Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents

Elderly people are particularly vulnerable to COVID-19, with a high risk of developing severe disease and a reduced immune response to the COVID-19 vaccine. A randomized, placebo-controlled, double-blind trial to assess the effect of the consumption of the probiotic Loigolactobacillus coryniformis K8 CECT 5711 on the immune response generated by the COVID-19 vaccine in an elderly population was performed. Two hundred nursing home residents >60 yrs that had not COVID-19 were randomized to receive L. coryniformis K8 or a placebo daily for 3 months. All volunteers received a complete vaccination schedule of a mRNA vaccine, starting the intervention ten days after the first dose. Specific IgG and IgA antibody levels were analyzed 56 days after the end of the immunization process. No differences between the groups were observed in the antibody levels. During the intervention, 19 subjects had COVID-19 (11 receiving K8 vs. 8 receiving placebo, p = 0.457). Subgroup analysis in these patients showed that levels of IgG were significantly higher in those receiving K8 compared to placebo (p = 0.038). Among subjects >85 yrs that did not get COVID-19, administration of K8 tended to increase the IgA levels (p = 0.082). The administration of K8 may enhance the specific immune response against COVID-19 and may improve the COVID-19 vaccine-specific responses in elderly populations.

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Risperidone and Falls in Ambulatory Nursing Home Residents With Dementia and Psychosis or Agitation: Secondary Analysis of a Double-Blind, Placebo-Controlled Trial

American Journal of Geriatric Psychiatry ◽

10.1097/00019442-200409000-00008 ◽

2004 ◽

Vol 12 (5) ◽

pp. 499-508 ◽

Cited By ~ 38

Author(s):

Ira R. Katz ◽

Marcia Rupnow ◽

Chris Kozma ◽

Lon Schneider

Keyword(s):

Nursing Home ◽

Controlled Trial ◽

Secondary Analysis ◽

Nursing Home Residents ◽

Double Blind ◽

Double Blind Placebo

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The effect of probiotic treatment on elderly patients with distal radius fracture: a prospective double-blind, placebo-controlled randomised clinical trial

Beneficial Microbes ◽

10.3920/bm2016.0067 ◽

2016 ◽

Vol 7 (5) ◽

pp. 631-637 ◽

Cited By ~ 19

Author(s):

M. Lei ◽

L-M. Hua ◽

D-W. Wang

Keyword(s):

Clinical Trial ◽

Elderly Patients ◽

Distal Radius Fracture ◽

Distal Radius ◽

Lactobacillus Casei ◽

Radius Fracture ◽

Double Blind ◽

Double Blind Placebo ◽

Lactobacillus Casei Shirota ◽

Probiotic Treatment

Probiotic treatment has been shown to improve bone formation, increase bone mass density and prevent bone loss. We aimed to assess the effect of probiotic treatment on functional recovery in elderly patients with a distal radius fracture. A total of 417 elderly patients with an acute distal radius fracture were enrolled in this double-blind placebo-controlled clinical trial. They were randomised to receive skimmed milk containing either a commercial probiotic (Lactobacillus casei Shirota) or placebo daily for a period of 6 months after the fracture. Treatment outcomes were the DASH (disabilities of the arm, shoulder and hand) score, pain, complex regional pain syndrome (CRPS) score, active range of motion and grip strength, all of which were measured on a monthly basis. Throughout the duration of the study, DASH score, pain, CRPS score, wrist flexion and grip strength of patients receiving probiotics exhibited a significantly faster pace of improvement than those on placebo, with treatment outcomes of patients receiving Lactobacillus casei Shirota at month 4 at comparable levels with those of patients receiving placebo at month 6. In elderly patients with a fracture of the distal radius, administration of the probiotic could greatly accelerating the healing process.

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