Thermography in Animal Models of Cancer

2018 ◽  
pp. 132-158
Author(s):  
Rui M. Gil da Costa ◽  
António Ramos Silva ◽  
Ana Faustino Rocha ◽  
Paula Alexandra Oliveira ◽  
Joaquim Gabriel ◽  
...  
Keyword(s):  
Cancer Research ◽  
Animal Models ◽  
Imaging Techniques ◽  
Therapeutic Strategies ◽  
Cancer Development ◽  
Laboratory Animals ◽  
Major Goal ◽  
Laboratory Rodents ◽  
Carcinogenic Agents ◽  
Animal Models Of Cancer

Laboratory animals provide important models for studying human diseases, including many types of cancer. Mice are among the most commonly used laboratory animals, allowing for the study of carcinogenic agents, cancer development and for testing innovative preventive and therapeutic strategies. Thus, monitoring angiogenesis in animal models is a major goal for cancer research. Among the currently available imaging techniques, thermography is a useful approach for studying the superficial vascularization of cancer, based on their heat emissions. At this chapter emphasis is placed on thermography and its applications on laboratory animals, in comparison with other available and applicable imaging techniques. In conclusion, thermography may be usefully applied to the study of cancer vascularization in animal models, particularly when using laboratory rodents such as mice. Care is needed in adapting existing approaches to the specificities of each animal species.

Thermography in Animal Models of Cancer

2017 ◽  
pp. 237-263
Author(s):  
Rui M. Gil da Costa ◽  
António Ramos Silva ◽  
Ana Faustino Rocha ◽  
Paula Alexandra Oliveira ◽  
Joaquim Gabriel ◽  
...  
Keyword(s):  
Cancer Research ◽  
Animal Models ◽  
Imaging Techniques ◽  
Therapeutic Strategies ◽  
Cancer Development ◽  
Laboratory Animals ◽  
Major Goal ◽  
Laboratory Rodents ◽  
Carcinogenic Agents ◽  
Animal Models Of Cancer

Laboratory animals provide important models for studying human diseases, including many types of cancer. Mice are among the most commonly used laboratory animals, allowing for the study of carcinogenic agents, cancer development and for testing innovative preventive and therapeutic strategies. Thus, monitoring angiogenesis in animal models is a major goal for cancer research. Among the currently available imaging techniques, thermography is a useful approach for studying the superficial vascularization of cancer, based on their heat emissions. At this chapter emphasis is placed on thermography and its applications on laboratory animals, in comparison with other available and applicable imaging techniques. In conclusion, thermography may be usefully applied to the study of cancer vascularization in animal models, particularly when using laboratory rodents such as mice. Care is needed in adapting existing approaches to the specificities of each animal species.

Rodent models for ovarian cancer research

2003 ◽  
Vol 13 (4) ◽  
pp. 405-412 ◽  
Author(s):  
K. D. Sloan Stakleff ◽  
V. E. Von Gruenigen
Keyword(s):  
Ovarian Cancer ◽  
Cancer Research ◽  
Animal Models ◽  
Therapeutic Strategies ◽  
Future Research ◽  
Rodent Models ◽  
Advantages And Disadvantages ◽  
Progression Of Disease ◽  
Conducting Research

Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.

scholarly journals The contribution of laboratory animals to diagnostic imaging research in Greece

2018 ◽  
Vol 68 (1) ◽  
pp. 11
Author(s):  
S. TSELEPIDIS ◽  
K. VASSIOU ◽  
D. ARVANITIS ◽  
C. KALOGEROPOULOU ◽  
K. MARINOU
Keyword(s):  
Animal Models ◽  
Diagnostic Imaging ◽  
Imaging Techniques ◽  
Academic Research ◽  
Laboratory Animals ◽  
Large Animal ◽  
Research Centers ◽  
Large Animal Models ◽  
Imaging Research ◽  
Diagnostic Imaging Techniques

Biomedical research in Greece has rapidly developed during the last 30 years. Diagnostic imaging groundwork is a significant field of interest which has been developed by taking advantage of the basic and applied research capacities including the use of small and large animal models, conventional and/or genetically modified ones. This important outbreak in research has been enhanced by the construction of modern facilities in universities, medical and other academic research centers, the use of new advanced installed equipment, modern imaging techniques, specific contrast media and, of course, specialized personnel. In this manuscript, the research performed regarding diagnostic imaging techniques using animal models in Greece since 1983 is presented. More specifically a recording of the Greek research centers, the number of researchers, species and figures of animal models, diagnostic imaging techniques used, as well as the contribution of projects in the evolution of diagnostic imaging in medicine and veterinary science is presented.

scholarly journals New insights on CRISPR/Cas9-based therapy for breast Cancer

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Hussein Sabit ◽  
Shaimaa Abdel-Ghany ◽  
Huseyin Tombuloglu ◽  
Emre Cevik ◽  
Amany Alqosaibi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Animal Models ◽  
Human Cancer ◽  
Step Process ◽  
Cancer Initiation ◽  
Malignant State ◽  
Treat Breast Cancer

AbstractCRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result in the hallmark of the malignant state. The goal of cancer research is to identify these mutations and correlate them with the underlying tumorigenic process. Using CRISPR/Cas9 tool, specific mutations responsible for cancer initiation and/or progression could be corrected at least in animal models as a first step towards translational applications. In the present article, we review various novel strategies that employed CRISPR/Cas9 to treat breast cancer in both in vitro and in vivo systems.

Cytokines in animal models of cancer

Biotherapy ◽  
1996 ◽  
Vol 8 (3-4) ◽  
pp. 229-241 ◽  
Author(s):  
Frances Burke ◽  
Frances R. Balkwill
Keyword(s):  
Animal Models ◽  
Animal Models Of Cancer

scholarly journals Prebiotics, immune function, infection and inflammation: a review of the evidence

2008 ◽  
Vol 101 (5) ◽  
pp. 633-658 ◽  
Author(s):  
Amy R. Lomax ◽  
Philip C. Calder
Keyword(s):  
Animal Models ◽  
Immune Function ◽  
Intestinal Inflammation ◽  
Adaptive Immune System ◽  
Laboratory Animals ◽  
Beneficial Effects ◽  
Inflammatory Conditions ◽  
Intestinal Infections ◽  
Inflammatory Processes ◽  
Irritable Bowel

β2-1 Fructans are carbohydrate molecules with prebiotic properties. Through resistance to digestion in the upper gastrointestinal tract, they reach the colon intact, where they selectively stimulate the growth and/or activity of beneficial members of the gut microbiota. Through this modification of the intestinal microbiota, and by additional mechanisms, β2-1 fructans may have beneficial effects upon immune function, ability to combat infection, and inflammatory processes and conditions. In this paper, we have collated, summarised and evaluated studies investigating these areas. Twenty-one studies in laboratory animals suggest that some aspects of innate and adaptive immunity of the gut and the systemic immune systems are modified by β2-1 fructans. In man, two studies in children and nine studies in adults indicate that the adaptive immune system may be modified by β2-1 fructans. Thirteen studies in animal models of intestinal infections conclude a beneficial effect of β2-1 fructans. Ten trials involving infants and children have mostly reported benefits on infectious outcomes; in fifteen adult trials, little effect was generally seen, although in specific situations, certain β2-1 fructans may be beneficial. Ten studies in animal models show benefit of β2-1 fructans with regard to intestinal inflammation. Human studies report some benefits regarding inflammatory bowel disease (four positive studies) and atopic dermatitis (one positive study), but findings in irritable bowel syndrome are inconsistent. Therefore, overall the results indicate that β2-1 fructans are able to modulate some aspects of immune function, to improve the host's ability to respond successfully to certain intestinal infections, and to modify some inflammatory conditions.

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

2016 ◽  
Vol 53 (2) ◽  
pp. 327-348 ◽  
Author(s):  
S. A. Youssef ◽  
M. T. Capucchio ◽  
J. E. Rofina ◽  
J. K. Chambers ◽  
K. Uchida ◽  
...  
Keyword(s):  
Animal Models ◽  
Neurodegenerative Diseases ◽  
Laboratory Animals ◽  
Aging Brain

scholarly journals Spontaneous and Induced Animal Models for Cancer Research

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 660
Author(s):  
Anca Onaciu ◽  
Raluca Munteanu ◽  
Vlad Cristian Munteanu ◽  
Diana Gulei ◽  
Lajos Raduly ◽  
...  
Keyword(s):  
Cancer Research ◽  
Animal Models ◽  
Mouse Models ◽  
Behavioral Science ◽  
Laboratory Mouse ◽  
Human Tumor ◽  
Large Animal ◽  
Large Animal Models ◽  
Oncology Research ◽  
Genetically Engineered Mice

Considering the complexity of the current framework in oncology, the relevance of animal models in biomedical research is critical in light of the capacity to produce valuable data with clinical translation. The laboratory mouse is the most common animal model used in cancer research due to its high adaptation to different environments, genetic variability, and physiological similarities with humans. Beginning with spontaneous mutations arising in mice colonies that allow for pursuing studies of specific pathological conditions, this area of in vivo research has significantly evolved, now capable of generating humanized mice models encompassing the human immune system in biological correlation with human tumor xenografts. Moreover, the era of genetic engineering, especially of the hijacking CRISPR/Cas9 technique, offers powerful tools in designing and developing various mouse strains. Within this article, we will cover the principal mouse models used in oncology research, beginning with behavioral science of animals vs. humans, and continuing on with genetically engineered mice, microsurgical-induced cancer models, and avatar mouse models for personalized cancer therapy. Moreover, the area of spontaneous large animal models for cancer research will be briefly presented.

scholarly journals Translational Animal Models for Liver Cancer

2018 ◽  
Vol 2 ◽  
pp. 2 ◽  
Author(s):  
Michele Obeid ◽  
Ramzy C. Khabbaz ◽  
Kelly D. Garcia ◽  
Kyle M. Schachtschneider ◽  
Ron C. Gaba
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Research ◽  
Animal Models ◽  
Liver Cancer ◽  
Small Animal ◽  
Large Animal ◽  
Starting Point ◽  
Perfect Model ◽  
Small Animal Models ◽  
Human Primate

Animal models have become increasingly important in the study of hepatocellular carcinoma (HCC), as they serve as a critical bridge between laboratory-based discoveries and human clinical trials. Developing an ideal animal model for translational use is challenging, as the perfect model must be able to reproduce human disease genetically, anatomically, physiologically, and pathologically. This brief review provides an overview of the animal models currently available for translational liver cancer research, including rodent, rabbit, non-human primate, and pig models, with a focus on their respective benefits and shortcomings. While small animal models offer a solid starting point for investigation, large animal HCC models are becoming increasingly important for translation of preclinical results to clinical practice.

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