditional Bayesian statistics framework, including a loss function to penalize genetic variants that exhibit pleiotropic effects. The algorithm offers robust inference through the use of model averaging, as we illustrate by running it on a range of simulation scenarios and comparing it against established pleiotropy-robust Mendelian randomization methods. In a real data application, we study the effect of systolic and diastolic blood pressure on the risk of suffering from coronary heart disease. Based on a recent large-scale GWAS for blood pressure, we use 395 genetic variants for systolic and 391 variants for diastolic blood pressure. Both traits are shown to have significant risk-increasing effects on coronary heart disease risk.

scholarly journals Association of Cumulative Systolic Blood Pressure With Long-Term Risk of Cardiovascular Disease and Healthy Longevity

Hypertension ◽  
2020 ◽  
Author(s):  
Orna Reges ◽  
Hongyan Ning ◽  
John T. Wilkins ◽  
Colin O. Wu ◽  
Xin Tian ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Systolic Blood Pressure ◽  
Healthy Longevity ◽  
All Cause Mortality

Hypertension is a major risk factor for cardiovascular disease (CVD), but previous studies have mostly been limited to a single exam, a single cohort, a short follow-up period, or a limited number of outcomes. This study aimed to assess the association of 10-year cumulative systolic blood pressure (BP) in middle age with long-term risk of any CVD, coronary heart disease, stroke, heart failure, all-cause mortality, and healthy longevity. Individuals (11 502) from 5 racially/ethnically diverse US community-based cohorts were included in this study once they met all the inclusion criteria: ≥10 year of observation in the included cohort, aged 45 to 60 years, free of CVD, and had ≥3 visits with BP exams over the preceding 10 years. For each participant, systolic BP level was predicted for each year of the 10-year prior inclusion, based on the available exams (median of 4.0; spread over, 9.1 [range, 7.2–10] years). Lower 10-year cumulative systolic BP was associated with 4.1 years longer survival and 5.4 years later onset of CVD, resulting in living longer life with a shorter period with morbidity. Models adjusted for sociodemographic characteristics, cardiovascular risk factors, and index systolic BP demonstrated associations of 10-year cumulative systolic BP (per 130 mm Hg×year change, the threshold for stage-1 hypertension) with CVD (hazard ratio [HR], 1.28 [95% CI, 1.20–1.36]), coronary heart disease (HR, 1.29 [95% CI, 1.19–1.40]), stroke (HR, 1.33 [95% CI, 1.20–1.47]), heart failure (HR, 1.12 [95% CI, 1.02–1.23]), and all-cause mortality (HR, 1.21 [95% CI, 1.14–1.29]). These findings emphasize the importance of 10-year cumulative systolic BP as a risk factor to CVD, above and beyond current systolic BP.

Coronary heart disease mortality trends during 50 years as explained by risk factor changes: The European cohorts of the Seven Countries Study

2019 ◽  
Vol 27 (9) ◽  
pp. 988-998 ◽  
Author(s):  
Alessandro Menotti ◽  
Paolo E Puddu ◽  
Daan Kromhout ◽  
Anthony Kafatos ◽  
Hanna Tolonen
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Weibull Distribution ◽  
Serum Cholesterol ◽  
Coronary Heart Disease Mortality ◽  
Change Score ◽  
Disease Mortality ◽  
Seven Countries Study

Objectives The purpose of this study was to relate risk factor changes during decades with 50-year coronary heart disease mortality in European cohorts of middle-aged men of the Seven Countries Study. Material and methods In the 1950s–early 1960s, nine cohorts of 6518 men aged 40–59 years were examined in five European countries. Smoking habits, systolic blood pressure and serum cholesterol were measured at entry and five times during the next 35 years and a comprehensive Risk Factor Change Score was created. Coronary heart disease mortality data was collected during a 50-year follow-up, modelled by the Weibull distribution, whose shape (Weibull shape) was related to the Risk Factor Change Score by linear regression. Results The Risk Factor Change Score showed slight declines in the Finnish and Dutch cohorts, moderate or large increases in the other cohorts. These effects were related to a decrease of smoking habits in all cohorts, an increase of blood pressure in all cohorts except East Finland, a decrease of serum cholesterol in Finland and the Netherlands, whereas serum cholesterol increases were slight in Italy and large in Serbia and Greece. Weibull distribution shape for coronary heart disease mortality showed slight deceleration in one Finnish and the Dutch cohorts, large acceleration in the Serbian and Greek cohorts. The correlation coefficient of the Risk Factor Change Score versus Weibull shape for the nine cohorts was 0.78 ( R2 = 0.60; p = 0.0132). Conclusions Spontaneous long-term changes of major coronary risk factor levels were associated with changes in the same direction of coronary heart disease mortality risk modelled by the Weibull distribution, expressing a kind of ‘natural experiment’ with an outcome that matches those of controlled preventive trials.

scholarly journals Correlation between blood pressure and five food groups as a coronary heart disease risk factor in middle aged Indian male population

2017 ◽  
Vol 5 (2) ◽  
pp. 636
Author(s):  
Sharad Patel ◽  
Abhay Naik
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Food Group ◽  
Male Population ◽  
Disease Risk Factor ◽  
Heart Disease Risk

Background: Social and lifestyle changes are responsible for the increasing prevalence of coronary heart disease risk factors. Objective of the study was to correlate blood pressure and five food group as a coronary heart disease risk factor in Indian population.Methods: 31 male executives over the age of 30 years working in industry were included in the study. Systolic and diastolic blood pressures were measured with the help of a standard mercury sphygmomanometer.Results: Statistical analysis was carried out and Pearson Correlation was applied. The study showed significant correlation between systolic blood pressure and food group I and food group IV consumption.Conclusions: The present study highlights observation that the blood pressure as a risk factor for coronary heart disease is silently affecting the middle aged Indian male population due to unhealthy life style.

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