Self-Preservation in Individuals with Alzheimer's Disease

Advances in Psychology, Mental Health, and Behavioral Studies - Psychosocial Studies of the Individual's Changing Perspectives in Alzheimer's Disease ◽

10.4018/978-1-4666-8478-2.ch008 ◽

2015 ◽

pp. 183-207

Author(s):

Sam Fazio ◽

David B Mitchell

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Empirical Evidence ◽

Recent Literature ◽

The Self ◽

Language Usage ◽

Individualized Care ◽

Self Recognition ◽

Social Positioning

The purpose of this chapter is to highlight empirical evidence for the presence and persistence of self in individuals with Alzheimer's disease. First, the authors review their previous findings (Fazio & Mitchell, 2009) that revealed the persistence of self via language usage and delayed visual self-recognition data. Second, the authors present previously unpublished data demonstrating that both level of impairment (mild or moderate) and setting (residential or day center) are related to language usage. Third, the authors review the most recent literature about the self in individuals with Alzheimer's disease, as well as discuss social positioning and its impact on individualized care.

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The Self-Reference Effect on Episodic Memory Recollection in Young and Older Adults and Alzheimer’s Disease

Current Alzheimer Research ◽

10.2174/15672050113106660175 ◽

2013 ◽

Vol 10 (10) ◽

pp. 1107-1117 ◽

Cited By ~ 24

Author(s):

Jennifer Lalanne ◽

Johanna Rozenberg ◽

Pauline Grolleau ◽

Pascale Piolino

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Episodic Memory ◽

The Self ◽

Self Reference

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Covert versus overt self-recognition in late stage Alzheimer's disease

Journal of the International Neuropsychological Society ◽

10.1017/s1355617797001951 ◽

1997 ◽

Vol 3 (2) ◽

pp. 195-198 ◽

Cited By ~ 23

Author(s):

SANDRA M. BOLOGNA ◽

CAMERON J. CAMP

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Late Stage ◽

Memory Systems ◽

Self Recognition ◽

Nondeclarative Memory

Some persons with Alzheimer's disease (AD) lose the ability to recognize themselves, as when they cannot overtly recognize their reflection in a mirror. There is evidence, however, that covert or unconscious self-recognition might be displayed in such individuals. In this study, 3 persons with AD lacking the ability to overtly self-recognize demonstrated multiple instances of unconscious or covert self-recognition. A variety of interventions, inspired by research with prosopagnosics, was implemented to remediate this loss. Interventions enabled all participants to exhibit overt self-recognition, though each did so with the aid of a different intervention. In addition, successful overt self-recognition required a verbal probe and was entirely intervention-dependent: When the intervention was removed, overt self-recognition was lost. Results support a dissociation between explicit–declarative versus implicit–nondeclarative memory systems, and extends this dissociation into the realm of self-recognition in AD. (JINS, 1997, 3, 195–198.)

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Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

RSC Advances ◽

10.1039/c6ra21253k ◽

2016 ◽

Vol 6 (88) ◽

pp. 85058-85062 ◽

Cited By ~ 10

Author(s):

Mayaka Maeno ◽

Hiroya Kondo ◽

Etsuko Tokunaga ◽

Norio Shibata

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Asymmetric Synthesis ◽

Therapeutic Agent ◽

The Self ◽

Keto Ester ◽

Catalytic Asymmetric Synthesis ◽

Palladium Catalyzed ◽

Catalytic Asymmetric ◽

Decarboxylative Allylation

Catalytic asymmetric synthesis of fluorinated donepezil, a promising new therapeutic agent for Alzheimer's disease, was achieved.

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Looking back from loss: views of the self in Alzheimer's disease

Journal of Aging Studies ◽

10.1016/s0890-4065(02)00092-0 ◽

2003 ◽

Vol 17 (1) ◽

pp. 87-99 ◽

Cited By ~ 58

Author(s):

Anne Davis Basting

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

The Self ◽

Looking Back

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Molecular dynamics studies of a β-sheet blocking peptide with the full-length amyloid beta peptide of Alzheimer’s disease

Canadian Journal of Chemistry ◽

10.1139/cjc-2016-0267 ◽

2016 ◽

Vol 94 (10) ◽

pp. 833-841 ◽

Cited By ~ 4

Author(s):

Zohreh Amini ◽

Mohammad Hossein Fatemi ◽

Arvi Rauk

Keyword(s):

Alzheimer’S Disease ◽

Molecular Dynamics ◽

Amyloid Beta ◽

Recognition Site ◽

Full Length ◽

The Self ◽

Amyloid Beta Peptide ◽

Self Recognition ◽

Beta Peptide ◽

Β Sheet

The region encompassing residues 13–23 of the amyloid beta peptide (Aβ(13–23)) of Alzheimer’s disease is the self-recognition site that initiates toxic oligomerization and fibrillization. A number of pseudopeptides have been designed to bind to Aβ(13–23) and been computationally shown to do so with high affinity. More interactions are available in full-length Aβ than are available in the shorter peptide. We describe herein a study by molecular dynamics (MD) of nine distinct complexes formed by one such pseudopeptide, SGA1, with full-length beta amyloid, Aβ(1–42). The relative stabilities of the Aβ–SGA1 complexes were estimated by a combination of MD and ab initio methods. The most stable complex, designated AB1, was found to be one in which SGA1 is bound to the self-recognition site of Aβ(1–42) in an antiparallel β-sheet fashion. Another complex, designated AB3, also involved SGA1 binding to the self-recognition region of Aβ(1–42), albeit with lower affinity. In both AB1 and AB3, SGA1 formed antiparallel β-sheets but to opposite edges of Aβ. A complex, AB4, with similar stability to AB3, was found with a parallel β-sheet in the self-recognition site. A fourth complex, AB7, also with similar stability, formed a parallel β-sheet in the hydrophobic central region of Aβ. In all cases, complexation of SGA1 induced extensive β-sheet structure in Aβ(1–42).

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