scholarly journals Neuroprotective Therapy in Parkinson's Disease: Current Status and New Directions from Experimental and Genetic Clues

2005 ◽  
Vol 1 (2) ◽  
pp. 107 ◽  
Author(s):  
William Lin ◽  
Un Jung Kang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Current Status ◽  
Neuroprotective Therapy ◽  
New Directions

scholarly journals Tango Therapy: Current Status and the Next Perspective

2018 ◽  
Vol 3 (8) ◽  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dance Therapy ◽  
Well Being ◽  
Medical Application ◽  
Whole Body ◽  
Current Status ◽  
Argentine Tango ◽  
Systemic Analysis ◽  
Health And Well Being

Dance is basically a complex physical activity which either casually or formally organized in which people take part for fitness, health and well-being, social relationships or competition and a worldwide human activity that involves complex whole body movements through space synchronized to music. Dance-related reviews of evidence have examined the effectiveness of dance therapy on psychological and physical health and well-being outcomes in patients with cancer, for schizophrenia, and on depression. Dance therapy was officially described firstly in 1948. The medical application of dance therapy was well reviewed in neurologic conditions. Dance has been used extensively for the treatment of gait and balance dysfunction in individuals with Parkinson’s disease. Especially, Argentine tango is the most frequently employed dance form in the treatment of Parkinson’s disease. Tango therapy may hold promise as an intervention to improve gait, balance, and mobility in a variety of neurological conditions. Tango therapy was approached from dance therapy to the current status of medical application. A more systemic analysis of tango movement for proper and effective therapeutic application of tango is necessary for medical purposes.

Deep brain stimulation for Parkinson's disease: current status and future outlook

2016 ◽  
Vol 6 (4) ◽  
pp. 299-317 ◽  
Author(s):  
Kyle A Smith ◽  
Rajesh Pahwa ◽  
Kelly E Lyons ◽  
Jules M Nazzaro
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Current Status ◽  
Future Outlook ◽  
Deep Brain

scholarly journals Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
M. Flint Beal ◽  
Jayandra Chiluwal ◽  
Noel Y. Calingasan ◽  
Ginger L. Milne ◽  
Mikhail S. Shchepinov ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Fatty Acids ◽  
Parkinson's Disease ◽  
Polyunsaturated Fatty Acids ◽  
Mitochondrial Dysfunction ◽  
Hydrogen Abstraction ◽  
Neuronal Loss ◽  
Motor Deficits ◽  
Beneficial Effects ◽  
Neuroprotective Therapy

AbstractLipid peroxidation is a key to a portfolio of neurodegenerative diseases and plays a central role in α-synuclein (α-syn) toxicity, mitochondrial dysfunction and neuronal death, all key processes in the pathogenesis of Parkinson’s disease (PD). Polyunsaturated fatty acids (PUFAs) are important constituents of the synaptic and mitochondrial membranes and are often the first molecular targets attacked by reactive oxygen species (ROS). The rate-limiting step of the chain reaction of ROS-initiated PUFAs autoxidation involves hydrogen abstraction at bis-allylic sites, which can be slowed down if hydrogens are replaced with deuteriums. In this study, we show that targeted overexpression of human A53T α-syn using an AAV vector unilaterally in the rat substantia nigra reproduces some of pathological features seen in PD patients. Chronic dietary supplementation with deuterated PUFAs (D-PUFAs), specifically 0.8% D-linoleic and 0.3% H-linolenic, produced significant disease-modifying beneficial effects against α-syn-induced motor deficits, synaptic pathology, oxidative damage, mitochondrial dysfunction, disrupted trafficking along axons, inflammation and DA neuronal loss. These findings support the clinical evaluation of D-PUFAs as a neuroprotective therapy for PD.

Sign in / Sign up

Export Citation Format

Share Document