Complexity Analysis in Additive Manufacturing for the Production of Tissue Engineering Constructs

2020 ◽  
pp. 370-393
Author(s):  
Kouroush Jenab ◽  
Philip D. Weinsier
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Human Tissue ◽  
Complexity Analysis ◽  
Three Dimensional ◽  
Solid Object ◽  
Tissue Replacement ◽  
3D Solid ◽  
Process Complexity ◽  
Am Processes

Additive Manufacturing (AM) is a process of making a Three-Dimensional (3D) solid object of virtually any shape from a digital model that is used for both prototyping and distributed manufacturing with applications in many fields, such as dental and medical industries and biotech (human tissue replacement). AM refers to technologies that create objects through a sequential layering process. AM processes have several primary areas of complexity that may not be measured precisely, due to uncertain situations. Therefore, this chapter reports an analytical model for evaluating process complexity that takes into account uncertain situations and additive manufacturing process technologies. The model is able to rank AM processes based on their relative complexities. An illustrative example for several processes is demonstrated in order to present the application of the model.

Complexity Analysis in Additive Manufacturing for the Production of Tissue Engineering Constructs

2014 ◽  
pp. 240-257
Author(s):  
Kouroush Jenab ◽  
Philip D. Weinsier
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Human Tissue ◽  
Complexity Analysis ◽  
Three Dimensional ◽  
Solid Object ◽  
Tissue Replacement ◽  
3D Solid ◽  
Process Complexity ◽  
Am Processes

Additive Manufacturing (AM) is a process of making a Three-Dimensional (3D) solid object of virtually any shape from a digital model that is used for both prototyping and distributed manufacturing with applications in many fields, such as dental and medical industries and biotech (human tissue replacement). AM refers to technologies that create objects through a sequential layering process. AM processes have several primary areas of complexity that may not be measured precisely, due to uncertain situations. Therefore, this chapter reports an analytical model for evaluating process complexity that takes into account uncertain situations and additive manufacturing process technologies. The model is able to rank AM processes based on their relative complexities. An illustrative example for several processes is demonstrated in order to present the application of the model.

scholarly journals Advances in 3D Printing for Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3149
Author(s):  
Angelika Zaszczyńska ◽  
Maryla Moczulska-Heljak ◽  
Arkadiusz Gradys ◽  
Paweł Sajkiewicz
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Complex Structure ◽  
Three Dimensional ◽  
Computer Assisted ◽  
Scaffold Fabrication ◽  
Manufacturing Techniques ◽  
Printing Techniques ◽  
State Of Art

Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

scholarly journals Additive manufacturing in medical sciences: past, present and the future

2018 ◽  
Vol 5 (1) ◽  
pp. 201
Author(s):  
Lakshya P. Rathore ◽  
Naina Verma
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Biological Tissue ◽  
Patient Specific ◽  
Basic Fact ◽  
Medical Sciences ◽  
Novel Technique ◽  
Patient Specific Implants ◽  
Tissue Replacement ◽  
The Future

Additive manufacturing (AM) is a novel technique that despite having been around for more than 35 years, has been underutilized. Its great advantage lies in the basic fact that it is incredibly customizable. Since its use was recognized in various fields of medicine like orthopaedics, otorhinolaryngology, ophthalmology etc, it has proved to be one of the most promising developments in most of them. Customizable orthotics, prosthetics and patient specific implants and tracheal splints are few of its advantages. And in the future too, the combination of tissue engineering with AM is believed to produce an immense change in biological tissue replacement.

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

Advancements in Manufacturing Technology With Additive Manufacturing and Its Context With Industry 4.0

2021 ◽  
pp. 1-24
Author(s):  
Ganzi Suresh
Keyword(s):  
Additive Manufacturing ◽  
Industry 4.0 ◽  
Industrial Revolution ◽  
Three Dimensional ◽  
Metal Alloys ◽  
Layer By Layer ◽  
Post Processing ◽  
Clear Insight ◽  
Am Processes ◽  
Insight Into

Additive manufacturing (AM) is also known as 3D printing and classifies various advanced manufacturing processes that are used to manufacture three dimensional parts or components with a digital file in a sequential layer-by-layer. This chapter gives a clear insight into the various AM processes that are popular and under development. AM processes are broadly classified into seven categories based on the type of the technology used such as source of heat (ultraviolet light, laser) and type materials (resigns, polymers, metal and metal alloys) used to fabricate the parts. These AM processes have their own merits and demerits depending upon the end part application. Some of these AM processes require extensive post-processing in order to get the finished part. For this process, a separate machine is required to overcome this hurdle in AM; hybrid manufacturing comes into the picture with building and post-processing the part in the same machine. This chapter also discusses the fourth industrial revolution (I 4.0) from the perspective of additive manufacturing.

scholarly journals Polymer-Derived Biosilicate®-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5170
Author(s):  
Fulden Dogrul ◽  
Paulina Ożóg ◽  
Martin Michálek ◽  
Hamada Elsayed ◽  
Dušan Galusek ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Room Temperature ◽  
Three Dimensional ◽  
Glass Ceramics ◽  
Gas Release ◽  
Carbon Phase ◽  
Digital Light Processing ◽  
Direct Ink Writing ◽  
Additive Manufacturing Technology

Silicone resins, filled with phosphates and other oxide fillers, yield upon firing in air at 1100 °C, a product resembling Biosilicate® glass-ceramics, one of the most promising systems for tissue engineering applications. The process requires no preliminary synthesis of parent glass, and the polymer route enables the application of direct ink writing (DIW) of silicone-based mixtures, for the manufacturing of reticulated scaffolds at room temperature. The thermal treatment is later applied for the conversion into ceramic scaffolds. The present paper further elucidates the flexibility of the approach. Changes in the reference silicone and firing atmosphere (from air to nitrogen) were studied to obtain functional composite biomaterials featuring a carbon phase embedded in a Biosilicate®-like matrix. The microstructure was further modified either through a controlled gas release at a low temperature, or by the revision of the adopted additive manufacturing technology (from DIW to digital light processing).

scholarly journals On the Impact of Additive Manufacturing Processes Complexity on Modelling

2021 ◽  
Vol 11 (16) ◽  
pp. 7743
Author(s):  
Panagiotis Stavropoulos ◽  
Panagis Foteinopoulos ◽  
Alexios Papapacharalampopoulos
Keyword(s):  
Additive Manufacturing ◽  
Performance Indicators ◽  
Part Quality ◽  
Build Time ◽  
Modelling Techniques ◽  
And Performance ◽  
The Many ◽  
Process Complexity ◽  
The Impact ◽  
Am Processes

The interest in additive manufacturing (AM) processes is constantly increasing due to the many advantages they offer. To this end, a variety of modelling techniques for the plethora of the AM mechanisms has been proposed. However, the process modelling complexity, a term that can be used in order to define the level of detail of the simulations, has not been clearly addressed so far. In particular, one important aspect that is common in all the AM processes is the movement of the head, which directly affects part quality and build time. The knowledge of the entire progression of the phenomenon is a key aspect for the optimization of the path as well as the speed evolution in time of the head. In this study, a metamodeling framework for AM is presented, aiming to increase the practicality of simulations that investigate the effect of the movement of the head on part quality. The existing AM process groups have been classified based on three parameters/axes: temperature of the process, complexity, and part size, where the complexity has been modelled using a dedicated heuristic metric, based on entropy. To achieve this, a discretized version of the processes implicated variables has been developed, introducing three types of variable: process parameters, key modeling variables and performance indicators. This can lead to an enhanced roadmap for the significance of the variables and the interpretation and use of the various models. The utilized spectrum of AM processes is discussed with respect to the modelling types, namely theoretical/computational and experimental/empirical.

Importance of 3D Printing Technology in Medical Fields

2019 ◽  
pp. 21-40
Author(s):  
Ranjit Barua ◽  
Sudipto Datta ◽  
Amit Roychowdhury ◽  
Pallab Datta
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
New Technology ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Medical Field ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Proper Material

Three-dimensional or 3D printing technology is a growing interest in medical fields like tissue engineering, dental, drug delivery, prosthetics, and implants. It is also known as the additive manufacturing (AM) process because the objects are done by extruding or depositing the material layer by layer, and the material may be like biomaterials, plastics, living cells, or powder ceramics. Specially in the medical field, this new technology has importance rewards in contrast with conventional technologies, such as the capability to fabricate patient-explicit difficult components, desire scaffolds for tissue engineering, and proper material consumption. In this chapter, different types of additive manufacturing (AM) techniques are described that are applied in the medical field, especially in community health and precision medicine.

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