scholarly journals Polymer-Derived Biosilicate®-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5170
Author(s):  
Fulden Dogrul ◽  
Paulina Ożóg ◽  
Martin Michálek ◽  
Hamada Elsayed ◽  
Dušan Galusek ◽  
...  

Silicone resins, filled with phosphates and other oxide fillers, yield upon firing in air at 1100 °C, a product resembling Biosilicate® glass-ceramics, one of the most promising systems for tissue engineering applications. The process requires no preliminary synthesis of parent glass, and the polymer route enables the application of direct ink writing (DIW) of silicone-based mixtures, for the manufacturing of reticulated scaffolds at room temperature. The thermal treatment is later applied for the conversion into ceramic scaffolds. The present paper further elucidates the flexibility of the approach. Changes in the reference silicone and firing atmosphere (from air to nitrogen) were studied to obtain functional composite biomaterials featuring a carbon phase embedded in a Biosilicate®-like matrix. The microstructure was further modified either through a controlled gas release at a low temperature, or by the revision of the adopted additive manufacturing technology (from DIW to digital light processing).

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Matteo Caprioli ◽  
Ignazio Roppolo ◽  
Annalisa Chiappone ◽  
Liraz Larush ◽  
Candido Fabrizio Pirri ◽  
...  

AbstractSelf-healing hydrogels may mimic the behavior of living tissues, which can autonomously repair minor damages, and therefore have a high potential for application in biomedicine. So far, such hydrogels have been processed only via extrusion-based additive manufacturing technology, limited in freedom of design and resolution. Herein, we present 3D-printed hydrogel with self-healing ability, fabricated using only commercially available materials and a commercial Digital Light Processing printer. These hydrogels are based on a semi-interpenetrated polymeric network, enabling self-repair of the printed objects. The autonomous restoration occurs rapidly, at room temperature, and without any external trigger. After rejoining, the samples can withstand deformation and recovered 72% of their initial strength after 12 hours. The proposed approach enables 3D printing of self-healing hydrogels objects with complex architecture, paving the way for future applications in diverse fields, ranging from soft robotics to energy storage.


2021 ◽  
Author(s):  
Alexey Pustovarenko ◽  
Beatriz Seoane ◽  
Edy Abou-Hamad ◽  
Helen E King ◽  
Bert Weckhuysen ◽  
...  

3D printing, also known as additive manufacturing technology, has greatly expanded across multiple sectors of technology replacing classical manufacturing methods by combining processing speed and high precision. The scientific interest...


Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3149
Author(s):  
Angelika Zaszczyńska ◽  
Maryla Moczulska-Heljak ◽  
Arkadiusz Gradys ◽  
Paweł Sajkiewicz

Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.


Author(s):  
Laura Daniela Vallejo Melgarejo ◽  
Jose García ◽  
Ronald G. Reifenberger ◽  
Brittany Newell

This document condenses the results obtained when 3D printing lenses and their potential use as diffraction gratings using Digital Light Processing (DLP), as an additive manufacturing technique. This project investigated the feasibility of using DLP additive manufacturing for producing custom designed lenses and gratings. DLP was identified as the preferred manufacturing technology for gratings fabrication. Diffraction gratings take advantage of the anisotropy, inherent in additive manufacturing processes, to produce a collated pattern of multiple fringes on a substrate with completely smooth surfaces. The gratings are transmissive and were manufactured with slit separations of 10, 25 and 50 μm. More than 50 samples were printed at various build angles and mechanically treated for maximum optical transparency. The variables of the irradiance equation were obtained from photographs taken with an optical microscope. These values were used to estimate theoretical irradiance patterns of a diffraction grating and compared against the experimental 3-D printed grating. The resulting patterns were found to be remarkably similar in amplitude and distance between peaks when compared to theoretical values.


2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.


Author(s):  
Kouroush Jenab ◽  
Philip D. Weinsier

Additive Manufacturing (AM) is a process of making a Three-Dimensional (3D) solid object of virtually any shape from a digital model that is used for both prototyping and distributed manufacturing with applications in many fields, such as dental and medical industries and biotech (human tissue replacement). AM refers to technologies that create objects through a sequential layering process. AM processes have several primary areas of complexity that may not be measured precisely, due to uncertain situations. Therefore, this chapter reports an analytical model for evaluating process complexity that takes into account uncertain situations and additive manufacturing process technologies. The model is able to rank AM processes based on their relative complexities. An illustrative example for several processes is demonstrated in order to present the application of the model.


2020 ◽  
pp. 370-393
Author(s):  
Kouroush Jenab ◽  
Philip D. Weinsier

Additive Manufacturing (AM) is a process of making a Three-Dimensional (3D) solid object of virtually any shape from a digital model that is used for both prototyping and distributed manufacturing with applications in many fields, such as dental and medical industries and biotech (human tissue replacement). AM refers to technologies that create objects through a sequential layering process. AM processes have several primary areas of complexity that may not be measured precisely, due to uncertain situations. Therefore, this chapter reports an analytical model for evaluating process complexity that takes into account uncertain situations and additive manufacturing process technologies. The model is able to rank AM processes based on their relative complexities. An illustrative example for several processes is demonstrated in order to present the application of the model.


Traditional wires and brackets has been widely used as orthodontic devices for long time. The metal wires and brackets help to correct the position of teeth as well as fix the cavity. However, metal brace wires have quite a lot limitations. Patients wearing metal brace have many food restrictions and feel not comfortable. Brushing and flossing are required to remove the food debris frequently. Hence, clear plastic aligners have popped up recently. Since the metal brace fabrication process has associated with prolonged process time as a result of a long workflow process starting from brace mold presentation to the prosthesis execution. The growing of additive manufacturing technology make it possible to develop complex structures and shapes of dental brace. By combining 3D oral scanning, it is possible to shorten the lead time of orthodontic treatment process. This review, therefore, investigates the use of Digital Light Processing (DLP) Additive Manufacturing Technology for plastic dental brace development as a remedy to the problems associated with the traditional methods. The study reveals that it is feasible to fabricate these plastic braces utilising the DLP technology. DLP technology is affordable and arguably able to produce dental models with high levels of assurance and accuracy.


Author(s):  
Ranjit Barua ◽  
Sudipto Datta ◽  
Amit Roychowdhury ◽  
Pallab Datta

Three-dimensional or 3D printing technology is a growing interest in medical fields like tissue engineering, dental, drug delivery, prosthetics, and implants. It is also known as the additive manufacturing (AM) process because the objects are done by extruding or depositing the material layer by layer, and the material may be like biomaterials, plastics, living cells, or powder ceramics. Specially in the medical field, this new technology has importance rewards in contrast with conventional technologies, such as the capability to fabricate patient-explicit difficult components, desire scaffolds for tissue engineering, and proper material consumption. In this chapter, different types of additive manufacturing (AM) techniques are described that are applied in the medical field, especially in community health and precision medicine.


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