Antimicrobial and Wound Healing Potential of Canthium coromandelicum Leaf Extract-A Preliminary Study

Background: The process of wound healing is influenced by various factors such as age, hormones, and wound care. Wound care is done to accelerate wound healing which can be done by various methods, one of them is traditional care. Traditional wound care can use medicinal plants. Rhodomyrtus tomentosa is a medicinal plant that has an antioxidant, anti-inflammatory, antitumor and antibacterial content. Thus this study aims to evaluate the effectiveness of the antiseptic solution of the Rodhomyrtus tomentosa leaf extract on wound healing in male Wistar rats. Method: this research is pure experimental research with post test only control group design. Thirty male white rats were divided into five groups, namely negative control, positive control, Rhodomyrtus tomentosa leaf extract 15%, 30%, and 60%. Rhodomyrtus tomentosa leaf extraction was carried out by maceration method with 70% ethano solvent. The extraction results are divided into 3 concentrations (15%, 30% and 60%). The wound healing process was evaluated by measuring the length of the wound manually from 0 to 10 days in each group. Meanwhile, the number of fibroblast cells was calculated through hematoxylin eosin (HE) staining and observed using an Olympus CX41 microscope with a 10x magnification and objective lens magnification in 3 fields. Result: There was a significant difference in the reduction in wound length (p =< 0,000) between the five experimental groups (Rhodomyrtus tomentosa leaf extract solution 15%, 30% and 60%, negative control and positive control. Solution of rhodomyrtus tomentosa leaf extract accelerated the increase in the number of fibroblasts compared to the negative control group (p = 0.003), but did not make a difference (p = 0.403) with the positive control group. Rhodomyrtus tomentosa leaf extraction solution had the same microscopic effect on the number of fibroblasts with a positive control group given 0.9% NaCl solution. Conclusion: There was a significant difference in the number of fibroblasts between all groups, but no difference in wound healing length.

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Preliminary Study of Clinial Workflow Integration of Spatial Thermograms Application for the Assessment of Burn Wound Healing Process

Advances in Intelligent Systems and Computing - Information Technologies in Biomedicine, Volume 4 ◽

10.1007/978-3-319-06596-0_17 ◽

2014 ◽

pp. 187-195 ◽

Cited By ~ 1

Author(s):

Dominik Spinczyk

Keyword(s):

Wound Healing ◽

Healing Process ◽

Wound Healing Process ◽

Burn Wound ◽

Burn Wound Healing ◽

Workflow Integration ◽

Preliminary Study

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Characterization and Applications of Leaf Extracts of Hemigraphis Alternate

International Journal of Engineering and Advanced Technology - Regular Issue ◽

10.35940/ijeat.a1020.1291s619 ◽

2019 ◽

Vol 9 (1S6) ◽

pp. 108-114

Keyword(s):

Wound Healing ◽

Crude Extract ◽

Leaf Extract ◽

Cellular Migration ◽

Leaf Extracts ◽

Ic50 Value ◽

The Gift ◽

Healing Property ◽

Low Cytotoxicity ◽

Wound Healing Property

Natural products carry out various capabilities and a lot of them have thrilling and useful organic activities. The gift take a look at turned into undertaken to analyze the bioactive compounds and the pharmacological capacity of leaf extract of Hemigraphis alternata. The presence of numerous compounds become characterized by way of FTIR and GCMS. ROS effect and wound recuperation assets have been analyzed and it discovered that crude extract is greater powerful inhibiting ROS manufacturing and it has high wound healing property with properly cellular migration in dose based way. The cytotoxic nature of leaf extract also analyzed with the aid of MTT assay and it suggests low IC50 value of 329.95 µG/ml. The result discovered that the crude extract of H.Alternata leaf is a great wound healer with low cytotoxicity.

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Effects of 1% and 3% Mobe Leaf Extract Gel on Socket Wound Healing after Tooth Extraction

Dentika Dental Journal ◽

10.32734/dentika.v24i1.5327 ◽

2021 ◽

Vol 24 (1) ◽

pp. 1-5

Author(s):

Olivia Avriyanti Hanafiah ◽

Denny Satria ◽

Avi Syafitri

Keyword(s):

Wound Healing ◽

Tooth Extraction ◽

Leaf Extract ◽

Alveolar Bone ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Control Group ◽

P Value ◽

Gel Treatment

Tooth extraction is a process of removing teeth from the alveolar bone. In wound healing, fibroblast are very important cells. The main purpose of this study was to determine the effect of mobe leaf 1% and 3% extract gel (Artocarpus lakoocha) on fibroblast proliferation in post extraction tooth socket wound healing. This research used 16 samples of wistar rats, divided into 4 groups, a positive control group, a negative control group and a 1% and 3% mobe leaf extract gel group. The left mandibular incisors were extracted, then 1% and 3% gels of mobe leaf extract were applied on day 1 to day 7. Data analysis was calculated using the Kruskal-Wallis test on clinical data and one way ANOVA test for microscopic. The result of the socket wound healing activity test for a good concentration of mobe leaf extract gel was 3%. This research shows significant resultith p-value of 0.018 (< 0.05) on the closure of the socket wound clinically which means the closure of the wound accelerates because of the mobe leaf 3% extract gel treatment. The distance of fibroblast on microscopically shows significant resultith a p-value of 0.002 (< 0.05), which means that there was an enlargement of the distance fibroblast at the socket wound closure with application of mobe leaf 3% extract gel. From the results of the study it can be concluded that mobe leaf 3% extract gel has the best ability to show acceleration the closure of the socket wound either clinically or microscopically.

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